CN1063974C - Wound bandage with polymer layer - Google Patents

Wound bandage with polymer layer Download PDF

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CN1063974C
CN1063974C CN 89100413 CN89100413A CN1063974C CN 1063974 C CN1063974 C CN 1063974C CN 89100413 CN89100413 CN 89100413 CN 89100413 A CN89100413 A CN 89100413A CN 1063974 C CN1063974 C CN 1063974C
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layer
wound
dressing
fabric
adhesive
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CN 89100413
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CN1044405A (en
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拉尔夫·泽维尔·埃瓦尔
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Bf谷德里奇公司
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Abstract

公开能吸收伤口渗出液,且能将水分转移到空气中的包扎带,该包扎带由一种层状制品组成,该层状物含有一种粘结到织物层的亲水性吸收剂聚合层,施加该亲水性吸收剂聚合层的方法是把一种单体溶液注到织物层上,然后加以固化而制得聚合物层。 Discloses hydrophilic polymeric absorbent to absorb wound exudate, and can be transferred to a dressing of moisture in the air, the dressing composed of a layered article, the layer comprising an adhesive substance to the fabric layer layer, methods of applying the hydrophilic absorbent polymeric layer of the monomer solution is dispensed into the upper fabric layer, and then be cured to prepare a polymer layer. 当亲水吸收剂聚合层暴露于伤口渗出物时,自动地粘附到伤口部位;一个织物层在此之邻接,以及一种压敏粘附剂,用来保持高皮肤整合弹性膜与对面的织物层间的相互接触。 When the hydrophilic absorbent polymeric layer is exposed to the wound exudate, automatically adhered to the wound site; one fabric layer of this abutment, and a pressure-sensitive adhesive, for holding the elastic membrane with the high integration across skin mutual contact between the fabric layers.

Description

聚合的伤口包扎带 Polymerization wound dressing

本申请是1986年8月25日提交的系列号为06/899,575,标题为“伤口包扎带及其制造方法”申请的部分继续申请。 This application is a series of numbers August 25, 1986, it filed 06 / 899,575, entitled "Wound dressings and its manufacturing method" filed continuation application.

本发明与伤口包扎带相关,特别与那些用来覆盖伤口的包扎带有关,这类伤口在常规治疗时可能会渗出大量的液体。 The present invention is related to a wound dressing tape, especially those related to cover a wound dressing, treatment of such wounds in the regular amount of liquid may seep.

在医治过程中,许多类型的皮肤损伤处渗出液体是正常现象,这类伤口如溃疡的第Ⅱ和第Ⅲ阶段,二度和三度烧伤,皮肤移植和皮肤供体部位,真皮深部的擦伤和划破等。 In the treatment process, many types of skin lesions is normal exudate liquid, such as wound and ulcer Ⅱ Ⅲ first stage, second and third degree burns, skin grafts and skin donor sites, deep dermis of wiping scratched injury and so on. 常规的绷带或伤口包扎带虽易于吸收液体,当把它们用于上述损伤时,它们很快就被开放伤口中的渗出物浸透,因此需要经常更换绷带或包扎带。 While a conventional bandage or wound dressings readily absorb liquid, they are used when the above-described damage, they soon open wound exudate penetration, and therefore require frequent replacement bandage or dressing. 频繁的更换会刺激伤口给病人带来痛苦还会增加治疗费用。 Frequent replacement will stimulate wound to the patient suffering will increase the cost of treatment. 有一种伤口包扎带当渗出物在开放伤口表面一出现就能将它们吸收掉,并按一希望的速度把吸收的潮气通过包扎带转移到一种背衬中[Backing layer本文常把它称为包扎带的“远表面”(distal sur-face)],当把包扎带覆盖到伤口上时,它是距伤口最远的表面,在这里水份从覆盖伤口的包扎带中蒸发掉,所以是一种特别有用的伤口覆盖材料,由于和常规包扎带相比这种包扎带覆盖伤口的时间更长而不要进行更换,所以伤口不经常受到更换包扎带的扰动,病人受到由创伤引起的痛苦也少些。 There is a wound dressing in an open wound exudate when a speed of the surface will be able to absorb them, according to a desired moisture absorption appeared to be passed to the backing strip by wrapping [Backing layer it is often referred to herein "distal surface" of the dressing (distal sur-face)], when the dressing to cover the wound, which is furthest from the surface of the wound, where the water is evaporated from the dressing covering a wound, the so is a particularly useful wound covering material, as compared to conventional dressings such a bandage covering the wound with a longer time and not be replaced, the wound is not so often by replacing the dressing with disturbances, patients suffering from the trauma caused by the also less.

曾经做过多种努力试图提供一种能够更有效地吸收从开放伤口逸出渗出物的伤口包扎带。 I have done a variety of efforts to try to provide a more efficient absorption of wound exudate escaping from the open wound with a bandage.

在美国专利3,339,546中,描述过一种由不透水膜组成的包扎带,该带具有一种与不透水膜叠合起来的粘合剂层。 In U.S. Patent No. 3,339,546, there is described a live a dressing consisting of the impermeable membrane, the strip having one impermeable membrane laminated together with the adhesive layer. 描述的粘附剂层是一种水溶性或水溶胀性的水解胶体材料并充分地分散在一种非水溶性的粘滞性的弹性绷带中。 Described adhesive layer is a water-soluble hydrocolloid material or water-swellable and sufficiently dispersed in a non-water-soluble viscous elastic bandage.

美国专利3,972,328也描述过一种由三部分组成的伤口包扎带,即(1)由一种半开孔的韧性泡沫材料组成的中间层,(2)一种不透水的附加在中间层一个表面上的韧性膜,(3)一种压敏粘合剂层放在中间层的另一面。 U.S. Patent No. 3,972,328 also described a wound dressing composed of three parts, namely, (1) an intermediate layer made of a semi-open-cell foam material toughness, and (2) A water-impermeable added an intermediate layer of a ductile film on the surface, (3) a pressure-sensitive adhesive layer on the other surface of the intermediate layer. 压敏粘合组分由含有某种水溶性或水溶胀性水解胶体或水解胶体混合物的压敏弹性材料组成,另外还含有一种增粘剂和一种增塑剂或溶剂。 The pressure-sensitive adhesive component a pressure sensitive elastomeric material containing certain water-soluble or water-swellable hydrocolloid or mixture of hydrocolloid composition additionally contains a tackifier and a plasticizer or solvent.

虽然采用把水溶性或水溶胀性的水解胶体分散在伤口包扎带的粘合层中,可以借助水解胶体吸收伤口渗出物,但水解胶体颗粒吸收渗出物后,颗粒将发生溶胀从而过早地破坏了粘附剂膜的完整性,造成膜的破裂。 Although the use of the water-soluble or swellable hydrocolloids dispersed in the adhesive layer of water wound dressing, a hydrocolloid may be by means of absorbing wound exudate, but hydrocolloid particles absorb exudates, swell the particles occurs so early It undermines the integrity of the adhesive film, resulting in rupture of the membranes.

本发明提供的一种伤口包扎带能吸收从一种开放伤口中逸出的显著数量的伤口渗出物而不会破坏包扎带的完整性,在一种优选的设计中,该种包扎带能够以某一希望的速度把渗出物中的水份通过包扎带传送到包扎带的远表面,并在此蒸发到周围的大气中,从而延长了包扎带的使用寿命。 A wound dressing according to the present invention is provided to absorb a significant amount of escaping from an open wound of wound exudate without compromising the integrity of the dressing, in a preferred design, the kind of dressing can be a certain desired speed of moisture in the exudate through the dressing to the tape transport distal surface of the dressing, and this evaporates into the surrounding atmosphere, thus extending the life of the dressing. 根据本发明提供的伤口包扎带包括一种编织物层(本文有时称为织物层),在该层上沉积一种亲水材料的韧性连续薄膜,最好把亲水性吸收剂聚合物层涂复或浸渍到织物层中。 According to the present invention provides a wound dressing comprising a woven layer (sometimes herein referred to as fabric layer), depositing a layer of hydrophilic material on the toughness of a continuous film, the hydrophilic absorbent polymer is preferably coated with layers complex or impregnated into the fabric layer. 把一层压敏粘附材料粘合到织物层的一面以便把包扎带固定到病人身上,粘附材料是一种可粘附加到病人健康皮肤上而不与开放伤口粘连的材料。 The layer of pressure sensitive adhesive material bonded to the fabric layer to one side of the dressing to the patient is fixed, the adhesive material is an adhesive material applied to an open wound without adhesion on the skin of the patient's health. 为增加包扎带额外的整体性,提供一个外部覆盖层构成包扎带的远表面,远表面即把包扎带放在伤口上时,包扎带距伤口最远的表面。 To increase the integrity of the additional dressing, a covering layer constituting the outer distal surface of the dressing, i.e. the distal surface of the dressing when placed on the wound, the wound dressing furthest away from the surface. 在本发明的某些情况下,包扎带的组成层最好具有多孔性,使体液中含有的水份能够按所希望的速度透过包扎带而在包扎带背面或远表面蒸发掉。 In certain instances of the present invention, the composition layer dressing preferably has porosity, so that water can be contained in a body fluid by a desired speed in the rear or distal surface of the dressing through the dressing was evaporated.

本发明的最后一种方式是亲水性吸收济聚合层直接粘附到病人的伤口部位。 The last aspect of the present invention is a hydrophilic absorbent polymeric layer adhered directly to relief the wound site of a patient. 更具体地说就是提供一种处置伤口体液的伤口包扎带,通过快速地吸收掉伤口渗出物并把吸收液体中的水气转移到大气中,从而减少皮肤受到浸渍作用。 More specifically, to provide a body fluid disposal wound a wound dressing, and the absorption liquid in the water gas shift to the atmosphere by rapidly absorb wound exudate, thereby reducing skin by impregnation. 该包扎带由一附着在织物层上的含有亲水性吸收剂聚合物层的层状物组成,所说的亲水性吸收剂聚合物层的施加方法是把一种单体溶液加注到织物层中,然后加以固化而生成聚合物层。 The dressing was made an adhesion layer containing a hydrophilic absorbent polymer layer on the fabric layer composed of said absorbent polymer is applied to a hydrophilic layer is raised to the monomer solution fabric layer, and then be cured to form a polymer layer. 一旦亲水性吸收剂聚合物层与伤口渗出物相接触就自动粘附在伤口部位,织物层与其邻接;压敏粘附剂保持与皮肤高度配合弹性材料膜和织物层之间的接触。 Once the hydrophilic absorbent polymer layer is in contact with the wound exudate adhere to the wound site automatically, the fabric layer adjacent thereto; pressure sensitive adhesive remains in contact with the skin between the height of an elastic material with a film and a fabric layer. 另外种类的亲水吸收剂聚合层是一种高皮肤整合弹性材料细菌防护膜,以便形成与病人伤口部位的密切皮肤接触,并借助压敏粘附剂保持高皮肤整合弹性材料膜与对面织物层的接触包住伤口包扎带。 Further types of hydrophilic absorbent polymeric layer is a highly elastic material integrated skin bacterial pellicle, to form a skin in close contact with the patient's wound site, by means of a pressure sensitive adhesive and the skin to maintain a high integration of an elastic material and the film layer opposite the fabric contacting the wound dressing wrap. 其中每层的潮湿蒸汽传送速度,足以保证把吸收在伤口包扎带流体中的水蒸汽散发出去,从而减少新内皮伤口床和伤口周围部位受到的浸渍。 Wherein each layer of the moisture vapor transmission rate sufficient to ensure the absorption of water vapor in the tape wound dressing fluid dissipated, thus reducing impregnation of new endothelial wound bed and surrounding wound site exposed.

图1是一张说明本发明一种情况的一段伤口包扎带透视图;图2是一张说明本发明另外一种情况的一段包扎带透视图;图3是一张说明形成图1和2中伤口包扎带复合组成的示意图;图4是一张说明把两个复合组分结合在一起形成图1伤口包扎带的原理图;图5是一张用一种粘附层把两个复合组分结合起来形成图2伤口包扎带的原理图。 FIG 1 is an explanatory perspective view of a section of tape wound dressing of the present invention, one case; FIG. 2 is a perspective view of another section of tape wrap of the present invention will be described case; FIG. 3 is an explanatory formed in FIGS. 1 and 2 a schematic view of the composite tape consisting of a wound dressing; FIG. 4 is an explanatory combines two components together to form a composite wound dressing of FIG band diagram; FIG. 5 is an adhesive layer in a composite of the two components FIG. 2 combine to form a schematic diagram of a wound dressing tape.

根据本发明的第一种方式提供一种能够滞留伤口渗出物的吸收式伤口包扎带,它由一种由以下诸层构成的层状物组成。 According to a first embodiment provides the present invention capable of retention of wound exudate absorption of the wound dressing, which was one kind of a layer consisting of various layers.

(a)一种能让液体通过的粘附层。 (A) an adhesive layer allow the passage of liquid. 当与病人皮肤发生压触时,粘附层伤口包扎带粘附到皮肤上,而无需任何外部的固定措施;(b)一种织物层与上述粘附层粘结,以便在伤口包扎带暴露于伤口渗出物时保持结构完整性;(c)施加到织物层中的一种亲水吸收剂聚合物层,亲水性吸收剂聚合物层被涂复或浸渍到织物层中,生成的织物当伤口包扎带暴露于伤口渗出物中具有结构完整性以保持它与粘附层的粘合,当把伤口包扎带放在病人的皮肤上时,所说的亲水性吸收剂聚合物层能够把伤口渗出物的液体抽吸到伤口包扎带中;(d)至少一个吸留背衬层,选自某种膜,泡沫材料,泡沫材料一膜的层状物或纤维织物,该背衬层通过邻接的粘附层与伸出的纤维粘合。 When the pressure contact with the skin of the patient, the wound dressing the adhesive layer adhered to the skin, without any external fastening means; (b) a fabric layer and the adhesive layer is adhered to a wound dressing with exposed when held in the wound exudate structural integrity; (c) applying one hydrophilic absorbent polymer layer to the fabric layer, the hydrophilic absorbent polymer layer is coated or impregnated into the fabric layer, the resultant when the wound dressing is exposed fabric having structural integrity to the wound exudate to maintain its adhesion with the adhesive layer when the wound dressing on the patient's skin, said hydrophilic absorbent polymer the liquid layer can be drawn into the wound exudate in the wound dressing; (d) storing at least one backing layer selected from a certain film, a foam, a film, a foam material or a fibrous web-like layer, which the backing layer adjacent to the adhesive layer by projecting the fiber bonding.

对于本发明的各种情况来说,亲水性吸收剂聚合物层是公用的,可由不同的聚合物制作,它们能吸收2-20倍于本身重量的渗出物。 For each case of the present invention, the hydrophilic absorbent polymer layer is common, made by different polymers, they can absorb 2-20 times its weight of exudate. 这类亲水性材料包括羧甲基纤维素钠,各种聚丙烯酰胺,聚丙烯腈和丙烯酸聚合物,刺梧桐树胶和聚糖。 Such hydrophilic materials include sodium carboxymethylcellulose, various polyacrylamide, polyacrylonitrile and acrylic polymers, karaya gum, and polysaccharides. 一种由交联的丙烯酸聚合物组成的无毒的韧性薄膜层15可用下法制备,将重量为90-99.9%丙烯酸,其中50-100%的羧基在聚合前被碱或氢氧化氨中和后与重量为0.1-10%的多官能团交联剂和占丙烯酸与交联剂总重量0.1-5%的光引发剂一起进行光聚合或辐照聚合(在氮气氛中),发现1984,1,24发布的加拿大专利No. A non-toxic toughness film layer made of a crosslinked acrylic polymer consisting of 15 may dismount preparation, 90 to 99.9% by weight of acrylic acid, of which 50-100% of the carboxyl groups before the polymerization by an alkali or ammonium hydroxide polyfunctional crosslinking agent and 0.1 to 5% by weight of the total acrylic acid with a crosslinking agent and a photoinitiator of 0.1 to 10% by weight and after irradiation with the polymerization or photopolymerization (nitrogen atmosphere ), found 1984,1,24 issued Canadian Patent No. 1,160,984比较详细描述的这类聚合物是特别适用的。 Such polymers are described in detail Comparative 1,160,984 are particularly useful. 在美国专利Nos. In US Patent Nos. 4,062,817和4,066,583描述过另外一些有用的亲水材料,有用的聚合物和它们的制备方法也披露在共同所有专利上,(美国专利4,167,464和欧洲专利0,042,406,1985年6月19日发行)。 4,062,817 and 4,066,583 describe some additional useful hydrophilic materials, useful polymers and methods for their preparation are also disclosed in Commonly Owned patent (U.S. Patent No. 4,167,464 and European Patent No. 0 , 042,406, June 19, 1985 issue). 也可以用未取代的或取代过的丙烯酸和丙烯酸酯,具体内容参看文献说明。 It may be unsubstituted or substituted with acrylic acid and acrylic esters over specific contents described with reference to the literature.

按照本发明这种方式的一个较佳实施方案,其中的亲水性吸收剂是把某单体溶液涂敷或浸渍到纤维层内加以固化。 According to one preferred embodiment of this aspect of the present invention, wherein the hydrophilic absorbent is coated or impregnated with a monomer solution into the fiber layer to be cured. 在较佳实施中,单体溶液可以是单一的单体溶液,也可以是几种单体混合物的溶液,它们在浇注单体溶液固化时形成一种共聚物。 In the preferred embodiment, the monomer solution may be a single monomer solution, the solution may be a mixture of several monomers which form a copolymer in the casting solution solidifying monomer.

按照本发明这种方式的一个较佳实施方案,所说的粘附层是一种药用合格的多孔的压敏性丙烯酸类粘附物。 According to one preferred embodiment of this aspect of the present invention, it said adhesive layer is a pharmaceutically acceptable porous pressure-sensitive acrylic adhesive composition. 按照本发明这种方式的一个较佳实施方案,织物层是从一组旋绕结合,旋绕编织或点结合聚酯织物中选择的一种聚酯材料组成。 According to one preferred embodiment of this aspect of the present invention, the fabric layer from a set of binding convoluted, convoluted braided or in combination with one point of the polyester fabric material is polyester selected composition.

在某一实施中,亲水性吸收剂是一种交联的丙烯酸类材料,按照本发明这种方式的较佳实施方案,亲水性吸收剂聚合物是一种藻酸盐或羧甲基纤维素钠。 In one embodiment, the hydrophilic absorbent is a crosslinked acrylic material, according to the preferred embodiment of this aspect of the present invention, the hydrophilic absorbent polymer is an alginate or carboxymethylcellulose sodium carboxymethylcellulose.

按照本发明第一种方式的一个较佳实施,提供的是一种能滞留住伤口渗出物的吸留式伤口包扎带,它是由具有以下诸层的一种层状制品构成:(a)一个能允许液体透过的粘附层,当与病人的皮肤压接时,粘附层使伤口包扎带粘附在皮肤上,无需其它外部固定措施;(b)一种与上述粘附层粘结起来的织物层,该层在伤口包扎带暴露于伤口渗出物时保持结构的完整性;(c)附加到织物层中的一种亲水性吸收剂聚合物层,亲水性吸收剂聚合物被(1)涂敷或浸渍到织物层中;(2)刷到吸收剂/织物复合物顶表面以使大多数纤维露出;这种浸渍过的织物具有结构整体性以便在伤口包扎带暴露于伤口渗出物时保持与粘附层的粘结。 According to one preferred embodiment of a first aspect of the present invention, there is provided a storage type capable of retention of wound dressings live wound exudate, which is composed of a layered article of the layers having the following: (a ) allow a liquid permeable adhesive layer, when pressed against the patient's skin, the adhesive layer adhered to the wound dressing to the skin without other external fastening means; (b) one kind of the above-mentioned adhesive layer the bonded fabric layers, the exposed layer with a wound dressing in maintaining the integrity of the structure at the time of wound exudate; (c) attached to one hydrophilic absorbent polymer layer fabric layer, a hydrophilic absorbent polymers are (1) coating or impregnating the fabric layer; (2) to the brush absorbent / fabric composite so that the top surface of the majority of the fibers are exposed; such impregnated fabric having structural integrity to the wound dressing maintaining adhesion with the adhesive layer when exposed to wound exudate. 当把伤口包扎带放在病人受伤皮肤上时,亲水性吸收剂聚合物层能够吸收掉从伤口渗出物中抽吸到包扎带中的液体;(d)一种附加到经刷过的复合物上的粘附层,露出的纤维粘附到邻接的粘附层上。 When the wound dressing is placed on the wounded skin of a patient, the hydrophilic absorbent polymer layer capable of absorbing wound exudate away from the suction into the liquid in the dressing; (d) an additional brushed off to the adhesive layer on the composite, the fibers adhered to the exposed adhesive layer adjacent to.

(e)至少一层吸留背衬层,该从从某种膜,泡沫材料,泡沫材料一膜的多层或纤维织物中选取,该背衬层经由邻接的粘附层附着在露出的纤维上。 (E) storing at least one layer of the backing layer, from which certain selected from films, foams, foam material or a multilayer film of a fabric, the backing layer adhered to the fibers adjacent to the exposed adhesive layer via on.

按照本发明第二种方式,提供一种处置伤口流体的伤口包扎带,通过快速地吸收掉伤口渗出物并把来自吸收液体中的水气散发到大气中去从而减少了对皮肤的浸蚀。 According to a second aspect of the present invention, there is provided a wound fluid disposal wound dressing, and the water from the absorption liquid in the gas emitted into the atmosphere by rapidly absorb wound exudate to reduce the erosion of the skin . 该包扎带由一种具有下列诸层状制品组成:(a)一种能允许液体透过的粘附层,当与病人皮肤压触时,该粘附层使伤口包扎带粘附在皮肤上而无需任何外部固定措施;(b)一种与上述粘附层粘结的织物层,当伤口包扎带暴露于伤口渗出物时,该层保持住结构的整体性;(c)一种附着到织物层的亲水性吸收剂聚合物层,亲水性吸收剂聚合物层被加到或浸渍到织物层中,生成的具有结构完整性的织物层在伤口包扎带暴露到渗出物时以保持与粘附层的连结,当把伤口包扎带放在病人受伤皮肤上时,亲水性吸收剂聚合物能吸收掉从伤口渗出物中抽吸到伤口包扎带的液体;(d)至少一个背衬层,选自由一种膜,泡沫材料,泡沫材料-膜构成的一组层状制品或织物,背衬层经由邻接粘附层附着在露出的纤维上,包扎带的每一层具有的水气传送速度足以使来自吸收在伤口包 The dressing of having the following composition such layered article: (a) allow one kind of liquid-permeable adhesive layer, when the pressing contact with the patient's skin, the adhesive layer adhered to the wound dressing to the skin without any external fastening means; (b) a fabric layer of one of the above-described bonding adhesive layer when the wound dressing is exposed to the wound exudate, maintain the integrity of the layer structure of the living; (c) an adherent when the fabric layer is a hydrophilic absorbent polymer layer, a hydrophilic absorbent polymeric layer applied to or impregnated into the fabric layer, the resulting fabric layer having structural integrity in the wound dressing is exposed to the exudate in the coupling holding the adhesive layer when the wound dressing is placed on the wounded skin of a patient, the hydrophilic polymer absorbent can absorb wound exudate aspirated from the wound dressing to a liquid; (d) at least one backing layer selected from the group consisting of a membrane, foam, foam - a set of layered article or fabric, film, and backing layer attached to the fiber via the exposed adhesive layer adjacent to, with each layer of dressing It has a water vapor transmission rate sufficient to absorb from a wound 扎带中的液体的蒸汽散发掉,因此减少了对新内皮伤口床和周围伤口区域的浸蚀。 Liquid vapor dissipated in the cable tie, thus reducing the erosion of new endothelial wound bed and surrounding wound area.

按照本发明的这种方式的一个较佳实施,所述及的亲水性吸收剂是通过把单体溶液涂敷或浸渍到织物层中加以固化。 A preferred embodiment of this embodiment of the present invention according to, and the hydrophilic absorbent is cured by the monomer solution to be coated or impregnated into the fabric layer. 在本发明第一种方式中采用的单体材料也可在这里采用。 Monomeric materials employed in the first embodiment of the present invention may also be employed here. 按照本发明的这种方式的较佳实施方案,粘附层是某种药剂上合格的多孔的压敏丙烯酸粘附材料。 According to the preferred embodiment of this aspect of the present invention, the adhesive is of some pharmaceutically acceptable porous pressure-sensitive acrylic adhesive material. 按照本发明的这种方式的较佳实施方案,织物层是由一种聚酯类构成,该聚酯选自一组旋绕结合,旋绕编织或点结合的聚酯织物。 According to the preferred embodiment of this aspect of the present invention, the fabric layer is made from a polyester-based, polyester is selected from the group of a binding winding, convoluted braided polyester fabric or a point bonded. 按照本发明的这种方式的较佳实施方案,亲水性吸收剂是某种交联的丙烯酸类材料。 According to the preferred embodiment of this aspect of the present invention, the hydrophilic absorbent is some cross-linked acrylic material. 在另一方式中,亲水性吸收剂聚合物是一种藻酸盐或羧甲基纤维素钠,在该实施中亲水性吸收剂聚合物比较好地分散在苯乙烯-丁二烯-苯乙烯嵌段共聚物中。 In another embodiment, the hydrophilic absorbent polymer is an alginate or sodium carboxymethylcellulose, in this embodiment the relatively well dispersed in the hydrophilic absorbent polymer of styrene - butadiene - styrene block copolymer.

按照本发明第二种方式的另外实施方案,提供一种能成功处置伤口流体的伤口包扎带,由于对伤口渗出物快速吸收并使来自被吸收流体的水气散发到大气中去,因而减少皮肤的浸蚀,包扎带由具有以下诸层状结构组成:(a)一种能使液体透过的粘附层,在与病人皮肤压触时粘附层使伤口包扎带粘附在皮肤上而无需任何外部的固定措施;(b)一种与上述粘附层结合的织物层,当伤口包扎带暴露于伤口渗出物时,使之保持其结构的完整性;(c)一种附加到上述织物层的亲水性吸收剂聚合物层,该亲水性吸收剂聚合物层被施加或浸渍到织物层中,并刷所生成的吸收剂/纤维复合物的上表面使纤维露出;这种固化后的吸收剂聚合物层即具有结构完整性的浸渍过的织物,当伤口包扎带暴露子伤口渗出物时保持和粘附层的结合,当把伤口包扎带放到病人受伤皮肤上时 According to another embodiment of the second embodiment of the present invention, to provide a successful handling of the wound dressing of the wound fluid, due to the rapid absorption of wound exudate and moisture is absorbed from a fluid circulated into the atmosphere, thereby reducing etching the skin, dressing such a layered structure having the following composition: (a) an adhesion layer of a liquid permeable enables, when press-contact with the skin of the patient so that the wound dressing the adhesive layer adhere to the skin without any external fastening means; fabric layer (b) one binding with said adhesive layer when the wound dressing is exposed to the wound exudate, so as to maintain its structural integrity; (c) an additional absorbent polymer to the hydrophilic layer of the fabric layer, the hydrophilic absorbent polymer layer is applied or impregnated into the fabric layer, and the resulting absorbent brush / fiber composite on the surface of the fiber is exposed; such absorbent polymeric layer after curing has a structure that is impregnated fabric integrity, holding and bonding the adhesive layer when the wound dressing is exposed sub-band wound exudate, the wound dressing when the skin into the patient injury on time 水性吸收剂聚合物层能够把从伤口渗出物中抽吸到伤口包扎带中的液体吸收掉;(d)一种附加到刷毛的复合吸收剂聚合物层上的粘附层,露出的纤维粘结到邻接的粘附层上。 The aqueous absorbent polymer layer can be drawn from the wound exudate into the wound dressings of liquid absorbed; (d) an additional layer is adhered to the bristles absorbent composite polymer layer, the exposed fibers bonded to the adjacent adhesive layer.

(e)至少一层背衬层,该层由一组膜,泡沫材料,泡沫材料-膜层状物或纤维织物中选取,该背衬层通过邻接的粘附层附着在露出的纤维上。 (E) at least one layer of the backing layer, the layer of foam material, the foam material by a group of film - film or fabric was selected, through the backing layer adjacent to the adhesive layer attached to the fibers exposed. 以上每一层具有的传送水气速度足以把吸收在伤口包扎带中液体的水份散发出去。 Above each layer having a water vapor transmission rate sufficient to absorb moisture in the wound dressing liquid dissipated. 从而减少了对新内皮伤口床和伤口四周的浸蚀。 Thereby reducing erosion of new endothelial wound bed and wound around.

亲水性吸收剂是由涂敷或浸渍到织物层中的单体溶液固化而制得,按照本发明的这种方式的一个较佳实施方案,在本发明第一种方式中使用的单体可用于这种方式;按照本发明的这种方式的一个较佳实施方案,粘附层是医药上合格的一种压敏丙烯酸类粘附剂:按照本发明的这种方式的一个较佳实施方案,织物层由一种聚酯组成,该聚酯选自一种旋绕一结合,旋绕-编织或点-结合的聚酯材料,按照本发明的这种方式的一个较佳实施,亲水性吸收剂是一种交联的丙烯酸类。 Hydrophilic absorbent is coated or impregnated with a monomer solution into the cured fabric layer is prepared, in accordance with a preferred embodiment of this aspect of the present invention, used in a first embodiment of the present invention, the monomers It can be used in this way; in accordance with a preferred embodiment of this aspect of the present invention, the adhesive layer is a pharmaceutically acceptable acrylic a pressure-sensitive adhesive: according to one preferred embodiment of this aspect of the present invention. embodiment, the fabric layer is made of a polyester composition, the polyester is selected from one winding a binding, convoluted - braided or points - bonded polyester material, according to one preferred embodiment of this aspect of the present invention, hydrophilic absorber is a crosslinked acrylic. 在其它的方式中,亲水性吸收剂聚合物是一种藻酸盐或羧甲基纤维素钠,在该实施中,亲水性吸收剂聚合物能更好地分散到苯乙烯-丁二烯-苯乙烯嵌段共聚物中。 In another embodiment, the hydrophilic absorbent polymer is an alginate or sodium carboxymethylcellulose, in this embodiment, the hydrophilic absorbent polymer is better dispersed styrene - butadiene alkenyl - styrene block copolymer.

按照本发明第三种方式提供一种由下列诸层构成的伤口包扎带:(a)一种允许液体透过的粘附层,当与病人皮肤压触时该粘附层能把伤口包扎带粘附到皮肤上,无需任何外部固定措施;(b)一种粘结到粘附层上的织物层,该层在伤口包扎带暴露于伤口渗出物时保持住结构上的完整性;(c)一种施加到织物层上的亲水性吸收剂聚合物层,该层被涂敷到或浸渍到织物层中,生成的具有结构完整性的织物。 According to a third embodiment of the present invention to provide a wound dressing with one kind of the layers consisting of the following: (a) an adhesion layer allows a liquid permeable, the skin of the patient when the adhesive layer is press-contacted with a wound dressing can adhered to the skin, without any external fastening means; (b) an adhesive layer adhered to the fabric layer, which maintain the integrity of the living structure of a wound dressing is exposed to wound exudate; ( c) a hydrophilic absorbent polymer layer on the layer of the fabric layer is applied to or impregnated into the fabric layer, the resultant fabric having structural integrity to an applied,. 当伤口包扎带暴露于伤口渗出物时以便能粘结在粘附层上。 When the wound dressing is exposed to the wound so that exudate can be adhered on the adhesive layer. 上述亲水性吸收剂聚合物层在把伤口包扎带放在病人受伤皮肤上时,能把从伤口渗出物中抽吸到伤口包扎带上的液体吸收掉;(d)至少一个覆盖在(C)层上的背衬层,而在两层之间没有压敏粘附层;(e)一种两面带粘附层的冲切周边的背衬层,叠合到皮肤粘附层(a)第二表面上,也叠合到背衬层(d)的第二个表面上。 The hydrophilic absorbent polymer layer when the wound dressing on the patient's skin injuries, wound exudate is drawn from the can into a liquid absorbed by a wound dressing tape; (d) at least one cover ( C) on the backing layer, but not between the two pressure-sensitive adhesive layer; perimeter die cut backing layer (e) one kind of both sides with the adhesive layer, the adhesive layer laminated to the skin ( a) on the second surface also laminated to the backing layer (d) is a second surface.

在一种实施中提供的是一种吸留式伤口包扎带,它能滞留住伤口渗出物,其中的背衬层(d)是吸留式的,上述渗出物被保持在由于吸收了来自伤口的液体渗出物而膨胀的背衬层(d)中。 In one embodiment provided in a storage-type wound dressings, wound exudate can live retentate, wherein the backing layer (d) of storage type, said exudate being maintained due to absorption of liquid exudate from the wound and the backing layer expands in (d). 此外也提供一种妥善处理伤口流体的伤口包扎带,通过快速吸收伤口渗出物并能把来自吸收液体中的水蒸汽散发到大气中去,因而减轻了皮肤受到的浸蚀。 In addition to properly handle also provides a wound dressing of wound fluids by rapidly absorbing wound exudate and can absorb water vapor from the liquid circulated into the atmosphere, thus reducing the erosion of the skin of the subject. 在这里每一层具有的传送潮湿蒸汽的速度足以把来自吸收在伤口包扎带液体中的水气散发出去,因此减轻了新内皮伤口床和周围伤口区的浸蚀。 Here each layer having a moisture vapor transmission rate sufficient to absorb the wound dressing from the water vapor of the liquid to dissipate, thus mitigating Immersing endothelial wound bed and surrounding wound area.

不管哪种情况,在一种优选的实施中,亲水性吸收剂是利用把一种单体溶液涂敷或浸渍到织物层中被固化的。 In either case, in one preferred embodiment, the hydrophilic absorbent is the use of the monomer solution is applied or impregnated into the fabric layer is cured. 在一种较佳实施中,粘附层是一种制药上合格的多孔压敏丙烯酸类粘合剂,在另外的实施中,织物层是由一种聚酯物组成,该聚酯物从包括旋绕-结合,旋绕-编织或点-结合的聚酯材料中选取。 In one preferred embodiment, the adhesive layer is on the one pharmaceutically acceptable porous pressure-sensitive acrylic adhesive, in a further embodiment, the fabric layer is formed of a polyester composed of the polyester composition comprises from convoluted - binding, convoluted - braided or points - bonded polyester material selected. 在一种较佳实施中,亲水性吸收剂是一种藻酸盐或者亲水性吸收剂聚合层用羧甲基纤维素钠材料制作。 In one preferred embodiment, the hydrophilic absorbent is an alginate or hydrophilic absorbent polymeric layer of cellulose, sodium carboxymethyl material.

按照本发明的最后一种方式提供一种能妥善处理伤口流体的伤口包扎带,由于它快速地吸收掉伤口渗出物并能把来自吸收液体中的水气散发到大气中,因而减轻了对皮肤的浸蚀,该包扎带由含有下列诸层的一种层状制品组成:(a)一种高度皮肤整合弹性的细菌防护膜,该膜能与病人伤口部位皮肤紧密接触并覆盖在上述伤口包扎带上;(b)一种压敏粘附层保持高度皮肤整合弹性膜与相对织物层接触;(c)一种织物层;(d)一种附着在织物层上的亲水性吸收剂聚合物层,通过把一种单体溶液注入织物层随后固化生成聚合物层。 To provide a wound fluid can properly handle the wound dressing according to the last embodiment of the present invention, since it is quickly absorbed wound exudate and can absorb water from the air distributing liquid into the atmosphere, to thereby reduce the a layered article skin erosion, the dressing of the layers having the following compositions: (a) a highly integrated skin elasticity bacteria-impermeable film which can be brought into close contact with the patient's skin and wound site above the wound covering wrap strip; (b) a pressure-sensitive adhesive skin layer remains highly integrated elastic membrane in contact with the opposite fabric layer; (c) a fabric layer; (d) an adherent layer on the hydrophilic absorbent fabric polymer layer, followed by curing of the polymer layer by the monomer solution into the fabric layer. 当所说的亲水性吸收剂聚合物层暴露于伤口渗出物时,会自动粘附到伤口区。 When said hydrophilic absorbent polymer layer is exposed to the wound exudate, the wound area is automatically adhered to.

以上每层具有的水蒸汽转移速度足以使来自被吸收在伤口包扎带液体中的蒸汽发散出去,因而减轻了对新内皮伤口床和周围伤口区的浸蚀。 Each having the above water vapor transfer rate sufficient vapor is absorbed in the wound dressing from diverging out of the liquid, thus reducing the erosion of new endothelial wound bed and surrounding wound area.

在本发明最后方式中,提供一种交联的丙烯酸类物质作为亲水性吸收剂。 In the final embodiment of the present invention, there is provided a crosslinked acrylic material as the hydrophilic absorbers. 亲水性吸收剂聚合物层是用与本发明其它方式中使用的同种聚合物。 Hydrophilic absorbent polymer layer is the same with other polymers used in the present invention. 在本发明这个最后方式中,也是用一种医药上合格的多孔压敏丙烯酸类粘附剂作为粘附层,织物层可以由从旋绕-结合,旋绕-编织或点-结合的一组聚酯材料中选择的某种聚酯物组成。 In this last embodiment of the present invention, also with one pharmaceutically acceptable porous pressure-sensitive acrylic adhesive as the adhesive layer, a fabric layer may be formed from a convoluted - binding, convoluted - braiding point or - a group bonded polyester some materials selected from polyester composed.

附图说明 BRIEF DESCRIPTION

了本发明某些方式,图1表示的伤口包扎带10组成如下,织物层11叠合并粘附到一种粘附剂材料层12上盖住它的一个宽边表面(它的向内的宽边表面),另一个粘附材料层13盖在它的另一个宽边表面(它的向外宽边表面)上,最好是把粘附层12和13挤压到织物层11露出外面的纤维中,使得粘附剂是和从织物层11中露出的纤维末端粘结。 Certain embodiment of the present invention, the wound dressing 1 shown in FIG. 10 the following composition, 11 fabric layers were stacked and adhered to the adhesive layer of one material 12 covering the surface of one of its wide side (inwardly of its width edge surface), another adhesive layer 13 cover its other broadside face (its outer broad side surface), the adhesive layer 12 is preferably pressed into the fabric layers 13 and 11 are exposed outside fiber, such fiber ends and the adhesive is exposed from the adhesive layer 11 in the fabric. 把一种弹性亲水材料层15施加在粘附层12和13之间与织物层11之中。 An elastic layer of the hydrophilic material 15 is applied between the adhesive layers 12 and 13 within fabric layer 11. 把松脱(防粘)层复盖并可松脱地固定在粘附层12要暴露的宽边表面上,以便在包扎带10储存期间对粘附层12起保护作用,在把包扎带10施用在伤口上之前才把层16除去。 The release (release) layer covering and releasably secured to the wide side surfaces exposed to the adhesive layer 12, so that during dressing 10 is stored in the protective effect of the adhesive layer 12 from pairs, the dressing 10 only then removing the layer 16 before application on the wound. 另一个防护层17从外面覆盖在织物层11上面,通过粘附层13到织物层11上,覆盖层17不仅作为一种外保护层为包扎带10提供一种高度的结构完整性,而且还起到一种屏蔽的作用,防止污染进入包扎带内部并最终进入伤口。 Another 17 from outside the protective layer overlying fabric layer 11 by adhesive layer 13 to the fabric layer 11, cladding layer 17 not only as a protective layer for the outer wrap to provide a highly structural integrity of belt 10, but also to work as a shield to prevent contamination from entering the interior of tape wrapped and ultimately into the wound.

织物层11是一种具有高韧性的无毒织物,具有足够的结构完整性并经得住常规处理,加工和使用。 Fabric layer 11 is a non-toxic fabric having a high toughness, and having sufficient structural integrity to withstand routine handling, processing and use. 织物层11可以用任何无毒的纤维制作,如棉、尼龙、人造纤维、聚酯和聚酯纤维素纤维,如果是一种非纺织物,最好具有一种旋绕结合或旋绕-编织的结构,尽管湿涂布或空气涂布(Wet-laid or air-laid)结构也可以使用。 Fabric layer 11 may be made of any non-toxic fibers, such as cotton, nylon, rayon, polyester, and polyester cellulose fibers, if it is a non-woven fabric, preferably having one or convoluted convoluted binding - knitted structure , although air or wet coating applied (wet-laid or air-laid) structure may be used. 织物层最好有许多纤维从其宽边表面伸出来,有利于织物层11和粘附层12,13之间牢固机械结合。 Fabric layer preferably has a plurality of fibers sticking out, strongly favor a mechanical bond between fabric layer 11 and adhesive layers 12, 13 from the wide side surfaces. 在本发明中,用作伤口包扎带特别好的织物层是由E. In the present invention, particularly preferred as the wound dressing is a fabric layer by E. I. I. 杜邦的尼莫尔斯(Nemeurs)公司出售的商品名为“Reerny”厚度为4-14密耳(mie=0.001时)的旋绕结合聚酯材料的纤维织物。 DuPont Nemo Wales (Nemeurs) sold under the trade name "Reerny" with a thickness of 4-14 mils (mie = 0.001 time) binding convoluted polyester fabric material.

粘附层12也可以由任何压敏、无毒适于粘附到健康正常人皮肤上的粘附剂制作,该粘附剂对开放伤口本身的粘合倾向即使有也很小,因此减少任何对正常治疗可能发生的干扰,并减少脱除包扎带对新外表皮的损伤,除了无毒之外,粘附层12最好还是可借常规方法进行灭菌的(例如幅照,热或蒸汽的方法,虽然7射线或电子束照射灭菌作用更好),无细胞毒性的无过敏性的并具有合适的潮湿水气迁移速度(MVTR),当按照ASTM操作No. Adhesive layer 12 may be made of any pressure-sensitive, non-toxic, adhesive suitable for adhesion to healthy normal human skin produced on the open wound itself adhesive bond tends to little, if any, thus reducing any normal therapeutic interference may occur, and reduce the damage to the dressing removal new outer skin, in addition to non-toxic, adhesive layer 12 is preferably a conventional method, or may by sterilizing (e.g. radiations, heat or steam method, while gamma rays or electron beam irradiation sterilization better), non-cytotoxic non-allergenic and has a suitable wet moisture migration rate (the MVTR), when operating in accordance with ASTM No. E96-80测量时,在50%相对湿度,36℃时MVTR值至少为每平方米每24小时200克水,最好在300-800克水之间。 When E96-80 measured at 50% relative humidity, 36 ℃ MVTR value of at least 24 hours per square meter per 200 grams of water, preferably between 300-800 grams of water. 合适的压敏皮肤粘附剂为压敏聚丙烯皮肤粘附剂[比如购自多布尔特涂镀制品公司(Daubert Coated Products Company),艾弗尔国际股份公司,法森分公司(Fasson Division of Aevery International Corporation)和塞顿公司塞梅克斯医药部(Semax Medical of Seton Company)],压敏聚乙烯醚粘附剂和压敏聚亚胺酯粘附剂。 Suitable pressure-sensitive skin adhesive is a pressure sensitive polyacrylic skin adhesives [Duobuerte available from such coating products company (Daubert Coated Products Company), Eifel International AG, Fasson branch (Fasson Division of Aevery International Corporation) and Seton company seme Phoenix pharmaceutical portion (Semax Medical of Seton company)], polyvinyl ether pressure sensitive adhesives and pressure-sensitive polyurethane adhesive.

粘附层13可以用与粘附层12相同的粘附剂成份制作,也可以用不同的粘附剂制作,该粘附剂可用常规方法进行灭菌。 The adhesion layer 13 may be made using the same adhesive composition the adhesive layer 12 may be made with a different adhesive, the adhesive sterilized using conventional methods. 当用ASTM操作步骤No. When using ASTM Procedure No. E96-80进行测量时,在50%相对湿度,36℃下其MVTR值至少为每平方米每24小时200克水,为300-800克水更好。 E96-80 when measured at 50% relative humidity, at its MVTR value of at least 36 ℃ square meter per 24 hours per 200 g of water, 300 to 800 g of water better.

放置在织物层11内和粘附层12,13之间的亲水性材料韧性层15可以是任何韧性无毒的亲水性材料,即使是吸收了2-20倍于它本身重量的渗出物时仍能保持自身的完整性。 11 is placed in its own weight of exudate fabric layer and a hydrophilic layer of ductile material 15 may be any non-toxic hydrophilic material toughness, even absorbing 2 to 20 times between the adhesive layer 12, 13 still maintain their own integrity when objects. 这类亲水性材料包括羧甲基纤维素钠,各种聚丙烯胺,聚丙烯腈和丙烯酸聚合物,刺梧桐树胶和聚糖。 Such hydrophilic materials include sodium carboxymethylcellulose, various polyacrylamide, polyacrylonitrile and acrylic polymers, karaya gum, and polysaccharides. 一种无毒的韧性膜层15由一种交联的丙烯酸聚合物组成,该聚合物可以通过光或辐照聚合(在一种氮气氛中)重量百分比为90-99.9%的丙烯酸,其中的50-100%羧基在聚合作用前已用碱金属和氨的氢氧化物中和过,与0.1-10%的聚合官能团交联剂和按丙烯酸加交联剂总重量计算为0.1-5%的光引发剂的方法制备。 A non-toxic acrylic polymer toughness layer 15 composed of a crosslinked, the polymer may be polymerized by light or radiation (In a nitrogen atmosphere) 90 to 99.9% by weight of acrylic acid, wherein 50-100% of the carboxyl groups had with hydroxides of alkali metals and ammonia and before the polymerization, and 0.1-10% of the polymerizable functional group of the acrylic crosslinking agent and the total weight of the crosslinking agent added is 0 the method of preparation of .1-5% of a photoinitiator. 在1984年1月24日发布的加拿大专利No. In January 24, 1984 issued Canadian Patent No. 1,160,984中比较详细叙述的这类聚合物特别有效。 1,160,984 Such polymers are described in detail particularly effective. 另外有用的亲水性材料为美国专利Nos. Additional useful hydrophilic materials are U.S. Patent Nos. 4,062,817和4,066,583描述的材料,在共同所有专利,美国专利4,167,464和欧洲专利说明0,042,406,(1985年6月9日发行),披露了一些有用的聚合物和它们的制取方法。 4,062,817 and 4,066,583 describe the material, common in all patent, US Patent No. 4,167,464 and European Patent Specification 0,042,406, (June 9, 1985 issue), revealed some useful polymers and their method of preparation. 丙烯酸类或丙烯酸酯类,它们是未取代的也可以是各种不同取代的,可以具体地根据文献说明加以采用。 Acrylic or acrylates, which are unsubstituted or may be substituted with a variety of different, in particular can be employed according to the literature described.

覆盖层17可由任一种常规方法灭菌的无毒材料构成,按照ASTM步骤No. The cover layer 17 may be any conventional non-toxic method of sterilizing a material, the steps in accordance with ASTM No. E96-80测量时,在50%相对湿度和36℃条件下,它们的MVTR值至少为每平米每24小时200克水较好,为300-800克水更好。 E96-80 when measured at 50% relative humidity and 36 ℃ conditions thereof MVTR value of at least 24 hours per square meter per 200 grams of water is preferably, 300 to 800 g of water better. 覆盖层17最好厚0.5-20密耳(mil),具有代表性的覆盖层17是聚酯、聚亚胺酯、聚醚聚亚胺酯、聚乙烯、共聚酯或聚醚嵌段酰亚胺膜。 The cover layer 17 is preferably 0.5 to 20 mils thick (MIL), typically having a cover layer 17 is a polyester, polyurethane, polyether polyurethane, polyethylene, copolyester, or polyether block polyimide film segment.

为使包扎带传送潮气的能力和按ASTM步骤No. For dressing ability and moisture transfer step by ASTM No. E96-80测量时,在50%相对湿度和3H℃条件下,其MVTR值为每平米每24小时300-800克水,这就要求包扎带10的所有各层当按ASTM步骤No. E96-80 measured at 50% relative humidity and 3H ℃ conditions, the MVTR value per square meter per 24 hours 300-800 g of water, which requires dressing layers when all the steps according to ASTM No. 10 E96-80测量时,在50%相对湿度和36℃条件下它们的MVTR值至少为每平米每24小时300克水,而覆盖层17的MVTR值最好在300-800克水之间。 E96-80 when measured at 50% relative humidity and 36 ℃ conditions thereof MVTR value of at least 24 hours per square meter per 300 grams of water, and the MVTR of the cover layer 17 is preferably between 300-800 grams of water.

依据本发明设想的另一种伤口包扎带渗出物处理系统是一种吸留式伤口包扎带,能够滞留伤口渗出液体,在这种实施中至少有一层最好是覆盖层17具有较低的MVTR值。 According to the present invention contemplates another wound dressing exudate handling system is a storage-type wound dressings, wound exudate liquid can be retained in this embodiment preferably at least one layer has a lower clad layer 17 the MVTR values. 按这种设计,液体被吸收在伤口包扎带的织物/水凝胶复化物中。 In this design, the liquid is absorbed in the wound dressing is a fabric / hydrogel complex compound of.

图2所示的伤口包扎带20包括一种织物层21,压敏粘附材料层22覆盖在层21的一个宽边表面上,第二个粘附材料层23覆盖在另一个宽边表面上,层22和23与包扎带的粘附层12和13相似。 The wound dressing shown in FIG. 2 layer 20 comprises a fabric 21, a pressure sensitive adhesive material layer covers a wide side surface 22 on layer 21, a second adhesive material layer 23 is coated on the other wide side surfaces layer 22 and the adhesive layer 23 and the dressing 12 and 13 is similar. 包扎带20的粘附层22和23最好被挤压到从织物层21两宽边表面伸出来的纤维里,从而加强了粘附层22和23与织物层21之间的机械结合性能,把一种韧性亲水性材料层施加到层22和23之间及层21之中。 Adhesive layer 20 of dressing 22 and 23 are preferably pressed into the fiber 21 projecting from the two wide side surface of the fabric layer's, thereby enhancing the adhesion layer 22 and mechanical bonding properties between the fabric layers 21 and 23, one kind of the toughness of the hydrophilic material layer is applied between layer 22 and the layers 23 and 21 into. 把一种可松脱的保护层25盖在粘附层22暴露的宽边表面上以便在贮存时保护粘附层22,把包扎带20复盖在伤口上之前揭去层25。 The A releasable protective layer 25 on the wide side surface of the cap adhesion layer 22 so as to protect the exposed adhesive layer 22 during storage, the dressing 20 on the wound before covering layer 25 peeled. 把一种开孔泡沫材料层26粘附到粘附层23的外部宽边表面上,泡沫层26在把包扎带放到伤口上面时具有减震保护作用,减小施加在包扎带20上的外力对伤口的影响。 The layer 26 is an open-cell foam material adhered to the outer surface of the broad side of the adhesive layer 23, the protective foam layer 26 having a cushioning effect when the dressing into the wound above, decreasing the voltage applied on the dressing 20 the impact of external forces on the wound. 把任选的一种覆盖层27盖在和粘附到层26上面,它不仅赋于包扎带20结构完整性,而且还可作为一种屏蔽层防止污染进入包扎带20的内部。 The optionally a cover layer 27 and the cover 26 is adhered to the top layer, which not only confers structural integrity to dressing 20, but also as a shielding layer to prevent contamination from entering the interior of dressing 20. 包扎带20的层21,22,23,24,25和27在功能上分别与包扎带10的层11,12,13,15,16和17相对应,诸层可用与包扎带10中对应物的同样材料制成。 Dressing layer 20 and the layer 21, 22, 10, 11,12,13,15,16 and 17, 27 respectively correspond to the functional dressing, the dressing of the layers can be used in the counterpart 10 It made of the same material.

泡沫层26可用任何一种韧性,开孔蜂窝状材料制成,该材料应具有足够的整体性,能经受住临床使用并可用常规方法进行灭菌。 The foam layer 26 may be any of a ductile, open honeycomb material is made, the material should have sufficient integrity to withstand clinical use and sterilized by conventional methods. 而当采用ASTM步骤No. When using ASTM Step No. E96-80进行测量时,在50%相对湿度,36℃条件下该材料的MVTR值最好每平方米每24小时不低于200克水。 E96-80 when measured at 50% relative humidity, the MVTR values ​​of the material under the conditions of 36 ℃ per 24 hours is preferably not less than 200 grams of water per square meter. 层26的厚度大约为1-25mm,但厚度为1-3mm更为好。 The thickness of layer 26 is about 1-25mm, but the thickness of 1-3mm others well. 具有每英寸40-100孔(PPI)的乳胶海绵状橡胶,聚氯乙烯泡沫塑料,聚乙烯泡沫塑料和聚亚胺酯泡沫塑料是用于制作泡沫层26典型的蜂窝状材料。 With 40-100 pores per inch (PPI) of the rubber-like latex foam, polyvinylchloride foam, polyethylene foam and polyurethane foams are typically used to make cellular material 26 of the foam layer. 如果泡沫层26有一个外部蒙层,该层可以代替覆盖层27。 If the outer foam layer 26 has a mask layer which covers the layer 27 may be replaced. 德国泡沫塑料公司或德国毛毡(Felt)工业股份公司Scotfoam公司出售的80PPI的开孔聚亚胺酯泡沫塑料对于制作泡沫层26尤为适用。 Polyurethane open cell foam or foam companies Germany Germany felts (Felt) Gazprom Scotfoam sold 80PPI suitable for production of the foam layer 26 particularly. 通过用一种合适的方法,例如火焰粘合或是用一种与粘附层22和23的粘附材料相同的粘附层(没画出)或者用其它兼容性的粘结系统可以把层26粘合或粘附到层27上面。 By treatment with a suitable method, such as flame bonding or adhesion of a material with the adhesive layer 22 and adhesive layer 23 of the same (not shown) or with other compatible bonding system layer can 26 bonded or adhered to layer 27 above.

如果要求包扎带20具有每平方米每24小时300-800克水的速度转移水份的能力,该速度是按ASTM步骤No. If the dressing of claim 20 having a capacity per square meter per 24 hours 300-800 g of water moisture transfer rate, the speed steps in accordance with ASTM No. E96-80方法测定时,在50%相对湿度和36℃条件下,每一层的MVTR值必须不低于每平方米每24小时300克水,而且至少有一层,最好是覆盖层27的MVTR值在300-800克水之间。 Method E96-80 measured at 50% relative humidity and 36 ℃ conditions, the MVTR value of each layer must be not less than 24 hours per square meter per 300 grams of water, and at least one layer, preferably cover layer 27 MVTR values ​​between 300-800 g of water.

至少包扎带的一层具有低MVTR值的吸留式类型也属于具有泡沫材料层或泡沫材料/膜层的包扎带。 Occlusive dressing typed at least one layer having a low MVTR values ​​are also within the dressing having a foam layer or foam / film layer.

在包扎带10的制造中,把织物层11,粘附层12和松脱层16的连续片状材料结合在一起构成一个复合物“A”的连续片材料。 In the manufacture of dressing 10, the fabric layer 11, a continuous sheet of material 12 and the adhesive layer of the release layer 16 are combined to form a composite "A" of continuous sheet material. 例如把支承在松脱层16上的粘附层12的一个连续片状原材料施加到织物层11的一个宽边表面上,然后让这三个组分在压辊(未画出)之间通过,把从织物层11中伸出的纤维挤压到与它相对的粘附层12中,使织物层11和粘附层12之间的结合牢固,把复合物“A”的连续膜绕在辊30上保存备用。 The continuous sheet material, for example, a release layer 16 is supported on the adhesive layer 12 is applied to a broad side surface of the fabric layer 11, and let the press roll between the three components (not shown) through , the protruding fibers from the fabric layer 11 and pressed into its opposite adhesive layer 12, the fabric layer 11 and adhesive layer 12 bond between the solid, the compound "a" continuous film around were stored on the roll 30.

如图3所示,按以下方式可在织物层11中形成亲水材料层,松开卷在滚筒30上的复合物“A”的膜,使其在辊31和32的上面通过,使送进的复合物A膜的织物层11面朝上,下面正对着利用喷嘴35喷射亲水成膜(film-producing)材料的喷雾器或贮存器34。 3, may be formed in the following manner in the fabric layer of hydrophilic material layer 11, release the "A" of the composite film roll on the drum 30, so that the upper rollers 31 and 32 by the feed into the fabric layer 11 facing the composite film on a, below by the nozzle 35 facing the injection hydrophilic film-forming (film-producing) material or a nebulizer reservoir 34. 随后让沉积亲水性成膜材料的复合物A在刮浆刀37的下方通过,刮浆刀37把亲水性成膜材料挤压到织物层11的中心区并控制生成亲水膜15的厚度。 A composite then allowed hydrophilic film-forming material deposited at the bottom 37 by a doctor blade, the doctor blade 37 hydrophilic film-forming material is pressed into the central area of ​​the fabric layer 11 and the hydrophilic film 15 generates control thickness. 然后根据采用的亲水成膜材料是只需要进行简单干燥,还是需要进行聚合的具体情况让此复合物通过干燥箱或聚合室38,如果亲水性成膜材料是那些在加拿大专利No. The hydrophilic film forming material is then used only needs to make simple drying, or the need for this specific case of polymerization so that complex through a drying oven or a polymerization chamber 38, if the hydrophilic film-forming materials are those in Canadian Patent No. 1,160,894上描述的需要进行聚合的材料,聚合室38可含有电子束或紫外(UV)光源,使亲水性成膜材料发生聚合反应。 1,160,894 describes the material needs to be polymerized, polymerization chamber 38 may contain an electron beam or ultraviolet (UV) light source, a hydrophilic film forming material polymerization reaction. 最后生成的。 The last generation. 由织物层11,沉积在织物层11中的亲水膜层15,粘附层12和可松脱层16构成的复合物“B”的连续膜绕到辊39上存放。 A layer of composite fabric 11, the fabric layer 11 is deposited in the hydrophilic layer 15, adhesive layer 12 and release layer 16 may be composed of "B" continuous film wound onto a storage roll 39.

借助任一合适的方法把粘附层13的连续膜和覆盖层17结合在一起形成了含有粘附层13和覆盖层17的一种复合物“c”的连续膜。 By means of a suitable method of any of the continuous film 17 in conjunction with the adhesive layer and the cover layer 13 together to form the adhesive layer containing a composite material 13 and the cover layer 17 "c" of a continuous film. 例如把粘附层13的一种连续性膜盖在覆盖层17的上面,然后使其在压力辊(未画出)之间通过生成这种复合物,将复合物c的连续膜绕到另一滚筒40上贮存备用。 For example, the one continuity of the film adhesive layer 13 cover the top of cover 17, and then passed through the generation of such composite, the composite is a continuous film around c between the pressure roller (not shown) other a spare storage drum 40.

如图4所示,复合物c的粘附层13与复合物B的织物层11面对面,利用该粘附层可以把复合物B和复合物C结合在一起,然后使复合物B与C结合后的膜从滚筒41和42中间通过,把织物层11伸出的纤维挤压到粘附层13中,使两者粘合在一起即完成了伤口包扎带10的制造。 4, the composite adhesive layer 13 and the c-face fabric layer 11 of composite B, with which the adhesive layer can be bonded together composite B and composite C, then B and C complex binding from the film after the intermediate cylinders 41 and 42 by the fabric layer 11 protruding fibers pressed into the adhesive layer 13, so that the two are bonded together to complete the manufacture of the belt 10 wound dressings. 此外的工艺就是将此复合物膜按包扎带要求的尺寸进行剪切与封装。 Furthermore this process is the composite film is cut and packaged according to the required dressing size. 在这中间也可把包扎带10的连续膜绕在滚轴44上,当然如果希望的话包扎带10的制造工艺可设计为一种连续操作。 In the middle may be a continuous film wound dressing 10 on the roller 44, of course, if desired, the manufacturing process of dressing 10 may be designed as a continuous operation.

另外,也可以把一个粘附层叠加到复合膜B上生成一种改型的复合物B′,然后让粘附面朝上的复合物B′与覆盖层17一起通过压力辊而生成完整的包扎带。 Further, the adhesive laminate may be applied to a generation of a modified B complex composite film B ', and B so that the composite on the adhesive side facing' together with the clad layer 17 by the pressure roller to generate the complete dressing.

在该工艺中,当进行粘附叠合之前,需要把复合物B的上表面(织物/水凝胶)刷毛以保证有足够数量的纤维伸出,以使粘附层与织物层间牢固结合。 In this process, when the adhesive prior to laminating, the upper surface of the composite need of B (fabric / hydrogel) bristles to ensure a sufficient number of protruding fibers such that the adhesive layer between the fabric layer is firmly bound . 这一点对于改型复合物B′的结构完整性来说是十分重要的。 It is important for the modification of complex B 'for structural integrity.

伤口包扎带20也可按图5所示的工艺制造,绕在滚筒39上面的复合物B(如上所述)的膜,通过生成包扎带20中粘附层23的粘附材料“B”的连续膜与卷在滚轴50上的复合物E的连续膜叠合在一起,复合物E是利用火焰粘合,热粘合或另一种粘附层(未画出)等方法将泡沫层26粘结到覆盖层27上构成的。 Process for producing the wound dressing 20 shown in FIG. 5 can also be wound around the drum 39 above the composite B (as described above) film dressing 20 by generating the adhesion of the adhesive layer 23 of "B" a continuous film laminated composite continuous film roll on the roller 50 is E together, E is the use of composite flame bonding, thermal bonding, or another adhesive layer (not shown) or the like foam layer 26 bonded to cover layer 27 thereof. 在借助粘附层D将复合物B和E粘结时,织物层21的暴露面与粘附膜D的一个面接触,泡沫材料层26的暴露面与粘附层D的另一个面接触。 When by means of the adhesive layer D and E B adhesive composite, the exposed surface of the fabric layer in contact with a surface 21 of the adhesive film D, the exposed surface of the foam layer to another surface of the adhesive layer 26 in contact D. 然后让上述组合件通过压力辊51和52之间的辊隙,从而把粘附膜同时粘结到泡沫层26和织物层21上组成包扎带20。 By the above-described assembly is then let the pressure roller 51 and the nip between the 52, thereby simultaneously bonded to the adhesive film dressing 20 consisting of 21 layers of foam 26 and fabric layer. 可以把生成的包扎带20绕到滚筒53上留待剪切成合适的尺寸和封装。 The dressing may be generated around 20 left cut to size and packaged on the drum 53. 此外制备组合包扎带20的各步骤也可以按一种连续操作方式完成。 Further dressing compositions prepared with the steps 20 may be completed as a continuous operation.

此外,也可以在粘附层D与泡沫材料或泡沫材料/膜复合物E进行叠合前,先把粘附层D粘结到复合物B上形成一种改型的复合物B′,然后将具有粘附面向上的改型复合物B′与复合物E一起通过压力辊而形成完整的包扎带。 Further, the adhesive layer may be performed in the D material or a foam material with a foam / film composite laminated before E, D first adhesive layer bonded to the composite B to form a modified composite B ', and compound B having modifications on the adhesion face 'and E complex to form a complete dressing together by pressure rollers.

在该工艺中,粘附叠合前,要先把复合物B的上表面(织物/水凝胶)刷毛以保证露出的纤维数量足够多,使粘附层与织物层之间的结合牢固,这一点对于改型复合物B′的结构完整性来说是十分重要的。 In this process, before the adhesive laminated to the first surface of the composite of B (fabric / hydrogel) bristles to ensure sufficient number of fibers are exposed, so that the bond between the adhesive layer and the fabric layer is firmly, it is important for the modification of complex B 'for structural integrity.

伤口包扎带最好对氧具有渗透性,当包扎带被伤口渗出物浸湿时,其提供输送氧的性能如按ASTM操作No. Performance wound dressing preferably has a permeability to oxygen, when the dressing is wet wound exudate, which provides oxygen transport operation as per ASTM No. D3985-81测量时,在25℃和相对湿度为20-55%条件下,至少为每平方米每24小时2000毫升氧,最好为5000毫升。 When D3985-81 measured at 25 deg.] C and a relative humidity of 20-55% under the condition of at least 1 square meter per 24 hours oxygen 2000 ml, preferably 5000 ml.

这一申请书收编在1985.6.19日刊出的美国专利4,167,464和欧洲专利说明书0042,406中,以下诸例对本发明进行说明:例1:一种用作底衬的粘附剂一织物结合层的特性如下:把MDD129(Semex),一种多孔性聚丙烯酸酯叠合在Reemy2214(Reemy公司)上生成一种复合物。 Incorporated in this application 1,985,619 published Day U.S. Patent 4,167,464 and European Patent No. 0042,406 specification, the following various embodiments of the present invention will be described: Example 1: A use as adhesion underlay a binding agent properties of the fabric layers are as follows: the MDD129 (Semex), a porous polyacrylate produce a composite laminated on Reemy2214 (Reemy Corporation).

将丙烯酸钠/丙烯酸单体乳胶涂复到上述复合物的织物面上,利用UV辐照固化生成厚0.075mm重1.2g/ft2的涂层。 The sodium acrylate / acrylic monomer to the latex coated surface of the composite fabric, with UV radiation curing of a thickness of 0.075mm weight 1.2g / ft2 of coating. 本发明伤口包扎带的厚度和涂层重量参数最好在大约0.01-0.5mm和1.0-5.0g/ft2之间。 Wound dressings of the present invention, the thickness and coating weight parameters and preferably between about 0.01-0.5mm 1.0-5.0g / ft2. 当把伤口包扎带暴露到伤口渗出物时,生成的织物能结构完整的地粘结在粘附层上。 When the wound dressing is exposed to the wound exudate, the resulting fabric can complete structure bonded to the adhesive layer. 当把伤口包扎带放在病人的受伤皮肤上时,聚合物能吸收掉从伤口渗出物抽提到伤口包扎带中的液体。 When the wound dressing is placed on the wounded skin of a patient, the polymer can absorb a liquid pump mentioned band wound dressing from the wound exudate.

例Ⅱ把具有高潮湿气迁移速率的聚丙烯酸盐粘附剂Ⅰ-780(Aevery)附加到例Ⅰ产物的聚合物面上,再把一种液体不能透过进入大气的聚乙烯吸留膜粘附到粘附剂的上面。 Example Ⅱ the polyacrylate adhesive Ⅰ-780 (Aevery) having a peak rate of migration of moisture attached to the surface of the polymer product of Example Ⅰ, then a liquid impermeable polyethylene film is occluded into the atmosphere sticky the above is attached to the adhesive agent.

例Ⅲ-Ⅴ除用以下的材料替代例Ⅱ中的吸留膜外,其他遵循例Ⅱ的步骤:膜 聚氯乙烯泡沫材料 聚氯乙烯泡沫塑料泡沫-膜 具有聚乙烯覆盖膜的聚氯乙烯泡沫塑料泡沫材料 聚乙烯泡沫塑料膜 聚偏二氯乙烯例Ⅵ遵循例Ⅰ的操作步骤,但在聚合物层固化后,将固化的聚合物的表面刷毛。 Example Ⅲ-Ⅴ Ⅱ in other embodiments is replaced with the following absorbing material remaining film, the other following the steps of Example Ⅱ: PVC film PVC foam foam foam - a foam polyvinyl chloride film having a polyethylene cover film polyethylene foam plastic foam material film ⅰ procedure of Example polyvinylidene chloride embodiment of ⅵ followed, but after the polymer layer is cured, the bristle surface of the cured polymer.

例Ⅶ-Ⅹ遵循例Ⅲ-Ⅴ的操作步骤,但用例Ⅵ方法制得的刷毛聚合物背衬取代把吸留衬层粘附到例Ⅰ的产物上,由于刷毛织物表面凹凸不平得到的结构完整性更好。 Example Ⅶ-Ⅹ following the procedure of Example Ⅲ-Ⅴ, but the bristles polymer was prepared as in Example Ⅵ substituted the backing layer is adhered to the occlusive product Ⅰ embodiment, since the uneven surface structure of the fabric obtained bristle complete better.

例ⅩⅣ一种用作底衬的粘附剂一织物结合层,具有以下特性:把MDO129(Semcx)叠合到Reemay2414旋绕结合的聚酯物上(Reemay,Inc。),该复合物以CM5383-02(Semex)商品名出售。 Example ⅩⅣ adhesive bonding layer for use as a backing fabric having the following characteristics: the MDO129 (Semcx) laminated onto a polyester Reemay2414 convoluted binding was the complex to CM5383- (Reemay, Inc.) 02 (Semex) sold under the tradename.

把一种藻酸钙盐膜涂盖在复合物的织物面上,生成涂层厚度为0.2mm,涂层重量为3g/ft2。 The fabric side one kind of calcium alginate film is coated with the composite cover, generating a coating thickness of 0.2mm, a coating weight of 3g / ft2.

例ⅩⅤ用分散在Shells Kraton SBS G160中的羧甲基纤维素钠取代例ⅩⅣ中藻酸盐而制备一种类似物。 Example ⅩⅤ an analog prepared in Example ⅩⅣ substituted with alginate, sodium carboxymethyl cellulose dispersed in Shells Kraton SBS G160.

例ⅩⅢ-ⅩⅤ在例Ⅰ和Ⅷ,ⅩⅣ和ⅩⅤ中,不带吸留衬层的,涂包着聚合物的织物能被制成一种可以妥善处理伤口液体的包扎带,由于它能迅速地吸收伤口渗出物并能把吸收液中的水气转移到大气中去,从而减少了对皮肤的浸蚀。 Example ⅩⅢ-ⅩⅤ Ⅰ and in Examples VIII, XIV and XV, the liner without occlusion, wrapped fabric coated with the polymer can be properly handled to prepare a wound dressing of the liquid, because it can rapidly absorbing wound exudate and can absorb liquid water gas shift into the atmosphere, thus reducing the erosion of the skin.

本发明这一方式背衬层的特性是一种膜,泡沫材料,泡沫材料一膜的层状制品或织物。 Features of this embodiment of the present invention, the backing layer is a film, a foam, a fabric or foam material layered article is a film. 它们具有的潮湿蒸汽的迁移速率足可以把来自吸收在伤口包扎带中液体的蒸汽散发出去,因此减少了新内皮伤口床和伤口四周受到的浸蚀,例如,把一种网状聚亚胺酯泡沫塑料背衬层叠加到前述的复合物上,该层带有聚亚胺酯膜或聚醚嵌段酰亚胺或聚酯类的高潮气迁移速率薄膜。 They have sufficient moisture vapor rate of migration can be absorbed in the wound dressing from a vapor of a liquid to dissipate, thus reducing endothelial Immersing been wound around the wound bed and, for example, one kind of the reticulated polyurethane the foam backing layer is superimposed on the composite, the rate of migration of the thin film layer having gas climax polyurethane or polyether block imide film, or polyesters.

例ⅩⅩ一种作为底衬的粘附剂一织物结合层具有以下特性:把MDO129(Semex),一种多孔的聚丙烯酸(酯)粘附剂叠合到Reemay2214(Reemay,Inc.)上形成一种复合物,该复合物以CM5383-02(Semex)商品出售。 Example ⅩⅩ as one kind of a fabric underlay adhesive bonding layer has the following characteristics: the MDO129 (Semex), a porous polyacrylic acid (acrylate) adhesive laminated to form an upper Reemay2214 (Reemay, Inc.) species complex, which complex is sold CM5383-02 (Semex) product.

把聚氨磺酰涂复到复合物的织物面,通过UV辐照固化,生成涂层厚度为0.5mm,涂层重为5g/ft2。 Polysulfonamide to the coated surface of the fabric composite, curing by UV irradiation to produce a coating thickness of 0.5mm, a coating weight of 5g / ft2. 生成的织物具有结构完整性以保持把伤口包扎带暴露于伤口渗出物时与粘附剂的接合,另外,当把包扎带放置于病人受伤皮肤上时,聚合物可以把从伤口渗出物抽吸到包扎带中的液体吸收掉。 The resulting fabric has structural integrity to the wound dressing to maintain engagement with the adhesive when the tape is exposed to the wound exudate, further, when the dressing is placed on the wounded skin of a patient, the polymer can be from wound exudate drawn into the liquid absorbed in the dressing.

例ⅩⅪ一种能妥善处置伤口液体的伤口包扎带,通过快速吸收伤口渗出物并把吸收液体中的水气散发到大气中去,从而减少了皮肤受到的浸蚀。 Example ⅩⅪ one kind can properly dispose the wound dressing of wound fluid, and the moisture absorption liquid circulated into the atmosphere by rapidly absorbing wound exudate, thereby reducing erosion of the skin subjected. 不用借助粘附剂而直接放到例Ⅰ产物聚合物面上的是一种允许液体透过而进入大气中去的一种衬里层。 By means of an adhesive without directly into the surface of the product of Example Ⅰ polymer is a liquid-permeable and allows enter into a backing layer to the atmosphere. 把一种模切周边的两面都有粘附剂的衬垫层,1522双面聚乙烯胶带(3M)叠加到例Ⅰ产物的皮肤粘附剂上,同时也叠加到衬里层的另一表面上,得到一种更快的散发速率。 Both surfaces of the backing layer has one kind of die cut outside the adhesive, double-sided 1522 polyethylene tape (3M) superimposed on the product of Example Ⅰ skin adhesive also superimposed on the other surface of the backing layer to obtain a faster emission rates.

例ⅩⅫ-ⅩⅩⅢ分别采用一种聚酯膜和网状聚亚胺酯泡沫材料作为背衬层重复例ⅩⅪ的工艺,例ⅩⅩⅣ该例子用来说明一种可以妥善处理伤口液体的伤口包扎带,通过快速吸收伤口渗出物并把吸收掉液体中的水气散发到大气中去,而减少对皮肤的浸蚀。 Example ⅩⅫ-ⅩⅩⅢ respectively polyester film and a polyurethane reticulated foam backing layer as in Example ⅩⅪ process is repeated, for example the embodiment ⅩⅩⅣ illustrates a wound dressing can properly handle wound fluid by quickly absorb wound exudate and to absorb moisture distributing liquid into the atmosphere, to reduce erosion on the skin. 这种包扎带包括:一种高皮肤整合韧性细菌防护膜,为一种聚亚胺酯膜;一种压敏粘附剂位于防护膜与织物,MDO129(Semex)之间;一种Reemay旋绕结合聚酯类的织物层;和一种附加到织物层的亲水性吸收剂聚合层,为一种聚合(丙烯酸钠。)生成产物的潮湿蒸汽迁移速率足以把吸收到包扎带中液体的水蒸汽散发出去,从而减少了对新内皮伤口床和伤口四周的浸蚀,例ⅩⅩⅤ用藻酸钙取代例ⅩⅩⅥ中的聚合(丙烯酸钠)而制得到类似结果。 Such dressing comprising: a high-toughness bacterial skin integrated pellicle, as a polyurethane film; a pressure-sensitive adhesive film and a protective fabric positioned between MDO129 (Semex); Reemay one kind of binding convoluted polyester-based fabric layer; (. sodium acrylate) and one additional hydrophilic absorbent polymeric layer to the fabric layer, as a product of the polymerization of the migration rate of moisture vapor absorbed into the dressing of sufficient liquid water vapor dissipated, thereby reducing erosion of new endothelium and wound around the wound bed, the polymerization ⅹⅩⅥ embodiment (sodium acrylate) of Example ⅹⅩⅤ substituted prepared using calcium alginate obtained similar results.

例ⅩⅩⅥ用分布在苯乙烯-丁二烯-苯乙烯中的羧甲基纤维素代替例ⅩⅩⅣ中的聚合(丙烯酸钠)制取了一种类似产物。 Example ⅩⅩⅥ distributed with styrene - butadiene - styrene carboxymethylcellulose embodiment ⅩⅩⅣ polymerization (sodium acrylate) preparation of a similar product in place.

例ⅩⅩⅦ-ⅩⅩⅨ用一种聚醚嵌段酰亚胺膜代替例ⅩⅩⅣ-ⅩⅩⅥ中的聚亚胺酯膜背衬层制取了类似产物。 Polyurethane film of Example ⅩⅩⅣ-ⅩⅩⅥ Example ⅩⅩⅦ-ⅩⅩⅨ replaced with one polyether block imide film backing preparing similar products.

例ⅩⅩⅩ给病人施用的某些药物可以放在包扎带内,例如可以把药用的Chorhexidine分散到聚合物层中,而在应用这种伤口包扎带时它就扩散到伤口部位。 Example ⅩⅩⅩ administration to a patient of certain drugs may be placed in dressing, for example, the pharmaceutically acceptable Chorhexidine dispersed polymer layer, and the use of such a wound dressing to the wound site when it is diffused band.

Claims (10)

1. 1. 包括具有下面诸层的层状物的伤口包扎带:(a)一种允许液体通过的粘附层,当该粘附层与病人皮肤压触时,伤口包扎带能粘附到皮肤上而无需粘附到伤口上;(b)一种与粘附层相结合的织物层,当伤口包扎带暴露于伤口渗出物时,其可保持结构上的完整性;(c)一种亲水吸附聚合层,其包括浸渍于织物层中的亲水吸附聚合物,当伤口包扎带暴露于伤口渗出物时,所得织物仍保留与粘附层结合的完整性,所说的亲水吸收剂聚合物层能够在伤口包扎带放在病人受伤皮肤上时,吸收掉从伤口渗出物抽吸到包扎带中的液体;(d)至少一个背衬层选自膜,泡沫,泡沫-膜的层状物或织物,并经由邻近层把背衬层附到所述织物上。 A layer comprising a substance beneath the layers of wound dressing: (a) a liquid by allowing the adhesive layer, the adhesive layer when the pressing contact with the skin of the patient, the wound dressing adheres to the skin without adhering to the wound; (b) a fabric layer and the adhesive layer of one combination, when the wound dressing is exposed to the wound exudate, can maintain its structural integrity; (c) one hydrophilic adsorption polymeric layer comprising hydrophilic absorbent polymer in the impregnated fabric layer when the wound dressing is exposed to the wound exudate, yet retain the integrity of the resulting fabric in combination with the adhesive layer, said hydrophilic absorbent polymeric when the dressing layer can be placed on the wounded skin of a patient at the wound, absorb wound exudate drawn from the liquid in the dressing; (d) at least one backing layer selected from a film, foam, foam - layer film or fabric-like, and the via layer adjacent the backing layer is attached to the fabric.
2. 2. 权利要求1的伤口包扎带,其中亲水性吸附聚合物是通过把一种单体溶液浸渍到织物层后加以固化的。 The wound dressing of claim 1, wherein the hydrophilic polymer is adsorbed by the monomer solution is impregnated into the fabric layer to be cured.
3. 3. 权利要求1或2的伤口包扎带,其中所述粘附层是药用多孔压敏丙烯酸类粘附剂。 1 or a wound dressing according to claim 2, wherein said adhesive layer is a pharmaceutically acceptable porous pressure-sensitive acrylic adhesive.
4. 4. 权利要求1或3的伤口包扎带,其中所述织物层由聚酯组成,该聚酯选自旋绕结合,旋绕编织或点结合的聚酯。 1 or wound dressing of claim 3, wherein said fabric layer is composed of polyester, the polyester is selected from rounding binding, convoluted braided polyester or a combination of points.
5. 5. 权利要求2的伤口包扎带,其中所述亲水吸附聚合物是一种交联的丙烯酸类材料。 The wound dressing of claim 2, wherein said hydrophilic absorbent polymer is a crosslinked acrylic material.
6. 6. 权利要求1的伤口包扎带,其中所述亲水吸附聚合物是聚丙烯酸酯,藻酸盐或羧甲基纤维素钠。 The wound dressing of claim 1, wherein said hydrophilic absorbent polymer is a polyacrylate, alginate or sodium carboxymethylcellulose.
7. 7. 前述任一权利要求的伤口包扎带,其中所得吸附/织物层的顶部有许多表面能够起毛的织物,所述背衬层通过邻近粘附层附着到上述起毛织物上。 A wound according to any preceding claim dressing, wherein the resulting adsorption / top fabric layer can be many napped fabric surface, the backing layer is attached to said pile fabric through adjacent adhesive layer.
8. 8. 前述任一权利要求的伤口包扎带,其中每层都具有足够湿蒸汽迁移速度,以便将来自所述包扎带中吸收的液体的蒸汽散发出去。 Any one of the preceding claims wound dressing tape, wherein each layer has a sufficient moisture vapor migration speed, in order from the dressing liquid with vapor absorbed dissipated.
9. 9. 前述任一权利要求的伤口包扎带,其还可包括一个两面带粘附剂的模切周边底衬层,其叠合到粘附层(a)上,也叠合到背衬层(d)上。 Any one of the preceding claims wound dressing, which may also include a die cutting on both sides with the periphery of the bottom adhesive layer, which is laminated on the adhesive layer (A), also laminated to the backing layer (d )on.
10. 10. 前述任一权利要求的伤口包孔带,其中背衬层包括与皮肤高度相容的弹性的细菌层障膜,其使皮肤与患者伤口区密切结合并覆盖住所述伤口包扎带。 Any one of the preceding claims with the wound hole, wherein the backing layer is highly compatible with the skin comprises an elastic membrane of the bacterial barrier layer, which is closely integrated with the skin wound region of the patient and covers the wound dressing.
CN 89100413 1989-01-25 1989-01-25 Wound bandage with polymer layer CN1063974C (en)

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CN 89100413 CN1063974C (en) 1989-01-25 1989-01-25 Wound bandage with polymer layer

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Application Number Priority Date Filing Date Title
CN 89100413 CN1063974C (en) 1989-01-25 1989-01-25 Wound bandage with polymer layer

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CN1063974C true CN1063974C (en) 2001-04-04

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Publication number Priority date Publication date Assignee Title
US7144390B1 (en) 1999-04-02 2006-12-05 Kinetic Concepts, Inc. Negative pressure treatment system with heating and cooling provision
CN101254145B (en) 2007-02-28 2011-03-23 周长忠;石佳儒 Multilayer shallow layer trauma special hydrophilic dressing
TWI504420B (en) * 2011-11-29 2015-10-21 Kang Na Hsiung Entpr Co Ltd
CN104652125B (en) * 2013-11-25 2018-12-11 3M创新有限公司 Fabric structure and manufacturing method

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