CN107693851A - A kind of medical catheter surface hydrophilic coating lubricating fluid reagent, medical catheter surface treatment method and medical catheter - Google Patents
A kind of medical catheter surface hydrophilic coating lubricating fluid reagent, medical catheter surface treatment method and medical catheter Download PDFInfo
- Publication number
- CN107693851A CN107693851A CN201710273184.2A CN201710273184A CN107693851A CN 107693851 A CN107693851 A CN 107693851A CN 201710273184 A CN201710273184 A CN 201710273184A CN 107693851 A CN107693851 A CN 107693851A
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- CN
- China
- Prior art keywords
- medical catheter
- lubricating fluid
- reagent
- solution
- coating lubricating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/02—Methods for coating medical devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/08—Coatings comprising two or more layers
Abstract
The present invention provides a kind of medical catheter surface hydrophilic coating lubricating fluid reagent, medical catheter surface treatment method and medical catheter, hydrophilic coating lubricating fluid reagent, including No. 1 solution and No. 2 solution, the component of No. 1 solution：Amino silicone alkanes 1 2%, water 8 10%, organic solvent, surplus；The component of No. 2 solution is：Hydrophilic polymer 2 3%, organic solvent, surplus.Medical catheter surface treatment method, the surface of medical catheter is handled with above-mentioned hydrophilic coating lubricating fluid reagent, medical catheter, this is using mentioned reagent and is surface-treated according to the method described above.All components have no adverse reaction to human body in the reagent that the present invention is configured, and have good security, resting period length.The lubricity for the coating that the medical catheter surface of the present invention is formed by mentioned reagent is relatively good, and skin-friction coefficient can at most reduce by 80%.
Description
Technical field
The present invention relates to medical catheter, medical catheter surface treatment agent and surface treatment method.
Background technology
The medical catheter used at present on clinical medicine includes catheter, stomach tube, anal canal, trachea cannula, sputum aspirator tube, nose
Cannula cavity etc. is internal intubation, is typically all that common medical TPU pipes and PVC hose are made, existing deficiency is in use
The surface of body and the surface contact friction resistance of body cavities are big, and patient suffering is big during infusion therapy, and doctor implements behaviour
Make difficult.Rubbed to reduce, a kind of method is to coat lubricating fluid in conduit outer wall.United States Patent (USP) U S5077352 disclose one kind
Lubricating fluid, coated in catheter surface using the method for step coating, polymerize in lubricating fluid used containing isocyanates, polyhydroxy
Thing and polyethylene glycol oxide, it is that the resting period after lubricating fluid is made is fairly limited the shortcomings that this technology, isocyanates therein
There is very high reactivity between polyhydroxylated polymer, thus the resting period of lubricating fluid is very short.In addition, with this method
The lubricity of obtained catheter surface coating is general, and therefore, the Coating Durability and uniformity so obtained is all undesirable, coating
After touching water, polyethylene glycol oxide can be lost in water, so as to cause coating lubricity to decline.
The content of the invention
Technical problems to be solved first of the invention are to provide a kind of medical catheter surface hydrophilic coating lubricating fluid reagent, use
The agent treatment medical catheter surface, skin friction resistance reduction after medical catheter coating can be made.
The technical proposal for solving the technical problem of the invention is：A kind of medical catheter surface hydrophilic coating lubricating fluid examination
Agent, including No. 1 solution and No. 2 solution, wherein, the component of No. 1 solution is：
A：Amino silicone alkanes 1-2%,
B：Water 8-10%,
C：Organic solvent, surplus；
The component of No. 2 solution is：
D：Hydrophilic polymer 2-3%,
C：Organic solvent, surplus；
It is percent by volume above.
Further, component A amino silicone alkanes is gamma-aminopropyl-triethoxy-silane, N- (β-aminoethyl)-γ-ammonia
Hydroxypropyl methyl dimethoxysilane forms combined type amino silane.
Further, component B wet concentration is from one kind in distilled water, purified water.
Further, component C organic solvent is ethanol.
Further, component D hydrophilic polymer is PVP（pvp）Hydrophilic polymer.
The present invention also provides a kind of medical catheter surface treatment method, and this method is with above-mentioned hydrophilic coating lubricating fluid reagent
The surface of medical catheter is handled, and comprised the following steps：
（1）Medical catheter is impregnated into No. 1 solution, dried；
（2）By step（1）After the completion of medical catheter be impregnated into No. 2 solution, dry.
The present invention also provides a kind of medical catheter, and this is using mentioned reagent and is surface-treated according to the method described above.Make
Obtain the hydrophilic coating lubricating fluid that the medical catheter surface is made up of mentioned reagent and form one layer of coating, mantle friction can be reduced
Power.
The beneficial effects of the invention are as follows：
1st, middle all components have no adverse reaction to human body in the reagent that the present invention is configured, and have good security, resting period
It is long.
2nd, the lubricity for the coating that medical catheter surface of the invention is formed by mentioned reagent is relatively good, skin-friction coefficient
80% can at most be reduced.
3rd, with the method for two-layer coating, improved medical catheter face coat durability and uniformity;
4th, medical catheter face coat is not lubricated in dry state, and its good lubricity is just shown in water, is easy to doctor to grasp
Make.
5th, hydrophilic coating coating processes of the invention are easy, workable.
Embodiment
Technical scheme is further illustrated with reference to embodiments, and embodiment is only used for the implementation to the present invention
Scheme is described, so that technical scheme is clearer, but can not be limited the scope of the invention.
Embodiment 1.
Medical catheter surface hydrophilic coating lubricating fluid reagent is made up of No. 1 reagent and No. 2 reagents, No. 1 reagent and No. 2 reagents
It is respectively configured, it is immiscible, and substep uses.
The total amount of No. 1 reagent is 100ml, including,
Gamma-aminopropyl-triethoxy-silane 1ml,
N- (β-aminoethyl)-γ-aminopropyltriethoxy dimethoxysilane 1ml,
Distilled water 10ml,
Ethanol, surplus.
In No. 1 reagent, amino silicone alkanes is used to configure stable polymer solution, coated in substrate surface, as lubrication
The bottom of coating.Water is used to aid in the reagent to be solidificated in medical catheter surface, each component that organic solvent is used in solvent soln.
Organic solvent is ethanol.
The total amount of No. 2 reagents is 100ml, including,
D：PVP（pvp）Hydrophilic polymer 2ml,
C：Ethanol, surplus.
PVP（pvp）Hydrophilic polymer uses in secondary coating, as the top layer of lubricant coating,
The water swelling in aqueous environments, show fabulous lubricity.
Embodiment 2.
Medical catheter surface hydrophilic coating lubricating fluid reagent is made up of No. 1 reagent and No. 2 reagents, No. 1 reagent and No. 2 reagents
It is respectively configured, it is immiscible, and substep uses.
The total amount of No. 1 reagent is 100ml, including,
Gamma-aminopropyl-triethoxy-silane 1ml,
N- (β-aminoethyl)-γ-aminopropyltriethoxy dimethoxysilane 1ml,
Distilled water 10ml,
Ethanol, surplus.
In No. 1 reagent, amino silicone alkanes is used to configure stable polymer solution, coated in substrate surface, as lubrication
The bottom of coating.Water is used to aid in the reagent to be solidificated in medical catheter surface, each component that organic solvent is used in solvent soln.
Organic solvent is ethanol.
The total amount of No. 2 reagents is 100ml, including,
D：PVP（pvp）Hydrophilic polymer 2ml,
C：Ethanol, surplus.
PVP（pvp）Hydrophilic polymer uses in secondary coating, as the top layer of lubricant coating,
The water swelling in aqueous environments, show fabulous lubricity.
Embodiment 3.
Medical catheter is impregnated into No. 1 solution of embodiment 1 or embodiment 2, dried, form thickness in 0.15-
Bottom between 0.18nm；
The medical catheter for having coated bottom is impregnated into No. 2 solution, dried, one layer of lubricant coating is formed in the outside of bottom,
Lubricant coating is fitted tightly over the outer surface of bottom, and the coefficient of friction between lubricant coating and bottom is not less than 2.5
The frictional resistance ＜ 0.02kgf of lubricant coating outer surface, 45 ° of the contact angle ＜ with water.
Claims (7)
1. a kind of medical catheter surface hydrophilic coating lubricating fluid reagent, it is characterised in that the reagent includes No. 1 solution and No. 2 molten
Liquid, wherein, the component of No. 1 solution is：
A：Amino silicone alkanes 1-2%,
B：Water 8-10%,
C：Organic solvent, surplus；
The component of No. 2 solution is：
D：Hydrophilic polymer 2-3%,
C：Organic solvent, surplus；
It is percent by volume above.
A kind of 2. medical catheter surface hydrophilic coating lubricating fluid reagent according to claim 1, it is characterised in that component A
Amino silicone alkanes for gamma-aminopropyl-triethoxy-silane, N- (β-aminoethyl)-γ-aminopropyltriethoxy dimethoxysilane shape
Into combined type amino silane.
A kind of 3. medical catheter surface hydrophilic coating lubricating fluid reagent according to claim 1, it is characterised in that component B
Wet concentration from one kind in distilled water, purified water.
A kind of 4. medical catheter surface hydrophilic coating lubricating fluid reagent according to claim 1, it is characterised in that component C
Organic solvent be ethanol.
A kind of 5. medical catheter surface hydrophilic coating lubricating fluid reagent according to claim 1, it is characterised in that：Component D
Hydrophilic polymer be PVP（pvp）Hydrophilic polymer.
A kind of 6. medical catheter surface treatment method, it is characterised in that parent of this method any one of with claim 1-5
Water coating lubricating fluid reagent is handled the surface of medical catheter, and is comprised the following steps：
（1）Medical catheter is impregnated into No. 1 solution, dried；
（2）By step（1）After the completion of medical catheter be impregnated into 2 good solution, dry.
A kind of 7. medical catheter, it is characterised in that it uses the reagent any one of claim 1-5, or according to power
Profit requires that the method described in 6 is surface-treated.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710273184.2A CN107693851A (en) | 2017-04-25 | 2017-04-25 | A kind of medical catheter surface hydrophilic coating lubricating fluid reagent, medical catheter surface treatment method and medical catheter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710273184.2A CN107693851A (en) | 2017-04-25 | 2017-04-25 | A kind of medical catheter surface hydrophilic coating lubricating fluid reagent, medical catheter surface treatment method and medical catheter |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107693851A true CN107693851A (en) | 2018-02-16 |
Family
ID=61169586
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710273184.2A Withdrawn CN107693851A (en) | 2017-04-25 | 2017-04-25 | A kind of medical catheter surface hydrophilic coating lubricating fluid reagent, medical catheter surface treatment method and medical catheter |
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| CN (1) | CN107693851A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1537643A (en) * | 2003-04-17 | 2004-10-20 | 山东省医疗器械研究所 | Medical lubricating liquid its use method and medical lubricating catheter |
| US20050170071A1 (en) * | 2004-01-29 | 2005-08-04 | Scimed Life Systems, Inc. | Lubricious composition |
| CN104448375A (en) * | 2013-09-12 | 2015-03-25 | 上海康德莱企业发展集团股份有限公司 | Method for preparing surface hydrophilic lubricant coating for PVC catheter |
| CN105597217A (en) * | 2016-02-29 | 2016-05-25 | 浙江曙光科技有限公司 | PVC ultra-smooth hydrophilic catheter and preparation method thereof |
| CN206103090U (en) * | 2016-02-29 | 2017-04-19 | 浙江曙光科技有限公司 | PVC ultra -smooth hydrophilicity catheter |
-
2017
- 2017-04-25 CN CN201710273184.2A patent/CN107693851A/en not_active Withdrawn
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1537643A (en) * | 2003-04-17 | 2004-10-20 | 山东省医疗器械研究所 | Medical lubricating liquid its use method and medical lubricating catheter |
| US20050170071A1 (en) * | 2004-01-29 | 2005-08-04 | Scimed Life Systems, Inc. | Lubricious composition |
| CN104448375A (en) * | 2013-09-12 | 2015-03-25 | 上海康德莱企业发展集团股份有限公司 | Method for preparing surface hydrophilic lubricant coating for PVC catheter |
| CN105597217A (en) * | 2016-02-29 | 2016-05-25 | 浙江曙光科技有限公司 | PVC ultra-smooth hydrophilic catheter and preparation method thereof |
| CN206103090U (en) * | 2016-02-29 | 2017-04-19 | 浙江曙光科技有限公司 | PVC ultra -smooth hydrophilicity catheter |
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| PB01 | Publication | ||
| PB01 | Publication | ||
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| WW01 | Invention patent application withdrawn after publication | ||
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Application publication date: 20180216 |