CN1229146C - 具有生物活性和治疗骨质疏松的骨粘固剂 - Google Patents
具有生物活性和治疗骨质疏松的骨粘固剂 Download PDFInfo
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- CN1229146C CN1229146C CNB008180539A CN00818053A CN1229146C CN 1229146 C CN1229146 C CN 1229146C CN B008180539 A CNB008180539 A CN B008180539A CN 00818053 A CN00818053 A CN 00818053A CN 1229146 C CN1229146 C CN 1229146C
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- bone cement
- biological activity
- activity bone
- powder
- peptide
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- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
- A61L24/0084—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing fillers of phosphorus-containing inorganic compounds, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/406—Antibiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
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- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Surgery (AREA)
- Plastic & Reconstructive Surgery (AREA)
- Dispersion Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Composite Materials (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
成分 | 重量份 |
双酚A二环氧甘油醚二甲基丙烯酸酯(D-GMA) | 50 |
三甘醇二甲基丙烯酸酯(TEGDMA) | 45 |
聚甲基丙烯酸乙二醇酯 | 4.5 |
N,N-二羟基丙基-p-甲苯胺 | 0.5 |
成分 | 重量份 |
含锶羟基磷灰石 | 95 |
热解法二氧化硅 | 4.5 |
过氧化苯甲酰 | 0.5 |
成分 | 重量份 |
双酚A二环氧甘油醚二甲基丙烯酸酯(D-GMA) | 50 |
三甘醇二甲基丙烯酸酯(TEGDMA) | 47 |
聚甲基丙烯酸乙二醇酯 | 2.75 |
N,N-二羟基丙基-p-甲苯胺 | 0.25 |
成分 | 重量份 |
含锶羟基磷灰石 | 95 |
热解法二氧化硅 | 4.5 |
过氧化苯甲酰(BPO) | 0.5 |
状况(情况) | 未受损(N/mm) | 开裂(N/mm) | 用粘固剂粘固的骨头(N/mm) | 在加疲劳载荷后 | 失效强度(N) |
刚度(平均值±标准差) | 1304.3±145.8 | 694.6±90.2 | 1462.4±154 | 1247.3±130.6 | 5055.8±682 |
未受损骨的% | 100 | 53.3 | 112.1 | 95.6 | n/a(未得到) |
成分 | 重量份 |
双酚A二环氧甘油醚二甲基丙烯酸酯(D-GDMA) | 50 |
三甘醇二甲基丙烯酸酯(TEGDMA) | 47 |
聚甲基丙烯酸乙二醇酯 | 2.75 |
N,N-二羟基丙基-p-甲苯胺 | 0.25 |
成分 | 重量份 |
含锶羟基磷灰石 | 95 |
热解法二氧化硅 | 5 |
成分 | 重量份 |
双酚A二环氧甘油醚二甲基丙烯酸酯(D-GDMA) | 50 |
三甘醇二甲基丙烯酸酯、(TEGDMA) | 47 |
聚甲基丙烯酸乙二醇酯 | 3 |
过氧化苯甲酰(BPO) | 0.25 |
成分 | 重量份 |
双酚A二环氧甘油醚二甲基丙烯酸酯(D-GDMA) | 50 |
三甘醇二甲基丙烯酸酯(TEGDMA) | 45 |
聚甲基丙烯酸乙二醇酯 | 4.5 |
N,N-二羟基丙基-p-甲苯胺 | 0.5 |
成分 | 重量份 |
含锶羟基磷灰石 | 95 |
热解法二氧化硅 | 5 |
成分 | 重量份 |
双酚A二环氧甘油醚二甲基丙烯酸酯(D-DGMA) | 50 |
三甘醇二甲基丙烯酸酯(TEGDMA) | 45 |
聚甲基丙烯酸乙二醇酯 | 5 |
成分 | 重量份 |
含锶羟基磷灰石 | 95 |
热解法二氧化硅 | 5 |
Claims (31)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17420400P | 2000-01-03 | 2000-01-03 | |
US60/174,204 | 2000-01-03 | ||
US09/710,536 US6593394B1 (en) | 2000-01-03 | 2000-11-09 | Bioactive and osteoporotic bone cement |
US09/710,536 | 2000-11-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1414868A CN1414868A (zh) | 2003-04-30 |
CN1229146C true CN1229146C (zh) | 2005-11-30 |
Family
ID=26869991
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB008180539A Expired - Lifetime CN1229146C (zh) | 2000-01-03 | 2000-12-08 | 具有生物活性和治疗骨质疏松的骨粘固剂 |
Country Status (8)
Country | Link |
---|---|
US (1) | US6593394B1 (zh) |
EP (1) | EP1246651B1 (zh) |
JP (1) | JP2003518989A (zh) |
CN (1) | CN1229146C (zh) |
CA (1) | CA2395910C (zh) |
DE (1) | DE60041782D1 (zh) |
HK (1) | HK1046378B (zh) |
WO (1) | WO2001049327A2 (zh) |
Cited By (1)
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CN102405064A (zh) * | 2009-03-03 | 2012-04-04 | 格里福特斯公司 | 掺镓磷质钙化合物 |
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-
2000
- 2000-11-09 US US09/710,536 patent/US6593394B1/en not_active Expired - Lifetime
- 2000-12-08 JP JP2001549693A patent/JP2003518989A/ja active Pending
- 2000-12-08 CN CNB008180539A patent/CN1229146C/zh not_active Expired - Lifetime
- 2000-12-08 EP EP00988982A patent/EP1246651B1/en not_active Expired - Lifetime
- 2000-12-08 DE DE60041782T patent/DE60041782D1/de not_active Expired - Lifetime
- 2000-12-08 CA CA002395910A patent/CA2395910C/en not_active Expired - Lifetime
- 2000-12-08 WO PCT/IB2000/002012 patent/WO2001049327A2/en active Application Filing
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2002
- 2002-11-04 HK HK02108005.4A patent/HK1046378B/zh not_active IP Right Cessation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102405064A (zh) * | 2009-03-03 | 2012-04-04 | 格里福特斯公司 | 掺镓磷质钙化合物 |
Also Published As
Publication number | Publication date |
---|---|
HK1046378B (zh) | 2009-07-17 |
CA2395910A1 (en) | 2001-07-12 |
WO2001049327A2 (en) | 2001-07-12 |
HK1046378A1 (en) | 2003-01-10 |
WO2001049327A3 (en) | 2002-01-03 |
JP2003518989A (ja) | 2003-06-17 |
CA2395910C (en) | 2009-09-22 |
DE60041782D1 (de) | 2009-04-23 |
EP1246651B1 (en) | 2009-03-11 |
EP1246651A4 (en) | 2007-09-26 |
EP1246651A2 (en) | 2002-10-09 |
CN1414868A (zh) | 2003-04-30 |
US6593394B1 (en) | 2003-07-15 |
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