CN1226178A - Wound dressing - Google Patents
Wound dressing Download PDFInfo
- Publication number
- CN1226178A CN1226178A CN97196710A CN97196710A CN1226178A CN 1226178 A CN1226178 A CN 1226178A CN 97196710 A CN97196710 A CN 97196710A CN 97196710 A CN97196710 A CN 97196710A CN 1226178 A CN1226178 A CN 1226178A
- Authority
- CN
- China
- Prior art keywords
- wound dressing
- wound
- upper strata
- layer
- dressing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000463 material Substances 0.000 claims abstract description 66
- 241001465754 Metazoa Species 0.000 claims abstract description 8
- 239000012530 fluid Substances 0.000 claims abstract description 3
- 229920000642 polymer Polymers 0.000 claims description 34
- 239000000835 fiber Substances 0.000 claims description 30
- 238000000034 method Methods 0.000 claims description 27
- 238000011084 recovery Methods 0.000 claims description 19
- 230000000844 anti-bacterial effect Effects 0.000 claims description 17
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 16
- 239000002904 solvent Substances 0.000 claims description 16
- 229920001577 copolymer Polymers 0.000 claims description 13
- 230000008569 process Effects 0.000 claims description 13
- 210000001124 body fluid Anatomy 0.000 claims description 10
- 239000010839 body fluid Substances 0.000 claims description 10
- 239000008187 granular material Substances 0.000 claims description 9
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Natural products OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 8
- 239000000084 colloidal system Substances 0.000 claims description 8
- 239000004310 lactic acid Substances 0.000 claims description 8
- 235000014655 lactic acid Nutrition 0.000 claims description 8
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 8
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 7
- 229920002635 polyurethane Polymers 0.000 claims description 7
- 239000004814 polyurethane Substances 0.000 claims description 7
- 239000004753 textile Substances 0.000 claims description 7
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 6
- 238000010521 absorption reaction Methods 0.000 claims description 6
- 229920002674 hyaluronan Polymers 0.000 claims description 6
- 229960003160 hyaluronic acid Drugs 0.000 claims description 6
- 230000004888 barrier function Effects 0.000 claims description 5
- 239000000758 substrate Substances 0.000 claims description 5
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 claims description 4
- 229920000954 Polyglycolide Polymers 0.000 claims description 4
- 229960002684 aminocaproic acid Drugs 0.000 claims description 4
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 claims description 4
- 238000006384 oligomerization reaction Methods 0.000 claims description 4
- 239000002245 particle Substances 0.000 claims description 4
- 229920000728 polyester Polymers 0.000 claims description 4
- 239000004633 polyglycolic acid Substances 0.000 claims description 4
- 239000001384 succinic acid Substances 0.000 claims description 4
- 229940070710 valerate Drugs 0.000 claims description 4
- 229920001661 Chitosan Polymers 0.000 claims description 3
- 102000008186 Collagen Human genes 0.000 claims description 3
- 108010035532 Collagen Proteins 0.000 claims description 3
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims description 3
- 102000013275 Somatomedins Human genes 0.000 claims description 3
- 229920001436 collagen Polymers 0.000 claims description 3
- 238000001704 evaporation Methods 0.000 claims description 3
- 150000004676 glycans Chemical class 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 230000008520 organization Effects 0.000 claims description 3
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 3
- 239000004626 polylactic acid Substances 0.000 claims description 3
- 229920001282 polysaccharide Polymers 0.000 claims description 3
- 239000005017 polysaccharide Substances 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 102000004169 proteins and genes Human genes 0.000 claims description 3
- 108090000623 proteins and genes Proteins 0.000 claims description 3
- 229950000845 politef Drugs 0.000 claims description 2
- 235000019994 cava Nutrition 0.000 claims 2
- -1 polydesoxazon Polymers 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 239000002158 endotoxin Substances 0.000 claims 1
- 229920006008 lipopolysaccharide Polymers 0.000 claims 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 230000035876 healing Effects 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 description 155
- 208000027418 Wounds and injury Diseases 0.000 description 155
- 239000010410 layer Substances 0.000 description 64
- 210000000416 exudates and transudate Anatomy 0.000 description 15
- 238000005984 hydrogenation reaction Methods 0.000 description 10
- 210000002540 macrophage Anatomy 0.000 description 7
- 206010072170 Skin wound Diseases 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 239000011148 porous material Substances 0.000 description 5
- 230000036760 body temperature Effects 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 230000002209 hydrophobic effect Effects 0.000 description 4
- 239000013047 polymeric layer Substances 0.000 description 4
- 241000233866 Fungi Species 0.000 description 3
- 239000004721 Polyphenylene oxide Substances 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 229920000570 polyether Polymers 0.000 description 3
- 229920005862 polyol Polymers 0.000 description 3
- 150000003077 polyols Chemical class 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 238000009413 insulation Methods 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 210000004872 soft tissue Anatomy 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 230000032258 transport Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 229920003043 Cellulose fiber Polymers 0.000 description 1
- 206010054923 Inflammation of wound Diseases 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000007541 cellular toxicity Effects 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000005213 imbibition Methods 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive plasters or dressings
- A61F13/0203—Adhesive plasters or dressings having a fluid handling member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive plasters or dressings
- A61F13/023—Adhesive plasters or dressings wound covering film layers without a fluid handling layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/425—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/64—Use of materials characterised by their function or physical properties specially adapted to be resorbable inside the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00902—Plasters containing means
- A61F2013/0091—Plasters containing means with disinfecting or anaesthetics means, e.g. anti-mycrobic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00902—Plasters containing means
- A61F2013/00927—Plasters containing means with biological activity, e.g. enzymes for debriding wounds or others, collagen or growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00902—Plasters containing means
- A61F2013/00927—Plasters containing means with biological activity, e.g. enzymes for debriding wounds or others, collagen or growth factors
- A61F2013/00931—Plasters containing means with biological activity, e.g. enzymes for debriding wounds or others, collagen or growth factors chitin
Abstract
A wound dressing (10; 110; 210) for dressing a wound (2; 102; 202) on a tissue structure of a living human or animal body comprising a lower section (1; 101; 201) which when the wound dressing dresses the wound is disposed adjacent the wound, the lower section being fluid permeable and comprising a bioresorbable material which promotes the healing process in the wound, and an upper section (3; 103; 203) which when the dressing dresses the wound overlies the lower section, the upper section being permeable to vapour and impermeable to bacteria.
Description
The present invention relates to be used to wrap up the Wound dressing of the wound of the inside of human body alive or animal body or outside organization.
Existing Wound dressing has many shortcomings.Usually, gauze dressing is used for the treatment of wound and for example burns, otch, abrasion and the imbalance of its hetero-organization.But such dressing needs frequent conversion, and uses such dressing and alternative and to remove this dressing from wound be painful to the patient with fresh dressing subsequently.In fact, some dressing are inconvenient, and they make the patient joint stiff.
Our animal of instruction comprises that the recovery from illness of human soft tissue can not have the foraminous flexible thin slice of proteinic biological absorbable polymer to improve by use in EP-A-0349505 (Astra Meditec AB), the pore size that described thin slice has allows water and salt to see through, but cell and other tissue particles are blocked in the outside.Disclosed this thin slice causes that the formation to the macrophage of soft tissue has specific stimulation, and this macrophage discharges the somatomedin that stimulates the tissue recovery from illness.The suitable polymers material that is used to prepare thin slice that is described in EP-A-0349505 is based on polyglycolic acid, the copolymer of glycolic and lactic acid, lactic acid and episilon amino caproic acid, lactide polymer, polydesoxazon, poly-(3-butyric ester), the copolymer of poly-(3-butyric ester) and 3-hydroxyl valerate, those polymer of the copolymer of succinic acid and crosslinked hyaluronic polyester.By will pushing together according to the fiber of disintegrating-being spun into of poly-(the 3-butyric ester) of US-A-4603070 people such as () Steel preparation, EP-A-0349505 has prepared the non-woven thin slice that known poly-(3-butyric ester) with requisite characteristic forms.
Because the size in the aperture of the thin slice of EP-A-0349505 is enough to allow water to see through, so antibacterial may enter wound through this thin slice.For the situation that thin slice uses as inside, that is to say thin slice is placed human body or the inner situation that covers inner wound of animal body that such thin slice may not can go wrong, but for example trouble will occur during skin wounds for being applied to outside wound.
GB-A-2166354 (Imperial Chemical Industries) discloses a kind of Wound dressing, and it comprises and be dissolved in or suctioned for example poly-(the 3-butyric ester) of chloroform of volatile solvent, preferably the copolymer that forms with 3-hydroxyl valerate unit.This material of solution or gel form is covered the polymer foil that wound obtains to have with area for treatment maximum contact.It is believed that poly-(3-butyric ester) is hydrophilic, reduced demand outside hydrophobic layer.This dressing is specially adapted to protection fast needs the interim wound site that covers.
The thin layer of disclosed hydrophilic poly-(3-butyric ester) has many shortcomings as Wound dressing in GB-A-2166354.At first, because poly-(3-butyric ester) thin layer is not can absorb especially, the exudate of wound can not see through this thin layer, does not therefore guard against measure to removing excessive liquid.Moreover it is difficult removing dressing from the wound that cuts, and it is cellular toxicity that volatile solvent wherein trends towards, and causes the inflammation of wound site.And the substep that will gather pore size on (3-butyric ester) thin layer is prepared as near the pore size of wound less than the size away from the aperture of wound.Therefore exist owing to antibacterial enters the probability that dressing makes traumatic infection.
In a word, prior art does not solve the problem that is provided at the Wound dressing easily that uses in the recovery from illness process gradually of wound, described dressing can be applied to wound easily or remove from wound if desired, this dressing provides body temperature and the maintenance wound humidity of heat-blocking action to keep health at the wound near surface, also allows to remove excessive liquid from wound.
The objective of the invention is to improve this situation.
According to the present invention, the Wound dressing of the wound of the inside that is used to wrap up human body alive or animal body or outside organization is provided, it comprises the bottom section, when this Wound dressing wrapping wound, this section is placed contiguous wound, this bottom section is that body fluid is permeable, fluid permeable for example, and comprise biological absorbable material, this material promotes the recovery from illness process of wound, and this dressing comprises the upper strata section, when this dressing wrapping wound, this section covers the bottom section, and permeable steam of upper strata section and antibacterial are impermeable.
Such dressing is simple relatively during fabrication.And this dressing is easy to use, and goes for removing easily.Moreover this dressing provides heat-blocking action with the body temperature on maintenance wound surface and when the humidity that keeps wound when wound is removed excessive body fluid.Can guarantee that the upper strata section is impermeable to antibacterial basically, that is to say provides the barrier layer with the appearance of protecting from infection.
If transudate after away from the upper surface accumulation of the bottom section of wound transudate can not flow out, stoped like this from wound transportation transudate.For example the defence measure of the upper strata section by the permeable steam of micropore addresses this problem by allowing that transudate is slowly distributed by evaporation.In addition, the steam that comes from the wound surrounding tissue also can see through the upper strata section.
From wound transudate being drained into the bottom section evaporates excessive humidity subsequently and has produced to enter the flow of material of atmosphere direction from wound.This flow of material has further stoped antibacterial to see through with opposite direction, and appearance therefore prevents infections.
Wound dressing of the present invention allows to place the long relatively time.This is meant that comparing it with dressing up to now needs the number of times of conversion few, therefore avoids interference the recovery from illness process, reduces patient's misery.
The use of the upper strata section of permeable steam guarantees that wound keeps moistening, no matter the effect of removing excess body fluid from wound how, stops the dry may command patient's of wound misery.
For first kind of form of the present invention, this Wound dressing is a kind of overall structure.
For second kind of form of the present invention, this Wound dressing is a kind of bonded structure.For example, upper strata section and bottom section can be provided by upper strata and bottom Wound dressing layer respectively, and two-layer dressing layer interosculates before guaranteeing wound.
For the third form of the present invention, in case wound is wrapped up, this Wound dressing has just formed, and for example upper strata section and bottom section can be provided by upper strata that is applied to wound separately and bottom Wound dressing layer respectively.
Wound dressing have the bottom Wound dressing for example the bottom section of sheet form mean that it is easy to be fixed on certain position, and be used as promotion with transudate from wound transportation and keep from the barrier layer that wound transports transudate.
In one embodiment of the invention based on form separately, Wound dressing further comprises a middle discontinuity surface between upper strata section and the bottom section, and this section is applicable to absorption liquid.This dressing advantageous particularly when running into a large amount of transudates.For second and the third invention form, middle discontinuity surface can be any suitable material, for example cellulose fibre of Chu Liing or polyacrylic acid.But the hydrogenation colloid is specially suitable.Usually the hydrogenation colloid can absorb 4 to 6 times liquid of itself volume, has reported that new hydrogenation colloid can absorb 20 times of itself volume.The hydrogenation colloid also is adsorbed onto skin, and the hydrogenation colloid can be carried out the dual-use function at the adhesion edge of intermediate absorption layer and this dressing like this.Second and the middle discontinuity surface of the third invention form can be in the middle of Wound dressing layer or substitute with the upper strata of Wound dressing or the part of bottom Wound dressing layer.
In the working of an invention scheme of first kind of form, Wound dressing is formed by having the bottom that comprises bioabsorbable material and the upper strata and the bottom section of upper strata section.Bioabsorbable material can be special or fibers form.For example, Wound dressing can comprise and is arranged in the host material for example granule or the fiber of the bioabsorbable material of hyaluronic gel-type vehicle or the like.On the other hand, Wound dressing can be the sheets of fibres of bioabsorbable material, for example the non-textile fiber thin slice.
Second and the embodiment of the third invention form in, one or more Wound dressing layers are forms of one or more Wound dressing thin slices.
In the embodiment of second kind of invention form, Wound dressing is made up of the upper strata and the bottom Wound dressing layer of the bottom dressing layer with the bottom surface that adheres to upper strata Wound dressing layer.Another kind of optionally method, Wound dressing layer in the middle of Wound dressing comprises, the upper strata and the bottom surface of Wound dressing layer in the middle of upper strata and bottom Wound dressing layer adhere to respectively.
In the embodiment of second kind of invention form, bottom Wound dressing layer is screened the remainder of Wound dressing releasedly.For example, bottom Wound dressing layer is screened the bottom surface of upper strata Wound dressing layer or the bottom surface of middle Wound dressing layer releasedly.
In various forms of embodiment preferred of the present invention, the bottom section of Wound dressing does not have volatile solvent basically.
Of the present invention second and the embodiment of the third invention form in, bottom Wound dressing layer is by one deck granulometric composition of bioabsorbable material.This granule can be subjected to host material for example to comprise the support of hyaluronic gel-type vehicle.
In the embodiment of second kind of invention form; by the granule in the solvent is mixed; with the mixture bag by to this bottom surface, evaporating solvent then, but the biology absorbing particles material adhesion of bottom Wound dressing layer is to the upper strata or the bottom surface of middle Wound dressing layer.Chloroform mentioned above is suitable solvent.
In the embodiment of the third invention form, when Wound dressing wrapping wound, the bottom section is provided by one deck discrete particles or the fiber of the bioabsorbable material that is positioned wound.Another kind of optionally method, bottom Wound dressing layer can be bags by to the gel that comprises bioabsorbable material of wound or cover one or more bottom Wound dressing thin slices of wound.
Of the present invention second and the embodiment of the third invention form in, the bioabsorbable material of bottom Wound dressing is a fibers form, for example is subjected to the support of the gel-type vehicle that substrate for example forms by hyaluronic acid.Another kind of optionally method, bottom Wound dressing layer can be got the form of one or more bottom Wound dressing sheets of fibres, for example formed by non-textile fiber, in this case, preferably the bottom surface of bottom Wound dressing layer can be fluffyly to contact with end fiber.
In various forms of embodiments of the present invention, the bioabsorbable material of bottom section is a polymer.For example polymer be do not have proteinic, the example of such polymer be poly-(3-butyric ester) (PHB), polylactic acid, polyglycolic acid, the copolymer of glycolic and lactic acid, lactic acid and episilon amino caproic acid, lactide polymer, polydesoxazon, the copolymer of poly-(3-butyric ester) and 3-hydroxyl valerate, the copolymer of succinic acid and crosslinked hyaluronic polyester.
As if use does not have proteinic biologically absorbable polymer can resist surrounding and operate as cell growth skeleton by forming the barrier layer in the bottom section, by means of stimulating macrophage to promote to fully recover during decay.Cover the tissue of wound by the invasion of the macrophage that does not have proteinic polymer to cause, and controlled the pain of wound at first or two day effectively.Also be subjected to the stimulation of this polymer vascularization and microcirculation to occur.And some does not have for example degraded of the PHB effect that has antibacterial and suppress fungus of proteinic polymer, and helps the recovery from illness of skin wounds.The invasive macrophage also has Bactericidal effect.Because its characteristic Wound dressing with antibacterial and inhibition fungus can place long period and made wound recovery from illness environment below dressing.The dressing number of transitions means to the interference of recovery from illness process less and patient painful less less.
Poly-(3-butyric ester) is the preferable material that is used as the bottom section, because the applicant has been found that PHB has with the speed greater than other polymer of being tested and attracts the ability of macrophage to the wound site.As if PHB also causes vascularization to increase, and may be the effect by the macrophage of PHB startup.In addition, in the time will using PHB, because the characteristic of antibacterial and inhibition fungus increases such fact in the whole process of PHB, the wrapping stage is further strengthened.
Moreover, form the form of fibrous PHB thin slice for the bottom section, the situation that for example has the non-woven thin slice of hydrophobic fiber, the characteristic of PHB fiber is to be convenient to thin slice to have capillary sheet surface tension ability, this help from wound get rid of transudate and remain on thin slice and the upper strata section between the zone.And, although fiber is hydrophobic, because its structure, in first non-woven PHB sheets of fibres imbibition in 10 days or added the blood constituent and the cell of surrounding tissue.The result is, will allow wound " breathing " as the PHB sheets of fibres of the bottom section of Wound dressing, and can transit steam, thereby keeps the suitable humidity in wound surface.
When selecting poly-(3-butyric ester), also can in the bottom section, comprise the oligomerization (3-butyric ester) that for example has the 3-10 monomer unit or can form the bottom section by this oligomerization (3-butyric ester).
Various other materials are fit to the function of bottom section, and this is conspicuous to those skilled in that art, and non-limitative example is polysaccharide for example chitosan, collagen and a protein.
In various forms of embodiments of the present invention, Wound dressing is flexible, thereby can make this dressing follow for example a kind of recessed wound of profile of wound.
Of the present invention second and the embodiment of the third invention form in, the profile that bottom Wound dressing layer can change with wound for example is flexible.
In order to help wound recovery from illness process, the bottom section of various forms of Wound dressings of the present invention can be supported one or more somatomedin.
Of the present invention second and the embodiment of the third invention form in, the upper strata Wound dressing layer of Wound dressing comprises polymeric material.This polymeric material can be biological absorbable and further be do not have proteinic.As an example, the upper strata section comprises poly-(3-butyric ester).Another kind of optionally method, the upper strata section can comprise the abiotic abiotic degradable material that absorbs, non-limiting examples of polymers is polyurethane and politef.
In various forms of embodiments of the present invention, the upper strata section of Wound dressing is foraminous.When upper strata section and bottom section all are foraminous, the size in the aperture in section hole, upper strata is less than the pore size in the hole of bottom section.Usually, the aperture of upper strata section is less than about 0.25 micron.
In various forms of embodiments of the present invention, Wound dressing provides the adhesiveness edge that adheres to the contiguous organizational structure surface of wound with being used for release property.This helps the application and the removal of dressing or its top section.
Of the present invention second and the embodiment of the third invention form in, upper strata Wound dressing layer provides the adhesiveness edge, Wound dressing layer in upper strata can fully surround bottom Wound dressing layer in this case.The about 10-15 millimeter of ideal covering boundary.In upper strata Wound dressing layer comprises during discontinuity surface, by the middle discontinuity surface of upper strata Wound dressing layer by the adhesiveness edge.
Of the present invention second and the embodiment of the third invention form in, middle Wound dressing layer provides the adhesiveness edge.
According to the present invention, the method of the wound of the organizational structure for the treatment of human body alive or animal body also is provided, this method comprises the step that the permeable bottom of the body fluid of the absorbable material of biology is applied to wound, this material helps the recovery from illness process of wound, and use breathable, the impermeable upper strata of antibacterial covers bottom.
The present invention further provides the method that is used to prepare Wound dressing, comprised the permeable bottom of the body fluid of the absorbable material of biology is coupled to breathable, the step of antibacterial impermeable barrier, wherein said material starts the recovery from illness process.
According to the present invention, also provide poly-(the 3-butyric ester) of the fiber that do not have volatile solvent basically or powder-form to be used for the application of the Wound dressing of skin in preparation.
Now by means of embodiment and with reference to the accompanying drawings described scheme of the present invention is described, wherein:
Accompanying drawing 1 is the cross-sectional side view of first kind of Wound dressing of the present invention;
Accompanying drawing 2 is cross-sectional side view of second kind of Wound dressing of the present invention;
Accompanying drawing 3 is cross-sectional side view of the third Wound dressing of the present invention.
From accompanying drawing 1 as can be seen, Wound dressing 10 according to the present invention comprises absorbable material layer 1, it starts wound recovery from illness process, in this case, poly-(the 3-butyric ester) of non-woven sheet form that is applied to the trickle shape of skin wounds 2 do not have the microporous layers 3 of the outside of volatile solvent and polyether polyols with reduced unsaturation basically.The hole of outside polymeric layer 3 has less than 0.22 micron pore size.This makes layer 3 permeable steam and gas, keeps layer 3 impermeable basically antibacterial simultaneously.
Dressing 10 can be used and remove easily, further provides effect of heat insulation to keep the body temperature of wound near surface by means of external polymer layer 3.Because its permeable moistening steam dressing 10 also keeps the humidity of wound 2, can remove excessive body fluid from wound 2.It stops the teleneuron drying of wound and the patient's who follows pain.
For application and the removal that promotes dressing 10, external polymer layer 3 has adhering edge 4.
The PHB fiber of dressing 10 shows hydrophobic property.The characteristic of PHB fiber makes transudate get rid of and remain in interval between PHB layer 1 and PHB layer 1 and the external polymer layer 3 from wound 2.
In accompanying drawing 2, show second Wound dressing 110 of the present invention, it comprises the PHB layer 101 that is applied to skin wounds 102 and the micropore skin 103 of polyether polyols with reduced unsaturation, these 101 layers is the non-textile fiber thin slice, does not have volatile solvent basically.The PHB101 layer is the pad that is surrounded by external polymer layer 103 fully, keeps the 10-15 millimeter edge (m) of outside polymeric layer 103 around PHB pad 101.The size of PHB pad 101 changes according to the size of wound 102.
Moreover, the intermediate absorption layer 105 of hydrogenation colloidal materials is provided.This layer absorbs the transudate that PHB pad 101 transports out from wound 102, and helps the transportation of other transudate.Polyurethane skin 103 has micropore and means that transudate disperses at leisure, and wound 102 still keeps moistening simultaneously, and gets rid of antibacterial simultaneously.The steam that comes from wound 102 surrounding skins also can see through outside polymeric layer 103.
Outside polymeric layer 103 has adhering edge, helps the application and the removal of dressing 10.
Turn to accompanying drawing 3 now, the third Wound dressing 210 of the present invention comprises the PHB layer 201 that is applied to skin wounds 202 and the micropore skin 203 of polyether polyols with reduced unsaturation, and these 201 layers is the non-textile fiber thin slice, does not have volatile solvent basically.This PHB also is the form of the pad that surrounded by external polymer layer 203 fully, keeps the 10-15 millimeter edge (m) of polymer around the PHB pad.The intermediate absorption layer 205 of hydrogenation colloidal materials also is provided, in this case, has prepared inner hydrogenation colloid layer 205 and have outside polymer and become 03.Because the hydrogenation colloidal materials adheres to skin, it is adhered to skin by its edge 204.Therefore the hydrogenation colloid has the dual-use function at the adhesiveness edge of middle adsorption layer and exterior layer 203.
Those skilled in that art are easy to recognize that the present invention is not limited only to the embodiment of the specific Wound dressing described above with reference to accompanying drawing, and the present invention can have various ways or comprises within the scope of the invention.
The applicant has observed Wound dressing should satisfy following purpose:
● effect of heat insulation keeps the body temperature on wound surface.
● should keep that but wound is moistening should remove excessive body fluid.
● but dressing should permeable steam impermeable antibacterial.
● dressing should be can absorb with respirable
● should pain management.
● this dressing should be easy to use, and is easy to remove when needs.
● this dressing should promote recovery from illness.
● this dressing should can be used for other treatment, for example allows to provide the compressibility binder of external and deposits the dead bark skin effectively.
● this dressing should be biocompatible and nontoxic.
● this dressing can not make the patient fetter.
These purposes have been satisfied with reference to the above-described Wound dressing of accompanying drawing in the mode of simple and non-costliness.
In comparative test, with Wound dressing of the present invention with comprise one deck polyurethane (Tagerderm
TM) Wound dressing of thin slice is used to wrap up the skin wounds of mammalian body.This dressing of the present invention is made up of the bottom section of PHB non-textile fiber sheet form and the upper strata section of sheet of polyurethane.Compare Wound dressing of the present invention with the sheet of polyurethane Wound dressing and produce the recovery from illness wound that improves.It is characterized in that the wound of fully recovering is covered by Wound dressing of the present invention, compare with the wound of the recovery from illness that covers by the sheet of polyurethane Wound dressing and have thicker and the cuticular cellulose of the regenerating tissues form of good quality more.
Claims (99)
1. be used to wrap up the Wound dressing of the wound of the inside of human body alive or animal body or outside organization, it comprises the bottom section, when this Wound dressing wrapping wound, this section is placed contiguous wound, this bottom section is that body fluid is permeable, and comprise biological absorbable material, this material promotes the recovery from illness process of wound, and this dressing comprises the upper strata section, when this dressing wrapping wound, this upper strata section covers bottom section, and section ventilative and antibacterial in upper strata is impermeable.
2. Wound dressing according to claim 1 is characterized in that the bottom section is a fluid permeable.
3. Wound dressing according to claim 1 and 2 is characterized in that the bottom section of this Wound dressing does not have volatile solvent basically.
4. according to each described Wound dressing of claim 1-3, it is characterized in that this Wound dressing is an overall structure.
5. Wound dressing according to claim 4 is characterized in that this Wound dressing is the form with Wound dressing of upper strata and bottom section.
6. Wound dressing according to claim 5 is characterized in that what this Wound dressing was made up of upper strata with the bottom that comprises bioabsorbable material and upper strata section and bottom section.
7. Wound dressing according to claim 5 is characterized in that this Wound dressing further comprises the middle discontinuity surface between upper strata and bottom section, and it is applicable to absorption liquid.
8. according to the described Wound dressing of claim 5,6 or 7, it is characterized in that this Wound dressing is a sheet form.
9. according to each described Wound dressing of claim 5-8, it is characterized in that bioabsorbable material is granule or fibers form.
10. according to each described Wound dressing of claim 5-8, it is characterized in that Wound dressing comprises the granule or the fiber of the bioabsorbable material that is arranged in host material.
11. Wound dressing according to claim 10, when be subordinated to claim 5-7 each the time, it is characterized in that this substrate is gel-type vehicle.
12. Wound dressing according to claim 11 is characterized in that this gel-type vehicle is a hyaluronic acid.
13. Wound dressing according to claim 9 when being subordinated to claim 8, is characterized in that this Wound dressing is the sheets of fibres of bioabsorbable material.
14. Wound dressing according to claim 13 is characterized in that this Wound dressing is the non-textile fiber thin slice.
15. Wound dressing according to claim 14 is characterized in that the bottom surface of this Wound dressing is roughened (roughened) with the exposed fibers end.
16., it is characterized in that the bioabsorbable material of bottom section comprises polymer according to each described Wound dressing of claim 5-15.
17. Wound dressing according to claim 16 is characterized in that this polymer is nonprotein.
18. Wound dressing according to claim 17, it is characterized in that this polymer be poly-(3-butyric ester) (PHB), polylactic acid, polyglycolic acid, the copolymer of glycolic and lactic acid, the copolymer of lactic acid and episilon amino caproic acid, lactide polymer, polydesoxazon, copolymer, succinic acid polyester or the crosslinked hyaluronic acid of poly-(3-butyric ester) and 3-hydroxyl valerate.
19. Wound dressing according to claim 16 is characterized in that this bottom section comprises poly-(3-butyric ester) and oligomerization (3-butyric ester).
20., it is characterized in that the bioabsorbable material of bottom section comprises polysaccharide for example chitosan, collagen or protein according to each described Wound dressing of claim 5-15.
21. according to each described Wound dressing of claim 5-20, it is characterized in that this Wound dressing is flexible, thereby this dressing can adapt to the profile of the wound wound that for example caves in.
22., it is characterized in that the bottom section is foraminous according to each described Wound dressing of claim 5-21.
23., it is characterized in that the upper strata section of this Wound dressing is porose according to each described Wound dressing of claim 5-22.
24. Wound dressing according to claim 23, when being subordinated to claim 22, the aperture in hole that it is characterized in that the upper strata section is less than the aperture in the hole of bottom section.
25. according to claim 23 or 24 described Wound dressings, the aperture that it is characterized in that the hole of upper strata section is less than about 0.25 micron.
26., it is characterized in that Wound dressing is the integrated structure form according to the described Wound dressing of claim 1,2 or 3.
27. Wound dressing according to claim 26 is characterized in that upper strata section and bottom section are provided by upper strata and bottom Wound dressing layer respectively, they are mutual coupling before the wrapping wound.
28. Wound dressing according to claim 27 is characterized in that the bottom section is foraminous.
29. Wound dressing according to claim 27 is characterized in that the bottom section bores a hole.
30. according to each described Wound dressing of claim 27-29, the dressing that it is characterized in that boring a hole further comprises the middle discontinuity surface between upper strata section and bottom section, it is applicable to absorption liquid.
31. Wound dressing according to claim 30, discontinuity surface is the form of middle Wound dressing layer in it is characterized in that.
32. Wound dressing according to claim 30, discontinuity surface is the upper strata or the bottom Wound dressing layer of this Wound dressing in it is characterized in that.
33. according to claim 27-29 each and 32 described Wound dressings, it is characterized in that this Wound dressing is made up of upper strata and bottom Wound dressing layer, described dressing layer has the bottom Wound dressing layer of the bottom surface that adheres to upper strata Wound dressing layer.
34. Wound dressing according to claim 31 is characterized in that upper strata and bottom Wound dressing layer adhere to the upper strata and the bottom surface of middle Wound dressing layer respectively.
35., it is characterized in that the remainder of bottom Wound dressing layer release property ground shielding Wound dressing according to the described Wound dressing of claim 27-34.
36. Wound dressing according to claim 35, when being subordinated to claim 27-29,32 or 33 o'clock, it is characterized in that the bottom surface of shielding upper strata, bottom Wound dressing layer release property ground Wound dressing layer.
37. Wound dressing according to claim 35 when being subordinated to claim 31 or 34, is characterized in that the bottom surface of the middle Wound dressing layer of bottom Wound dressing layer release property ground shielding.
38., it is characterized in that bottom Wound dressing layer is that granular layer by bioabsorbable material provides according to the described Wound dressing of claim 27-37.
39., it is characterized in that this granule can be supported by host material according to the described Wound dressing of claim 38.
40., it is characterized in that this substrate is gel-type vehicle according to the described Wound dressing of claim 39.
41., it is characterized in that gel-type vehicle comprises hyaluronic acid according to the described Wound dressing of claim 40.
42. according to the described Wound dressing of claim 38; it is characterized in that by granule is mixed into solvent; with this mixture bag by to bottom surface, evaporating solvent then, but the biology absorbing particles material adhesion of bottom Wound dressing layer is to the upper strata or the bottom surface of middle Wound dressing layer.
43., it is characterized in that chloroform is used as solvent according to the described Wound dressing of claim 42.
44., it is characterized in that the form that one or more Wound dressing layers are one or more Wound dressing thin slices according to each described Wound dressing of claim 27-43.
45., just formed Wound dressing in case it is characterized in that the wrapping wound according to the described Wound dressing of claim 1,2 or 3.
46., it is characterized in that upper strata and bottom section are respectively to be provided by upper strata that is applied to wound separately and bottom wound sectional layer according to the described Wound dressing of claim 45.
47., it is characterized in that the bottom section is foraminous according to the described Wound dressing of claim 46.
48., it is characterized in that the bottom section bores a hole according to the described Wound dressing of claim 46.
49., it is characterized in that this Wound dressing further comprises to be applicable to the upper strata that absorbs liquid and the middle discontinuity surface between the bottom section according to each described Wound dressing of claim 46-48.
50. according to the described Wound dressing of claim 49, discontinuity surface is the form of middle Wound dressing layer in it is characterized in that.
51. according to the described Wound dressing of claim 49, discontinuity surface is the upper strata of this Wound dressing or the part of bottom Wound dressing layer in it is characterized in that.
52., it is characterized in that bottom Wound dressing layer is that granular layer by bioabsorbable material provides according to each described Wound dressing of claim 46-51.
53., it is characterized in that this granule is supported by host material according to the described Wound dressing of claim 52.
54., it is characterized in that this substrate is gel-type vehicle according to the described Wound dressing of claim 53.
55., it is characterized in that this gel-type vehicle comprises hyaluronic acid according to the described Wound dressing of claim 54.
56., it is characterized in that when this Wound dressing wrapping wound that the bottom section is that loose granule layer or the fibrous layer by the bioabsorbable material that is positioned wound provides according to each described Wound dressing of claim 46-50.
57., it is characterized in that bottom Wound dressing layer is the gel that comprises the bioabsorbable material that is arrived wound according to each described Wound dressing of claim 46-50.
58., it is characterized in that the form that one or more Wound dressing layers are one or more Wound dressing thin slices according to each described Wound dressing of claim 46-57.
59., when being subordinated to claim 46-51, it is characterized in that bottom Wound dressing layer is to be provided by one or more bottom Wound dressing thin slices that cover wound according to the described Wound dressing of claim 58.
60. according to claim 27-37,44,46-51,58 or 59 each described Wound dressings is characterized in that the bioabsorbable material of bottom Wound dressing layer is a fibers form.
61., it is characterized in that the bio-absorbable fibers material is supported by substrate according to the described Wound dressing of claim 60.
62., it is characterized in that the bio-absorbable fibers material is supported by gel-type vehicle according to the described Wound dressing of claim 61.
63., it is characterized in that the bio-absorbable fibers material is to be subjected to support from the gel-type vehicle that hyaluronic acid forms according to the described Wound dressing of claim 62.
64., it is characterized in that bottom Wound dressing layer is provided by one or more bottom Wound dressing sheets of fibres according to the described Wound dressing of claim 60.
65., it is characterized in that bottom Wound dressing sheets of fibres or several thin slice form from non-textile fiber according to the described Wound dressing of claim 64.
66., it is characterized in that the bottom surface of bottom Wound dressing layer is roughened with the exposed fibers end according to the described Wound dressing of claim 65.
67., it is characterized in that the bioabsorbable material of bottom section comprises polymer according to each described Wound dressing of claim 26-66.
68. according to the described Wound dressing of claim 67, it is characterized in that polymer be do not have proteinic.
69. according to the described Wound dressing of claim 68, it is characterized in that polymer be poly-(3-butyric ester) (PHB), polylactic acid, polyglycolic acid, the copolymer of glycolic and lactic acid, the copolymer of lactic acid and episilon amino caproic acid, lactide polymer, polydesoxazon, copolymer, the polyester of succinic acid or the crosslinked hyaluronic acid of poly-(3-butyric ester) and 3-hydroxyl valerate.
70., it is characterized in that this bottom section comprises poly-(3-butyric ester) and oligomerization (3-butyric ester) according to the described Wound dressing of claim 67.
71., it is characterized in that the bioabsorbable material of bottom section comprises polysaccharide for example lipopolysaccharide or chitosan, collagen or protein according to the described Wound dressing of claim 67.
72. according to each described Wound dressing of claim 26-71, it is characterized in that this Wound dressing is flexible, thereby this dressing can adapt to the profile of the wound wound that for example caves in.
73., it is characterized in that and bottom Wound dressing layer can be changed to adapt to the profile of wound according to claim 27-44 or each described Wound dressing of 46-71.
74., it is characterized in that bottom Wound dressing layer is flexible according to the described Wound dressing of claim 73.
75., it is characterized in that the bottom section supports one or more somatomedin according to the described Wound dressing of each claim of front.
76., it is characterized in that the upper strata Wound dressing layer of this Wound dressing comprises polymeric material according to each described Wound dressing of claim 26-75.
77., it is characterized in that polymeric material is biological absorbable according to the described Wound dressing of claim 76.
78. according to the described Wound dressing of claim 77, it is characterized in that polymeric material be do not have proteinic.
79., it is characterized in that the upper strata section comprises poly-(3-butyric ester) according to the described Wound dressing of claim 78.
80., it is characterized in that the upper strata section comprises abiotic absorbable material according to each described Wound dressing of claim 26-75.
81. 0 described Wound dressing is characterized in that the upper strata section comprises abiotic absorbable material according to Claim 8.
82. 1 described Wound dressing is characterized in that polymeric material is polyurethane or politef according to Claim 8.
83., it is characterized in that the upper strata section of this Wound dressing is foraminous according to each described Wound dressing of claim 26-82.
84. 3 described Wound dressings according to Claim 8, when being subordinated to claim 28 or 47, the aperture in hole that it is characterized in that the upper strata section is less than the aperture in the hole of bottom section.
85. 3 or 84 described Wound dressings according to Claim 8, the aperture that it is characterized in that the hole of upper strata section is less than about 0.25 micron.
86., it is characterized in that Wound dressing provides the adhesiveness edge on the organizational structure surface that is used to adhere to contiguous wound according to the described Wound dressing of each claim of front.
87. 6 described Wound dressings according to Claim 8, when being subordinated to claim 27-44,46-71,73 or 74 each the time, it is characterized in that upper strata Wound dressing layer provides the adhesiveness end.
88. 7 described Wound dressings is characterized in that upper strata Wound dressing layer surrounds the remainder of Wound dressing fully according to Claim 8.
89. 7 or 88 described Wound dressings is characterized in that upper strata Wound dressing layer has been covered the remainder of Wound dressing by the edge of about 10-15 millimeter according to Claim 8.
90. 6 described Wound dressings according to Claim 8, when being subordinated to claim 31 or 51, it is characterized in that upper strata Wound dressing layer comprise in discontinuity surface and adhesiveness edge be that middle discontinuity surface by upper strata Wound dressing layer provides.
91. 6 described Wound dressings when being subordinated to claim 31 or 50, is characterized in that middle Wound dressing layer provides the adhesiveness edge according to Claim 8.
92. according to claim 30,31,32,34,37,49,50,51,90 or 91 described Wound dressings, discontinuity surface comprises the ionization colloid in it is characterized in that.
93. the method for the wound of the human body that treatment is lived or the organizational structure of animal body, this method comprises the step that the permeable bottom of the body fluid of the absorbable material of biology is applied to wound, this material helps the recovery from illness process of wound, and use breathable, the impermeable upper strata of antibacterial covers bottom.
94. prepare the method for Wound dressing, comprise the permeable bottom of the body fluid of the absorbable material of biology is coupled to breathable, the step of antibacterial impermeable barrier, wherein said material starts the recovery from illness process.
95., it is characterized in that bioabsorbable material is a biologically absorbable polymer according to claim 93 or 94 described methods.
96. according to the described method of claim 95, it is characterized in that polymer be do not have proteinic.
97., it is characterized in that polymer comprises poly-(3-butyric ester) according to the described method of claim 96.
98. there is not poly-(3-butyric ester) application in the Wound dressing of preparation skin of the fiber or the powder type of volatile solvent basically.
99., it is characterized in that in fiber or powder, not containing solvent according to the described application of claim 98.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9602200A SE9602200D0 (en) | 1996-06-03 | 1996-06-03 | Wound dressing |
SE9602200-9 | 1996-06-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN1226178A true CN1226178A (en) | 1999-08-18 |
Family
ID=20402870
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN97196710A Pending CN1226178A (en) | 1996-06-03 | 1997-05-30 | Wound dressing |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0906126A1 (en) |
JP (1) | JP2000511446A (en) |
KR (1) | KR20000016251A (en) |
CN (1) | CN1226178A (en) |
AR (1) | AR007386A1 (en) |
BR (1) | BR9709639A (en) |
CA (1) | CA2255627A1 (en) |
CZ (1) | CZ388398A3 (en) |
HU (1) | HUP0003151A3 (en) |
ID (1) | ID17733A (en) |
IL (1) | IL127107A0 (en) |
IS (1) | IS4898A (en) |
NO (1) | NO985628L (en) |
NZ (1) | NZ332950A (en) |
PL (1) | PL330307A1 (en) |
SE (1) | SE9602200D0 (en) |
TR (1) | TR199802501T2 (en) |
TW (1) | TW347318B (en) |
WO (1) | WO1997046265A1 (en) |
ZA (1) | ZA974846B (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1809390B (en) * | 2003-06-26 | 2010-11-17 | 株式会社瑞光 | Wound dressing and wound dressing kit |
CN105688260A (en) * | 2016-03-21 | 2016-06-22 | 江苏广达医材集团有限公司 | Biodegradable medical abdominal surgery wound dressing |
CN105816903A (en) * | 2016-05-12 | 2016-08-03 | 东华大学 | Drug-loaded hyaluronic acid nanofiber composite dressing and preparation method thereof |
CN109069285A (en) * | 2016-05-04 | 2018-12-21 | 科洛普拉斯特公司 | Adhesive sheet with neutralizer matrix |
CN109125781A (en) * | 2018-11-16 | 2019-01-04 | 南阳市中心医院 | A kind of liver and gall surgical department's antiseptic dressing |
US11491254B2 (en) | 2017-11-08 | 2022-11-08 | Coloplast A/S | Adhesive wafer with a neutralizer matrix |
US11911310B2 (en) | 2017-11-08 | 2024-02-27 | Coloplast A/S | Adhesive wafer with a neutralizer matrix |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2781679B1 (en) * | 1998-07-31 | 2001-06-08 | Lhd Lab Hygiene Dietetique | NEW WATERPROOF HYDROCELLULAR DRESSING AND USE OF A HYDROCOLLOID ADHESIVE MASS |
ATE314034T1 (en) * | 1999-03-02 | 2006-01-15 | Tatjana Meyer-Schwarz | PATCH FOR APPLICATION TO THE SKIN WITH PROJECTIONS ON THE PATCH |
EP1303239B2 (en) | 2000-07-18 | 2013-05-01 | Coloplast A/S | A dressing |
GB0025084D0 (en) * | 2000-10-13 | 2000-11-29 | Cambridge Meditech | Improvements in detection |
US7041868B2 (en) * | 2000-12-29 | 2006-05-09 | Kimberly-Clark Worldwide, Inc. | Bioabsorbable wound dressing |
US7700819B2 (en) * | 2001-02-16 | 2010-04-20 | Kci Licensing, Inc. | Biocompatible wound dressing |
EP1455849B1 (en) | 2001-12-21 | 2005-11-23 | Coloplast A/S | A wound care device |
DE102004063599B4 (en) | 2004-12-30 | 2007-07-12 | Bayer Innovation Gmbh | Shortened wound healing processes by means of novel fiber fleeces |
CN103170005A (en) * | 2011-12-23 | 2013-06-26 | 闳晖实业股份有限公司 | Wound dressing |
US9561136B2 (en) | 2014-03-13 | 2017-02-07 | Gregory Troy Williams | Bandage |
WO2015186101A1 (en) * | 2014-06-05 | 2015-12-10 | University Of The Witwatersrand, Johannesburg | Wound dressing |
KR101577140B1 (en) | 2014-06-30 | 2015-12-11 | 박성훈 | Soluble wound dressing materials of film type |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2524304B1 (en) * | 1982-03-31 | 1985-06-14 | Delalande Sa | ARTIFICIAL SKIN |
GB8424950D0 (en) * | 1984-10-03 | 1984-11-07 | Ici Plc | Non-woven fibrous materials |
GB2166354B (en) * | 1984-10-10 | 1987-12-09 | Ici Plc | Wound dressings |
SE8802414D0 (en) * | 1988-06-27 | 1988-06-28 | Astra Meditec Ab | NEW SURGICAL MATERIAL |
GB2272645B8 (en) * | 1992-11-23 | 2010-02-10 | Johnson & Johnson Medical | Wound dressing |
-
1996
- 1996-06-03 SE SE9602200A patent/SE9602200D0/en unknown
-
1997
- 1997-05-30 JP JP10500486A patent/JP2000511446A/en active Pending
- 1997-05-30 CZ CZ983883A patent/CZ388398A3/en unknown
- 1997-05-30 TR TR1998/02501T patent/TR199802501T2/en unknown
- 1997-05-30 WO PCT/SE1997/000946 patent/WO1997046265A1/en not_active Application Discontinuation
- 1997-05-30 KR KR1019980709824A patent/KR20000016251A/en not_active Application Discontinuation
- 1997-05-30 BR BR9709639A patent/BR9709639A/en not_active IP Right Cessation
- 1997-05-30 NZ NZ332950A patent/NZ332950A/en unknown
- 1997-05-30 CA CA002255627A patent/CA2255627A1/en not_active Abandoned
- 1997-05-30 HU HU0003151A patent/HUP0003151A3/en unknown
- 1997-05-30 PL PL97330307A patent/PL330307A1/en unknown
- 1997-05-30 CN CN97196710A patent/CN1226178A/en active Pending
- 1997-05-30 EP EP97926340A patent/EP0906126A1/en not_active Withdrawn
- 1997-05-30 IL IL12710797A patent/IL127107A0/en unknown
- 1997-06-02 ZA ZA974846A patent/ZA974846B/en unknown
- 1997-06-03 TW TW086107606A patent/TW347318B/en active
- 1997-06-03 ID IDP971882A patent/ID17733A/en unknown
- 1997-06-03 AR ARP970102408A patent/AR007386A1/en unknown
-
1998
- 1998-11-19 IS IS4898A patent/IS4898A/en unknown
- 1998-12-02 NO NO985628A patent/NO985628L/en not_active Application Discontinuation
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1809390B (en) * | 2003-06-26 | 2010-11-17 | 株式会社瑞光 | Wound dressing and wound dressing kit |
CN105688260A (en) * | 2016-03-21 | 2016-06-22 | 江苏广达医材集团有限公司 | Biodegradable medical abdominal surgery wound dressing |
CN109069285A (en) * | 2016-05-04 | 2018-12-21 | 科洛普拉斯特公司 | Adhesive sheet with neutralizer matrix |
CN109069285B (en) * | 2016-05-04 | 2021-06-22 | 科洛普拉斯特公司 | Adhesive sheet with neutralizer matrix |
US11278640B2 (en) | 2016-05-04 | 2022-03-22 | Coloplast A/S | Adhesive wafer with a neutralizer matrix |
CN105816903A (en) * | 2016-05-12 | 2016-08-03 | 东华大学 | Drug-loaded hyaluronic acid nanofiber composite dressing and preparation method thereof |
US11491254B2 (en) | 2017-11-08 | 2022-11-08 | Coloplast A/S | Adhesive wafer with a neutralizer matrix |
US11911310B2 (en) | 2017-11-08 | 2024-02-27 | Coloplast A/S | Adhesive wafer with a neutralizer matrix |
CN109125781A (en) * | 2018-11-16 | 2019-01-04 | 南阳市中心医院 | A kind of liver and gall surgical department's antiseptic dressing |
Also Published As
Publication number | Publication date |
---|---|
SE9602200D0 (en) | 1996-06-03 |
PL330307A1 (en) | 1999-05-10 |
WO1997046265A1 (en) | 1997-12-11 |
TR199802501T2 (en) | 1999-02-22 |
NZ332950A (en) | 2000-05-26 |
CA2255627A1 (en) | 1997-12-11 |
AU3112897A (en) | 1998-01-05 |
IL127107A0 (en) | 1999-09-22 |
NO985628D0 (en) | 1998-12-02 |
IS4898A (en) | 1998-11-19 |
HUP0003151A3 (en) | 2002-05-28 |
BR9709639A (en) | 1999-08-10 |
CZ388398A3 (en) | 1999-04-14 |
TW347318B (en) | 1998-12-11 |
ID17733A (en) | 1998-01-22 |
KR20000016251A (en) | 2000-03-25 |
AU719419B2 (en) | 2000-05-11 |
NO985628L (en) | 1999-02-03 |
ZA974846B (en) | 1998-12-02 |
EP0906126A1 (en) | 1999-04-07 |
AR007386A1 (en) | 1999-10-27 |
JP2000511446A (en) | 2000-09-05 |
HUP0003151A2 (en) | 2001-02-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN1226178A (en) | Wound dressing | |
KR100860896B1 (en) | Bioabsorbable Wound Dressing | |
EP3672655B1 (en) | Biomaterial and methods of making and using said biomaterial | |
AU2017201139B2 (en) | Hemostatic Devices | |
US5676967A (en) | Mesh matrix wound dressing | |
EP0475807B1 (en) | Wound-covering materials | |
US4655758A (en) | Microbial polysaccharide articles and methods of production | |
US8303551B2 (en) | Wound dressings | |
CN101400379A (en) | Methods for producing silver-bonded antimicrobial moist wound dressings and moist wound dressings produced by the methods | |
GB2531344A (en) | Composite wound dressing | |
CN104383585B (en) | A kind of three-dimensional manometer composite adhesive bandage and preparation and application thereof | |
KR102090576B1 (en) | Multi-layer dressing material for wound treatment | |
Mao et al. | Nonwoven wound dressings | |
RU2240140C2 (en) | Medicinal multilayer bandage and articles based on such bandage | |
CN1063974C (en) | Wound bandage with polymer layer | |
JP2001212170A (en) | Wound cover material | |
CA2959946A1 (en) | A coherent blood coagulation structure of water-insoluble chitosan and water-dispersible starch coating | |
JPH05337151A (en) | Wound cover material | |
JP2001017532A (en) | Wound dressing | |
JP2001017531A (en) | Wound dressing | |
JPH03242142A (en) | Artificial skin and production thereof | |
CA1295327C (en) | Pliant, water-absorbent, laminar mass of microbial cellulose | |
MXPA98010047A (en) | Aposito for heri | |
JPH05337174A (en) | Cut covering material | |
JP2001017530A (en) | Wound dressing |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
WD01 | Invention patent application deemed withdrawn after publication | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: WD Ref document number: 1021945 Country of ref document: HK |