CN1233426C - Medical lubricating liquid its use method and medical lubricating catheter - Google Patents
Medical lubricating liquid its use method and medical lubricating catheter Download PDFInfo
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- CN1233426C CN1233426C CN 03121883 CN03121883A CN1233426C CN 1233426 C CN1233426 C CN 1233426C CN 03121883 CN03121883 CN 03121883 CN 03121883 A CN03121883 A CN 03121883A CN 1233426 C CN1233426 C CN 1233426C
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Abstract
The present invention discloses a medical lubricating liquid which can be coated on the surface of medical catheters to reduce frictional resistance, a use method of the lubricating liquid on medical catheters and a medical catheter coated with the lubricating liquid by the method. The medical lubricating liquid comprises a solution A and a solution B which are respectively prepared and used, wherein in the solution A, every 100 portions by volume of organic solvents are prepared from 1.0 to 10 portions by weight of cellulose esters, 0 to 10 portions by weight of adhesion polymers and 1.0 to 10 portions by weight of plasticizing agents; in the solution B, every 100 portions part by volume of solvents are prepared from 1.0 to 20 portions by weight of hydrophilic polymers and 0.3 to 10 portions by weight of cellulose esters; the solutions are coated on the medical catheter in two steps. After the medical lubricating liquid of the present invention is coated to the surface of the medical catheter, the lubricity is good, and the surface friction coefficient can be reduced by 78% at most; in addition, the surface coating of the medical catheter has no lubricity in the dry state, and high lubricity of the surface coating is performed in water environment, which is convenient for doctors to operate.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to be used for the composition of the lubricating fluid of medical equipment, the medical catheter that relates to the using method of this lubricating fluid simultaneously and apply this lubricating fluid.
Background technology
The medical catheter that uses on the clinical medicine comprises that catheter, stomach tube, anus catheter, tracheal intubation, sputum aspirator tube, nasal cavity intubate etc. are the body interpolation pipe at present, generally all be that common medical rubber hose and PVC flexible pipe are made, in use the deficiency of Cun Zaiing is that the surperficial contact friction resistance of the surface of body and body cavities is big, the patient suffering is big in the infusion therapy process, doctor's implementation and operation difficulty.
For reducing friction, a kind of way is to apply lubricating fluid at conduit outer wall.U.S.Pat.NO.5 has used a kind of lubricating fluid in 077,352 patent, the method that adopts a step to apply applies at catheter surface, contains isocyanates, polyhydroxylated polymer and polyethylene glycol oxide in the used lubricating fluid.The shortcoming of this method is that the resting period after lubricating fluid is made is quite limited, has very high reactivity between isocyanates wherein and the polyhydroxylated polymer, thereby the resting period of lubricating fluid is very short.In addition, the lubricity of the catheter surface coating that obtains with this method is general.
Other has U.S.Pat.NO.5, has used a kind of structural plastic and a kind of high molecular weight polymers (polyethylene glycol oxide) to reduce the coefficient of friction of catheter surface in 041,100 patent.Structural plastic is meant and the plastics that can form entity structure (as coated film) after polyethylene glycol oxide mixes, can is polyurethane, vinylite, polyolefin (polyethylene, polypropylene or both copolymers) etc.But the coating durability and the uniformity that obtain like this are all undesirable, and coating touches after the water, and polyethylene glycol oxide can be lost in the water, thereby cause the coating lubricity to descend.
Summary of the invention
The object of the invention provides a kind of conduit that makes and applies the lubricating fluid that rear surface frictional resistance reduces.
Another object of the present invention is to provide the using method of above-mentioned lubricating fluid on medical catheter.
A present invention also purpose is to provide the medical catheter that applies above-mentioned lubricating fluid with said method.
For achieving the above object, the present invention takes following design:
A kind of medical lubricating fluid provided by the invention comprises 1# solution and the 2# solution preparing respectively and use, wherein:
Contained each component is in the 1# solution:
A cellulose esters 1.0～10 weight portions,
B adhesiveness polymer 0～10 weight portion,
C plasticizer 1.0～10 weight portions, and
D organic solvent 100 parts by volume;
Contained each component is in the 2# solution:
E hydrophilic polymer 1.0～20 weight portions,
A cellulose esters 0.3～10 weight portion, and
D organic solvent 100 parts by volume.
Wherein, the corresponding relation of weight portion and parts by volume is: when unit of weight was gram, corresponding volume unit was a milliliter, and the rest may be inferred.
Aforesaid medical lubricating fluid, described cellulose esters are selected from a kind of or any two the above combinations in ethyl cellulose, nitrocellulose, cellulose acetate and the cellulose acetate butyrate, are preferably nitrocellulose; Described adhesiveness polymer is selected from a kind of or any two the above combinations in polyurethane, polyester, styrene polybutadiene, acrylic resin and the Merlon; Described plasticizer is selected from a kind of or any two the above combinations in Camphora, Oleum Ricini, DBP (dibutyl phthalate), alkyl resin, dibutyl sebacate and the polyvinyl butyral resin; Described organic solvent is a kind of or any two the above combinations that are selected from ethanol, acetone, ethyl acetate, toluene, lactone, oxolane, ethylene glycol butyl ether, acetic acid Arrcostab, acetic acid, dimethyl formamide and the acetonitrile; Described hydrophilic polymer is the hydrophilic polymer of PVP (polyvinyl pyrrolidone) or PVP-vinyl acetate esters.
Aforesaid medical lubricating fluid, in described 1# solution and the 2# solution in the 100 parts by volume D organic solvents each constituent content be preferably:
1# solution:
A cellulose esters 2.0～7.0 weight portions,
B adhesiveness polymer 1.0～5.0 weight portions,
C plasticizer 1.0～5.0 weight portions, and
2# solution:
E hydrophilic polymer 5.0～10 weight portions,
A cellulose esters 0.5～6.0 weight portion.
The present invention also provides the using method of above-mentioned medical lubricating fluid, in two steps lubricating fluid being coated on the medical catheter:
Step 1: conduit is flooded 1# solution, oven dry;
Step 2: will go up the step conduit and flood 2# solution again, oven dry.
The present invention further provides the medical catheter that applies above-mentioned lubricating fluid with said method, this medical catheter outer surface forms a coating by medical lubricating fluid.
Adopt the advantage of technique scheme to be:
1, all components is to the reaction of human body nonirritant in the medical lubricating fluid, and the resting period is long;
2, the lubricity of the coating that formed by medical lubricating fluid of medical catheter surface is relatively good, and skin-friction coefficient can reduce by 78% at most;
3,, make catheter surface coating durability and uniformity obtain improvement with the method for two-layer coating;
4, the medical catheter face coat is not lubricated when dry state, just shows its good lubricity in aqueous environments, is convenient to doctor's operation.
5, the coating coating processes is easy, and is workable.
The specific embodiment
Among the present invention, lubricating fluid is by 1# solution and 2# solution composition.1# solution and 2# solution are prepared respectively and substep uses, wherein 1# solution by A, the B of constant weight, C three class substance dissolves in the D of certain volume class material, 2# solution by the A of constant weight, E two class substance dissolves in the D of certain volume class material.Wherein, all kinds of materials can be selected for use:
A: cellulose esters comprises: ethyl cellulose, nitrocellulose, cellulose acetate, cellulose acetate butyrate etc., wherein, nitrocellulose the best.
B: adhesiveness polymer: can be polyurethane, polyester, styrene polybutadiene, acrylic resin, Merlon etc.
C: plasticizer: can be Camphora, Oleum Ricini, DBP (dibutyl phthalate), alkyl resin, dibutyl sebacate, polyvinyl butyral resin etc.
D: organic solvent: for acetone, ethyl acetate, toluene, lactone, oxolane, ethylene glycol butyl ether, acetic acid Arrcostab, acetic acid, dimethyl formamide, acetonitrile etc. than common organic solvent.
E: hydrophilic polymer: the hydrophilic polymer that can be PVP (polyvinyl pyrrolidone) or PVP-vinylacetate one class.
Above-mentioned all kinds of material is the commercially available prod, and in the present invention, A, B, C, E select for use " gram " to be measurement unit by weight in the specific embodiment; D is an organic solvent, and by volume selects for use " milliliter " to be measurement unit in the specific embodiment.But when expanding the scale of production, unit of weight can be " kilogram ", and this moment, corresponding volume unit was " liter ".Above-mentioned all kinds of material function in the present invention is respectively:
A: be used to dispose stabilization of polymer solution, be coated in substrate surface, as the bottom of lubricant coating.
B: the adhesiveness polymer is used to improve the adhesion of coating to substrate.
C: plasticizer is used to improve the pliability of coating, makes coating can adapt to case of bending in the use.
D: organic solvent: each component in the solvent soln.
E: hydrophilic polymer: be used to dispose hydrophilic polymer solution, use when secondary applies, as the top layer of lubricant coating, imbibition in aqueous environments shows fabulous lubricity.
Embodiment one:
With nitrocellulose 5.23g, DBP3.5g, acetone 2.5ml, ethanol 45.3ml, ethyl acetate 44ml, toluene 46.8ml, isopropyl alcohol 1.4ml, dimethyl formamide 10ml is mixed with 1# solution; The latex material catheter was immersed in the 1# solution 0.5～1.0 minute, takes out, 60～70 ℃ of oven dry 5～10 minutes down;
With PVP10g, nitrocellulose 1.2g, ethanol 100ml, dimethyl formamide 40ml, ethyl acetate 30ml are mixed with 2# solution; The catheter of drying was above immersed in the 2# solution 0.5～1.0 minute, take out the back, pack afterwards in 60～70 ℃ of bakings 5～10 minutes down.
Embodiment two: with nitrocellulose 3.23g, and polyurethane 1.12g, DBP1.22g, polyvinyl butyral resin 1.12g, acetone 15.0ml, ethyl acetate 44ml, toluene 46.8ml, isopropyl alcohol 16.2ml, dimethyl formamide 28ml is mixed with 1# solution; With PVP17g, nitrocellulose 2.4g, acetone 10ml, ethanol 90ml, dimethyl formamide 30ml, ethyl acetate 40ml are mixed with 2# solution, adopt the method processing PVC material stomach tube identical with embodiment one, obtain the stomach tube after the lubricated.
Embodiment three: with nitrocellulose 3.23g, and DBP4.22g, acetone 12.2ml, ethyl acetate 44ml, toluene 46.8ml, isopropyl alcohol 10ml, dimethyl formamide 20ml, ethanol 17ml is mixed with 1# solution; With PVP5.0g, nitrocellulose 0.6g, ethanol 90ml, dimethyl formamide 30ml, ethyl acetate 30ml, oxolane 20ml is mixed with 2# solution, adopts the method processing PVC material tracheal intubation identical with embodiment one, obtains the tracheal intubation after the lubricated.
Embodiment four: with nitrocellulose 3.0g, DBP 1.22g, polyvinyl butyral resin 2.5g, ethanol 45ml, ethyl acetate 35ml, toluene 45ml, isopropyl alcohol 15ml, acetone 10ml, PVP 1.0g, dimethyl formamide 20ml is mixed with 1# solution, with PVP6.0g, nitrocellulose 1.0g, ethanol 105ml, dimethyl formamide 40ml, ethyl acetate 15ml, acetonitrile 10ml is mixed with 2# solution, adopts the method identical with embodiment one to handle the interior interventional therapy conduit of modified nylon materials system blood vessel, obtains the interior interventional therapy conduit of blood vessel after the lubricated.
Embodiment five: with nitrocellulose 7.8g, polyurethane 2.4g, DBP2.22g, Camphora 1.80g, acetone 2.5ml, ethanol 25ml, butyl acetate 22.5ml, ethyl acetate 44ml, toluene 46.8ml, isopropyl alcohol 4.2ml, dimethyl formamide 5.0ml is mixed with 1# solution, PVP8.5g, nitrocellulose 0.9g, ethanol 90ml, dimethyl formamide 35ml, ethyl acetate 25ml, ethylene glycol butyl ether 20ml are mixed with 2# solution, adopt the method identical to handle the interior interventional therapy conduit (modification of nylon) of blood vessel, obtain the body interpolation pipe after the lubricated with embodiment one.
Embodiment six: with nitrocellulose 3.23g, polyvinyl butyral resin 1.22g, DBP 1.22g, Camphora 0.90g, acetone 5.3ml, ethanol 20ml, butyl acetate 22.5ml, ethyl acetate 44ml, toluene 46.8ml, isopropyl alcohol 1.4ml, dimethyl formamide 10ml is mixed with 1# solution, with PVP 5.0g, and nitrocellulose 0.5g, ethanol 90ml, dimethyl formamide 40ml, ethyl acetate 35ml, acetone 5.0 is mixed with 2# solution, adopt the method processing catheter (latex) identical, obtain the body interpolation pipe after the lubricated with embodiment one.
Effect data
1, catheter surface measuring friction coefficient method:
Test according to the method after the ASTM1894-90 standard is improved.During test, conduit is put into thermostatic water bath, there is the twice groove tank bottom surface in order to A/C, puts a piece of stainless steel on the conduit, on press " L " glass slide, the load of putting on glass.Glass slide is passed smooth pulley by the nylon in lightweight rope and is linked to each other with ergometer.Thereby the pulling glass slide drives piece of stainless steel and slides, and can measure frictional force.During test, the sliding speed of piece of stainless steel is 10mm/min, and load can according to circumstances change.
2, measurement result
Relatively good according to the catheter surface lubricity that embodiment 6 makes, recording its skin-friction coefficient is 0.15.Uncoated catheter surface coefficient of friction is 0.68.
Embodiment seven to embodiment ten:
According to the form below assembly and consumption preparation 1# solution and 2# solution adopt the method identical with embodiment one to handle medical catheter, and with the coefficient of friction of above-mentioned measuring friction coefficient method mensuration catheter surface, data and result such as following table:
| Component | Embodiment seven | Embodiment eight | Embodiment nine | Embodiment ten | ||
| 1# solution | A | Ethyl cellulose (g) | 1.5 | 6.0 | ||
| Nitrocellulose (g) | 2.3 | 5.0 | ||||
| Cellulose acetate (g) | 4.0 | |||||
| Cellulose acetate butyrate (g) | 10.5 | 2 | ||||
| B | Polyurethane (g) | 2.2 | 5.2 | |||
| Polyester (g) | 1.5 | |||||
| Styrene polybutadiene (g) | 3.5 | |||||
| Acrylic resin (g) | 4 | 5.6 | ||||
| Merlon (g) | 4.2 | |||||
| C | Camphora (g) | 0.9 | 1.8 | 5.0 | ||
| Oleum Ricini (g) | 2.5 | 4.0 | ||||
| DBP(g) | 0.6 | 4.0 | ||||
| Alkyl resin (g) | 1.7 | 4.0 | ||||
| Dibutyl sebacate (g) | 2.0 | |||||
| Polyvinyl butyral resin (g) | 1.5 | 1.0 | ||||
| D | Acetone (ml) | 10 | 20 | 2.5 | 5.0 | |
| Ethyl acetate (ml) | 50 | 40 | 30 | |||
| Toluene (ml) | 40 | 45 | 40 | |||
| Lactone (ml) | 20 | |||||
| Oxolane (ml) | 22 | 30 | 24 | |||
| Ethylene glycol butyl ether (ml) | 40 | 20 | ||||
| Acetic acid Arrcostab (ml) | 38 | 20 | ||||
| Acetic acid (ml) | 15 | |||||
| Dimethyl formamide (ml) | 10 | 20 | 31 | |||
| Acetonitrile (ml) | 25 | 2.5 | ||||
| 2# solution | A | Ethyl cellulose (g) | 0.51 | 3 | ||
| Nitrocellulose (g) | 8.0 | |||||
| Cellulose acetate (g) | 14 | |||||
| Cellulose acetate butyrate (g) | 10.2 | |||||
| E | PVP(g) | 1.7 | 5.0 | 21 | ||
| PVP-vinylacetate (g) | 8.0 | 13 | ||||
| D | Acetone (ml) | 15 | 30 | |||
| Ethyl acetate (ml) | 98 | 60 | 38 | |||
| Toluene (ml) | 35 | 30 | 40 | 10 | ||
| Lactone (ml) | 10 | 42 | ||||
| Oxolane (ml) | 10.5 | 20 | 30 | |||
| Ethylene glycol butyl ether (ml) | 10.5 | 20 | 10 | |||
| Acetic acid Arrcostab (ml) | 11 | 10 | ||||
| Acetic acid (ml) | 1.0 | 13 | 25 | |||
| Dimethyl formamide (ml) | 15 | 6.0 | 16 | 40 | ||
| Acetonitrile (ml) | 5.0 | 9.0 | 20 | |||
| The catheter surface coefficient of friction | 0.35 | 0.29 | 0.23 | 0.20 | ||
The medical catheter after lubricated that the various embodiments described above provide, face coat is not lubricated when dry state, is easy to encapsulation, keeping and transportation, and can shows good lubricity in aqueous environments, earlier conduit is soaked in distilled water during use, just can be used for operation.
Claims (5)
1, a kind of medical lubricating fluid is characterized in that, comprises 1# solution and the 2# solution preparing respectively and use, wherein:
Contained each component is in the 1# solution:
A cellulose esters 1.0～10 weight portions,
B adhesiveness polymer 0～10 weight portion,
C plasticizer 1.0～10 weight portions, and
D organic solvent 100 parts by volume;
Contained each component is in the 2# solution:
E hydrophilic polymer 1.0～20 weight portions,
A cellulose esters 0.3～10 weight portion, and
D organic solvent 100 parts by volume;
Wherein, the corresponding relation of weight portion and parts by volume is: when unit of weight was gram, corresponding volume unit was a milliliter, and the rest may be inferred;
Described component A cellulose esters is selected from a kind of or any two the above combinations in ethyl cellulose, nitrocellulose, cellulose acetate and the cellulose acetate butyrate;
Described B component adhesiveness polymer is selected from a kind of or any two the above combinations in polyurethane, polyester, styrene polybutadiene, acrylic resin and the Merlon;
Described component C plasticizer is selected from a kind of or any two the above combinations in Camphora, Oleum Ricini, dibutyl phthalate, alkyl resin, dibutyl sebacate and the polyvinyl butyral resin;
Described component D organic solvent is a kind of or any two the above combinations that are selected from acetone, ethyl acetate, toluene, lactone, oxolane, ethylene glycol butyl ether, acetic acid Arrcostab, acetic acid, dimethyl formamide and the acetonitrile;
Described component E hydrophilic polymer is the hydrophilic polymer of polyvinyl pyrrolidone or polyvinyl pyrrolidone-vinylacetate.
2, medical lubricating fluid according to claim 1 is characterized in that: described component A cellulose esters is a nitrocellulose.
3, medical lubricating fluid according to claim 1 and 2 is characterized in that: in described 1# solution and the 2# solution in the 100 parts by volume organic solvents each constituent content be:
1# solution:
A cellulose esters 2.0～7.0 weight portions,
B adhesiveness polymer 1.0～5.0 weight portions, and
C plasticizer 1.0～5.0 weight portions;
2# solution:
E hydrophilic polymer 5.0～10 weight portions, and
A cellulose esters 0.5～6.0 weight portion.
4, the using method of the arbitrary medical lubricating fluid of a kind of claim 1 to 3 is characterized in that, in two steps lubricating fluid is coated on the medical catheter:
Step 1: conduit is flooded 1# solution, oven dry;
Step 2: will go up the step conduit and flood 2# solution again, oven dry.
5, medical lubrication conduit is characterized in that: described medical catheter surface is lubricated processing with the arbitrary medical lubricating fluid of claim 1 to 3 through the described method of claim 4, forms the lubricating fluid coating on the medical catheter surface.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03121883 CN1233426C (en) | 2003-04-17 | 2003-04-17 | Medical lubricating liquid its use method and medical lubricating catheter |
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| CN 03121883 CN1233426C (en) | 2003-04-17 | 2003-04-17 | Medical lubricating liquid its use method and medical lubricating catheter |
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| CN1537643A CN1537643A (en) | 2004-10-20 |
| CN1233426C true CN1233426C (en) | 2005-12-28 |
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| CN 03121883 Expired - Fee Related CN1233426C (en) | 2003-04-17 | 2003-04-17 | Medical lubricating liquid its use method and medical lubricating catheter |
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101455861B (en) * | 2008-12-17 | 2013-01-02 | 东南大学 | Lubricity coatings preparation method on the medical catheter polymers surface |
| CN102166377A (en) * | 2011-01-05 | 2011-08-31 | 北京泰杰伟业科技有限公司 | Composition, preparation method and use method of lubricating hydrophilic coating for medical catheter |
| CN102973986A (en) * | 2012-07-19 | 2013-03-20 | 黄斌 | Medical super-lubricity antibacterial catheter coating liquid |
| CN104941007A (en) * | 2015-06-19 | 2015-09-30 | 青岛普瑞森医药科技有限公司 | Double-layer crosslinking hydrophilic anti-bacterial coating solution and using method thereof |
| CN106938061B (en) * | 2017-04-17 | 2020-10-16 | 科睿驰（深圳）医疗科技发展有限公司 | Coating method for improving surface of interventional instrument |
| CN107693851A (en) * | 2017-04-25 | 2018-02-16 | 浙江善仁医疗设备制造有限公司 | A kind of medical catheter surface hydrophilic coating lubricating fluid reagent, medical catheter surface treatment method and medical catheter |
| CN107376029A (en) * | 2017-07-17 | 2017-11-24 | 江西丰临医疗科技股份有限公司 | A kind of medical hydrophilic lubrication coating and its method for coating |
| CN111840657A (en) * | 2020-08-21 | 2020-10-30 | 湖南利德森医疗器械有限公司 | Coating preparation for gastroscope detection tube |
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Application publication date: 20041020 Assignee: Beijing Compont Medical Devices Co.,Ltd. Assignor: Inst. of Medical Apparatus, Shandong Prov. Contract record no.: 2012110000143 Denomination of invention: Medical lubricating liquid its use method and medical lubricating catheter Granted publication date: 20051228 License type: Exclusive License Record date: 20120816 |
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