CN1238187A

CN1238187A - Chinese herbal medicine for radically treating hepatitis B

Info

Publication number: CN1238187A
Application number: CN 98103472
Authority: CN
Inventors: 姜彬
Original assignee: Individual
Current assignee: Individual
Priority date: 1998-08-04
Filing date: 1998-08-04
Publication date: 1999-12-15

Abstract

A Chinese-herbal medicine for radically treating hepatitis B is prepared from 16 Chinese medicinal materials including Chinese bothriospermum, cottonsedge, lonicera, patrinia scabiosaefolla, red sage root, etc through conventional process to obtain different forms. Its advantages include high cure rate, high total effective rate up to more than 95%, short course of treatment, low cost, and no toxic by-effect.

Description

A kind of Chinese herbal and crude drugs preparations of radically treating hepatitis B

The present invention relates to a kind of Chinese herbal and crude drugs preparations of radically treating hepatitis B, belong to tcm field.

Hepatitis B has caused the concern of countries in the world with its popular wide, characteristics such as infectiousness is strong, sickness rate is high, harm is serious, is listed in one of world's pertinacious disease by The World Health Organization (WHO).China is the hepatitis B district occurred frequently, has people more than 600,000,000 must cross hepatitis B approximately, and 1.2 hundred million hepatitis B virus carrierss are arranged at present approximately, accounts for half of the world.Annual 300000 people that account for because of hepatopathy death, wherein 50% is the constitutional hepatitis relevant with hepatitis C or hepatitis B.In recent years, the quantity of hepatitis B patient is growing on and on, this is because China's exist actually the surprising source of infection--1,200 ten thousand hepatitis B patients and 1.2 hundred million hepatitis B virus carrierss, the multiple route of transmission of hepatitis B makes this huge source of infection constitute very big threat for the crowd of Community health.

In the medicine of treatment hepatitis B, adopt the liver protecting therapy method at present, clinical symptoms is improved very fast more, but the formation of liver function recovery and interferon is not ideal enough, and especially hepatitis B virus still duplicates in vivo.Elimination is present in the intravital hepatitis B virus of patient though many Chinese and western drugses to improving liver function, alleviate clinical symptoms, suppress virus replication and obtained certain achievement, are difficult to thoroughly, and patient usually has virus and leaves hospital, and relapse rate is also higher.Aspect the research of antiviral, conciliation body's immunity, do not make a breakthrough as yet, still there are not specific medicament and specific short so far.Also extremely expensive aspect the medical expense of treatment hepatitis B, several thousand yuan at least, tens thousand of at most units rescue a routine hepatitis gravis and expend 1～2.5 ten thousand yuan approximately, have brought white elephant for family and unit.According to incompletely statistics: China was used for the free medical treatment expense of hepatitis B in 1991 unexpectedly up to 22.6 hundred million yuans.In sum, the treatment of hepatitis B research has become the important brainstorm project of China and even world medical circle.

The objective of the invention is: motherland's Chinese medicine theory specifically is applied in the clinical treatment of hepatitis B, deficiency at existing medicine, provide a kind of can the radically treating hepatitis B, and short treating period, cost is low, production technology is easy, without any side effects pure Chinese herbal and crude drugs preparations and compound method thereof.

Design of the present invention is: forms by 16 flavor Chinese herbal medicine compatibilities altogether, wherein speckle grass, Herba Turczaninowiae Fastigiatae, Aleuritopteris argentea (Gmel.) Fee, bear cold grass, the Radix Rehmanniae, YELAN Artemisia, indigo-blue, the grass roots of trembling with fear and account for 50～70%; Tsuchikane tea root, Huang Yu, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Patrinia scabiosaefolia Fisch grass, Radix Angelicae Sinensis account for 20～40%; Herba Wedeliae Wallichii, Fructus Citri Sarcodactylis account for 5～10%.

Aforementioned pharmaceutical compositions of the present invention, pharmaceutical preparation technology routinely can be made into any pharmaceutical dosage form that is suitable for clinical use, as pill, tablet, powder, oral liquid, capsule etc.To not reach therapeutic effect of the present invention if be lower than the low limit value of prescription, the ceiling value that is higher than prescription is with the toxigenicity side effect.

The present invention is extensively collecting on the basis of the earthwork among the people, folk prescription, proved recipe, secret recipe, widely collects current expert again, the well-known doctor parent offers efficacious medicine,divination,and similar arts, selects its elite and partly forms, and is precious.Compound compatibility is rigorous, usage is easy, determined curative effect: eliminating evil and not high suddenly, comfort just and not dullly, and act on gentle.Select medicine with strong points, both can be eliminating evil with conditioning functions, can comfort again and just improve immunity.Though various medicines are targeted, but complement each other, and bring out the best in each other, and containing extremely rich experience and working people's crystallization of wisdom in the tcm field.Through clinical verification, its total effective rate is compared with domestic and international similar drug up to more than 95%, has very significant technological progress.The present invention overcome the Western medicine antiviral therapy, adjusted body's immunity (immunopotentiating agent and immunoregulatory agent), toxic and side effects is big in the clinical practices such as liver protecting therapy, the HBsAg negative conversion rate is low, cost an arm and a leg, easily wait many defectives repeatedly after the drug withdrawal in, also demonstrated fully the characteristic of the multistage multichannel of motherland's medical science, whole regulation and control.

Analysis-by-synthesis the present invention, its effect characteristics mainly contain following four aspects:

1, eliminating damp-heat: clearing away heat-damp and promoting diuresis or heat-clearing and toxic substances removing medicine mainly are antiviral, anti-inflammation, promoting the function of the gallbladder to alleviate jaundice to the effect of hepatitis.Hbs antigen is had than the obvious suppression effect, have direct anti-virus ability.At the initial stage of a disease, with antiphlogistic and bactericidal, effective disease controlling, for the damp and hot liver and gall that check, so that bile pent-up, long-term high jaundice patient then has significant jaundice eliminating effect.In addition, can also strengthen phagocytic function by eliminating damp-heat, regulate immunity, increase the burst size of rat macrophage hydrogen peroxide and the reduction reaction of enhancing macrophage nitrogen blue tetrazole, increase the generation of macrophage bacteriolyze, and the generation of macrophage prostaglandin E is reduced, its antibacterial Detoxication also may be by adjusting body's immunity, comprise the chemotaxis that promotes neutrophilic granulocyte and mobility at random,, improve SC C to strengthen the peritoneal macrophage phagocytic function ₃Bypass promotes specific humoral immunity and cellular immune function to reach the regulating action to the spleen killer cell.

2, function of spleen and stomach regulating: the taste imbalance is the hepatitis patient common sympton, poor appetite often arranged, detest oil, transformation and transportation of the spleen and stomach such as distension and fullness in the abdomen and borborygmus, loose stool is lacked of proper care deficient symptom, these symptoms often through the course of disease all the time, by the spleen invigorating activating the spleen, the spleen and stomach regulating, the mediation Liver and kidney reaches and improves the symptom purpose, corrects the turbid effect of Moschus moschiferous simultaneously in addition.

3, QI and blood regulating: disorder of QI and blood is one of main pathological change of hepatitis, and because of the main catharsis of blood stored in the liver, liver is wet, and must cause the stagnation of QI, and QI and blood accompanies, and the stagnation of QI then stasis is not all right.Various hepatitis all has microcirculation disturbance and blood stasis.By soothing the liver releasing symptom, improve liver function.The utilization blood circulation promoting and blood stasis dispelling, it is unusual to reach correction hemorheology and blood viscosity, and conditioning tissue metabolism improves human immunity reaction purpose.

4, nourishing the liver and kidney: deficiency of the liver and kindey is the common pattern of syndrome of hepatitis.Especially for chronic hepatitis patient, the hepatic and renal YIN deficiency is the principal character that healthy energy degradation phenomenon occurs, adopts YIN nourishing and the production of body fluid promoting, nourishing the liver and kidney, and assistant then is one of rule of treatment for the treatment of both the principal and secondary aspects of a disease with dehumidifying.

From the modern pharmacological research analysis, the present invention is being contained antiviral, is reconciling immunity, is being recovered several key links that hepatopathys are treated in liver function and histopathology improvement etc.Clinical practice explanation: the present invention is to inappetence, the dyspepsia of hepatitis, shortness of breath and fatigue, costalgia abdominal distention, hypomnesis, and diseases such as hepatosplenomegaly, xerostomia dark coloured urine, spontaneous sweating, jaundice have very significant curative effect.But and transaminase lowering, alleviate hepatic injury, remove, eradication hepatitis b virus, promote the liver and spleen retraction deliquescing, prevent liver tissue fibrosis, promote hepatocellular regeneration and reparation.Can bring out human body and produce fresh and alive, rich powerful interferon, human body immunity improving power is recovered the liver homergy, and liver is reborn, thereby is fundamentally reaching the double effects for the treatment of hepatitis and preventing the hepatopathy canceration.Capturing in the following years of hepatitis B, the present invention will shine bigger potential, makes bigger contribution, for more effectively treating hepatitis B shows finer prospect both at home and abroad!

Embodiment:

Speckle grass, Herba Turczaninowiae Fastigiatae, Aleuritopteris argentea (Gmel.) Fee, to bear cold grass, the Radix Rehmanniae, YELAN Artemisia, indigo-blue, cold grass roots total weight be 64g; It is 30g that tsuchikane tea root, Huang Yu, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Patrinia scabiosaefolia Fisch grass, Radix Angelicae Sinensis add up to weight; It is 6g that Herba Wedeliae Wallichii, Fructus Citri Sarcodactylis add up to weight.

Said medicine is mixed in proportion, through pulverize, sieve, behind the sterilization, in the 0# capsule of packing into, sealed packaging promptly becomes the capsule formulation of specific treatment hepatitis B of the present invention.

Claims

1, a kind of Chinese herbal and crude drugs preparations of radically treating hepatitis B is characterized in that: be made up of 16 flavor Chinese herbal medicine compatibilities altogether.Wherein speckle grass, Herba Turczaninowiae Fastigiatae, bear cold grass, the Radix Rehmanniae, YELAN Artemisia, indigo-blue, the grass roots of trembling with fear and account for 50～70%; Tsuchikane tea root, Huang Yu, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Patrinia scabiosaefolia Fisch grass, Radix Angelicae Sinensis account for 20～40%; Herba Wedeliae Wallichii, Fructus Citri Sarcodactylis account for 5～10%.

2, the Chinese herbal and crude drugs preparations of a kind of radically treating hepatitis B according to claim 1, it is characterized in that: according to the pharmaceutical preparation technology of routine, can be made into any pharmaceutical dosage form that is suitable for using clinically, as pill, tablet, powder, oral liquid, capsule etc.

3, the Chinese herbal and crude drugs preparations of a kind of radically treating hepatitis B according to claim 1 is characterized in that: medicine is mixed in proportion, through pulverizing, sieve, behind the sterilization, in the 0# capsule of dress back, promptly becoming the capsule formulation among the present invention.