CN106938061B - Coating method for improving surface of interventional instrument - Google Patents
Coating method for improving surface of interventional instrument Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/148—Materials at least partially resorbable by the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D1/00—Processes for applying liquids or other fluent materials
- B05D1/36—Successively applying liquids or other fluent materials, e.g. without intermediate treatment
- B05D1/38—Successively applying liquids or other fluent materials, e.g. without intermediate treatment with intermediate treatment
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D3/00—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
- B05D3/02—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by baking
- B05D3/0254—After-treatment
- B05D3/0263—After-treatment with IR heaters
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D3/00—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
- B05D3/06—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to radiation
- B05D3/061—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to radiation using U.V.
- B05D3/065—After-treatment
- B05D3/067—Curing or cross-linking the coating
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D7/00—Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials
- B05D7/50—Multilayers
- B05D7/52—Two layers
- B05D7/54—No clear coat specified
- B05D7/546—No clear coat specified each layer being cured, at least partially, separately
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/06—Coatings containing a mixture of two or more compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/08—Coatings comprising two or more layers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D2451/00—Type of carrier, type of coating (Multilayers)
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D2503/00—Polyurethanes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D2518/00—Other type of polymers
Abstract
The invention relates to a coating method for improving the surface of an interventional instrument, belonging to the technical field of medical instrument manufacturing. A coating method for improving the surface of an interventional device is characterized in that a bottom layer solution is coated on the surface of the interventional device, a first curing treatment is carried out, then a top layer solution is coated, and a second curing treatment is carried out. The invention has the advantages that: the coating solution has simple formula, easy realization, simple process, safety and reliability; not only can provide a coating with excellent biocompatibility and hydrophilicity for the interventional instrument, but also avoids the damage of organic solvent to the surface of the polymer interventional instrument and the organic solvent residue in the preparation process. The interventional device prepared by the method can smoothly pass through the blood vessels, non-blood vessels and other parts of the human body, reduces the damage of the device to the vessel wall and realizes good targeted delivery.
Description
Technical Field
The invention relates to a coating method for improving the surface of an interventional instrument, belonging to the technical field of medical instrument manufacturing.
Background
Percutaneous puncture (percutaneous puncture technique) is the basis of interventional radiology, and aims to establish channels including blood vessel and non-blood vessel channels, and most interventional techniques need to complete diagnosis and treatment processes through the channels, so that a conveying appliance reaches a lesion target part, and the aim of accurate treatment is fulfilled.
The blood vessel and the non-blood vessel channel are established in a human body, generally, a polymer pipe is adopted to carry to a human target part along a guide wire through percutaneous puncture, instruments, medicines and implants are conveyed to a pathological change part through the inside of the polymer pipe, therefore, a hydrophilic material is coated on the outer layer of the polymer pipe, the smooth factor of the pipe is increased, the damage to the wall of the human body when the pipe passes through is reduced, the modified hydrophilic and lubricated surface can improve the anti-bacterial adhesion capability of the interventional catheter, the complications such as septicemia or phlebitis caused by interventional diagnosis and treatment are prevented, and the anti-infection performance of the interventional catheter is indirectly improved. The catheter is coated with a hydrophilic coating to form an ultra-smooth surface, the formula and the process of the catheter are important research projects for scientific researchers engaged in polymer medical instruments, and most of the adopted materials have good biocompatibility and blood compatibility.
Polyvinyl alcohol (PVA) is white powder of a hydrolysate of polyvinyl acetate, and is soluble in water. The medical grade polyvinyl alcohol is an extremely safe high molecular organic matter, has no toxicity or side effect on a human body, has good biocompatibility and anticoagulation, and is widely applied to ophthalmic water-based gel, wound dressing, artificial joints, skin repair and the like in medical treatment.
The polyurethane material has good hydrophilic performance, is soft under the conditions of drying and water absorption, and has good biocompatibility and blood compatibility, excellent physical and mechanical properties, good stability, no distortion effect and no anaphylactic reaction due to the special chemical structure; the toxicity test meets the medical requirements; excellent toughness and elasticity and good processing performance, and further develops the application of the polyurethane material in biomedicine. Products which have been in history for over 50 years include artificial heart assist devices, medical catheters and vascular prostheses, polyurethane dressings, polyurethane medical film products, artificial skins, prostheses, polyurethane bandages, artificial kidneys, artificial lungs, artificial livers, and the like.
The medical grade polyvinylpyrrolidone (PVP) has excellent biocompatibility, does not cause any stimulation to human skin, mucous membrane, eyes and the like, is one of the internationally advocated medical dressings, can be used as tablets, capsules, lubricants and coating film forming agents, has the effects of detoxifying, stopping bleeding, improving the dissolution concentration, preventing peritoneal adhesion, promoting blood circulation and the like, and is used for increasing the hydrophilicity and the lubricity of the invisible eyes.
We have found that a top-layer solution of liquid polyurethane and polyvinylpyrrolidone in a specific concentration can provide the surface of a polymeric interventional device with excellent hydrophilicity and biocompatibility. However, since the polyurethane is dissolved by the volatile organic solvent, if the polyurethane is directly coated on the surface of the medical equipment made of the polymer material, the surface of the medical equipment is damaged, and after the top layer solution is rapidly cured, part of the solvent is absorbed by the polymer interventional instrument, so that the solvent is remained, the biological performance of the medical equipment is affected, and the surface of the interventional instrument is seriously dissolved to deform, so that the product quality is affected.
Disclosure of Invention
The technical problem to be solved by the invention is to provide a coating method for improving the surface of an interventional instrument, which can avoid residual solvent on the top layer.
In order to achieve the purpose, the invention adopts the following technical scheme:
a coating method for improving the surface of an interventional device comprises the steps of coating a bottom solution on the surface of the interventional device, carrying out primary curing treatment, then coating a top solution, and carrying out secondary curing treatment;
wherein the formulation of the bottom layer solution is as follows:
100 ml of water;
5-15 g (preferably 8-12 g, more preferably 10 g) of polyvinyl alcohol;
the preparation method of the bottom layer solution comprises the following steps: adding 5-15 g of polyvinyl alcohol (PVA) into every 100 ml of deionized water, heating to 70-80 ℃, stirring at a constant speed, and cooling the solution to room temperature while stirring after the PVA is completely dissolved.
The top layer solution has excellent tissue compatibility and is prepared according to the following formula:
100 ml of liquid polyurethane solution;
5-20 g (preferably 8-15 g, more preferably 10 g) of polyvinylpyrrolidone;
800.2-2 ml of Tween (preferably 0.5-1 ml, more preferably 0.5 ml);
wherein the formula of the liquid polyurethane solution is as follows:
100 ml of dioxane;
8-10 g of polyurethane;
and 800.2-2 ml (preferably 0.5-1 ml, and more preferably 0.5 ml) of Tween.
The preparation method of the top layer solution comprises the following steps:
(1) adding 8-10 g of polyurethane into 100 ml of dioxane solvent, adding 0.2-2 ml of Tween 80, and stirring for dissolving to obtain a liquid polyurethane solution;
(2) and (2) taking 100 ml of the liquid polyurethane solution obtained in the step (1), adding 5-20 g of polyvinylpyrrolidone, adding 0.2-2 ml of Tween 80, and stirring at a constant speed at room temperature until the polyvinylpyrrolidone is dissolved.
The invention adopts the bottom layer solution as the protective layer of the surface of the medical polymer interventional instrument, and the polyvinyl alcohol (PVA) contains a large amount of hydrophilic group hydroxyl, so that the polyvinyl alcohol (PVA) shows strong affinity to water in the external dry-wet change, and the infrared light curing ensures that the polyvinyl alcohol (PVA) solution forms a protective film on the surface of the interventional instrument to tightly coat the instrument, thereby being beneficial to the volatilization of water molecules of the polymer interventional instrument. And polyvinyl alcohol (PVA) is difficult to dissolve in organic solvent, so that the residual of the organic solvent in the top layer solution in the interventional device is effectively avoided, and the damage to the surface layer of the medical interventional device made of high polymer materials is avoided.
The curing treatment method is infrared light curing or ultraviolet light curing, preferably infrared light curing, and most preferably mid-infrared light curing. The curing method of the invention has short time, wherein the ultraviolet curing has stricter requirements on the environment. The infrared spectrum wavelength range is 0.75-830 mu m, and the frequency wave number range is 13330-12 cm-1The method is divided into three areas: near infrared, mid infrared, far infrared. Most medical intervention instruments are made of high polymer materials, and the pursuit of approach to human skin tissues shows that near infrared penetrates into human tissues by 5-15 mm, far infrared penetrates through the tissues by less than 2 mm, and according to a formula E of Planck, where E is energy, ν is frequency, and h is Planck constant ν λ c, so that E ═ hc/λ is smaller than obvious wavelength λ, and E is larger. It shows that the near infrared generates high heat energy and the far infrared generates low heat energy. Through research, the curing by using the mid-infrared light can avoid the height of the near-infrared lightThe surface of the polymer interventional instrument is softened by heat energy, and the problem of small penetration depth of far infrared light can be avoided, so that the invention preferably adopts mid-infrared light curing.
The medium infrared light curing method comprises the following steps: using a continuous wavelength of 2.5-15.4 μm and a frequency of 4000-650 cm-1The interventional instrument coated with the bottom layer solution or the top layer solution is irradiated by the infrared light waves, and the curing time is 1-8 minutes. The curing time depends on the number and power of the curing light sources, for example, when a 300W mid-infrared lamp is used, the curing time is 1 minute, while when a 50W mid-infrared lamp is used, the curing time is 8 minutes, and when a plurality of 50W mid-infrared lamps are used, the curing time is correspondingly shortened.
Methods of coating include, but are not limited to, dip coating, spray coating, ultrasonic spray coating, and the like. The specific situation needs to be determined according to the size and the shape of the instrument. For conventional polymeric medical devices, dip coating methods may be used, namely: immersing the interventional instrument into the bottom layer solution, coating the bottom layer solution on the surface of the interventional instrument, then extracting the medical instrument from the bottom layer solution, and carrying out primary curing treatment by adopting infrared light for 1-8 minutes; and then immersing the cured interventional instrument into the top layer solution, coating the surface of the interventional instrument with the bottom layer solution, then extracting the medical instrument from the top layer solution, and performing secondary curing treatment by adopting infrared light for 1-8 minutes. The immersion and withdrawal operations are preferably slow, stable, and uniform. After the interventional device is immersed in the solution every time, the interventional device can be immersed for a certain time (for example, 0.5-30 minutes), and can also be directly extracted without immersion.
It is a further object of the present invention to provide a material that can be coated directly on the surface of an interventional device, where the performance and biocompatibility of the interventional device is improved.
A hydrophilic coating composition for improving the surface of an interventional device comprises a bottom layer solution and a top layer solution;
wherein the formulation of the bottom layer solution is as follows:
100 ml of water;
5-15 g (preferably 8-12 g, more preferably 10 g) of polyvinyl alcohol;
wherein the formula of the top layer solution is as follows:
100 ml of liquid polyurethane solution;
5-20 g (preferably 8-15 g, more preferably 10 g) of polyvinylpyrrolidone;
800.5 ml of Tween (preferably 0.5-1 ml, most preferably 0.5 ml);
wherein the formula of the liquid polyurethane solution is as follows:
100 ml of dioxane;
8-10 g (preferably 10 g) of polyurethane;
tween 800.5 ml (preferably 0.5-1 ml, more preferably 0.5 ml)
The dosage of the raw materials can be simultaneously expanded or reduced in equal proportion according to the actual use requirement.
A third object of the present invention is to provide a medical interventional device prepared by the novel coating method of the present invention. The surface of the interventional device has excellent biocompatibility and blood compatibility, and the interventional device matrix made of high polymer materials does not contain organic solvent residues in a top layer solution, so that the surface is smooth and clean. The coating has good lubricity and strong adhesive force after being wetted.
The invention is suitable for hydrophilic modification of the surfaces of most polymer materials, wherein the polymer materials comprise single-component high polymer materials such as polyethylene, polypropylene, vinyl chloride, polystyrene, polyamide, polyurethane, polyester, silicon rubber and the like, or various modified products or composite products thereof.
The invention is applicable to most medical instruments of different shapes and specifications, including but not limited to catheters, thrombus suction tubes, dilation tubes, angiographic catheters, endoscopy devices, angioplasty balloons, drainage tubes, arteriovenous separators, gastric tubes, urethral cannulas, laparoscopic devices or implants, and is particularly applicable to medical instruments that need to be inserted into and eventually exit the body during a surgical procedure.
The surface of the interventional instrument is protected by a polyvinyl alcohol (bottom layer solution) film material, a mixed solution (top layer solution) of liquid polyurethane and polyvinylpyrrolidone (PVP) is coated on the polyvinyl alcohol (bottom layer solution) film material by utilizing the characteristic that the polyvinyl alcohol (bottom layer solution) film material is insoluble in an organic solvent, and finally the organic solvent in the top layer solution is volatilized by infrared light irradiation, so that the interventional instrument reaches the safe use standard, and the surface modification of the interventional instrument is completed.
The invention has the advantages that: the coating solution has simple formula, easy realization, simple process, safety and reliability; not only can provide a coating with excellent biocompatibility and hydrophilicity for the interventional instrument, but also avoids the damage of organic solvent to the surface of the polymer interventional instrument and the organic solvent residue in the preparation process. The interventional device prepared by the method can smoothly pass through the blood vessels, non-blood vessels and other parts of the human body, reduces the damage of the device to the vessel wall and realizes good targeted delivery.
The invention is further illustrated by the following detailed description, which is not to be construed as limiting the invention. All such equivalent alterations and modifications in the field, which are intended to be part of this disclosure, are intended to be within the scope of this invention.
Detailed Description
Example 1
Materials (I) and (II)
1. Bottom layer solution: adding 10 g of polyvinyl alcohol into 100 ml of deionized water, heating to 70-80 ℃, stirring at a constant speed, and cooling the solution to room temperature while stirring after the polyvinyl alcohol is completely dissolved.
2. Top layer solution: adding 10 g of polyurethane into 100 ml of dioxane solvent, adding 0.5 ml of Tween 80, and stirring for dissolving to obtain a liquid polyurethane solution; and taking 100 ml of the obtained liquid polyurethane solution, adding 10 g of polyvinylpyrrolidone, then adding 0.5 ml of Tween 80, and stirring at a constant speed at room temperature until the polyvinylpyrrolidone is dissolved.
Second, method
1. Slowly, stably and uniformly immersing an interventional instrument (catheter) into the bottom layer solution to coat the surface of the interventional instrument with the bottom layer solution, taking the interventional instrument out of the bottom layer solution in the same operation mode, carrying out primary curing treatment, adopting 3 medium infrared lamps with the power of 50W as a curing light source, and using continuous wavelength of 2.5-15.4 mu m and frequencyThe rate is 4000-650 cm-1Irradiating the interventional instrument with the infrared light waves for 5 minutes;
2. slowly, stably and uniformly immersing the cured interventional instrument into the top layer solution to coat the surface of the interventional instrument with the top layer solution, then taking the interventional instrument out of the top layer solution in the same operation mode, performing secondary curing treatment, taking 3 medium infrared lamps with the power of 50W as a curing light source, and using continuous wavelength of 2.5-15.4 mu m and the frequency of 4000-650 cm-1The interventional instrument was irradiated for 5 minutes.
Three, result in
Experiments prove that the interventional instrument has excellent biocompatibility and hydrophilicity, the coating has good lubricity after being wetted, the adhesive force is strong, the surface of the interventional instrument is smooth and has no damage, and the interventional instrument has no organic solvent residue in a top layer solution.
Example 2
Materials (I) and (II)
1. Bottom layer solution: adding 5 g of polyvinyl alcohol into 100 ml of deionized water, heating to 70-80 ℃, stirring at a constant speed, and cooling the solution to room temperature while stirring after the polyvinyl alcohol is completely dissolved.
2. Top layer solution: adding 8 g of polyurethane into 100 ml of dioxane solvent, adding 0.2 ml of Tween 80, and stirring for dissolving to obtain a liquid polyurethane solution; and taking 100 ml of the obtained liquid polyurethane solution, adding 5 g of polyvinylpyrrolidone, then adding 0.5 ml of Tween 80, and stirring at a constant speed at room temperature until the polyvinylpyrrolidone is dissolved.
Second, method
1. Slowly, stably and uniformly immersing an interventional instrument (a thrombus suction tube) into the bottom layer solution to coat the surface of the interventional instrument with the bottom layer solution, taking the interventional instrument out of the bottom layer solution in the same operation mode, carrying out primary curing treatment, taking 4 medium infrared lamps with the power of 50W as a curing light source, and using a continuous wavelength of 2.5-15.4 mu m and a frequency of 4000-650 cm-1Irradiating the interventional instrument with the infrared light waves for 3 minutes;
2. the interventional device after the curing treatment is slowly, stably and uniformly immersed into the top layer solution, so that the surface of the interventional device is coated with the top layer solution and then runs in the same running modeThe interventional instrument is lifted out of the top layer solution for the second curing treatment, 4 medium infrared lamps with the power of 50W are used as curing light sources, and the continuous wavelength is 2.5-15.4 mu m, and the frequency is 4000-650 cm-1The interventional instrument was irradiated for 3 minutes.
Three, result in
Experiments prove that the interventional instrument has excellent biocompatibility and hydrophilicity, the coating has good lubricity after being wetted, the adhesive force is strong, the surface of the interventional instrument is smooth and has no damage, and the interventional instrument has no organic solvent residue in a top layer solution.
Example 3
Materials (I) and (II)
1. Bottom layer solution: adding 15 g of polyvinyl alcohol into 100 ml of deionized water, heating to 70-80 ℃, stirring at a constant speed, and cooling the solution to room temperature while stirring after the polyvinyl alcohol is completely dissolved.
2. Top layer solution: adding 9 g of polyurethane into 100 ml of dioxane solvent, adding 2 ml of Tween 80, and stirring for dissolving to obtain a liquid polyurethane solution; and taking 100 ml of the obtained liquid polyurethane solution, adding 20 g of polyvinylpyrrolidone, then adding 0.5 ml of Tween 80, and stirring at a constant speed at room temperature until the polyvinylpyrrolidone is dissolved.
Second, method
1. Slowly, stably and uniformly immersing an interventional instrument (drainage tube) into the bottom layer solution to coat the surface of the interventional instrument with the bottom layer solution, then taking the interventional instrument out of the bottom layer solution in the same operation mode, carrying out primary curing treatment, and adopting continuous wavelength of 2.5-15.4 mu m and frequency of 4000-650 cm-1Irradiating the interventional instrument with the infrared light waves for 6 minutes;
2. slowly, stably and uniformly immersing the cured interventional instrument into the top layer solution to coat the surface of the interventional instrument with the top layer solution, then taking the interventional instrument out of the top layer solution in the same operation mode, performing secondary curing treatment, and adopting continuous wavelength of 2.5-15.4 mu m and frequency of 4000-650 cm-1The interventional instrument was irradiated for 6 minutes.
Three, result in
Experiments prove that the interventional instrument has excellent biocompatibility and hydrophilicity, the coating has good lubricity after being wetted, the adhesive force is strong, the surface of the interventional instrument is smooth and has no damage, and the interventional instrument has no organic solvent residue in a top layer solution.
Example 4
Materials (I) and (II)
1. Bottom layer solution: adding 8 g of polyvinyl alcohol into 100 ml of deionized water, heating to 70-80 ℃, stirring at a constant speed, and cooling the solution to room temperature while stirring after the polyvinyl alcohol is completely dissolved.
2. Top layer solution: adding 9 g of polyurethane into 100 ml of dioxane solvent, adding 1 ml of Tween 80, and stirring for dissolving to obtain a liquid polyurethane solution; and taking 100 ml of the obtained liquid polyurethane solution, adding 8 g of polyvinylpyrrolidone, then adding 0.2 ml of Tween 80, and stirring at a constant speed at room temperature until the polyvinylpyrrolidone is dissolved.
Second, method
1. Slowly, stably and uniformly immersing an interventional instrument (stomach tube) into the bottom layer solution to coat the surface of the stomach tube with the bottom layer solution, then taking the interventional instrument out of the bottom layer solution in the same operation mode, carrying out primary curing treatment, and adopting continuous wavelength of 2.5-15.4 mu m and frequency of 4000-650 cm-1Irradiating the interventional instrument with the infrared light waves for 7 minutes;
2. slowly, stably and uniformly immersing the cured interventional instrument into the top layer solution to coat the surface of the interventional instrument with the top layer solution, then taking the interventional instrument out of the top layer solution in the same operation mode, performing secondary curing treatment, and adopting continuous wavelength of 2.5-15.4 mu m and frequency of 4000-650 cm-1The interventional instrument was irradiated with infrared light waves for 7 minutes.
Three, result in
Experiments prove that the interventional instrument has excellent biocompatibility and hydrophilicity, the coating has good lubricity after being wetted, the adhesive force is strong, the surface of the interventional instrument is smooth and has no damage, and the interventional instrument has no organic solvent residue in a top layer solution.
Example 5
Materials (I) and (II)
1. Bottom layer solution: adding 12 g of polyvinyl alcohol into 100 ml of deionized water, heating to 70-80 ℃, stirring at a constant speed, and cooling the solution to room temperature while stirring after the polyvinyl alcohol is completely dissolved.
2. Top layer solution: adding 10 g of polyurethane into 100 ml of dioxane solvent, adding 1.5 ml of Tween 80, and stirring for dissolving to obtain a liquid polyurethane solution; and taking 100 ml of the obtained liquid polyurethane solution, adding 15 g of polyvinylpyrrolidone, adding 2 ml of Tween 80, and stirring at a constant speed at room temperature until the polyvinylpyrrolidone is dissolved.
Second, method
1. Slowly, stably and uniformly immersing an interventional instrument (a urethral intubation tube) into the bottom layer solution to coat the bottom layer solution on the surface of the interventional instrument, then taking the interventional instrument out of the bottom layer solution in the same operation mode, carrying out primary curing treatment, taking 1 medium infrared lamp with the power of 50W as a curing light source, and using a continuous wavelength of 2.5-15.4 mu m and the frequency of 4000-650 cm-1Irradiating the interventional instrument with the infrared light waves for 8 minutes;
2. slowly, stably and uniformly immersing the cured interventional instrument into the top layer solution to coat the surface of the interventional instrument with the top layer solution, then taking the interventional instrument out of the top layer solution in the same operation mode, performing secondary curing treatment, taking 1 medium infrared lamp with the power of 50W as a curing light source, and using the medium infrared lamp with the continuous wavelength of 2.5-15.4 mu m and the frequency of 4000-650 cm as a curing light source-1The interventional instrument was irradiated for 8 minutes.
Three, result in
Experiments prove that the interventional instrument has excellent biocompatibility and hydrophilicity, the coating has good lubricity after being wetted, the adhesive force is strong, the surface of the interventional instrument is smooth and has no damage, and the interventional instrument has no organic solvent residue in a top layer solution.
Example 6
Materials (I) and (II)
1. Bottom layer solution: adding 9 g of polyvinyl alcohol into 100 ml of deionized water, heating to 70-80 ℃, stirring at a constant speed, and cooling the solution to room temperature while stirring after the polyvinyl alcohol is completely dissolved.
2. Top layer solution: adding 10 g of polyurethane into 100 ml of dioxane solvent, adding 0.5 ml of Tween 80, and stirring for dissolving to obtain a liquid polyurethane solution; and taking 100 ml of the obtained liquid polyurethane solution, adding 12 g of polyvinylpyrrolidone, adding 1 ml of Tween 80, and stirring at a constant speed at room temperature until the polyvinylpyrrolidone is dissolved.
Second, method
1. Slowly, stably and uniformly immersing an interventional instrument (a thrombus suction tube) into the bottom layer solution to coat the surface of the interventional instrument with the bottom layer solution, then taking the interventional instrument out of the bottom layer solution in the same operation mode, carrying out primary curing treatment, taking 1 medium infrared lamp with the power of 300W as a curing light source, and using a continuous wavelength of 2.5-15.4 mu m and the frequency of 4000-650 cm-1Irradiating the interventional instrument with the infrared light waves for 1 minute;
2. slowly, stably and uniformly immersing the cured interventional instrument into the top layer solution to coat the surface of the interventional instrument with the top layer solution, then taking the interventional instrument out of the top layer solution in the same operation mode, performing secondary curing treatment, taking 1 medium infrared lamp with the power of 300W as a curing light source, and using the medium infrared lamp with the continuous wavelength of 2.5-15.4 mu m and the frequency of 4000-650 cm as a curing light source-1The interventional instrument was irradiated for 1 minute.
Three, result in
Experiments prove that the interventional instrument has excellent biocompatibility and hydrophilicity, the coating has good lubricity after being wetted, the adhesive force is strong, the surface of the interventional instrument is smooth and has no damage, and the interventional instrument has no organic solvent residue in a top layer solution.
Claims (11)
1. A coating method for improving the surface of an interventional device, comprising: coating a bottom layer solution on the surface of the interventional device, performing primary curing treatment, then coating a top layer solution, and performing secondary curing treatment; the curing treatment method is infrared light curing or ultraviolet light curing;
wherein the formulation of the bottom layer solution is as follows:
100 ml of water;
8-12 g of polyvinyl alcohol;
the formula of the top layer solution is as follows:
100 ml of liquid polyurethane solution;
8-15 g of polyvinylpyrrolidone;
800.5-1 ml of Tween;
wherein the formula of the liquid polyurethane solution is as follows:
100 ml of dioxane;
8-10 g of polyurethane;
tween 800.5-1 ml.
2. A coating method for improving the surface of an interventional device as defined in claim 1, wherein: the formulation of the bottom layer solution is as follows:
100 ml of water;
10 g of polyvinyl alcohol;
the formula of the top layer solution is as follows:
100 ml of liquid polyurethane solution;
10 g of polyvinylpyrrolidone;
tween 800.5 ml;
wherein the formula of the liquid polyurethane solution is as follows:
100 ml of dioxane;
10 g of polyurethane;
tween 800.5 ml.
3. A coating method for improving the surface of an interventional device according to any one of claims 1 or 2, characterized in that: the infrared light curing is mid-infrared light curing.
4. A coating method for improving the surface of an interventional device as set forth in claim 3, wherein the mid-infrared curing method comprises: using a continuous wavelength of 2.5-15.4 μm and a frequency of 4000-650 cm-1The interventional instrument coated with the bottom layer solution or the top layer solution is irradiated by the infrared light waves, and the curing time is 1-8 minutes.
5. A coating method for improving the surface of an interventional device according to claim 1 or 2, characterized in that: the coating method is a dip coating method or a spraying method.
6. A coating method for improving the surface of an interventional device as defined in claim 5, wherein: the spraying method is an ultrasonic spraying method.
7. A hydrophilic coating composition for modifying the surface of an interventional device, the hydrophilic coating composition comprising: dividing the solution into a bottom layer solution and a top layer solution;
wherein the formulation of the bottom layer solution is as follows:
100 ml of water;
8-12 g of polyvinyl alcohol;
the formula of the top layer solution is as follows:
100 ml of liquid polyurethane solution;
8-15 g of polyvinylpyrrolidone;
800.5-1 ml of Tween;
wherein the formula of the liquid polyurethane solution is as follows:
100 ml of dioxane;
8-10 g of polyurethane;
tween 800.5-1 ml.
8. The hydrophilic coating composition for improving the surface of an interventional device as defined in claim 7, wherein the formulation of the primer solution is as follows:
100 ml of water;
10 g of polyvinyl alcohol;
the formula of the top layer solution is as follows:
100 ml of liquid polyurethane solution;
10 g of polyvinylpyrrolidone;
tween 800.5 ml;
wherein the formula of the liquid polyurethane solution is as follows:
100 ml of dioxane;
10 g of polyurethane;
tween 800.5 ml.
9. Medical device obtained by the method according to any one of claims 1 to 6, characterized in that: the medical device is a catheter, an endoscopic device, an angioplasty balloon, an arteriovenous separator, or an implant.
10. The medical device of claim 9, wherein: the catheter is a thrombus suction tube, an expansion tube, a radiography catheter, a drainage tube, a stomach tube or a urethra intubation tube.
11. The medical device of claim 9, wherein: the endoscopy device is a laparoscopy device.
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| CN110170076A (en) * | 2019-03-18 | 2019-08-27 | 苏州恒瑞宏远医疗科技有限公司 | Head end can elute microtubular |
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