CN109957265A - A kind of medical instrument coating composition - Google Patents

A kind of medical instrument coating composition Download PDF

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Publication number
CN109957265A
CN109957265A CN201711404359.5A CN201711404359A CN109957265A CN 109957265 A CN109957265 A CN 109957265A CN 201711404359 A CN201711404359 A CN 201711404359A CN 109957265 A CN109957265 A CN 109957265A
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Prior art keywords
coating composition
medical instrument
agent
thickener
instrument coating
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CN201711404359.5A
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Chinese (zh)
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杨泰安
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Individual
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Individual
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Priority to CN201711404359.5A priority Critical patent/CN109957265A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/085—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D4/00—Coating compositions, e.g. paints, varnishes or lacquers, based on organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond ; Coating compositions, based on monomers of macromolecular compounds of groups C09D183/00 - C09D183/16
    • C09D4/06—Organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond in combination with a macromolecular compound other than an unsaturated polymer of groups C09D159/00 - C09D187/00
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D5/00—Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced; Filling pastes
    • C09D5/14—Paints containing biocides, e.g. fungicides, insecticides or pesticides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
    • A61L2300/206—Biguanides, e.g. chlorohexidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00—Materials or methods for coatings medical devices
    • A61L2420/06—Coatings containing a mixture of two or more compounds

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Materials Engineering (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Plant Pathology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Paints Or Removers (AREA)

Abstract

The present invention provides a kind of medical instrument coating composition, it is characterised in that it includes the component of following parts by weight: the component including following parts by weight: polyvinyl acetate 19-32, methyl methacrylate 8-17, gluconic acid polyhexamethylene guanide 7-18, azodiisobutyronitrile 5-11, polyvinyl alcohol 13-29, dispersing agent 7-12, thickener 5-9, alfalfa antibacterial peptide 31-38, defoaming agent 4-7, pH adjusting agent 1-3, ferroso-ferric oxide hollow magnetic nanosphere 42-59, zinc hydride ferrite ceramics powder 31-47, distilled water 17-26.The present invention has excellent antibacterial ability and extraordinary surface adhesion energy, is suitble to promote the use of on a large scale.

Description

A kind of medical instrument coating composition
Technical field
The invention belongs to medical apparatus surface field of material technology, and in particular to a kind of medical instrument coating composition.
Background technique
Minimally Interventional Therapy is, using instruments such as specific puncture needle, seal wire or conduits, not have to open under image-guided Tissue can accurately reach the medicine new technology that diseased region carries out diagnosing and treating.Medical polyurethane is that interposing catheter is normal Material, intervention apparatus require the surface with lubricity when entering or extracting human body and move in human body, with Avoid damage to in-vivo tissue.Medical polyurethane conduit itself is hydrophobic material, and surface does not have lubricity, although using lubrication Agent or gel coat can obtain temporary lubricity, but lasting lubricity only passes through modified material itself or material table Face and obtain.The modified method in surface can make material keep possessed physical and mechanical property itself and make material surface With necessary surface property；In addition, medical polyurethane conduit is usually applied to the environment contacted with body fluid (water), and in water In environment, high water wetted material can more reduce absorption of the surface to cell and protein etc. than high hydrophobic material.Therefore, pass through poly- ammonia The hydrophilic modifying on ester surface increases surface polar groups to obtain surface lubrication, just becomes Chang Chong in polyurethane lubricating modification Want method.
In the surface modification of medical intervention material, coating material and technology are crucial.Exploitation has good biological compatible The medical coating material of the surface propertys such as property, super lubricity becomes more and more important.In China, made by medical coating material etc. About, high-end interventional medical instrument generally relies on import, at high price.Meanwhile existing method of modifying is complex, production Higher cost, the sample with lubricating coating of Some Domestic research, the problem of being primarily present is that coating is easy to fall off, can not It is widely applied and promotes.
Summary of the invention
In view of this, the present invention provides a kind of medical instrument coating composition, the present invention has excellent antibacterial ability And extraordinary surface adhesion energy, it is suitble to promote the use of on a large scale.
The technical solution of the present invention is as follows: a kind of medical instrument coating composition, which is characterized in that including following parts by weight Several component: the component including following parts by weight: polyvinyl acetate 19-32, methyl methacrylate 8-17, glucose Sour polyhexamethylene guanide 7-18, azodiisobutyronitrile 5-11, polyvinyl alcohol 13-29, dispersing agent 7-12, thickener 5-9, purple Russian fenugreek herb antibacterial peptide 31-38, defoaming agent 4-7, pH adjusting agent 1-3, ferroso-ferric oxide hollow magnetic nanosphere 42-59, hydrogenation Zn ferrite ceramic powder 31-47, distilled water 17-26.
Alfalfa antibacterial peptide of the invention can be reached by the synergistic effect with gluconic acid polyhexamethylene guanide Excellent fungistatic effect.Particularly, alfalfa antibacterial peptide of the invention it is mixed enter ferroso-ferric oxide hollow magnetic nanosphere, In zinc hydride ferrite ceramics powder, long-acting antibacterial layer is formed in coating surface.
Further, the dispersing agent is lauryl sodium sulfate, methyl anyl alcohol, polyacrylamide, guar gum, fatty acid One of macrogol ester.
Further, the thickener is propyldimethoxy-silane.
Further, the defoaming agent is tributyl phosphate.
Further, the pH adjusting agent is diethanol amine.
The synergistic compounding of middle each component, the present invention are able to solve coating surface tension and generate change of gradient through the invention, Phenomena such as system viscosity increases, and filler dispersion is uneven, Yi Fasheng orange peel, shrinkage cavity, mist shadow, has excellent levelling effect； There is the present invention excellent antibiotic property and salt spray resistance ability, lubricity to greatly improve, and coating is not fallen off through 15 frictions, attachment Fastness is good, can meet the requirement of high-end interventional medical device coating application.
Specific embodiment
Technical solution of the present invention is clearly and completely described below in conjunction with embodiment, it is clear that described reality Applying example is only a part of the embodiment of the present invention, instead of all the embodiments.
Embodiment 1
A kind of medical instrument coating composition, which is characterized in that the component including following parts by weight: including following parts by weight Several component: polyvinyl acetate 19, methyl methacrylate 8, gluconic acid polyhexamethylene guanide 7, azodiisobutyronitrile 5, polyvinyl alcohol 13, dispersing agent 7, thickener 5, alfalfa antibacterial peptide 31, defoaming agent 4, pH adjusting agent 1, four aoxidize Three-iron hollow magnetic nanosphere 42, zinc hydride ferrite ceramics powder 31, distilled water 17.
Alfalfa antibacterial peptide of the invention can be reached by the synergistic effect with gluconic acid polyhexamethylene guanide Excellent fungistatic effect.Particularly, alfalfa antibacterial peptide of the invention it is mixed enter ferroso-ferric oxide hollow magnetic nanosphere, In zinc hydride ferrite ceramics powder, long-acting antibacterial layer is formed in coating surface.
Further, the dispersing agent is lauryl sodium sulfate.
Further, the thickener is propyldimethoxy-silane.
Further, the defoaming agent is tributyl phosphate.
Further, the pH adjusting agent is diethanol amine.
The synergistic compounding of middle each component, the present invention are able to solve coating surface tension and generate change of gradient through the invention, Phenomena such as system viscosity increases, and filler dispersion is uneven, Yi Fasheng orange peel, shrinkage cavity, mist shadow, has excellent levelling effect； There is the present invention excellent antibiotic property and salt spray resistance ability, lubricity to greatly improve, and coating is not fallen off through 15 frictions, attachment Fastness is good, can meet the requirement of high-end interventional medical device coating application.
Embodiment 2
A kind of medical instrument coating composition, which is characterized in that the component including following parts by weight: including following parts by weight Several component: polyvinyl acetate 32, methyl methacrylate 17, gluconic acid polyhexamethylene guanide 18, two isobutyl of azo Nitrile 11, polyvinyl alcohol 29, dispersing agent 12, thickener 9, alfalfa antibacterial peptide 38, defoaming agent 7, pH adjusting agent 3, four Fe 3 O hollow magnetic nanosphere 59, zinc hydride ferrite ceramics powder 47, distilled water 26.
Further, the dispersing agent is methyl anyl alcohol.
Further, the thickener is propyldimethoxy-silane.
Further, the defoaming agent is tributyl phosphate.
Further, the pH adjusting agent is diethanol amine.
Embodiment 3
A kind of medical instrument coating composition, which is characterized in that the component including following parts by weight: including following parts by weight Several component: polyvinyl acetate 23, methyl methacrylate 11, gluconic acid polyhexamethylene guanide 12, two isobutyl of azo Nitrile 7, polyvinyl alcohol 16, dispersing agent 9, thickener 6, alfalfa antibacterial peptide 33, defoaming agent 5, pH adjusting agent 1.5, four Fe 3 O hollow magnetic nanosphere 45, zinc hydride ferrite ceramics powder 34, distilled water 19.
Further, the dispersing agent is guar gum.
Further, the thickener is propyldimethoxy-silane.
Further, the defoaming agent is tributyl phosphate.
Further, the pH adjusting agent is diethanol amine.
Embodiment 4
A kind of medical instrument coating composition, which is characterized in that the component including following parts by weight: including following parts by weight Several component: polyvinyl acetate 25, methyl methacrylate 13, gluconic acid polyhexamethylene guanide 15, two isobutyl of azo Nitrile 8, polyvinyl alcohol 23, dispersing agent 10, thickener 7, alfalfa antibacterial peptide 36, defoaming agent 6, pH adjusting agent 2, four Fe 3 O hollow magnetic nanosphere 52, zinc hydride ferrite ceramics powder 38, distilled water 23.
Further, the dispersing agent is polyacrylamide.
Further, the thickener is propyldimethoxy-silane.
Further, the defoaming agent is tributyl phosphate.
Further, the pH adjusting agent is diethanol amine.
Embodiment 5
A kind of medical instrument coating composition, which is characterized in that the component including following parts by weight: including following parts by weight Several component: polyvinyl acetate 30, methyl methacrylate 15, gluconic acid polyhexamethylene guanide 16, two isobutyl of azo Nitrile 10, polyvinyl alcohol 27, dispersing agent 10, thickener 8, alfalfa antibacterial peptide 37, defoaming agent 6, pH adjusting agent 2.7, Ferroso-ferric oxide hollow magnetic nanosphere 57, zinc hydride ferrite ceramics powder 45, distilled water 24.
Further, the dispersing agent is fatty acid polyethylene glycol ester.
Further, the thickener is propyldimethoxy-silane.
Further, the defoaming agent is tributyl phosphate.
Further, the pH adjusting agent is diethanol amine.
Comparative example 1
A kind of medical instrument coating composition, which is characterized in that the component including following parts by weight: including following parts by weight Several components: methyl methacrylate 11, gluconic acid polyhexamethylene guanide 12, azodiisobutyronitrile 7, polyvinyl alcohol 16, Dispersing agent 9, thickener 6, alfalfa antibacterial peptide 33, defoaming agent 5, pH adjusting agent 1.5, ferroso-ferric oxide hollow magnetic are received Meter Wei Qiu 45, zinc hydride ferrite ceramics powder 34, distilled water 19.
Further, the dispersing agent is guar gum.
Further, the thickener is propyldimethoxy-silane.
Further, the defoaming agent is tributyl phosphate.
Further, the pH adjusting agent is diethanol amine.
Comparative example 2
A kind of medical instrument coating composition, which is characterized in that the component including following parts by weight: including following parts by weight Several component: polyvinyl acetate 23, methyl methacrylate 11, gluconic acid polyhexamethylene guanide 12, two isobutyl of azo Nitrile 7, polyvinyl alcohol 16, dispersing agent 9, thickener 6, defoaming agent 5, pH adjusting agent 1.5, ferroso-ferric oxide hollow magnetic nanometer Microballoon 45, zinc hydride ferrite ceramics powder 34, distilled water 19.
Further, the dispersing agent is guar gum.
Further, the thickener is propyldimethoxy-silane.
Further, the defoaming agent is tributyl phosphate.
Further, the pH adjusting agent is diethanol amine.
Coating performance test
Identical prior art preparation is respectively adopted in embodiment 1-5 and comparative example 1-2 and obtains coating, is coated on polyurethane respectively In test piece and aluminium alloy test piece, aluminium alloy test piece selects 6063.After paint spraying, stands 48 hours and film forming is fully cured to coating After tested.Adhesive force test, neutral salt spray test, anti-microbial property test are carried out to above-mentioned coating, test method is according to phase It closes national standard to carry out, test result is as follows table.
It is obvious to a person skilled in the art that invention is not limited to the details of the above exemplary embodiments, Er Qie In the case where without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power Benefit requires rather than above description limits, it is intended that all by what is fallen within the meaning and scope of the equivalent elements of the claims Variation is included within the present invention.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art The other embodiments being understood that.It is noted that the technical characteristic being not described in detail in the present invention, can pass through this Field any prior art is realized.

Claims (5)

1. a kind of medical instrument coating composition, which is characterized in that the component including following parts by weight: including following weight The component of number: polyvinyl acetate 19-32, methyl methacrylate 8-17, gluconic acid polyhexamethylene guanide 7-18, idol Nitrogen bis-isobutyronitrile 5-11, polyvinyl alcohol 13-29, dispersing agent 7-12, thickener 5-9, alfalfa antibacterial peptide 31-38, disappear Infusion 4-7, pH adjusting agent 1-3, ferroso-ferric oxide hollow magnetic nanosphere 42-59, zinc hydride ferrite ceramics powder 31-47, Distilled water 17-26.
2. medical instrument coating composition according to claim 1, which is characterized in that the dispersing agent is dodecyl One of sodium sulphate, methyl anyl alcohol, polyacrylamide, guar gum, fatty acid polyethylene glycol ester.
3. medical instrument coating composition according to claim 1, which is characterized in that the thickener is dimethylamine Oxysilane.
4. medical instrument coating composition according to claim 1, which is characterized in that the defoaming agent is tricresyl phosphate fourth Ester.
5. medical instrument coating composition according to claim 1, which is characterized in that the pH adjusting agent is diethanol Amine.
CN201711404359.5A 2017-12-22 2017-12-22 A kind of medical instrument coating composition Pending CN109957265A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110531075A (en) * 2019-10-16 2019-12-03 军事科学院军事医学研究院军事兽医研究所 Based on antibacterial peptide-phosphate nano compound pathogenic bacteria immunoassay biosensor and its preparation method and application

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110531075A (en) * 2019-10-16 2019-12-03 军事科学院军事医学研究院军事兽医研究所 Based on antibacterial peptide-phosphate nano compound pathogenic bacteria immunoassay biosensor and its preparation method and application
CN110531075B (en) * 2019-10-16 2022-06-14 军事科学院军事医学研究院军事兽医研究所 Pathogenic bacteria immunoassay biosensor based on antibacterial peptide-phosphate nano compound and preparation method and application thereof

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