CN105816903A - Drug-loaded hyaluronic acid nanofiber composite dressing and preparation method thereof - Google Patents
Drug-loaded hyaluronic acid nanofiber composite dressing and preparation method thereof Download PDFInfo
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- CN105816903A CN105816903A CN201610312502.7A CN201610312502A CN105816903A CN 105816903 A CN105816903 A CN 105816903A CN 201610312502 A CN201610312502 A CN 201610312502A CN 105816903 A CN105816903 A CN 105816903A
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- hyaluronic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Abstract
The invention discloses a drug-loaded hyaluronic acid/nanofiber composite dressing and a preparation method thereof. The composite dressing comprises a hydrogel layer and a nanofiber layer which are composited and formed by crosslinking of hyaluronic acid macromonomers. The hydrogel layer is loaded with drug-loaded nanogel. The preparation method comprises the steps that drug-loaded nanogel is prepared; hyaluronic acid macromolecule photo-crosslinking or chemical crosslinking monomers are synthesized; a hyaluronic acid monomer solution is subjected to crosslinking, meanwhile, the drug-loaded nanogel is mixed, and hyaluronic acid base hydrogel is obtained; the hyaluronic acid base hydrogel and a nanofiber membrane are composited, and the drug-loaded hyaluronic acid/nanofiber composite dressing is obtained. The adopted raw materials have the good biocompatibility, the two structures of hydrogel and nanofiber are combined, wound fluid is absorbed and guided, meanwhile, the overall stability of the dressing is improved, and the drug-loaded hyaluronic acid/nanofiber composite dressing has the functions of long-acting bacterium resistance, protein adsorption resistance, pollution resistance, heat insulation and the like.
Description
Technical field
The invention belongs to medical material tech field, particularly relate to a kind of medicine carrying hyaluronic acid-based/nanofiber combine dressing and preparation method thereof.
Background technology
Skin has self-repair function, but wound surface once reaches deep wounds rank, its repair function will degradation, to this end, people use dressing to assist wound repair.Dressing is divided into traditional dressing and new pattern compress, and traditional dressing is deposited in use easily adhesion wound and caused secondary damage, hemostatic strong, and easy infection, dressing usage amount is big waits shortcomings.New pattern compress comes from doctor Winter of London University in 1962 and proposes " moisture treatment " concept, he finds in zoopery, in airtight moist environment, healing rate is more fast again than the dry wound surface being exposed in air, thus proposes the new ideas of wound healing under moist environment.
The anion natural polymer with linear polysaccharide structure that hyaluronic acid is made up of the repetitive structure of 2-Acetamido-2-deoxy-D-glucose and D-Glucose aldehydic acid, this material is present in extracellular matrix, the moisture in extracellular matrix can be kept, promote cell migration and differentiation.Hyalomitome has good biocompatibility, moisture retention, biodegradability, meanwhile, research proves, in the wound healing stage, reparation to fibroblastic propagation and epithelial tissue has facilitation, and therefore hyaluronic acid composition can be applicable to dressing preparation and tissue repair.Such as, domestic patent CN103705971 designs a composite transparent matter acid dressing, and nonwoven layer is combined by this patent with hyaluronic acid dressing layer, and wherein functional layer is based on hyaluronic acid material, in conjunction with vaseline, Cera Flava and carbomer material, this dressing advantage is imbibition moisturizing, it is comfortable to lubricate.Hyaluronic acid component injection is covered in wound surface on film dressing by United States Patent (USP) US20030021834A1, and this dressing can effectively shorten the time of wound healing.
Two examples of summary, we have found that and there is existing the having some limitations property of dressing containing hyaluronic acid composition, on the one hand there is inflammatory reaction due to wound surface, dressing need to be given further with antibacterial functions, especially ensure the long-acting of this antibacterial effect and stability, on the other hand, other performances of dressing are optimized, including heat insulation, anti-soil, anti-protein adsorption etc..
Summary of the invention
To be solved by this invention is that the existing adjuvant antibacterial functions containing hyaluronic acid composition is poor, and other performances, the bad problem such as the most heat insulation, anti-soil, anti-protein adsorption.
In order to solve the problems referred to above, the invention provides a kind of medicine carrying hyaluronic acid nano fiber combine dressing, it is characterized in that, be cross-linked with each other the hydrogel layer and nanofiber layer formed including the most compound hyaluronic acid macromonomer, is loaded with medicament-carried nano gel in described hydrogel layer.
Present invention also offers the preparation method of the above-mentioned multi-functional dressing of medicine carrying hyaluronic acid-based, it is characterised in that comprise the following steps:
The first step: use biological degradation method to prepare medicament-carried nano gel；
Second step: the synthesis of hyaluronic acid macromonomer；
3rd step: hyaluronic acid macromonomer solution is carried out Cross-linked, mixes medicament-carried nano gel simultaneously, prepares hyaluronic acid based aquagel；
4th step: hyaluronic acid based aquagel and nano fibrous membrane are combined, obtains medicine carrying hyaluronic acid-based combine dressing.
Preferably, the raw material nano gel that medicament-carried nano gel in the described first step uses is that biodegradable amino acids (includes lysine, histidine, the multiple water-soluble amino acid such as arginine) false albumen (polyester ammonia) hydrogel degradation product in any one or a few combination.
Preferably, the material medicine that the medicament-carried nano gel in the described first step uses is any one or a few combination in extensive pedigree antibiotic.
It is highly preferred that described extensive pedigree antibiotic is specially many peptides, Macrolide, phosphorous polysaccharide, polyethers, aminoglycosides or chemosynthesis class.
Preferably, the medicament-carried nano gel Chinese medicine in the described first step is 0.1～50% (drug quality mark is antibacterials quality and nanogel mass ratio) with the mass percent of nanogel.
Preferably, the hyaluronic acid in described second step uses high molecular weight hyaluronic acid or low-molecular-weight hyaluronic acid (number-average molecular weight is at 10000-2000000).
Preferably, the synthesis of the hyaluronic acid macromonomer in described second step is included in grafted olefin monomer on hyaluronan molecule, is grafted any one or a few in sulfanilamide salt, phosphamidon salt, carboxylic amine salt and quaternary ammonium salt simultaneously.
Preferably, the mass concentration of the hyaluronic acid macromonomer solution in described second step is 0.5～20%, and solvent is deionized water.
Preferably, the raw material of the nano fibrous membrane in described 4th step includes that, by one or more in natural high polymer, synthetic high polymer (polyester ammonia vacation albumen), preparation method uses method of electrostatic spinning.
Compared with prior art, the invention has the beneficial effects as follows:
(1) raw material that the present invention relates to has the advantages such as source is wide, environmental protection, good biocompatibility, degradable.
(2) the hydrogel material crosslink density obtained by the present invention, mechanical strength is controlled, according to different application demand, the physicalchemical structure of material can be carried out accuracy controlling；Inside has migration and the propagation of the pore passage structure of connection, beneficially cell.
(3) hyaluronic acid related in the present invention is by grafting amine salt and the rapid shaping of olefinic monomer, beneficially hydrogel structure, is effectively improved the anti-protein adsorption performance of dressing simultaneously.Hydrogel material moisture retention is strong, adhesion, the secondary damage that causes because of dressing and wound adhesion when can avoid more change dressings.
(4) it is loaded with medicament-carried nano gel in dressing of the present invention, therefore there is long-acting stable antibacterial functions.Using antibacterial standard GB/T20944.1-2007 agar plate diffusion method that Gram-positive S staphylococcus and Gram-E. coli are carried out antibacterial contrast test the anti-bacterial hydrogel dressing of preparation, antibacterial processed aerogel dressing can kill antibacterial；
(5) dressing related in the present invention is composited by hydrogel and nanofiber, be conducive to wound fluid in the conduction of multilamellar Dressing Room, thus make up the problem that hydrogel structure liquid absorption is few, reinforcing simultaneously and stablize hydrogel, in conjunction with hemostasis, imbibition, moistening, heat insulation, antibacterial, anti-soil, anti-protein adsorption, promotion, blood capillary and epithelization formation etc. are multi-functional is integrated.
Accompanying drawing explanation
Fig. 1 is the preparation flow figure of medicament-carried nano gel；
Fig. 2 is the synthesis schematic diagram of hyaluronic acid macromonomer；
Fig. 3 is the structural representation of medicine carrying hyaluronic acid-based aerogel dressing.
Detailed description of the invention
For making the present invention become apparent, hereby with preferred embodiment, and accompanying drawing is coordinated to be described in detail below.
Embodiment 1
A kind of medicine carrying hyaluronic acid/nanofiber hydrogels dressing, including hyaluronic acid macromonomer, described hyaluronic acid macromonomer is cross-linked with each other the hydrogel structure formed and the combine dressing with nanofiber layer composition thereof, and its preparation method is:
A) preparation of medicament-carried nano gel:
First medicine carrying lysine based aquagel is prepared: take Lys-4 monomer 1g and NA monomer 0.7628g, mix 10mg triclosan antimicrobial medicine simultaneously, it is dissolved in 2gN under the conditions of 50 DEG C, in N-dimethyl acetylamide, adding 1.59g triethylamine until completely dissolved, mixed solution fully reaction 1h under 80 DEG C of oil bath environment i.e. obtains lysine based aquagel.By hydrogel with after acetone soak 4h, then with deionized water rinsing to remove the chemical substance of residual, obtain macromolecule hydrogel.The lysine based aquagel of 0.1g is put in 10mL and contains in the tryptic PBS of 1mg (pH=7.4,0.1M), continuous degradation 7 days under 37 DEG C of environment, period, in order to keep the activity of enzyme, change PBS every day.The nanogel degraded is put in the bag filter of 100000 molecular weight dialysis 1 day, freeze-dried obtains medicament-carried nano gel.
B) preparation of hyaluronic acid macromonomer:
Take hyaluronic acid 1g (number-average molecular weight 100,000) to be dissolved in 100mL deionized water, 24h is stood under 4 DEG C of environment, NHS and EDC of the material amounts such as addition, regulation PH is 4～6, low rate mixing 24h, afterwards with 2-aminoethyl methacrylate hydrochlorate (AEMA) hybrid reaction 24h, the hyaluronic acid macromonomer solution obtained is dialysed 3 days in the bag filter that molecular weight is 8000, freeze-dried obtain hyaluronic acid macromonomer.
C) preparation of medicine carrying hyaluronic acid/nanofiber combine dressing:
Make the flat board hydrogel forming one piece of 4cm*4cm, method particularly includes: hyaluronic acid macromonomer is dissolved in deionized water, stand under 4 DEG C of environment, until completely dissolved by medicament-carried nano gel dispersion wherein, ultrasonic make it dispersed, add Ammonium persulfate. light trigger, aforesaid liquid is instilled in mould, it is 365nm ultra violet lamp 20 minutes with wavelength, obtains medicine carrying hyaluronic acid based aquagel.Flat board hydrogel and polyester ammonia nanofiber are combined closely thus prepares combine dressing.
Embodiment 2
A kind of medicine carrying hyaluronic acid-based aerogel dressing, including hyaluronic acid macromonomer, described hyaluronic acid macromonomer is cross-linked with each other the hydrogel structure formed and the combine dressing with nanofiber layer composition thereof, and its preparation method is:
A) preparation of medicament-carried nano gel:
First medicine carrying lysine based aquagel is prepared: take Lys-4 monomer 1g and NA monomer 1.1442g, mix 20mg levofloxacin antimicrobial drug simultaneously, it is dissolved in 2gN under the conditions of 50 DEG C, in N-dimethyl acetylamide, adding 1.59g triethylamine until completely dissolved, mixed solution fully reaction 1h under 80 DEG C of oil bath environment i.e. obtains lysine based aquagel.By hydrogel with after acetone soak 4h, then with deionized water rinsing to remove the chemical substance of residual, obtain lysine hydrogel.The lysine hydrogel of 0.1g is put in 10mL and contains in the tryptic PBS of 1mg (pH=7.4,0.1M), continuous degradation 7 days under 37 DEG C of environment, period, in order to keep the activity of enzyme, change PBS every day.The nanogel degraded is put in the bag filter of 100000 molecular weight dialysis 1 day, freeze-dried obtains medicament-carried nano gel.
B) preparation of hyaluronic acid macromonomer:
Take hyaluronic acid 1g (number-average molecular weight 100,000) to be dissolved in 100mL deionized water, 24h is stood under 4 DEG C of environment, NHS and EDC of the material amounts such as addition, regulation PH is 4～6, low rate mixing 24h, afterwards with Guttae Sulfacetamidi Natrici hybrid reaction 12h, the hyaluronic acid-based macromolecular solution obtained is dialysed 3 days in the bag filter that molecular weight is 8000, freeze-dried obtain hyaluronic acid macromonomer.
C) preparation of medicine carrying hyaluronic acid/nanofiber combine dressing:
Make the flat board hydrogel forming one piece of 4cm*4cm, method particularly includes: hyaluronic acid macromonomer is dissolved in deionized water, stand under 4 DEG C of environment, until completely dissolved by medicament-carried nano gel dispersion wherein, ultrasonic make it dispersed, add potassium peroxydisulfate light trigger, aforesaid liquid is instilled in mould, it is 365nm ultra violet lamp 15 minutes with wavelength, obtains medicine carrying hyaluronic acid based aquagel.Flat board hydrogel and polyurethane nanofiber are combined closely thus prepares formation combine dressing.
Embodiment 3
A kind of medicine carrying hyaluronic acid-based aerogel dressing, including hyaluronic acid-based macromole, described hyaluronic acid-based macromole is cross-linked with each other the hydrogel structure formed and the combine dressing with nanofiber layer composition thereof, and its preparation method is:
A) preparation of medicament-carried nano gel:
First medicine carrying arginine based aquagel is prepared: take Arg-4 monomer 1g and NA monomer 0.7628g, mix 10mg hibitane antimicrobial drug simultaneously, it is dissolved in 2gN under the conditions of 50 DEG C, in N-dimethyl acetylamide, adding 1.59g triethylamine until completely dissolved, mixed solution fully reaction 1h under 80 DEG C of oil bath environment i.e. obtains arginine based aquagel.By hydrogel with after acetone soak 4h, again with deionized water rinsing to remove the chemical substance of residual, obtain macromolecule hydrogel the arginine based aquagel of 0.1g is put in 10mL to contain (pH=7.4 in the tryptic PBS of 1mg, 0.1M), continuous degradation 7 days under 37 DEG C of environment, period, in order to keep the activity of enzyme, change culture medium every day.The nanogel degraded is put in the bag filter of 100000 molecular weight dialysis 1 day, freeze-dried obtains medicament-carried nano gel.
B) preparation of hyaluronic acid macromonomer:
Take hyaluronic acid 0.1g (number-average molecular weight 1,000,000) to be dissolved in 100mL deionized water, 24h is stood under 4 DEG C of environment, NHS and EDC of the material amounts such as addition, regulation PH is 4～6, low rate mixing 24h, afterwards with thymolphthalein monophosphate di-ammonium salts hybrid reaction 24h, the hyaluronic acid macromonomer solution obtained is dialysed 3 days in the bag filter that molecular weight is 8000, freeze-dried obtain hyaluronic acid macromonomer.
C) preparation of medicine carrying hyaluronic acid-based combine dressing:
Make the flat board hydrogel forming one piece of 4cm*4cm, method particularly includes: hyaluronic acid macromonomer is dissolved in deionized water, stand under 4 DEG C of environment, until completely dissolved by medicament-carried nano gel dispersion wherein, ultrasonic make it dispersed, add TEMED, aforesaid liquid is instilled in mould, stand 2h, obtain medicine carrying hyaluronic acid based aquagel.Flat board hydrogel and polyurethane nanofiber are combined closely thus prepares formation combine dressing.
Medicine carrying hyaluronic acid nano fiber combine dressing that embodiment 1-3 prepares is as it is shown on figure 3, include that mutually compound hyaluronic acid macromonomer is cross-linked with each other the hydrogel layer 1 and nanofiber layer 2 formed, and is loaded with medicament-carried nano gel 1-1 in described hydrogel layer 1.
Claims (10)
1. a medicine carrying hyaluronic acid nano fiber combine dressing, it is characterized in that, be cross-linked with each other the hydrogel layer (1) and nanofiber layer (2) formed including the most compound hyaluronic acid macromonomer, is loaded with medicament-carried nano gel (1-1) in described hydrogel layer (1).
2. the preparation method of the medicine carrying hyaluronic acid nano fiber combine dressing described in a claim 1, it is characterised in that comprise the following steps:
The first step: use biological degradation method to prepare medicament-carried nano gel；
Second step: the synthesis of hyaluronic acid macromonomer；
3rd step: hyaluronic acid macromonomer solution is carried out Cross-linked, mixes medicament-carried nano gel simultaneously, prepares hyaluronic acid based aquagel；
4th step: hyaluronic acid based aquagel and nano fibrous membrane are combined, obtains medicine carrying hyaluronic acid-based combine dressing.
3. the preparation method of medicine carrying hyaluronic acid nano fiber combine dressing as claimed in claim 2, it is characterized in that, any one or a few the combination in the degradation product that raw material nano gel is biodegradable amino acids vacation protein hydrogel that the medicament-carried nano gel in the described first step uses.
4. the preparation method of medicine carrying hyaluronic acid nano fiber combine dressing as claimed in claim 2, it is characterised in that the material medicine that the medicament-carried nano gel in the described first step uses is any one or a few combination in extensive pedigree antibiotic.
5. the preparation method of medicine carrying hyaluronic acid nano fiber combine dressing as claimed in claim 4, it is characterised in that described extensive pedigree antibiotic is specially many peptides, Macrolide, phosphorous polysaccharide, polyethers, aminoglycosides or chemosynthesis class.
6. the preparation method of medicine carrying hyaluronic acid nano fiber combine dressing as claimed in claim 2, it is characterised in that the medicament-carried nano gel Chinese medicine in the described first step is 0.1～50% with the mass percent of nanogel.
7. the preparation method of medicine carrying hyaluronic acid nano fiber combine dressing as claimed in claim 2, it is characterised in that the hyaluronic acid in described second step uses high molecular weight hyaluronic acid or low-molecular-weight hyaluronic acid.
8. the preparation method of medicine carrying hyaluronic acid nano fiber combine dressing as claimed in claim 2, it is characterized in that, the synthesis of the hyaluronic acid macromonomer in described second step is included in grafted olefin monomer on hyaluronan molecule, is grafted any one or a few in sulfanilamide salt, phosphamidon salt, carboxylic amine salt and quaternary ammonium salt simultaneously.
9. the preparation method of medicine carrying hyaluronic acid nano fiber combine dressing as claimed in claim 2, it is characterised in that the mass concentration of the hyaluronic acid macromonomer solution in described second step is 0.5～20%, and solvent is deionized water.
10. the preparation method of medicine carrying hyaluronic acid nano fiber combine dressing as claimed in claim 2, it is characterized in that, the raw material of the nano fibrous membrane in described 4th step includes that, by one or more in natural high polymer, synthetic high polymer, preparation method uses method of electrostatic spinning.
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Cited By (7)
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| CN107854453A (en) * | 2017-12-18 | 2018-03-30 | 济南格莱威医疗科技有限公司 | A kind of medical aquogel eyeshield dressing |
| CN109481737A (en) * | 2017-09-12 | 2019-03-19 | 中国人民解放军第三军医大学第附属医院 | Bionical double-deck dressing of one kind and preparation method thereof |
| CN109943976A (en) * | 2019-04-25 | 2019-06-28 | 中国科学院长春应用化学研究所 | A kind of Multifunctional static electricity spinning fibre dressing and preparation method thereof |
| CN110743034A (en) * | 2019-09-29 | 2020-02-04 | 中山大学 | Multifunctional hydrogel dressing for internal and external synergistic treatment of diabetic ulcer and preparation method and application thereof |
| CN112064193A (en) * | 2020-08-28 | 2020-12-11 | 华东理工大学 | Preparation method of cellulose diacetate based three-dimensional scaffold with antibacterial and biocompatibility functions |
| CN115569230A (en) * | 2022-09-14 | 2023-01-06 | 东华大学 | High-moisturizing and quick self-healing double-layer nanofiber composite hydrogel dressing |
| CN115837091A (en) * | 2023-02-16 | 2023-03-24 | 首都医科大学附属北京安贞医院 | Composite material used as wound dressing and preparation method thereof |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109481737A (en) * | 2017-09-12 | 2019-03-19 | 中国人民解放军第三军医大学第附属医院 | Bionical double-deck dressing of one kind and preparation method thereof |
| CN109481737B (en) * | 2017-09-12 | 2021-07-06 | 中国人民解放军第三军医大学第一附属医院 | Bionic double-layer dressing and preparation method thereof |
| CN107854453A (en) * | 2017-12-18 | 2018-03-30 | 济南格莱威医疗科技有限公司 | A kind of medical aquogel eyeshield dressing |
| CN109943976A (en) * | 2019-04-25 | 2019-06-28 | 中国科学院长春应用化学研究所 | A kind of Multifunctional static electricity spinning fibre dressing and preparation method thereof |
| CN110743034A (en) * | 2019-09-29 | 2020-02-04 | 中山大学 | Multifunctional hydrogel dressing for internal and external synergistic treatment of diabetic ulcer and preparation method and application thereof |
| CN112064193A (en) * | 2020-08-28 | 2020-12-11 | 华东理工大学 | Preparation method of cellulose diacetate based three-dimensional scaffold with antibacterial and biocompatibility functions |
| CN115569230A (en) * | 2022-09-14 | 2023-01-06 | 东华大学 | High-moisturizing and quick self-healing double-layer nanofiber composite hydrogel dressing |
| CN115569230B (en) * | 2022-09-14 | 2023-11-21 | 东华大学 | High-moisture-retention and rapid self-healing double-layer nanofiber composite hydrogel dressing |
| CN115837091A (en) * | 2023-02-16 | 2023-03-24 | 首都医科大学附属北京安贞医院 | Composite material used as wound dressing and preparation method thereof |
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