CN104448375A - Method for preparing surface hydrophilic lubricant coating for PVC catheter - Google Patents
Method for preparing surface hydrophilic lubricant coating for PVC catheter Download PDFInfo
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- CN104448375A CN104448375A CN201310414975.4A CN201310414975A CN104448375A CN 104448375 A CN104448375 A CN 104448375A CN 201310414975 A CN201310414975 A CN 201310414975A CN 104448375 A CN104448375 A CN 104448375A
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Abstract
The invention discloses a method for preparing a surface hydrophilic lubricant coating for PVC catheter. A composite silane coupling agent is used as a bridge to organically combine polyvinylpyrrolidone to the surface of the catheter to form a firm lubricant uniform coating, so as to effectively improve the lubricity of the PVC catheter surface. For usage, the catheter prepared by the method has only needs to be soaked in sterile water, and the surface becomes very lubricant after swelling. The catheter is easy to use, and has broad application prospects. The preparation method is simple and easy for industrialization.
Description
Technical field
The present invention relates to a kind of preparation method of PVC catheter surface hydrophilic lubrication coating.
Background technology
Polyvinyl chloride (PVC) is as a kind of medical macromolecular materials, and because its price comparison is cheap, transparency, pliability are good, have a wide range of applications at biomedical sector.
Although catheter is one " little " product in medicine equipment, its quantity is very large.As disposable product, with regard to economic performance, the catheter of PVC material is still best selection, and such as on American market, family expenses catheter major part is PVC.
But because PVC is hydrophobic material, during use, frictional force is comparatively large, patient, often with calcination and pain, easily causes blood vessel, cavity organization's damage and brings complication.Therefore, need the oilness improving catheter surface, reduce catheter when inserting or extract human body to the damage of tissue and adhesion, thus alleviate patient's misery.What usually adopt was that lubricating oil (as glycerine, silicone oil etc.) is coated to catheter surface in the past, but this treatment process poor to catheter lubricity effect, be difficult to lasting and be unfavorable for operation.
The physical and mechanical property that surface modification can make material maintenance itself have, can make again material surface have necessary surface property.At present domestic and international to PVC surface study on the modification maximum be improve its wetting ability by Cement Composite Treated by Plasma, but the surface after Cement Composite Treated by Plasma, in placement long-time rear surface, wetting ability will worsen; Although the wetting ability of the method for chemical graft hydrophilic radical to PVC makes moderate progress, its complex process, cost is higher, brings difficulty to industrial production.
Summary of the invention
Object of the present invention, provides a kind of preparation method of PVC catheter surface hydrophilic lubrication coating exactly in order to solve the problem.
The object of the present invention is achieved like this:
The preparation method of a kind of PVC catheter surface hydrophilic lubrication coating of the present invention, comprises the following steps:
Adopt ethanol purge PVC catheter surface, coupling agent solution is coated in the surface of PVC catheter as bottom, then dries, then hydrophilic coating solution is bonded on described bottom as top layer, after oven dry, namely obtain the hydrophilic lubrication coating under dry state.
The preparation method of above-mentioned a kind of PVC catheter surface hydrophilic lubrication coating, wherein, described coupling agent solution is mixed by the component of following weight part:
The preparation method of above-mentioned a kind of PVC catheter surface hydrophilic lubrication coating, wherein, described silane coupling agent is that silane coupling agent KH-792 and silane coupling agent KH-602 forms by equal proportion is composite.
The preparation method of above-mentioned a kind of PVC catheter surface hydrophilic lubrication coating, wherein, described hydrophilic coating solution is mixed by the component of following weight part:
There are some researches show that high hydrophilic or high hydrophobic surface all has oilness, but in water surrounding, high water-wetted surface oilness is better than high hydrophobic surface, therefore, the present invention obtains high lubricity by making catheter surface have high-hydrophilic exactly.
In recent years, the hydrophilic coating containing unique group became the focus of people's research, and itself, with hydrophilic radical, is easy to form hydrophilic gel with water molecules, has good oilness and biocompatibility, biomedicine obtains extensive utilization.
The present invention adopts compound silane coupling agent as bridge, and polyvinylpyrrolidone is organically attached to catheter surface, can form firm, lubrication, uniform coating, effectively improve the oilness of PVC catheter surface.Utilize the obtained catheter of this method only it need be infiltrated in sterilized water in use, namely swelling rear surface becomes lubricates very much, easy to use, has broad application prospects.And this preparation method is simple, is easy to realize industrialization.
Embodiment
Below in conjunction with embodiment, the invention will be further described.
The invention discloses a kind of preparation method of PVC catheter surface hydrophilic lubrication coating, comprise the steps:
First, coupling agent solution is prepared according to the following ratio:
And, prepare hydrophilic coating solution according to the following ratio:
Adopt ethanol purge PVC catheter surface, coupling agent solution is coated in the surface of PVC catheter as bottom, then dries, then hydrophilic coating solution is bonded on described bottom as top layer, after oven dry, namely obtain the hydrophilic lubrication coating under dry state.
The performances such as the wetting ability of coating prepared by the present invention, oilness and water-fast persistence are investigated by measuring the water contact angle of catheter surface, tack and frictional coefficient etc.
Experimental result shows, the water contact angle of modified catheter surface reduces greatly, is only 36.5; Frictional coefficient is also only 1.4% of ordinary urethral catheter, and in water, the change of long-time immersion its coating adhesion amount rear is very little, does not almost come off, illustrates that its lubrication persistence is better.Therefore, the present invention effectively can improve the oilness on ordinary urethral catheter surface, and coating difficult drop-off, lubrication persistence is better.
Above embodiment is used for illustrative purposes only, but not limitation of the present invention, person skilled in the relevant technique, without departing from the spirit and scope of the present invention, various conversion or modification can also be made, therefore all equivalent technical schemes also should belong to category of the present invention, should be limited by each claim.
Claims (4)
1. a preparation method for PVC catheter surface hydrophilic lubrication coating, is characterized in that, comprise the following steps:
Adopt ethanol purge PVC catheter surface, coupling agent solution is coated in the surface of PVC catheter as bottom, then dries, then hydrophilic coating solution is bonded on described bottom as top layer, after oven dry, namely obtain the hydrophilic lubrication coating under dry state.
2. the preparation method of a kind of PVC catheter surface hydrophilic lubrication coating as claimed in claim 1, it is characterized in that, described coupling agent solution is mixed by the component of following weight part:
3. the preparation method of a kind of PVC catheter surface hydrophilic lubrication coating as claimed in claim 2, is characterized in that, described silane coupling agent is that silane coupling agent KH-792 and silane coupling agent KH-602 forms by equal proportion is composite.
4. the preparation method of a kind of PVC catheter surface hydrophilic lubrication coating as claimed in claim 1, it is characterized in that, described hydrophilic coating solution is mixed by the component of following weight part:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310414975.4A CN104448375A (en) | 2013-09-12 | 2013-09-12 | Method for preparing surface hydrophilic lubricant coating for PVC catheter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310414975.4A CN104448375A (en) | 2013-09-12 | 2013-09-12 | Method for preparing surface hydrophilic lubricant coating for PVC catheter |
Publications (1)
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| CN104448375A true CN104448375A (en) | 2015-03-25 |
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| CN201310414975.4A Pending CN104448375A (en) | 2013-09-12 | 2013-09-12 | Method for preparing surface hydrophilic lubricant coating for PVC catheter |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105597217A (en) * | 2016-02-29 | 2016-05-25 | 浙江曙光科技有限公司 | PVC ultra-smooth hydrophilic catheter and preparation method thereof |
| CN107281614A (en) * | 2017-07-06 | 2017-10-24 | 武汉智迅创源科技发展股份有限公司 | A kind of hydrophilic coating sputum aspirator tube and its implementation |
| CN107693851A (en) * | 2017-04-25 | 2018-02-16 | 浙江善仁医疗设备制造有限公司 | A kind of medical catheter surface hydrophilic coating lubricating fluid reagent, medical catheter surface treatment method and medical catheter |
| CN107899092A (en) * | 2017-11-23 | 2018-04-13 | 湘潭大学 | A kind of medical intervention wire guide surface hydrophilic lubricant coating and preparation method thereof |
| CN113499485A (en) * | 2021-07-08 | 2021-10-15 | 深圳先进技术研究院 | Lubricating coating for surface of medical instrument and preparation method thereof |
| CN114163925A (en) * | 2021-12-06 | 2022-03-11 | 中国科学院兰州化学物理研究所 | Method for modifying hydrogel lubricating coating on surface of universal equipment and universal equipment modified with hydrogel lubricating coating |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101455861A (en) * | 2008-12-17 | 2009-06-17 | 东南大学 | Lubricity coatings preparation method on the medical catheter polymers surface |
| CN101812265A (en) * | 2009-02-24 | 2010-08-25 | 赛诺医疗科学技术有限公司 | Hydrophilic coat solution applied to surface of medicinal instrument and preparation method thereof |
-
2013
- 2013-09-12 CN CN201310414975.4A patent/CN104448375A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101455861A (en) * | 2008-12-17 | 2009-06-17 | 东南大学 | Lubricity coatings preparation method on the medical catheter polymers surface |
| CN101812265A (en) * | 2009-02-24 | 2010-08-25 | 赛诺医疗科学技术有限公司 | Hydrophilic coat solution applied to surface of medicinal instrument and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 曲祥军: ""医用导管表面的亲水改性"", 《中国优秀硕士学位论文全文数据库 医药卫生科技辑》 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105597217A (en) * | 2016-02-29 | 2016-05-25 | 浙江曙光科技有限公司 | PVC ultra-smooth hydrophilic catheter and preparation method thereof |
| CN107693851A (en) * | 2017-04-25 | 2018-02-16 | 浙江善仁医疗设备制造有限公司 | A kind of medical catheter surface hydrophilic coating lubricating fluid reagent, medical catheter surface treatment method and medical catheter |
| CN107281614A (en) * | 2017-07-06 | 2017-10-24 | 武汉智迅创源科技发展股份有限公司 | A kind of hydrophilic coating sputum aspirator tube and its implementation |
| CN107281614B (en) * | 2017-07-06 | 2020-02-18 | 武汉智迅创源科技发展股份有限公司 | Hydrophilic coating sputum suction tube and implementation method thereof |
| CN107899092A (en) * | 2017-11-23 | 2018-04-13 | 湘潭大学 | A kind of medical intervention wire guide surface hydrophilic lubricant coating and preparation method thereof |
| CN113499485A (en) * | 2021-07-08 | 2021-10-15 | 深圳先进技术研究院 | Lubricating coating for surface of medical instrument and preparation method thereof |
| CN114163925A (en) * | 2021-12-06 | 2022-03-11 | 中国科学院兰州化学物理研究所 | Method for modifying hydrogel lubricating coating on surface of universal equipment and universal equipment modified with hydrogel lubricating coating |
| CN114163925B (en) * | 2021-12-06 | 2022-06-10 | 中国科学院兰州化学物理研究所 | Method for modifying hydrogel lubricating coating on surface of universal equipment and universal equipment modified with hydrogel lubricating coating |
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Application publication date: 20150325 |
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