CN107376029A - A kind of medical hydrophilic lubrication coating and its method for coating - Google Patents
A kind of medical hydrophilic lubrication coating and its method for coating Download PDFInfo
- Publication number
- CN107376029A CN107376029A CN201710580230.3A CN201710580230A CN107376029A CN 107376029 A CN107376029 A CN 107376029A CN 201710580230 A CN201710580230 A CN 201710580230A CN 107376029 A CN107376029 A CN 107376029A
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- coating
- coating solutions
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- medical
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/06—Coatings containing a mixture of two or more compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/08—Coatings comprising two or more layers
Abstract
A kind of medical hydrophilic lubrication coating, including 1# solution coatings and 2# solution coatings, and 1# solution coatings are coated by 1# coating solutions, 2# solution coatings are coated by 2# coating solutions；Wherein, each component mass fraction is in 1# coating solutions：Adhesive polymer is 30%~70%, and nonionic surfactant is 20%~50%, and light trigger is 5%~10%, No. 1 solvent 3%~10%；Each component mass fraction is in 2# coating solutions：Adhesive polymer is 5%~20%, light trigger 0.2%~5%, high molecular weight hydrophilic polymer is 70%~90%, No. 2 solvents are 0.2%~10%, by coating two layers of hydrophilic lubricant coating on conduit, catheter surface is not lubricated in the dry state, hydrophily lubricant coating is quickly formed after water suction, so as to substantially reduce the coefficient of friction of catheter surface, to mitigate the damage to tissue, offered convenience for interventional therapy operation.
Description
Technical field
The present invention relates to inorganic functional material technical field, more particularly to a kind of medical hydrophilic lubrication coating and its side of coating
Method.
Background technology
With the development of medical technology, various interventional therapy conduits are widely applied in clinical treatment；Many conduits
Be implanted into human vas, need short-term or contacted for a long time with tissue, thus tissue may be caused damage and then
Trigger the adverse reactions such as inflammation.Therefore to reduce operation risk, mitigate patient's pain, clinic is frequently with lubricant such as silicone oil, paraffin
Oil, vaseline etc. coat catheter surface, but the conduit of this series lubricant agent processing is difficult to persistently, and lubricity is bad, and is unfavorable for hand
Art operates.
The content of the invention
Technical problem solved by the invention is to provide a kind of medical hydrophilic lubrication coating and its method for coating, to solve
The shortcomings that in above-mentioned background technology.
Technical problem solved by the invention is realized using following technical scheme：
A kind of medical hydrophilic lubrication coating, including 1# solution coatings and 2# solution coatings, and 1# solution coatings are by 1# coating solutions
Coat, 2# solution coatings are coated by 2# coating solutions；Wherein, 1# coating solutions by certain mass adhesive polymer, it is non-from
Sub- surfactant and light trigger are dissolved in No. 1 solvent of certain volume, and each component mass fraction is in solution：Adhesiveness
Polymer is 30%~70%, and nonionic surfactant is 20%~50%, and light trigger is 5%~10%, No. 1 solvent 3%~10%；
2# coating solutions are dissolved in No. 2 solvents of certain volume by adhesive polymer, light trigger and high molecular weight hydrophilic polymer,
Each component mass fraction is in solution：Adhesive polymer is 5%~20%, light trigger 0.2%~5%, hydrophilic high mol polymerization
Thing is 70%~90%, and No. 2 solvents are 0.2%~10%.
In the present invention, the adhesive polymer is polyethyleneglycol diacrylate, polyester, acrylic resin, acetic acid
One kind in vinyl acetate or the combination more than any two.
In the present invention, the nonionic surfactant is in polyoxypropylene oxygen ethene polymers, polyoxyethylene-type
One or more kinds of combinations.
In the present invention, the light trigger is one kind in benzophenone, alkylbenzene ketone.
In the present invention, No. 1 solvent is the two or more groups in water, ethanol, isopropanol, acetone, ethyl acetate
Close.
In the present invention, the high molecular weight hydrophilic polymer is in polyvinylpyrrolidone, polyethylene glycol oxide, polyvinyl alcohol
One or more kinds of combinations.
In the present invention, No. 2 solvents are the two or more groups in water, ethanol, isopropanol, acetone, ethyl acetate
Close.
A kind of medical hydrophilic lubrication coating method for coating, is comprised the following steps that：
1）1# coating solutions and 2# coating solutions are prepared first, by polyethyleneglycol diacrylate 150mg, polyethylene glycol~poly- third
Glycol~polyethylene glycol triblock copolymer 120mg and benzophenone 25mg is dissolved in ethanol 6ml, isopropanol 4ml mixing
1# coating solutions are configured in liquid；Polyethylene glycol oxide 60mg and water 15ml are put into heating stirring in beaker, are cooled to after dissolving
Room temperature, adding PVPK30 00mg, polyethyleneglycol diacrylate 500mg, benzophenone 25mg and ethanol
15ml stirring and dissolvings are configured to 2# coating solutions；
2）Catheter surface to be coated is cleaned；
3）Taken out after the conduit that cleaning finishes is submerged initially in into 1~10s of 1# coating solutions, then carry out ultraviolet light solidification, solidifying
Solidify 60~120s in the ultraviolet equipment that power is 3.0kw~4.5kw；
4）By step 3）Conduit after middle solidification immerses in 2# coating solutions again to be taken out after 1~10s, then carries out UV-curing
Change, solidify 60~120s in the ultraviolet equipment that solidification power is 3.0kw~4.5kw；
5）To solidifying the catheter packaging finished, sterilizing.
Beneficial effect：The present invention coats two layers of hydrophilic lubricant coating on conduit, to improve the profit coated on existing conduit
Lubrication prescription drawback, makes catheter surface not lubricate in the dry state, and hydrophily lubricant coating is quickly formed after water suction, so as to drop significantly
The coefficient of friction of low catheter surface, to mitigate the damage to tissue, offered convenience for interventional therapy operation.
Embodiment
In order that the technical means, the inventive features, the objects and the advantages of the present invention are easy to understand, tie below
Embodiment is closed, the present invention is expanded on further.
A kind of medical hydrophilic lubrication coating, including 1# solution coatings and 2# solution coatings, and 1# solution coatings are by 1# coatings
Solution is coated, and 2# solution coatings are coated by 2# coating solutions；Wherein, each component mass fraction is in 1# coating solutions：Adhesiveness
Polymer A is 40%~70%, and nonionic surfactant B is 20%~40%, and light trigger C is 6%~9%, No. 1 solvent D 3%~
8%；Each component mass fraction is in 2# coating solutions：Adhesive polymer A is 6%~15%, and light trigger C is 0.2%~5%, parent
Water high molecular polymer E is 75%~90%, and No. 2 solvent F are 0.2%~8%.
The adhesive polymer A is in polyethyleneglycol diacrylate, polyester, acrylic resin, vinylacetate
One kind or the combination more than any two；
The nonionic surfactant B be selected from polyoxypropylene oxygen ethene polymers, one or both of polyoxyethylene-type with
On combination；
The one kind of the light trigger C in benzophenone, alkylbenzene ketone；
Two or more combinations of No. 1 solvent D in water, ethanol, isopropanol, acetone, ethyl acetate；
The high molecular weight hydrophilic polymer E be polyvinylpyrrolidone, polyethylene glycol oxide, one or both of polyvinyl alcohol with
On combination；
Two or more combinations of No. 2 solvent F in water, ethanol, isopropanol, acetone, ethyl acetate.
A kind of medical hydrophilic lubrication coating method for coating, is comprised the following steps that：
1）1# coating solutions and 2# coating solutions are prepared, by polyethyleneglycol diacrylate（PEGDA）150mg, polyethylene glycol~
Polypropylene glycol~polyethylene glycol triblock copolymer（PEG~PPG~PEG）It is 120mg, benzophenone 25mg, ethanol 6ml, different
Propyl alcohol 4ml is configured to 1# coating solutions；By polyethylene glycol oxide（PEO）60mg and water 15ml is put into heating stirring in beaker, dissolves
After be cooled to room temperature after, add polyvinylpyrrolidone（PVP）3000mg, polyethyleneglycol diacrylate（PEGDA）500mg、
Benzophenone 25mg, ethanol 15ml stirring and dissolvings are configured to 2# coating solutions；
2）Catheter surface to be coated is cleaned；
3）Taken out after the conduit that cleaning finishes is submerged initially in into 3~8s of 1# coating solutions, then carry out ultraviolet light solidification, in solidification work(
Solidify 60~120s in the ultraviolet equipment that rate is 3.0kw~4.5kw；
4）By step 3）Conduit after middle solidification immerses in 2# coating solutions again to be taken out after 3~8s, then carries out ultraviolet light solidification,
Solidify 60~120s in the ultraviolet equipment that solidification power is 3.0kw~4.5kw；
5）To solidifying the catheter packaging finished, sterilizing.
General principle, principal character and the major advantage of the present invention has been shown and described above.The technical staff of the industry
It should be appreciated that the present invention is not limited to the above embodiments, simply illustrate the present invention described in above-described embodiment and specification
Principle, without departing from the spirit and scope of the present invention, various changes and modifications of the present invention are possible, these change and
Improvement all fall within the protetion scope of the claimed invention.The claimed scope of the invention is by appended claims and its equivalent
Thing defines.
Claims (10)
1. a kind of medical hydrophilic lubrication coating, it is characterised in that including 1# solution coatings and 2# solution coatings, and 1# solution applies
Layer is coated by 1# coating solutions, and 2# solution coatings are coated by 2# coating solutions；Wherein, 1# coating solutions by certain mass adhesion
Property polymer, nonionic surfactant and light trigger are dissolved in No. 1 solvent of certain volume, each component quality in solution
Fraction is：Adhesive polymer is 30%~70%, and nonionic surfactant is 20%~50%, and light trigger is 5%~10%, 1
Number solvent 3%~10%；2# coating solutions are dissolved in certain body by adhesive polymer, light trigger and high molecular weight hydrophilic polymer
In No. 2 long-pending solvents, each component mass fraction is in solution：Adhesive polymer is 5%~20%, light trigger 0.2%~5%,
High molecular weight hydrophilic polymer is 70%~90%, and No. 2 solvents are 0.2%~10%.
2. a kind of medical hydrophilic lubrication coating according to claim 1, it is characterised in that the adhesive polymer is poly-
One kind in glycol diacrylate, polyester, acrylic resin, vinylacetate or the combination more than any two.
A kind of 3. medical hydrophilic lubrication coating according to claim 1, it is characterised in that the nonionic surfactant
For combination more than one or both of polyoxypropylene oxygen ethene polymers, polyoxyethylene-type.
4. a kind of medical hydrophilic lubrication coating according to claim 1, it is characterised in that the light trigger is hexichol first
One kind in ketone, alkylbenzene ketone.
5. a kind of medical hydrophilic lubrication coating according to claim 1, it is characterised in that No. 1 solvent is water, second
Two or more combinations in alcohol, isopropanol, acetone, ethyl acetate.
A kind of 6. medical hydrophilic lubrication coating according to claim 1, it is characterised in that the high molecular weight hydrophilic polymer
For combination more than one or both of polyvinylpyrrolidone, polyethylene glycol oxide, polyvinyl alcohol.
7. a kind of medical hydrophilic lubrication coating according to claim 1, it is characterised in that No. 2 solvents are water, second
Two or more combinations in alcohol, isopropanol, acetone, ethyl acetate.
A kind of 8. medical hydrophilic lubrication coating according to claim 1, it is characterised in that each group sub-prime in 1# coating solutions
Measuring fraction is：Adhesive polymer is 40%~70%, and nonionic surfactant is 20%~40%, and light trigger is 6%~9%, 1
Number solvent 3%~8%；Each component mass fraction is in 2# coating solutions：Adhesive polymer is 6%~15%, and light trigger is
0.2%~5%, high molecular weight hydrophilic polymer is 75%~90%, and No. 2 solvents are 0.2%~8%.
9. a kind of medical hydrophilic lubrication coating method for coating, it is characterised in that comprise the following steps that：
1）1# coating solutions and 2# coating solutions are prepared first；
2）Catheter surface to be coated is cleaned；
3）Taken out after the conduit that cleaning finishes is submerged initially in into 1~10s of 1# coating solutions, then carry out ultraviolet light solidification；
4）By step 3）Conduit after middle solidification immerses in 2# coating solutions again to be taken out after 1~10s, then carries out UV-curing
Change；
5）To solidifying the catheter packaging finished, sterilizing.
10. a kind of medical hydrophilic lubrication coating method for coating according to claim 9, it is characterised in that curing process is joined
Number is：Solidify 60~120s in the ultraviolet equipment that solidification power is 3.0kw~4.5kw.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710580230.3A CN107376029A (en) | 2017-07-17 | 2017-07-17 | A kind of medical hydrophilic lubrication coating and its method for coating |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710580230.3A CN107376029A (en) | 2017-07-17 | 2017-07-17 | A kind of medical hydrophilic lubrication coating and its method for coating |
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| CN107376029A true CN107376029A (en) | 2017-11-24 |
Family
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| CN201710580230.3A Pending CN107376029A (en) | 2017-07-17 | 2017-07-17 | A kind of medical hydrophilic lubrication coating and its method for coating |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109966560A (en) * | 2019-03-13 | 2019-07-05 | 业聚医疗器械(深圳)有限公司 | A kind of medical catheter hydrophilic lubrication coating of photocuring and preparation method thereof |
| CN110237309A (en) * | 2019-06-24 | 2019-09-17 | 山东吉威医疗制品有限公司 | A kind of hydrophilic coating solution and preparation and application for foley's tube |
| CN114099790A (en) * | 2020-10-17 | 2022-03-01 | 河南驼人贝斯特医疗器械有限公司 | Lubricating coating of medical catheter and preparation method thereof |
| CN114515358A (en) * | 2022-02-15 | 2022-05-20 | 昆山韦睿医疗科技有限公司 | Hydrophilic coating and application thereof |
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| WO2002100559A1 (en) * | 2001-06-12 | 2002-12-19 | Biocoat Incorporated | Coatings appropriate for medical devices |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109966560A (en) * | 2019-03-13 | 2019-07-05 | 业聚医疗器械(深圳)有限公司 | A kind of medical catheter hydrophilic lubrication coating of photocuring and preparation method thereof |
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| CN114099790A (en) * | 2020-10-17 | 2022-03-01 | 河南驼人贝斯特医疗器械有限公司 | Lubricating coating of medical catheter and preparation method thereof |
| CN114515358A (en) * | 2022-02-15 | 2022-05-20 | 昆山韦睿医疗科技有限公司 | Hydrophilic coating and application thereof |
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