CN1228973A - Soft capsule of notoginseng extract and its preparing process - Google Patents
Soft capsule of notoginseng extract and its preparing process Download PDFInfo
- Publication number
- CN1228973A CN1228973A CN 98106596 CN98106596A CN1228973A CN 1228973 A CN1228973 A CN 1228973A CN 98106596 CN98106596 CN 98106596 CN 98106596 A CN98106596 A CN 98106596A CN 1228973 A CN1228973 A CN 1228973A
- Authority
- CN
- China
- Prior art keywords
- soft capsule
- gelatin
- notoginseng extract
- lecithin
- radix notoginseng
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007901 soft capsule Substances 0.000 title claims abstract description 24
- 235000003143 Panax notoginseng Nutrition 0.000 title claims abstract description 20
- 241000180649 Panax notoginseng Species 0.000 title claims abstract description 20
- 238000000034 method Methods 0.000 title description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 58
- 108010010803 Gelatin Proteins 0.000 claims abstract description 27
- 239000008273 gelatin Substances 0.000 claims abstract description 27
- 229920000159 gelatin Polymers 0.000 claims abstract description 27
- 235000019322 gelatine Nutrition 0.000 claims abstract description 27
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 27
- 235000011187 glycerol Nutrition 0.000 claims abstract description 20
- 238000003756 stirring Methods 0.000 claims abstract description 12
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 11
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 11
- 239000000787 lecithin Substances 0.000 claims abstract description 11
- 229940067606 lecithin Drugs 0.000 claims abstract description 11
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims abstract description 10
- 244000131316 Panax pseudoginseng Species 0.000 claims abstract description 10
- 235000003181 Panax pseudoginseng Nutrition 0.000 claims abstract description 10
- 235000010445 lecithin Nutrition 0.000 claims abstract description 10
- 238000002360 preparation method Methods 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 238000007872 degassing Methods 0.000 claims abstract description 5
- 239000002904 solvent Substances 0.000 claims abstract description 3
- 239000007788 liquid Substances 0.000 claims description 16
- 235000006708 antioxidants Nutrition 0.000 claims description 10
- 239000003085 diluting agent Substances 0.000 claims description 7
- 239000000375 suspending agent Substances 0.000 claims description 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
- 238000005516 engineering process Methods 0.000 claims description 6
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 4
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 4
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 claims description 4
- 239000002671 adjuvant Substances 0.000 claims description 4
- -1 dibenzylatiooluene Chemical compound 0.000 claims description 4
- 239000004615 ingredient Substances 0.000 claims description 4
- 210000000582 semen Anatomy 0.000 claims description 4
- 238000005303 weighing Methods 0.000 claims description 4
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 3
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims description 2
- LKAPTZKZHMOIRE-KVTDHHQDSA-N (2s,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbaldehyde Chemical compound OC[C@H]1O[C@H](C=O)[C@@H](O)[C@@H]1O LKAPTZKZHMOIRE-KVTDHHQDSA-N 0.000 claims description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 2
- 229920001817 Agar Polymers 0.000 claims description 2
- 229920002101 Chitin Polymers 0.000 claims description 2
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 2
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 claims description 2
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims description 2
- 229920000896 Ethulose Polymers 0.000 claims description 2
- 239000001856 Ethyl cellulose Substances 0.000 claims description 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 2
- 239000001859 Ethyl hydroxyethyl cellulose Substances 0.000 claims description 2
- 239000004471 Glycine Substances 0.000 claims description 2
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 claims description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 2
- 229920001479 Hydroxyethyl methyl cellulose Polymers 0.000 claims description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 2
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 claims description 2
- 240000008415 Lactuca sativa Species 0.000 claims description 2
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 claims description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 2
- 239000008272 agar Substances 0.000 claims description 2
- 235000010419 agar Nutrition 0.000 claims description 2
- 229940087168 alpha tocopherol Drugs 0.000 claims description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 2
- 235000010323 ascorbic acid Nutrition 0.000 claims description 2
- 239000011668 ascorbic acid Substances 0.000 claims description 2
- 229960005070 ascorbic acid Drugs 0.000 claims description 2
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims description 2
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims description 2
- 239000007766 cera flava Substances 0.000 claims description 2
- LKAPTZKZHMOIRE-UHFFFAOYSA-N chitose Natural products OCC1OC(C=O)C(O)C1O LKAPTZKZHMOIRE-UHFFFAOYSA-N 0.000 claims description 2
- 229960004106 citric acid Drugs 0.000 claims description 2
- 235000015165 citric acid Nutrition 0.000 claims description 2
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims description 2
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims description 2
- 229920001249 ethyl cellulose Polymers 0.000 claims description 2
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 2
- 235000019326 ethyl hydroxyethyl cellulose Nutrition 0.000 claims description 2
- 229960002449 glycine Drugs 0.000 claims description 2
- 150000002333 glycines Chemical class 0.000 claims description 2
- 229960004337 hydroquinone Drugs 0.000 claims description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 2
- 229940071826 hydroxyethyl cellulose Drugs 0.000 claims description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 2
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 claims description 2
- 229960000367 inositol Drugs 0.000 claims description 2
- 239000001630 malic acid Substances 0.000 claims description 2
- 235000011090 malic acid Nutrition 0.000 claims description 2
- 229940099690 malic acid Drugs 0.000 claims description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 2
- 229920000609 methyl cellulose Polymers 0.000 claims description 2
- 239000001923 methylcellulose Substances 0.000 claims description 2
- 235000010981 methylcellulose Nutrition 0.000 claims description 2
- 239000000467 phytic acid Substances 0.000 claims description 2
- 235000002949 phytic acid Nutrition 0.000 claims description 2
- 229940068041 phytic acid Drugs 0.000 claims description 2
- RWPGFSMJFRPDDP-UHFFFAOYSA-L potassium metabisulfite Chemical compound [K+].[K+].[O-]S(=O)S([O-])(=O)=O RWPGFSMJFRPDDP-UHFFFAOYSA-L 0.000 claims description 2
- 229940043349 potassium metabisulfite Drugs 0.000 claims description 2
- 235000010263 potassium metabisulphite Nutrition 0.000 claims description 2
- 235000012045 salad Nutrition 0.000 claims description 2
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 claims description 2
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 claims description 2
- 235000010378 sodium ascorbate Nutrition 0.000 claims description 2
- 229960005055 sodium ascorbate Drugs 0.000 claims description 2
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 claims description 2
- 235000010262 sodium metabisulphite Nutrition 0.000 claims description 2
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 claims description 2
- 229960000984 tocofersolan Drugs 0.000 claims description 2
- 239000000230 xanthan gum Substances 0.000 claims description 2
- 229920001285 xanthan gum Polymers 0.000 claims description 2
- 235000010493 xanthan gum Nutrition 0.000 claims description 2
- 229940082509 xanthan gum Drugs 0.000 claims description 2
- 239000000811 xylitol Substances 0.000 claims description 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 2
- 229960002675 xylitol Drugs 0.000 claims description 2
- 235000010447 xylitol Nutrition 0.000 claims description 2
- 239000002076 α-tocopherol Substances 0.000 claims description 2
- 235000004835 α-tocopherol Nutrition 0.000 claims description 2
- 235000013305 food Nutrition 0.000 abstract description 7
- 238000002156 mixing Methods 0.000 abstract description 2
- 239000002775 capsule Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000003825 pressing Methods 0.000 abstract 1
- 238000005086 pumping Methods 0.000 abstract 1
- 239000000047 product Substances 0.000 description 6
- 235000015112 vegetable and seed oil Nutrition 0.000 description 6
- 239000008158 vegetable oil Substances 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000007903 gelatin capsule Substances 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000009413 insulation Methods 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 206010013786 Dry skin Diseases 0.000 description 1
- 241000132521 Erigeron Species 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 208000026278 immune system disease Diseases 0.000 description 1
- 230000007365 immunoregulation Effects 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 239000010687 lubricating oil Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
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- 238000005406 washing Methods 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a soft capsule oral health-care food and its preparation process. Each product contains 10-400 mg of notoginseng extract, lecithin and edible auxiliary materials. The capsule shell contains 10 portions of gelatin and 3.25-3.35 portions of glycerin (weight ratio), and its preparation process includes adding proper quantity of water into gelatin, completely dissolving, adding glycerin, uniformly stirring, vacuum-pumping, degassing, heat-insulating and standing still for stand-by, mixing notoginseng extract with solvent, adding antioxidant, uniformly stirring, standing at room temperature, and pressing into soft capsule by using mould. The invention provides a soft capsule health (functional) food taking pseudo-ginseng extract as a main effective component, which is convenient to eat and carry and has strong health care function.
Description
The present invention relates to contain the oral health care of soft capsule (function) food and the preparation technology thereof of Radix Notoginseng extract effective dose.
Radix Notoginseng extract is a yellow powder, dissolves in methanol, ethanol, water, is insoluble to ether etc.Have significantly blood lipid regulation and immunoregulation effect.Evidence: the crowd to immune dysfunction and blood-lipid imbalance has auxiliary treatment effect preferably.Also have no side effect.
At present, not having as yet on the market with Radix Notoginseng extract is health care (function) food of main effective ingredient, does not more have the food of corresponding soft capsule.
The purpose of this invention is to provide a kind of pseudo-ginseng extract soft capsule and preparation technology thereof, product is health care (function) food, and its steady quality is easy to use, effective.
Product of the present invention is made of health care liquid and softgel shell two large divisions, health care liquid contains the Radix Notoginseng extract of effective dosage as effective ingredient, and contain edible adjuvant, it is characterized in that edible adjuvant comprises diluent, antioxidant, suspending agent, contain 10 parts in gelatin in the softgel shell, glycerol 3.25-3.35 part (weight ratio), health care liquid by weight every contain Radix Notoginseng extract 10-400 milligram, and also contain lecithin.
Diluent can be one or more in Oleum Arachidis hypogaeae semen, Semen Maydis oil, Oleum Glycines, Oleum Camelliae, the salad oil.
Antioxidant can be one or more in ethylenediaminetetraacetic acid, disodium EDTA, dibenzylatiooluene, D-xylose, xylitol, glycine, alpha-tocopherol, α-tocopheryl acetate, inositol, ascorbic acid, sodium ascorbate, lecithin, malic acid, hydroquinone, citric acid, succinic acid, phytic acid, sodium pyrosulfite, the potassium metabisulfite.
Suspending agent can be one or more in ethylhydroxyethylcellulose, chitin, lecithin, chitose, methylcellulose, ethyl cellulose, agar, xanthan gum, hydroxyethylmethyl-cellulose, hydroxyethyl-cellulose, hydroxypropyl emthylcellulose, hydroxypropyl cellulose, the Cera Flava etc.
In the process of research pseudo-ginseng extract soft capsule, solved a following main difficult problem:
1, gelatin, glycerol proportioning are difficult to grasp in the prescription of softgel shell prescription (being applicable to oil-soluble health care liquid) softgel shell.The amount of glycerol is too many, and softgel shell is softer, than being easier to extrusion; The amount of glycerol very little, softgel shell is harder, crisp, influences the quality stability and the disintegration time of soft capsule.We have carried out detailed experimental study to the gelatin of softgel shell, the proportioning of glycerol, have obtained a proportioning preferably at last.
An amount of gelatin is added in the rustless steel glue pot, add suitable quantity of water again, airtight, 70 ℃ are incubated 3 hours, add glycerol, the antiseptic of test consumption more respectively, stir, vacuumize degassing 2 hours, put into 70 ℃ of insulations of gelatin heat-preserving container standing over night, second day, the moulding ball, drying at room temperature, keep sample and investigate three months, examination softgel shell outward appearance and physical property, the result is as follows:
| Index/content of the test | Gelatin 10kg glycerol 3.0kg | Gelatin 10kg glycerol 3.2kg | Gelatin 10kg glycerol 3.25-3.35kg | Gelatin 10kg glycerol 3.4kg | Gelatin 10kg glycerol 3.6kg |
| Softgel shell outward appearance and physical property | Too firmly, easily crisp | Too firmly, easily crisp | Suitable | Softer, the easy moisture absorption | Softer, the easy moisture absorption |
Illustrate: the softgel shell prescription that is filtered out is applicable to the place of warm moist.
By above test, can reach a conclusion, should contain in the prescription of softgel shell: 10 parts in gelatin, glycerol 3.25-3.35 part (weight ratio).
2, health care formula of liquid
The softgel shell of soft capsule has determined that the used diluent of health care liquid can not be water, ethanol and the bigger organic solvent of some toxicity, and ideal is oil substances.But because Radix Notoginseng extract is difficult to be dissolved in vegetable oil, therefore, we are by a large amount of tests, selected for use a kind of toxicity less, can be dissolved in the vegetable oil, can well Radix Notoginseng extract be suspended in the vegetable oil, and can for a long time stable material--lecithin.
An amount of lecithin is dissolved in an amount of vegetable oil, again Radix Notoginseng extract is added wherein, add suitable antioxidant afterwards and to prevent the health care liquid in the soft capsule rotten (oxidation) takes place in storage process, every of soft gelatin capsule contains principal agent--and the amount of Radix Notoginseng extract is determined; Consider the size of economic factor and selected every ball easy to prepare, finally can determine the health care formula of liquid of embodiment.
Should contain in the optimum formula of product of the present invention: component amount (gram/grain) Radix Notoginseng extract 0.01-0.5 diluent 0.06-1.2 gelatin 0.04-0.5 glycerol (32.5-33.5% of gelatin amount) lecithin 0.002-0.022 suspending agent 0.005-0.009 antioxidant 0.0007-0.005
Annotate: optimum formula is only for the present invention is further illustrated, and the scope of product of the present invention is not subjected to the limitation of this optimum formula.
The preparation technology of pseudo-ginseng extract soft capsule may further comprise the steps:
Gelatin adds suitable quantity of water under stirring, treat that gelatin dissolves fully after, add glycerol, stir, be incubated set aside for use after the vacuumize degassing; Take by weighing Radix Notoginseng extract and mix with the solvent phase of formula ratio, add antioxidant etc. again after treating to mix fully, stir, room temperature leaves standstill;
The medicinal liquid for preparing is poured in the medicinal liquid bucket, pressed soft capsule with mould.
It is soft capsule health care (function) food of main effective ingredient that good effect of the present invention has provided with Radix Notoginseng extract, edible and carrying convenience, and health care is strong.
The present invention prepares as stated above; and its detailed component is provided by the following example, but protection scope of the present invention is not limited to this.1 ( / ) 0.05 0.22 0.11 0.04 0.007α- 0.00082 ( / ) 0.1 0.07 0.05 0.015 0.005 0.0053 ( / ) 0.02 0.1 0.05 0.017 0.006α- 0.0008 0.0034 ( / ) 0.1 0.2 0.1 0.12 0.04 0.006 0.00085 ( / ) 0.2 0.4 0.15 0.17 0.06 0.007α- 0.0008 0.0156 ( / ) 0.4 0.8 0.3 0.4 0.14 0.009α- 0.0008 0.020
The preparation technology of above embodiment product is:
Take by weighing gelatin and add 100L gelatin retort, under stirring, add suitable quantity of water, airtight, treat that gelatin dissolves fully after, add glycerol again, stir, vacuumize degassing 2 hours is put into the gelatin heat-preserving container, the insulation standing over night is stand-by.
Under room temperature suspending agent is added in the vegetable oil, take by weighing Radix Notoginseng extract, pulverize, sieve, mix with vegetable oil, treat to add antioxidant etc. again behind the complete mixing, stir, room temperature leaves standstill.
The gelatin heat-preserving container is suspended from certain altitude, the medicinal liquid for preparing is poured in the funnel, change mould and begin to press soft capsule, adjust the soft capsule loading amount to scope of design, drying at room temperature two days, reject the soft gelatin capsule of presentation quality difference, with soft gelatin capsule washing (removing the lubricating oil in the pelleting process), again in 24 ℃ of dryings two days, the erigeron breviscopus element soft capsule semi-finished product, the qualified back packing of quality testing, labeling, packing promptly get the pseudo-ginseng extract soft capsule finished product.
Claims (4)
1, a kind of pseudo-ginseng extract soft capsule, constitute by health care liquid and softgel shell two large divisions, health care liquid contains the Radix Notoginseng extract of effective dosage as effective ingredient, and contain edible adjuvant, it is characterized in that edible adjuvant comprises diluent, antioxidant, suspending agent, contain 10 parts in gelatin in the softgel shell, glycerol 3.25-3.35 part (weight ratio), health care liquid by weight every contain Radix Notoginseng extract 10-400 milligram, and also contain lecithin.
2, as the said pseudo-ginseng extract soft capsule of claim 1, it is characterized in that:
Diluent is one or more in Oleum Arachidis hypogaeae semen, Semen Maydis oil, Oleum Glycines, Oleum Camelliae, the salad oil,
Antioxidant is one or more in ethylenediaminetetraacetic acid, disodium EDTA, dibenzylatiooluene, D-xylose, xylitol, glycine, alpha-tocopherol, α-tocopheryl acetate, inositol, ascorbic acid, sodium ascorbate, lecithin, malic acid, hydroquinone, citric acid, succinic acid, phytic acid, sodium pyrosulfite, the potassium metabisulfite
Suspending agent is one or more in ethylhydroxyethylcellulose, chitin, lecithin, chitose, methylcellulose, ethyl cellulose, agar, xanthan gum, hydroxyethylmethyl-cellulose, hydroxyethyl-cellulose, hydroxypropyl emthylcellulose, hydroxypropyl cellulose, the Cera Flava etc.
3,, it is characterized in that containing in the prescription: component amount (gram/grain) Radix Notoginseng extract 0.01-0.5 diluent 0.06-1.2 gelatin 0.04-0.5 glycerol (32.5-33.5% of gelatin amount) lecithin 0.002-0.022 suspending agent 0.005-0.009 antioxidant 0.0007-0.005 as the said pseudo-ginseng extract soft capsule of claim 2
4, a kind of pseudo-ginseng extract soft capsule preparation technology is characterized in that may further comprise the steps:
Gelatin adds suitable water under stirring, treat that gelatin dissolves fully after, add glycerol, stir, be incubated set aside for use after the vacuumize degassing,
Take by weighing Radix Notoginseng extract and mix with the solvent phase of formula ratio, add antioxidant etc. again after treating to mix fully, stir, room temperature leaves standstill,
The medicinal liquid for preparing is poured in the medicinal liquid bucket, pressed soft capsule with mould.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98106596A CN1064258C (en) | 1998-03-17 | 1998-03-17 | Soft capsule of notoginseng extract and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98106596A CN1064258C (en) | 1998-03-17 | 1998-03-17 | Soft capsule of notoginseng extract and its preparing process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1228973A true CN1228973A (en) | 1999-09-22 |
| CN1064258C CN1064258C (en) | 2001-04-11 |
Family
ID=5219032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98106596A Expired - Lifetime CN1064258C (en) | 1998-03-17 | 1998-03-17 | Soft capsule of notoginseng extract and its preparing process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1064258C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1326518C (en) * | 2004-03-26 | 2007-07-18 | 石药集团中奇制药技术（石家庄）有限公司 | Xiaoyao soft capsule and its preparation technology |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1058615C (en) * | 1995-02-15 | 2000-11-22 | 昆明制药股份有限公司 | Compound notoginseng preparation |
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1998
- 1998-03-17 CN CN98106596A patent/CN1064258C/en not_active Expired - Lifetime
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| Publication number | Publication date |
|---|---|
| CN1064258C (en) | 2001-04-11 |
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