CN1235565C - Hair growing preparation containing compound of Chinese medicine and Western medicine - Google Patents
Hair growing preparation containing compound of Chinese medicine and Western medicine Download PDFInfo
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- CN1235565C CN1235565C CN 02111941 CN02111941A CN1235565C CN 1235565 C CN1235565 C CN 1235565C CN 02111941 CN02111941 CN 02111941 CN 02111941 A CN02111941 A CN 02111941A CN 1235565 C CN1235565 C CN 1235565C
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Abstract
The present invention discloses a hair restorer containing the compound of Chinese medicines and western medicines, which belongs to the technical field of cosmetics. The hair restorer contains the Chinese medicines of persimmon leaf, oriental arborvitae, ginseng leaf, milk vetch, glossy privet fruit, fleeceflower root, kudzuvine root and dried ginger, the western medicines of minoxidil, vitamin and cystine, and other ingredients. The hair restorer has conspicuous functions of phalacrosis restraint and hair restoration promotion, has good and quick effect, and has particularly conspicuous effect on seborrheic phalacrosis, pelade, etc., and the hair restorer is applicable to patients with phalacrosis caused by various reasons.
Description
Technical field:
The invention belongs to the cosmetics technical field.Be specifically related to an a kind of agent of educating that contains the Chinese medicine and western medicine compound recipe.
Background technology:
Alopecia and hair are rare no matter be to the male or the women is a very sensitive issue, and vexingly can't bear, and easily alopecia of worries, according to U.S.'s facial plasty and reconstructive surgery association, the women who surpasses 2/3 male and 1/5 is subjected to the puzzlement of alopecia.Alternative way is except that wig with reissuing, from medically saying two basic treatment approach: Drug therapy and surgical operation, surgical procedures relates to the minimizing of scalp and the transplanting of hair, this cosmetology needs skilled professional surgeon to do, be used for partial alopecia more, the most suitable male more than 30 years old, though this method is all the fashion, but whole process makes the patient very painful, 2～3 transplanting of the need that have just can be played the satisfied property covered up effect, and surgery cost is very expensive, in case and face-lifting make mistakes, can on scalp, mark for life, produce irreversible infringement.
Can alleviate alopecia though have many medicines and herbal medicinal product to claim, recover hair growth promoting, only have two kinds of medicines to obtain the approval of U.S. FDA at present, i.e. Minoxidil (Minoxidil) and Propecia (Finasteride, finasteride).Minoxidil is by the oral drugs of general strong (Upjohn) company at the treatment severe hypertension of the eighties of last century release sixties, owing to can occur hirsutism in various degree after patient takes medicine, be developed to the gelatinous medicine for external use of commodity " Regine " by name subsequently, but the ratio of its acquisition property covered up hair growth promoting effect is very low, onset time very long (more than 1 year), the back hair of stopping using can come off once again, whether its prescription is best prescription, and the untoward reaction that can produce Pruritus etc., these problems promptings: the hair regrowth of " Regine " is unsatisfactory.Finasteride (commodity are called " Propecia ") is a kind of inhibitor of 5, be originally the patient who is used for male prostatic hyperplasia, clinical practice finds to have hair regrowth, become the oral drugs of treatment alopecia by the exploitation of U.S. Merck drugmaker, obtained the FDA approval in 97 years, also obtained at present the approval of SDA, Chinese commodity " guarantor's method is ended " by name, it needs continuous oral just alopecia minimizing or hair restoration can occur more than three months, advise continuing to take just reaching optimum efficiency in one to two year, but according to its clinical research in 5 years abroad, took this medicine continuously 2 years, 5% obviously improvement of man's alopecia problem appearance is only arranged, 31% man moderate occurs and improves, 30% slight the improvement occur, other 34% patient is invalid, the percentage ratio that obvious improvement and moderate are improved the two addition also has only 36%, coming off once more of hair can appear within several months after the drug withdrawal, the birth defect that also can cause the baby, so not recommending women and children uses, and untoward reaction such as male sexual disorder can appear in the user, so it abroad and be out of favour.Carrying out many research in this field, as gene therapy, new chemical compound even folliculus transplanting etc.
The invention belongs to caused by cosmetics for special use or drug world, be specifically related to a kind of fine complex of forming by Chinese and western drugs of educating outbreak usefulness that has, be mainly used in alopecia and hair rareness or withered and yellow person, to improve the image of its appearance.Along with the rhythm of modern society is progressively accelerated, many extraneous factors such as operating pressure, chemical contamination, fast development of information technology, add heredity, the internal factor of the interior gonadal hormone of spirit, disease, medicine and body etc., cause present alopecia person's number progressively increasing, and present the tendency that becomes younger, increasing 20 or adolescent's progressively alopecia of three teens.It is reported: in state-owned at least 3,000 ten thousand alopecia crowd, there are 5,000 ten thousand hair loss patients in Japan, modal is that the alopecia of android type is called seborrheic alopecia and alopecia areata again, often treat clinically with hormone or immunomodulator, but side effect is bigger, generally unsuitable life-time service, not easy for patients to accept yet.The Western medicine of the oral or external of single component, effect is unsatisfactory and have tangible paying to act on,
Summary of the invention:
Technical problem to be solved by this invention is the agent of educating that research and development can effectively alleviate alopecia, recovery hair growth promoting.
The invention provides an a kind of agent of educating that contains the Chinese medicine and western medicine compound recipe.This is educated an agent and is made up of following traditional Chinese medicines and Western medicine.Every 1000ml educates to send out and contains following component in the agent:
Chinese medicine: Folium Kaki 10～200g, Cacumen Platycladi 10～200g, Folium Ginseng 10～100g, the Radix Astragali 10～200g, Fructus Ligustri Lucidi 5～100g, Radix Polygoni Multiflori 5～100g, Radix Puerariae 5～100g, Rhizoma Zingiberis 5～100g.
Western medicine: Minoxidil 1～100g, retinoic acid 0.01～1g, vitamin B
10.1～5g, vitamin B
20.1～5g, vitamin B
60.1～5g, vitamin E 0.1～5g, cystine 0.1～5g, serine 0.1～5g,, leucine 0.1～5g.
The natural anti-agent of itching: paeonol 0.1～50g, transdermal enhancer: azone 0.1～50ml.
From the basis of the Chinese medicine prescription of applicating history in several thousand and single proved recipe, in conjunction with experimental models such as the hair follicle organ of modern skin science and hair papilla cell cultivations, filter out effective plant material, design Chinese medicine preparation with traditional Chinese medicine theory, the multiple western medicine composition of compatibility again, the effective complex that combines.This product on the aspect of too many levels, many target spots, promotes the growth of hair at the complexity of the alopecia origin cause of formation, improves the effective percentage and the coverage rate of treatment alopecia, reduces side effect.
The present invention adopts the Folium Kaki with blood vessel dilating effect, Cacumen Platycladi is that principal agent (contains a large amount of vitamin Cs and multiple flavones ingredient in the Folium Kaki, the effect that has blood vessel dilating and increase blood flow, it has proliferation function and DNA to synthesize to the hair follicle cell of cultivating facilitation is arranged, Cacumen Platycladi also contains flavones ingredient, this flavor medicine is all arranged in effective prescription of many treatment alopecias from ancient times to the present, it is effective really to control and minimizing alopecia), the Folium Ginseng that cooperates the QI invigorating nourishing yin effect, the Radix Astragali, Fructus Ligustri Lucidi, (the effective ingredient ginsenoside in the Folium Ginseng is the activating agent of hair follicle cell to Radix Polygoni Multiflori, the Radix Astragali can increase this effect, Fructus Ligustri Lucidi and Radix Polygoni Multiflori have tangible hair regeneration effect, and Radix Polygoni Multiflori has certain effect to suppressing sebaceous secretion), cooperate the Rhizoma Zingiberis of invigorating blood circulation with the hair follicle stimulating effect, add of the effect of the isoflavones components of vegetal estrogenic component-Radix Puerariae to antiandrogen, natural pruritus paeonol, cooperate the Western medicine Minoxidil (to stimulate corium hair papilla cell overexpression VEGF VEGF, increase the protein expression of VEGFmRNA and VEGF, thereby the growth of hair follicle stimulating), the tretinoin and the derivant that suppress sebum secretion, compound vitamin B and derivant thereof, vitamin E and derivant thereof, several amino acids composition and transdermal enhancer azone, to increase the nutrition of hair, promote ingredient to see through cortex, infiltrate hair follicle and blood capillary on every side, better bring into play the local action of this product at the scalp layer.
Another object of the present invention provides above-mentioned a kind of preparation method of sending out agent of educating that contains the Chinese medicine and western medicine compound recipe, this method is to get each Chinese medicinal components to clean, and adds 10～90% ethanol of 1～20 times of amount, heating and refluxing extraction 0.5～5 hour or merceration 5～10 days, filter filtrate for later use; Get above-mentioned western medicine composition and anti-itch agent, transdermal enhancer, add an amount of propylene glycol, Chinese medicine extraction liquid, stirring, dissolving, filtration, fill obtain of the present invention educating and send out agent.
Of the present invention educating sent out agent after 50 routine volunteers are on probation, obtains well-content effect.The general use about fortnight, shave one's head and obviously to reduce, use about one month (1 bottle), promptly there is the fine hair of black to grow, after using two bottles, can see hair growth, alopecia areata patient can cover the alopecia position in general 3～6 months substantially, the seborrheic alopecia patient can cover the alopecia position in general 6～10 months substantially, and it is not only black but also bright to observe the hair that newly grows.
The present invention has obvious inhibition alopecia, trichogenous effect, effective, instant effect, be applicable to the hair loss patient that a variety of causes causes, especially obvious especially to effects such as intractable seborrheic alopecia (male pattern alopecia), alopecia areatas, also can be used for the alopecia that multiple reason such as alopecia universalis, alopecia totalis, chemicotherapy, immunologic hypofunction or medicine, heritability etc. causes, and do not have tangible untoward reaction.
The specific embodiment:
Embodiment 1
Take by weighing Chinese medicine: Folium Kaki 20g, Cacumen Platycladi 20g, Folium Ginseng 20g, Radix Astragali 20g, Fructus Ligustri Lucidi 10g, Radix Polygoni Multiflori 10g, Radix Puerariae 10g, Rhizoma Zingiberis 10g adds 30% ethanol of 5 times of amounts, heating and refluxing extraction 1 hour or merceration 6 days, filter, filtrate concentrates standby, takes by weighing each western medicine composition: Minoxidil 10g, retinoic acid 0.5g, vitamin B
10.5g, vitamin B
20.5g, vitamin B
60.5g, vitamin E 0.5g, cystine 0.5g, serine 0.5g,, leucine 0.5g, paeonol 2g, azone 5ml, merge with above-mentioned Chinese medicine extraction liquid, add an amount of propylene glycol and ethanol to 1000ml, stirring, dissolving, filtration, fill promptly get complex of the present invention.
Embodiment 2
Take by weighing Chinese medicine: Folium Kaki 50g, Cacumen Platycladi 50g, Folium Ginseng 40g, Radix Astragali 50g, Fructus Ligustri Lucidi 30g, Radix Polygoni Multiflori 30g, Radix Puerariae 30g, Rhizoma Zingiberis 30g adds 50% ethanol of 10 times of amounts, heating and refluxing extraction 2 hours or merceration 8 days, filter, filtrate concentrates standby, takes by weighing each western medicine composition: Minoxidil 40g, retinoic acid 1g, vitamin B
11g, vitamin B
21g, vitamin B
61g, vitamin e1 g, cystine 1g, serine 1g,, leucine 1g, paeonol 10g, azone 10ml merges with above-mentioned Chinese medicine extraction liquid, adds an amount of propylene glycol and ethanol to 1000ml, and stirring, dissolving, filtration, fill promptly get complex of the present invention.
Embodiment 3
Take by weighing Chinese medicine: Folium Kaki 90g, Cacumen Platycladi 90g, Folium Ginseng 60g, Radix Astragali 100g, Fructus Ligustri Lucidi 60g, Radix Polygoni Multiflori 50g, Radix Puerariae 60g, Rhizoma Zingiberis 50g adds 70% ethanol of 15 times of amounts, heating and refluxing extraction 3 hours or merceration 10 days, filter, filtrate concentrates standby, takes by weighing each western medicine composition: Minoxidil 60g, retinoic acid 2g, vitamin B
12g, vitamin B
22g, vitamin B
62g, vitamin 2g, cystine 2g, serine 2g, leucine 2g, paeonol 20g, azone 20ml merges with above-mentioned Chinese medicine extraction liquid, adds an amount of propylene glycol and ethanol to 1000ml, and stirring, dissolving, filtration, fill promptly get complex of the present invention.
Embodiment 4
Take by weighing Chinese medicine: Folium Kaki 150g, Cacumen Platycladi 150g, Folium Ginseng 90g, Radix Astragali 120g, Fructus Ligustri Lucidi 80g, Radix Polygoni Multiflori 80g, Radix Puerariae 80g, Rhizoma Zingiberis 80g adds 80% ethanol of 18 times of amounts, heating and refluxing extraction 4 hours or merceration 10 days, filter, filtrate concentrates standby, takes by weighing each western medicine composition: Minoxidil 80g, retinoic acid 4g, vitamin B
14g, vitamin B
24g, vitamin B
64g, vitamin E 4g, cystine 3g, serine 3g, leucine 3g, paeonol 10g, azone 10ml merges with above-mentioned Chinese medicine extraction liquid, adds an amount of propylene glycol and ethanol to 1000ml, and stirring, dissolving, filtration, fill promptly get complex of the present invention.
Claims (2)
1, a kind ofly contains educating of Chinese medicine and western medicine compound recipe and send out an agent, it is characterized in that this is educated to send out an agent and comprise following traditional Chinese medicines and western medicine composition that every 1000ml educates to send out and contains following component in the agent: Chinese medicine: Folium Kaki 10～200g, Cacumen Platycladi 10～200g, Folium Ginseng 10～100g, the Radix Astragali 10～200g, Fructus Ligustri Lucidi 5～100g, Radix Polygoni Multiflori 5～100g, Radix Puerariae 5～100g, Rhizoma Zingiberis 5～100g, Western medicine: Minoxidil 1～100g, retinoic acid 0.01～1g, vitamin B
10.1～5g, vitamin B
20.1～5g, vitamin B
60.1～5g, vitamin E 0.1～5g, cystine 0.1～5g, serine 0.1～5g,, leucine 0.1～5g.
2, a kind of a kind of preparation method of sending out agent of educating that contains the Chinese medicine and western medicine compound recipe as claimed in claim 1, it is characterized in that this method is Chinese medicine Folium Kaki, Cacumen Platycladi, Folium Ginseng, the Radix Astragali, Fructus Ligustri Lucidi, [Radix Polygoni Multiflori, Radix Puerariae and Rhizoma Zingiberis are cleaned, 10～90% the ethanol that adds 1～20 times of amount, heating and refluxing extraction 0.5～5 hour or merceration 5～10 days, filter, filtrate concentrates standby; Get Western medicine Minoxidil, vitamin A, vitamin B then
1, vitamin B
2, vitamin B
6, vitamin E, cystine, serine and leucine and anti-itch agent paeonol, transdermal enhancer azone, adds an amount of propylene glycol, Chinese medicine extraction liquid, stirring, dissolving, filtration, fill obtain that claim 1 is described educates an agent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02111941 CN1235565C (en) | 2002-06-04 | 2002-06-04 | Hair growing preparation containing compound of Chinese medicine and Western medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02111941 CN1235565C (en) | 2002-06-04 | 2002-06-04 | Hair growing preparation containing compound of Chinese medicine and Western medicine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1463693A CN1463693A (en) | 2003-12-31 |
| CN1235565C true CN1235565C (en) | 2006-01-11 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02111941 Expired - Fee Related CN1235565C (en) | 2002-06-04 | 2002-06-04 | Hair growing preparation containing compound of Chinese medicine and Western medicine |
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| CN (1) | CN1235565C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013059942A1 (en) * | 2011-10-28 | 2013-05-02 | Afexa Life Sciences Inc. | Use of a ginseng extract to prevent and treat alopecia areata |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107582500B (en) * | 2017-09-15 | 2020-07-03 | 洛阳市西工区神都牡丹香坊 | Hair-blackening and hair-nourishing shampoo preparation containing moutan bark and preparation method thereof |
| CN108403780A (en) * | 2018-04-07 | 2018-08-17 | 武汉名实生物医药科技有限责任公司 | A kind of drug and preparation method thereof with hair tonic function |
| CN112315879B (en) * | 2020-11-13 | 2022-12-23 | 浙江颜雪化妆品有限公司 | Biological factor eyelash nourishing liquid and preparation method thereof |
-
2002
- 2002-06-04 CN CN 02111941 patent/CN1235565C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013059942A1 (en) * | 2011-10-28 | 2013-05-02 | Afexa Life Sciences Inc. | Use of a ginseng extract to prevent and treat alopecia areata |
| GB2509439A (en) * | 2011-10-28 | 2014-07-02 | Afexa Life Sciences Inc | Use of a ginseng extract to prevent and treat alopecia areata |
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| Publication number | Publication date |
|---|---|
| CN1463693A (en) | 2003-12-31 |
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Granted publication date: 20060111 |