CN108785476A - The preparation method and application of solid composite containing A Sayi fruits and Herba Cistanches - Google Patents
The preparation method and application of solid composite containing A Sayi fruits and Herba Cistanches Download PDFInfo
- Publication number
- CN108785476A CN108785476A CN201810760204.3A CN201810760204A CN108785476A CN 108785476 A CN108785476 A CN 108785476A CN 201810760204 A CN201810760204 A CN 201810760204A CN 108785476 A CN108785476 A CN 108785476A
- Authority
- CN
- China
- Prior art keywords
- herba cistanches
- sayi
- sai
- fruit
- powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/64—Orobanchaceae (Broom-rape family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Nutrition Science (AREA)
Abstract
The present invention provides a kind of solid composite containing A Sayi fruits and Herba Cistanches, and the solid composite includes pulvis, granule, tablets and capsules；The present invention also provides the preparation methods of the solid composite, and prepare tonifying kidney and strengthening yang, anti-oxidant, antifatigue, anti-aging, it is antitumor, adjust immune, liver protecting drug in application.
Description
Technical field
The present invention relates to a kind of healthy product composition, and its preparation method and application, specifically A Sayi fruits and Herba Cistanches
Solid composite, with and its preparation method and application.Health product composition of the present invention, including but not limited to drug,
Special diet, special medicine purposes formula food, nutritious health product, health food, functional food or ordinary food etc..
Background technology
Ah Sai fruit is babassu A Sayi palms（Euterpe oleraceae mart.）Fruit, English name
Claim Acai, Chinese translation A Sayi.Ah Sai fruit is a kind of berry of purple, is originated from Amazon area, northern in Brazil
Several centuries are eaten, locals is always using the fruit of this mystery as " miraculous cure " being guaranteed to cure all diseases.By modern science
Studies have shown that containing a large amount of in A Sayi fruits（Flavone compound）Anthocyanidin and（Polyphenol compound）Procyanidine, together
When also have contain amino acid, unsaturated fatty acid, lecithin, vitamin, dietary fibre, protein and mineral matter and other components.From
And A Sayi fruits are in anti-oxidant, antitumor, antifatigue, anti-aging, and it is anti-inflammatory, adjust immune, lipid-loweringing, hypoglycemic, Antialcoholic liver-protecting is beautiful
Holding beauty treatment etc. has notable effect.
However, disadvantageously, A Sayi fruits are difficult to preserve, usually all it is that removal pericarp and fruit stone are fabricated to concentration fruit
Slurry or fruit powder.Since A Sayi fruits are rich in（Flavone compound）Anthocyanidin and（Polyphenol compound）The objects such as procyanidine
Matter, stability is poor, is vulnerable to the influence of the factors such as temperature, water, pH, especially in neutral or alkaline environment or in liquid environment
Storage 4 days, A Sayi fruit anthocyanidin absorbance values decline 50% or more, even if in the solid state, although A Sayi fruit powders are stablized
Property it is opposite can improve it is very much, can be in thermal environment or neutral environment or alkaline environment but for temperature and pH or more sensitive
Under gradually degrade, seriously affect product quality and product development, the preparation, storage, circulation etc. of product brought serious bad
It influences.
Herba Cistanches（Cistanche deserticola Ma）, alias boundary rue, very little rue, desert cistanche, look into it is dry accuse it is sub-（Mongolian）, belong to
Endangered species.Some researches show that there is Herba Cistanches tonifying kidney and strengthening yang, anti-oxidant, antifatigue, anti-aging, antitumor, adjusting to be immunized, protect
Protecting liver and other effects.Herba Cistanches are a kind of parasitic plants colonizing in desert trees sacsaoul root, draw and support from sacsaoul host
Point and moisture, be known as the good reputation of " desert ginseng ", medical value is high, is the rare traditional Chinese medicine of Chinese tradition.There is meat desert in China
Rong's platymiscium has 4 kind of 1 mutation, including Desert Herba Cistanches（C.deserticola Y. C. Ma）, white flower salt desert cistanche（C.
salsa var.albiflora P.F. Tu et Z. C. Lou）, halophilous herbage（C. salsa (C.A.Mey.) G.
Beck）, Cistanche tubulosa and husky desert cistanche（C. sinensis G.Beck）, it is distributed in the Inner Mongol, Ningxia, Gansu and Xinjiang etc.
Ground.Desert Herba Cistanches and the legal base plant that Cistanche tubulosa is Herba Cistanches, halophilous herbage is on Ningxia, Xinjiang and other places
Also it is used as Herba Cistanches.With being continuously increased and long-term indiscriminate mining and serious waste, the resource of Cistanche deserticola plant for market demand
Fall sharply, especially Desert Herba Cistanches, wild resource has been on the verge of exhaustion.In order to solve the resource problem of Herba Cistanches, meet market
The sustainable development of demand and Chinese Medicine Industry develops the big face of Desert Herba Cistanches in the Inner Mongol, Ningxia, Gansu and Xinjiang at present
Product cultivation develops the extensive cultivation of Cistanche tubulosa in the Southern Xinjiang in Xinjiang, the resource problem of Herba Cistanches has been effectively relieved,
Also wild resource is protected.
Invention content
Inventor has found A Sayi fruits and Herba Cistanches are there is good synergistic function, simultaneously by further investigation
Also the stability of A Sayi fruit anthocyanidin can be improved.
The object of the present invention is to provide a kind of solid composite of A Sayi fruits and Herba Cistanches, the A Sayi fruits and meat desert
Rong further includes their extract.
It is a further object to provide the preparation method of above-mentioned solid composite and applications.
Ah's Sai fruit of the present invention further includes the extract of the A Sayi fruits, such as contains A Sayi fruit cyanine
Element, the A Sayi berry extracts of procyanidine or A Sayi fruit crude extracts；Herba Cistanches of the present invention further include the meat
The extract of desert cistanche or the crude extract of Herba Cistanches.Ah's Sai fruit or Herba Cistanches are usually with complete dry product or its extract
Powder morphology uses.
The solid composite of a kind of A Sayi fruits and Herba Cistanches provided by the invention, a combination thereof mode be by A Sayi fruits with
Herba Cistanches exist in the form of the preparation of compound, and the dosage form of the solid composite be including but not limited to pulvis, powder,
The solid pharmaceutical preparations such as granule, tablet, pill, micropill preparation or capsule.Using corresponding pharmaceutical carrier or auxiliary material, using different
Preparation process can be made into different compound medicinal formulations.It should be appreciated that compound preparation refers to making A Sayi fruits and Herba Cistanches
Individual preparation is made for active constituents of medicine, can include but is not limited to pulvis, powder, granule, tablet, pill, micro-
The solid pharmaceutical preparations such as pill or capsule, preferably pulvis, granule, tablet.
Particularly, the solid composite of a kind of A Sayi fruits and Herba Cistanches provided by the invention, when the solid composite
Dosage form when being the solid pharmaceutical preparations such as pulvis, powder, granule, tablet, pill, micropill preparation or capsule, wherein A Sayi fruits or
Herba Cistanches are with composition made of micronized form, and preferably A Sayi fruits reach fine-powder and/or the Herba Cistanches of broken wall
Reach the fine-powder of broken wall and manufactured composition, such as A Sayi fruits and Herba Cistanches are to crush skill by low-temperature airflow broken wall
Art crushes, and powder size is more than 800 mesh, and preferably powder size is in 800~1000 mesh, or even the granularity of preferably powder is big
In 1000 mesh.
A kind of A Sayi fruits of present invention offer are combined with Herba Cistanches with arbitrary proportion, preferably with the drug dose of synergistic effect
Ratio existing for present invention combination, or preferably deposited with the ratio for enhancing the drug dose of the stability of A Sayi fruit anthocyanidin
Present invention combination, such as A Sayi fruits and Herba Cistanches with weight ratio for 1：（0.1~10）Ratio combination, preferably A Sayi
Fruit is with Herba Cistanches with weight ratio for 1：（0.2~6）Ratio combination, most preferably A Sayi fruits and Herba Cistanches with weight ratio for 1：
（0.25~4）Ratio combination, such as preferred A Sayi fruits and Herba Cistanches with weight ratio for 4:1,3:1,2:1,1:1,1:2,1:
3,1:4 equal ratio combinations.
On the other hand, the present invention provides a kind of preparation methods of the solid composite of A Sayi fruits and Herba Cistanches, it is wrapped
It includes a A Sayi fruits and Herba Cistanches crushes, its powder size is made to be all higher than 800 mesh, then by A Sayi fruits and Herba Cistanches powder
Mixing；Such as using corresponding pharmaceutical carrier or auxiliary material, acceptable on drug can be made into using different preparation processes and appoint
What pharmaceutical solid preparation, such as pulvis, powder, granule, tablet, pill, micropill preparation or capsule solid pharmaceutical preparation.Particularly,
It is prepared by means known in the art, is preferred for preparing pulvis, granule, the tablet used in pharmacy.
Inventor devises the solid compositions for A Sayi fruit powders, A Sayi fruit powders and Herba Cistanches by experimental study
Object, separately sampled 8 of each solid composite（n=8）, pass through Accelerated stability test（Under the conditions of 40 DEG C, humidity 75%）It puts
It sets 2 months, samples.The content of anthocyanidin in each sample is detected using HPLC methods, and by result compared with 0 day, when obtaining 2 months
Between put the content drop-out value of anthocyanidin, content drop-out value is smaller, illustrates that stability is higher, and data are handled with statistics software, real
Test as a result, it has been found that：The stability of anthocyanidin in the solid composite of Ah's Sai fruit and Herba Cistanches is higher than the flower in A Sayi fruit powders
Green element.
Further, the present invention also provides the compositions containing A Sayi fruits and Herba Cistanches to be used to prepare tonifying kidney and strengthening yang, resists
Oxidation, antifatigue, anti-aging, antitumor, adjusting is immune, the application in liver protecting drug.
Specific implementation mode
In the implementation process of the present invention, those of ordinary skill in the art are not departing from scope and spirit of the present invention reality
The various embodiments generated on the basis of matter and modification are obvious and are easy to perform.Pass through following implementation
Example is further elaborated with the application etc. of the present invention, it is not intended that embodiment limitation of the present invention.
Embodiment 1, the solid composite of A Sayi fruits and Herba Cistanches and its preparation
Recipe quantity by weight percentage, contains：
Ah's Sai fruit powder 60%~90%, preferably 75%,
Herba Cistanches powder 10%~40%, preferably 25%；
It prepares：The crushing of low-temperature airflow crushing technology is respectively adopted in A Sayi fruits, Herba Cistanches and reaches 800~1000 mesh, the two etc.
Amount is incremental to be uniformly mixed, and with 75% ethanol solution, wet granulation, 45 DEG C~70 DEG C dryings to moisture are less than 5%, whole grain, i.e.,
?.
Embodiment 2, the solid composite of A Sayi fruits and Herba Cistanches and its preparation
Recipe quantity by weight percentage, contains：
Ah's Sai fruit powder 20%~70%, preferably 60%,
Herba Cistanches powder 10%~30%, preferably 20%,
Glucose 10%~20%, preferably 17.9%,
Sodium carboxymethylcellulose 0.5%~2%, preferably 2%,
Sucralose 0.01%~0.5%, preferably 0.1%；
It prepares：Low-temperature airflow crushing technology is respectively adopted in A Sayi fruits, Herba Cistanches, glucose, sodium carboxymethylcellulose to crush
Reaching 800~1000 mesh, equal increments are uniformly mixed, and Sucralose is dissolved in 75% ethanol solution, wet granulation, 45 DEG C~
70 DEG C of dryings to moisture be less than 5%, whole grain to get.
Embodiment 3, the solid composite of A Sayi fruits and Herba Cistanches and its preparation
Recipe quantity by weight percentage, contains：
Ah's Sai fruit powder 20%~70%, preferably 60%,
Herba Cistanches powder 10%~30%, preferably 20%,
Glucose 10%~20%, preferably 17.6%,
Sodium carboxymethylcellulose 0.5%~2%, preferably 2%,
Citric acid 0.1%~0.5%, preferably 0.2%,
Malic acid 0.01%~0.1%, preferably 0.05%,
Sodium citrate 0.01%~0.1%, preferably 0.05%,
Sucralose 0.01%~0.5%, preferably 0.1%；
Wherein, citric acid, malic acid and sodium citrate are as acid regulator.
It prepares：Low-temperature airflow crushing technology powder is respectively adopted in A Sayi fruits, Herba Cistanches, glucose, carboxymethyl cellulose sodium
Broken to reach 800~1000 mesh, equal increments are uniformly mixed, and citric acid, malic acid, sodium citrate, Sucralose are dissolved in 75% second
Alcoholic solution, wet granulation, 45 DEG C~70 DEG C dryings to moisture be less than 5%, whole grain to get.
Stability test：Solid composite made from optimizing prescriptions in Example 1, embodiment 2, embodiment 3, separately takes
Product, each sample respectively sample 8 to Ah's Sai fruit powder as a contrast（n=8）, the data result of detection is averaged, and passes through stability
Accelerated test（Under the conditions of 40 DEG C, humidity 75%）It places 2 months, sample detection, anthocyanidin in each sample is detected using HPLC methods
Content obtain the content drop-out value of 2 months point anthocyanidin and by result compared with 0 day, at data statistics software
Reason；Detection method：Using People's Republic of China's agricultural industry criteria《Cyanine in the plant-derived food of NY/T 2640-2014
The measurement high performance liquid chromatography of element》Measure total anthocyanidin content, mobile phase A be containing 1% aqueous formic acid, Mobile phase B be containing
1% formic acid acetonitrile solution, 20 μ L of sample size, 35 DEG C, Detection wavelength 530nm of column temperature, retention time are more than 7min.Test result is such as
Under：
Sample（N=8 are averaged）Anthocyanidin content drop-out value
Reference substance（Ah's Sai fruit powder） 4.81%
Embodiment 1 3.67%
Embodiment 2 3.58%
Embodiment 3 2.86%
The result shows that the content drop-out value of the anthocyanidin of solid composite made from embodiment 1, embodiment 2, embodiment 3 is bright
It is aobvious to be less than blank control sample（Ah's Sai fruit powder）, the anthocyanidin drop-out value of solid composite made from embodiment 1 and embodiment 2
Without significant difference, the anthocyanidin drop-out value of solid composite made from embodiment 3 is significantly lower than blank control sample（Ah Sai fruit
Powder）, embodiment 1 and embodiment 2, and it is anisotropic with significance difference.
Solid composite of the invention has significant stability in summary, especially in addition acid regulator lemon
In the case of acid, malic acid and sodium citrate, significant stability is had more.
Embodiment 4, A Sayi pulp desert cistanche particles and preparation method thereof
Recipe quantity by weight percentage, contains：
Ah's Sai fruit powder 60%,
Herba Cistanches powder 20%,
Glucose 17.6%,
Sodium carboxymethylcellulose 2%,
Citric acid 0.2%,
Malic acid 0.05%,
Sodium citrate 0.05%,
Sucralose 0.1%；
It prepares：Low-temperature airflow crushing technology is respectively adopted in A Sayi fruits, Herba Cistanches, glucose, sodium carboxymethylcellulose to crush
Up to 1000 mesh, equal increments are uniformly mixed, and citric acid, malic acid, sodium citrate, Sucralose are dissolved in 75% ethanol solution,
Wet granulation, 45 DEG C~70 DEG C dryings to moisture are less than 5%, and whole grain is to get A Sayi pulp desert cistanche particles.
Embodiment 5, A Sayi pulp desert cistanche pieces and preparation method thereof
Recipe quantity by weight percentage, contains：
Ah's Sai fruit powder 60%,
Herba Cistanches powder 20%,
Glucose 17.1%,
Sodium carboxymethylcellulose 2%,
Citric acid 0.2%,
Malic acid 0.05%,
Sodium citrate 0.05%,
Sucralose 0.1%,
Magnesium stearate 0.5%；
It prepares：Low-temperature airflow crushing technology is respectively adopted in A Sayi fruits, Herba Cistanches, glucose, sodium carboxymethylcellulose to crush
Up to 1000 mesh, equal increments are uniformly mixed, and citric acid, malic acid, sodium citrate, Sucralose are dissolved in 75% ethanol solution,
Wet granulation, 45 DEG C~70 DEG C dryings to moisture are less than 5%, magnesium stearate mixing are added after whole grain, tabletting is to get Ah Sa
Her fruit Herba Cistanches piece.
Embodiment 6, A Sayi fruit cistanche extracts pieces and preparation method thereof
Recipe quantity by weight percentage, contains：
Ah's Sai fruit powder 60%,
Cistanche extracts 12%,
Glucose 17.1%,
Croscarmellose sodium 1%,
Microcrystalline cellulose 9%,
Citric acid 0.2%,
Malic acid 0.05%,
Sodium citrate 0.05%,
Sucralose 0.1%,
Magnesium stearate 0.5%；
It prepares：A Sayi fruits, cistanche extracts, microcrystalline cellulose, glucose, croscarmellose sodium are respectively adopted
Low-temperature airflow crushing technology is crushed up to 1000 mesh, and equal increments are uniformly mixed, citric acid, malic acid, sodium citrate, Sucralose
It is dissolved in 75% ethanol solution, wet granulation, 45 DEG C~70 DEG C dryings to moisture are less than 5%, magnesium stearate is added after whole grain
Mixing, tabletting is to get A Sayi fruit cistanche extracts pieces.
Wherein, the preparation method of the cistanche extracts is as follows：It takes Herba Cistanches to crush, the pure of 6~8 times of Herba Cistanches weight is added
After changing water immersion 30 minutes, decoction is secondary, 1.2~1.5 hours every time, collecting decoction, and filtering, filtrate is concentrated into 50~80 DEG C of phases
The thick paste for being 1.1~1.5 to density, ethyl alcohol, which is added, after cooling makes alcohol content up to 50%~75%, is sufficiently stirred, it is small to stand 8~10
When, supernatant is taken, is filtered, filtrate, recycling ethyl alcohol is taken to obtain concentrate to no alcohol taste.It is dried under reduced pressure or is spray-dried and consolidated
Body particle is ground into fine powder to get cistanche extracts.
Embodiment 7, the pure pulvis of A Sayi pulp desert cistanches and preparation method thereof
Recipe quantity by weight percentage, contains：
Ah's Sai fruit powder 75%,
Herba Cistanches powder 25%；
It prepares：The crushing of low-temperature airflow crushing technology is respectively adopted in A Sayi fruits, Herba Cistanches and reaches 1000 mesh, the two equal increments
It is uniformly mixed, is dried under vacuum to moisture and is less than 5%, filling, packaging is to get the pure pulvis of A Sayi pulp desert cistanches.
Embodiment 8, A Sayi pulp desert cistanche capsules and preparation method thereof
Recipe quantity by weight percentage, contains：
Ah's Sai fruit powder 75%,
Herba Cistanches powder 24%,
Magnesium stearate 1%；
It prepares：The crushing of low-temperature airflow crushing technology is respectively adopted in A Sayi fruits, Herba Cistanches and reaches 1000 mesh, the two equal increments
It is uniformly mixed, with 75% ethanol water wet granulation softwood, the sieve granulation of 30 mesh dries, whole grain, magnesium stearate is added, mixes
It is even, by gained granule filling to Capsules to get A Sayi pulp desert cistanche capsules.
The effect that is antifatigue and improving device endurance of embodiment 9, A Sayi fruit rain Herba Cistanches compositions
The ultra-micro powder composition for taking A Sayi fruits and Herba Cistanches, with Herba Cistanches ultra-micro powder group, A Sayi fruit ultra-micro powder groups
Compare, is measured using the mice burden swimming time, serum urea measurement, hepatic glycogen content measurement, study above-mentioned each group to mouse
Antifatigue effect.
Experimental animal：Cleaning grade Kunming mouse, weight（20±2）g.
Method：Mouse is randomly divided into control group（Normal diet is fed with, and does not add feeding drug powder）, Herba Cistanches ultra micro
Powder group（The 0.5g/kg feedings of Herba Cistanches Ultramicro-powder are added in normal diet）, A Sayi fruit ultra-micro powder groups（Add in normal diet
Ah's Sai fruit Ultramicro-powder 0.5g/kg is added to be fed with）, A Sayi fruits and Herba Cistanches ultra-micro powder composition group（Add in normal diet
Add the combination 0.5g/kg feedings of the ultra-micro powder of Ah's Sai fruit and Herba Cistanches）, each drug powder is fed in normal diet, often
Day is primary, and successive administration 30d carries out each index determining after last dose 40min.
Statistical method：Counted using variance analysis method in SPSS11.0 statistical softwares, calculate mean, standard deviation,
Homogeneity test of variance（F is examined）And t is examined between group.
（1）Swimming with a load attached to the body is tested：Mouse tail is born a heavy burden 5%, is placed in the ponds 40 × 60 × 36cm went swimming, depth of water 30cm,
25 ± 0.5 DEG C of water temperature, per 5, pond mouse, record mouse swimming started to the death time as the mice burden swimming time.
As a result：Influence of each group to mouse muscle power, it is as a result as follows：
Influence of Ah's Sai pulp desert cistanche composition to the mice burden swimming time
Group swimming time（min）
Control group 9.58 ± 1.31
Herba Cistanches ultra-micro powder group 13.11 ± 1.48
Ah's Sai fruit ultra-micro powder group 12.32 ± 1.59
The ultra-micro powder composition group of Ah's Sai fruit and Herba Cistanches（1:1）16.81 ± 1.61**, #
**：P compared with the control group<0.01, #：The p compared with Herba Cistanches group, A Sayi fruit groups<0.05.
From the above data, it can be seen that relative to control group, there is very significant difference（p<0.01）, relative to meat desert
Rong's group, A Sayi fruit groups, also all have significant difference（p<0.05）, show that A Sayi pulp desert cistanche compositions can significantly extend
The mice burden swimming time shows to have the function of significant antifatigue and improves device endurance.
（2）Serum urea measures：Swimming condition be 40 × 60 × 36cm of pond, depth of water 30cm, 30 ± 0.5 DEG C of water temperature, often
10, pond mouse plucks eyeball after mouse not swimming with a load attached to the body 90min and takes blood, and measuring serum urea with automatic clinical chemistry analyzer contains
Amount.
As a result：Influence of each group to mice serum urea, it is as a result as follows：
Influence of Ah's Sai pulp desert cistanche composition to mice serum urea
Group serum urea（mmol/L）
Control group 9.33 ± 1.29
Herba Cistanches ultra-micro powder group 9.87 ± 1.41
Ah's Sai fruit ultra-micro powder group 11.54 ± 1.49
7.97 ± 1.57 * of ultra-micro powder composition group of Ah's Sai pulp desert cistanche
* ：P compared with the control group<0.05, the p compared with Herba Cistanches group, A Sayi fruit groups<0.05.
The ultra-micro powder composition of A Sayi fruits and Herba Cistanches can significantly reduce mouse fortune it can be seen from the above-mentioned data of table
Serum urea after dynamic is horizontal（p<0.05）, show the effect of relieving fatigue.
（3）Hepatic glycogen measures：Cervical dislocation puts to death mouse, takes liver, is homogenized, and hepatic glycogen content is measured with anthrone method.
As a result：Influence of each group to mouse hepatic glycogen, it is as a result as follows.
Influence of Ah's Sai pulp desert cistanche composition to mouse hepatic glycogen
Group hepatic glycogen（Mg/100g hepatic tissues）
Control group 3758.7 ± 401.1
Herba Cistanches ultra-micro powder group 5115.3 ± 399.7
Ah's Sai fruit ultra-micro powder group 4417.9 ± 406.2
Ultra-micro powder composition group 5629.4 ± 431.6 the * *, # of Ah's Sai fruit and Herba Cistanches
**：P compared with the control group<0.01, the p compared with Herba Cistanches group, A Sayi fruit groups<0.05；
#：P compared with the control group<0.05.
From the above data, it can be seen that the ultra-micro powder composition of A Sayi fruits and Herba Cistanches can dramatically increase mouse glycogen
Former deposit, compared with the control group, difference is very notable（p<0.01）, compared with Herba Cistanches group, A Sayi fruit groups, it may have aobvious
Write difference（p<0.05）；Show good antifatigue effect.
Claims (5)
1. Ah's Sai pulp desert cistanche particle, recipe quantity by weight percentage, contain：
Ah's Sai fruit powder 60%,
Herba Cistanches powder 20%,
Glucose 17.6%,
Sodium carboxymethylcellulose 2%,
Citric acid 0.2%,
Malic acid 0.05%,
Sodium citrate 0.05%,
Sucralose 0.1%；
It prepares：Low-temperature airflow crushing technology is respectively adopted in A Sayi fruits, Herba Cistanches, glucose, sodium carboxymethylcellulose to crush
Up to 1000 mesh, equal increments are uniformly mixed, and citric acid, malic acid, sodium citrate, Sucralose are dissolved in 75% ethanol solution,
Wet granulation, 45 DEG C~70 DEG C dryings to moisture are less than 5%, and whole grain is to get A Sayi pulp desert cistanche particles.
2. Ah's Sai pulp desert cistanche piece, recipe quantity by weight percentage, contain：
Ah's Sai fruit powder 60%,
Herba Cistanches powder 20%,
Glucose 17.1%,
Sodium carboxymethylcellulose 2%,
Citric acid 0.2%,
Malic acid 0.05%,
Sodium citrate 0.05%,
Sucralose 0.1%,
Magnesium stearate 0.5%；
It prepares：Low-temperature airflow crushing technology is respectively adopted in A Sayi fruits, Herba Cistanches, glucose, sodium carboxymethylcellulose to crush
Up to 1000 mesh, equal increments are uniformly mixed, and citric acid, malic acid, sodium citrate, Sucralose are dissolved in 75% ethanol solution,
Wet granulation, 45 DEG C~70 DEG C dryings to moisture are less than 5%, magnesium stearate mixing are added after whole grain, tabletting is to get Ah Sa
Her fruit Herba Cistanches piece.
3. Ah's Sai fruit cistanche extracts piece, recipe quantity by weight percentage, contain：
Ah's Sai fruit powder 60%,
Cistanche extracts 12%,
Glucose 17.1%,
Croscarmellose sodium 1%,
Microcrystalline cellulose 9%,
Citric acid 0.2%,
Malic acid 0.05%,
Sodium citrate 0.05%,
Sucralose 0.1%,
Magnesium stearate 0.5%；
It prepares：A Sayi fruits, cistanche extracts, microcrystalline cellulose, glucose, croscarmellose sodium are respectively adopted
Low-temperature airflow crushing technology is crushed up to 1000 mesh, and equal increments are uniformly mixed, citric acid, malic acid, sodium citrate, Sucralose
It is dissolved in 75% ethanol solution, wet granulation, 45 DEG C~70 DEG C dryings to moisture are less than 5%, magnesium stearate is added after whole grain
Mixing, tabletting is to get A Sayi fruit cistanche extracts pieces.
4. the pure pulvis of Ah's Sai pulp desert cistanche, recipe quantity by weight percentage, contain：
Ah's Sai fruit powder 75%,
Herba Cistanches powder 25%；
It prepares：The crushing of low-temperature airflow crushing technology is respectively adopted in A Sayi fruits, Herba Cistanches and reaches 1000 mesh, the two equal increments
It is uniformly mixed, is dried under vacuum to moisture and is less than 5%, filling, packaging is to get the pure pulvis of A Sayi pulp desert cistanches.
5. Ah's Sai pulp desert cistanche capsule, recipe quantity by weight percentage, contain：
Ah's Sai fruit powder 75%,
Herba Cistanches powder 24%,
Magnesium stearate 1%；
It prepares：The crushing of low-temperature airflow crushing technology is respectively adopted in A Sayi fruits, Herba Cistanches and reaches 1000 mesh, the two equal increments
It is uniformly mixed, with 75% ethanol water wet granulation softwood, the sieve granulation of 30 mesh dries, whole grain, magnesium stearate is added, mixes
It is even, by gained granule filling to Capsules to get A Sayi pulp desert cistanche capsules.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810760204.3A CN108785476A (en) | 2018-07-11 | 2018-07-11 | The preparation method and application of solid composite containing A Sayi fruits and Herba Cistanches |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810760204.3A CN108785476A (en) | 2018-07-11 | 2018-07-11 | The preparation method and application of solid composite containing A Sayi fruits and Herba Cistanches |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108785476A true CN108785476A (en) | 2018-11-13 |
Family
ID=64076273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810760204.3A Pending CN108785476A (en) | 2018-07-11 | 2018-07-11 | The preparation method and application of solid composite containing A Sayi fruits and Herba Cistanches |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108785476A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109908263A (en) * | 2019-04-09 | 2019-06-21 | 恩施硒圣植物科技有限公司 | A kind of nourishment for vitality tablet and preparation method |
| CN109999135A (en) * | 2019-04-29 | 2019-07-12 | 恩施硒圣植物科技有限公司 | A kind of composition and preparation method improving testosterone |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104306617A (en) * | 2014-11-02 | 2015-01-28 | 福州乾正药业有限公司 | Maca and Acai-containing composition as well as preparation method and application thereof |
| CN105192512A (en) * | 2015-10-14 | 2015-12-30 | 北京康比特体育科技股份有限公司 | Composition for improving antioxidant capacity of human bodies in movement |
| JP2018083800A (en) * | 2016-11-17 | 2018-05-31 | 株式会社東洋新薬 | Oral composition |
-
2018
- 2018-07-11 CN CN201810760204.3A patent/CN108785476A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104306617A (en) * | 2014-11-02 | 2015-01-28 | 福州乾正药业有限公司 | Maca and Acai-containing composition as well as preparation method and application thereof |
| CN105192512A (en) * | 2015-10-14 | 2015-12-30 | 北京康比特体育科技股份有限公司 | Composition for improving antioxidant capacity of human bodies in movement |
| JP2018083800A (en) * | 2016-11-17 | 2018-05-31 | 株式会社東洋新薬 | Oral composition |
Non-Patent Citations (3)
| Title |
|---|
| 王业玲等: "《抗衰老民族医药研究》", 31 December 2017, 中央民族大学出版社 * |
| 王子晨等: "基于文献计量学的外来药物阿萨伊外文文献研究分析 ", 《中华中医药杂志》 * |
| 高路: "《薯中奇葩 紫甘薯》", 31 January 2009, 白山出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109908263A (en) * | 2019-04-09 | 2019-06-21 | 恩施硒圣植物科技有限公司 | A kind of nourishment for vitality tablet and preparation method |
| CN109999135A (en) * | 2019-04-29 | 2019-07-12 | 恩施硒圣植物科技有限公司 | A kind of composition and preparation method improving testosterone |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR20040029072A (en) | Composition comprising wenguanguo extracts, methods for preparing same and uses thereof | |
| CN104274509B (en) | Healthy product composition containing cordyceps sinensis and eucommia Bark male flower and its preparation method and application | |
| CN108785476A (en) | The preparation method and application of solid composite containing A Sayi fruits and Herba Cistanches | |
| CN107319553A (en) | A kind of health products of auxiliary hyperglycemic strengthen immunity and preparation method thereof | |
| CN107551001B (en) | A Chinese medicinal composition for preventing and treating alcoholic hepatic injury and its preparation method | |
| CN103566282B (en) | A kind of Traditional Chinese medicine composition with anti-tumor effect and preparation method | |
| CN101850039B (en) | Composition with auxiliary lipid-lowering function | |
| CN109985079B (en) | Preparation method and application of double-layer tablet containing ginseng and pseudo-ginseng flower | |
| Kagalkar et al. | Development and evaluation of herbal fast dissolving tablets of Tectona grandis Linn | |
| CN110269920A (en) | Alleviate the Traditional Chinese drug mixture and preparation method thereof of stomach disease | |
| CN102462743B (en) | Chinese medicine composition with auxiliary protection action on chemical hepatic injury as well as preparation method and application thereof | |
| CN115177702A (en) | Liver-protecting composition and preparation method and application thereof | |
| CN104095994B (en) | It is a kind of for Chinese medicine composition of functions of removing chloasma and preparation method thereof | |
| CN104352940B (en) | A kind of Chinese medicine composition for alleviating physical fatigue | |
| WO2013056508A1 (en) | Pharmaceutical composition regulating blood fat and preparation process thereof | |
| CN107997170A (en) | A kind of composition with hypolipemic function and preparation method thereof | |
| CN112316013A (en) | Composition containing guava and tylophora fruits and application thereof | |
| CN111714539A (en) | Liver-protecting composition and preparation method and application thereof | |
| CN110840950A (en) | Application of Russian tea and/or Russian tea extract in preparation of medicines for preventing and treating non-alcoholic liver disease and/or non-alcoholic liver injury | |
| Okolie et al. | Formulation design and evaluation of the physicotechnical and hypoglycaemic properties of tablets containing Dioscorea dumetorum fraction in alloxanized diabetic rats | |
| CN113456691B (en) | Product containing artemia cysts and preparation method thereof | |
| CN105146542A (en) | Health-care food with antioxidant function and preparation method thereof | |
| CN108686199A (en) | A kind of liver protecting composition | |
| CN102614253A (en) | Composition for nourishing and protecting liver and application of composition | |
| CN103006835B (en) | Pharmaceutical composition with effects of reducing blood fat and relaxing bowels and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20181113 |