CN1221384A - Codispensing of physically segregated dentifrices at consistant ratios - Google Patents
Codispensing of physically segregated dentifrices at consistant ratios Download PDFInfo
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- CN1221384A CN1221384A CN97195267A CN97195267A CN1221384A CN 1221384 A CN1221384 A CN 1221384A CN 97195267 A CN97195267 A CN 97195267A CN 97195267 A CN97195267 A CN 97195267A CN 1221384 A CN1221384 A CN 1221384A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
- B65D81/325—Containers having parallel or coaxial compartments, provided with a piston or a movable bottom for discharging contents
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D35/00—Pliable tubular containers adapted to be permanently or temporarily deformed to expel contents, e.g. collapsible tubes for toothpaste or other plastic or semi-liquid material; Holders therefor
- B65D35/22—Pliable tubular containers adapted to be permanently or temporarily deformed to expel contents, e.g. collapsible tubes for toothpaste or other plastic or semi-liquid material; Holders therefor with two or more compartments
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- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Cosmetics (AREA)
- Package Specialized In Special Use (AREA)
- Electroplating And Plating Baths Therefor (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Control Of El Displays (AREA)
- Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
- Detergent Compositions (AREA)
- Cleaning By Liquid Or Steam (AREA)
- Tubes (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
- General Preparation And Processing Of Foods (AREA)
Abstract
A method is disclosed for the coextrusion in controlled amounts of at least two dentifrice components stored and physically segregated in a multicompartmented collapsible dispenser provided with a partition which divides the interior volume of the container into separate compartments, the partition being moveable in response to a pressure differential developed thereacross upon the application of Compressive Force to the sidewalls, the individuals dentifrice components containing ingredients which interact when mixed, the dispenser sidewalls being formed of a resilient plastic material which is deflected upon the application thereto of a Deflective Force of about 1.0 or greater pounds, the dentifrice compnents being formulated to be equally extrudible at substantially equivalent compressive forces. When the dispenser sidewalls are compressed, there is extruded a single-banded unmixed multilayer stream of the components containing the reactive ingredients at ratios predetermined to provide optimum levels for interaction between the reacted ingredients when the extruded components are mixed in the oral cavity.
Description
Background of invention 1. invention fields
The present invention relates to a kind of storage and use physically separated component packages system in the polycomponent dentifrice simultaneously, this system can multilayer but unmixed mode use by constant preliminary election component ratio.2. prior art
The polycomponent Dentrifice composition is known for this area professional, wherein, each component that contains active component is physically separated in storage process, and cream or liquids that can viscosity be used simultaneously, and react when brushing teeth being mixed with each other between the composition, component is optimal efficacy and effect to use with composition proportion appointment bringing into play.
For example, known for a long time, contain the dentifrice of releasing fluorine compounds and can be used as anti-caries agent, and these cmpds have been proved to be able to effectively reduce the incidence of tooth dental cariesization.The validity of the fluoride of using will depend on the fluorine ion amount, because this ion is as being deposited on the pending dental tissue.So people wish to prepare the Dentrifice composition as dentifrice that maximum fluorine ion amount can be provided in the solution of brushing teeth.
A kind of method that fluoride effectively is deposited on the tooth is to utilize dual component dentifrice agent composite, and such composite comprises a calcic component and another fluoride component, thereby deposits calcium fluoride on tooth.
For example, US Patent 5,045, the 305 dual component dentifrice agent that provide a kind of tooth to fluoridize usefulness, a kind of component wherein contains calcium chloride and another component contains the fluorine ion of sodium fluoride form, before entering the oral cavity, the component of above-mentioned two kinds of separation is mixed rapidly, thereby forms the calcium fluoride precipitation effectively.
US Patent 5,145,668 disclose the method that a kind of tooth is fluoridized, and wherein, when brushing teeth, contain first component of soluble calcium salt (for example calcium chloride) and contain the compound fluorine compounds of hydrolyzable (sodium fluosilicate (Na for example
2Sf
6)) second component mix, the mixing of component is hydrolyzed compound fluorine compounds, is settled out calcium fluoride and is deposited on dental surface.
US Patent 5,476 discloses bi-component in 647 and has fluoridized the thing sedimentary system, and wherein, first component of system contains the calcium source of solubility and the complexing Ca ion of solubility, for example edetic acid, described calcium and calcium complexing agent generation part bonding.Second component contains fluoride salt, for example sodium fluoride or tin fluoride.When two kinds of components in conjunction with the time, calcium fluoride (CaF
2) accretion replaced the Free Ca from solution
2+, and the other Free Ca that discharges from the calcium complexing agent appears in the solution
2+, but these other Free Ca
2+New calcium fluoride precipitation will further be generated.
In 1996 _ _ _ _ _ _ application common pending trial U.S. Patent application No. in a kind of dentifrice of fluoridizing tooth is disclosed, it has adopted two kinds of physically separated semisolid dentifrice components of separating, component comprises fluoride salt and contains the abrasive components of calcium ion, react in blend and when being applied to tooth between these components, first component is moisture semisolid Dentrifice composition, said composition contains from salt, alkali metal salt for example, concrete as sodium fluoride discharges is present in fluorine ion in the carrier, and carrier is the composition that does not react with fluoride salt.Simultaneously, second component by the abrasive material that comprises calcium ions for example the carrier of the Dicalcium Phosphate of hydration form, each dentifrice components is the rheology equivalence substantially, and they are extruded in two-chamber containers simultaneously.When each composition in the component to be administered is in suitable reaction ratio, in the process that is used for tooth (as brushing teeth), the mixing of dentifrice components will produce the maximum fluoride degree of utilization in the calcium fluoride mode of precipitation.
Most convenient and the most economical method of using physically separated component in the polycomponent dentifrice are to adopt the plastic pipe folding, that compartment is arranged.The two intracavity flexible pipes that are used for two kinds of physically separated dentifrice components coextrusion simultaneously have been that these those skilled in the art are known, by this pipe of compression (as extruding), can use the multilayer band-type product of wall scroll.The body of an above-mentioned pair of intracavity pipe normally end seals and is made by plastic sheet.The structure of two intracavity pipes comprises that also the formation that is positioned at body separates the barrier film that chamber uses and be positioned at closed end not and the neck of relative rigidity, closed end does not have the opening of discharging, and, the outer surface of neck can be screw thread or other structure, thereby make lid can spiral or otherwise be connected above, to seal this pipe.These type of two intracavity tubular constructions that are used to use the polycomponent dentifrice are open in US Patent 4,481757 and 4,687663.
US Patent 4,487,757 disclose two intracavity flexible pipes, two chambers are separated one of them barrier film and this barrier film extends to the nozzle place of discharging purposes, this pipe can physically separate and discharge the bi-component toothpaste that contains active component, wherein, a kind of component contains alkali metal hydrogencarbonate (for example sodium bicarbonate) and another component contains acid or the acidic salt (for example citric acid) with bicarbonate reaction, thus discharge the unmixed layer of two components at the same time and they are mixed when brushing teeth fully after effervesce (carbon dioxide) can take place.
US Patent 4,687,663 disclose a kind of pair of intracavity pipe, and the dual component dentifrice agent of wherein using is made up of gel first component that contains hydrogen peroxide and second component that contains sodium bicarbonate.The barrier film that this pipe is extended to the application nozzle is divided into two chambers.
Disclosed bi-component application system in the prior art, disclosed system in for example above-mentioned patent documentation, in esse shortcoming is: when above-mentioned system being used for the extrudable oral health products of semisolid and for example containing the toothpaste of active component and tooth and use gel, since these product needed by constant hanking in advance use than the time could obtain the best use of, the interior dentifrice components of plastic pipe that therefore compartment is arranged then can not be obtained the optimum response of active component if unevenly use when two kinds of components are mixed in the process of brushing teeth.For example, US Patent 5,137,178 (1 hurdles, 29-39 is capable) described one known to the skilled in using the bi-component biologically active prod ubiquitous problem, be the relative flow of each component in uncontrollable pair of each chamber of intracavity container, then have more serious problem aspect extruding at the bi-component equal-volume.US Patent 5,020,694 (1 hurdles, 64 walk to 3 hurdles, 3 row) think that existing pair of intracavity pipe is (respectively in US Patent 4,487, discuss in 757 and 4,687,663) existing defective is, described pipe is used the dual component dentifrice agent material with the ratio of variation out of control, even component has similar rheological characteristic.
Inhomogeneous the using of component can cause that multilayer dentifrice part has and last time different component layers next time in the polycomponent dentifrice when using, therefore, even carry out dispensing next time of component synchronously, but the composition in the component of using out does not have the proportioning of the correct response thing of appropriate obtained optimum activity component reaction.In S.N_____ in the situation of disclosed polycomponent dentifrice type, in the mixed process of brushing teeth, can't obtain when using in that component is non-homogeneous as the best fluoride of calcium fluoride precipitation is efficient.
US Patent 5,020,694 and US Patent 5,038,963 described and be used for the stiff piston type multi-cavity type applying container two or more dentifrice components extruded jointly simultaneously with preset blending ratio.This class rigid container has the advantage of the controlled process of coextrusion.Yet, when producing them, need use a large amount of plastic material.Consider the problem of environmental protection and cost, it is desired to utilize the packing of a small amount of plastics to be only market.Therefore, this field needs nonrigid plastics compartment formula container or pipe, be used to store and use the physically separated dentifrice components that contains active component simultaneously, use the distribution ratio that is predetermined to be that can remain unchanged, by these, obtain the optimum response between active component, such container only needs a small amount of plastic raw materials to make.
Summary of the invention
Among the present invention, provide a kind of make physically separated contain different activities composition dentifrice components by predetermined ratio from multi-cavity type, non-rigid and have a constant common application process the container of collapsible sidewalls.This container comprises the collapsible body that (1) is formed by the plastic flagstone wall material, this material produces distortion about 1.0 pounds or higher adding under the deflection force effect, (2) be positioned at container body and limit the moving regulator of separating chamber, barrier film is the thin film of a kind of thickness container body sidewall, it promptly deforms under less than 0.5 pound deflection force, and it move with the container side wall pressurized time pressure reduction that transversely produces decide, the displacement basic neutralisation of film pressure reduction and dentifrice components that the compressive force that is subjected to is balancedly imposed in the container chamber to be contained, when formulation components, can reach according to designated ratio substantially constant ground thus component is used jointly, so the compressive force that pushing each dentifrice components needs is basic equating.
The explanation dentifrice components of preferred embodiment
Term herein " basic equate compressive force " is meant and requiredly when preparation each component of polycomponent dentifrice of the present invention impels mobile power, a kind of dentifrice components of independent splendid attire from container outlet extrude and other packing component between difference should not surpass 20%, like this, when component mixes the most at last, the reaction that can produce suitable proportioning between the different activities composition in the component.
Have been found that, when each dentifrice components that contains the different activities composition is subjected to different surfaces power from collapsible non-rigid container (described dentifrice components is contained in wherein) plastic sidewalls, component is extruded in container chamber, reach extruding jointly of each component, wherein, contained active component has pre-selected proportion in the component; Be used to prepare each dentifrice components carrier must by extruding of dentifrice components be adjusted to can deal with different surperficial stressed, thereby it is equal substantially to be used in the required compressive force of regulation and control coextrusion.
Further find, when each dentifrice components at about 0.5 to about 20 pounds, prepare when being used to extrude under preferred about 1 to 10 pound compressive force, the common application system of the present invention can be used jointly with the dentifrice components that contains the different activities composition is substantially invariable.
Term " compressive force " is in pound (Ibs), herein with appending claims in, it is meant under 23 ℃ with the speed of unmodified 150 mm/min (mm/min) extrudes 5 millimeters (mm) required power when long with the dentifrice components that 1-2g is contained in the rustless steel container from the perforate of diameter 3.8mm.For measuring this compressive force, dentifrice components is placed in the rustless steel container that internal diameter is 2.0cm.The flow measurement hole of a long 20mm, internal orifice dimension 0.38cm is equipped with in the bottom of rustless steel container.The nothing that overall diameter is identical with the rustless steel container interior diameter special teflon piston that rubs is placed on the top of dentifrice.Adopt Instron compression tester measure special teflon piston with 150mm/min speed move downward 5mm apart from the time firmly.Required compressive force is taken from the break place (slope change place) of the power of applying with respect to the distance curve of doing when extruding; Cause the mobile linear piston that changes until slope that increases of dentifrice components to apply the beginning that power represents that dentifrice components is extruded.The purpose of using for the equilibrium that reaches the packing dentifrice components, in the present invention's practice, each component from compressive force that break is measured should strictness be other component ± 20% scope in.
Effectively the required compressive force of extruding dentifrice components of the present invention can be mixed with active component in the described carrier by selecting to become to assign to regulate with concentrated dentifrice carrier.
The dentifrice carrier of using in the present invention's practice should transfer to can give dentifrice components pasty consistency, integral body and inviscid, and such character is the characteristic that conventional toothpaste and tooth are used gel.Do not react between carrier and dentifrice active component, and comprise water, suitable wetting agent, (for example glycerine, D-sorbite, propylene glycol, carbowax, or any their suitable compounds) and thickening agent.
The common dentifrice components about 10% of wetting agent is to about 70% (weight), and preferred about 20 to about 50% (weight).Water in the carrier accounts for about 6 to about 70%, preferred about 15% to about 40% of this composition weight.
The thickening agent that is mixed with in the dentifrice components of the present invention comprises natural and synthetic natural gum and colloid, their example comprises: iota carrageenan, kappa carrageenan, lamda carrageenan and their compound, xanthene glue, carboxymethyl cellulose, sodium carboxymethyl cellulose, starch, polyvinylpyrrolidone, ethylol propyl cellulose, hydroxy butyl methyl cellulose, hydroxypropyl methylcellulose, hydroxyethylcellulose, LAPONITE and aluminium-magnesium silicate.Preferred thickening is those thickening agents of giving the dentifrice components elastic construction, thereby avoids the multiviscosisty of dentifrice components incremental variations in storage.In the present invention's practice, when in the dentifrice components preparation, adopting above-mentioned thickening agent, extrude the required compressive force of dentifrice components and in storage process, do not change substantially.The example that can give the thickening agent of elastic construction comprises dissimilar carrageenans, LAPONITE, with commercially available aluminium-magnesium silicate of Veegum trade name and the polyox-yethylene-polyoxypropylene block copolymer of selling with " Pluronic " trade mark.
Among the present invention the most preferred thickening agent that can give dentifrice components expection elastic construction be from dry, spray is done or the compound of whole (bulk) is dry, coprocessing forms cellulose gel, microcrystalline cellulose and cellulose gum (for example carboxymethyl cellulose, xanthene glue or mosanom).The object lesson of the described cellulose gel product that to be those sold with trade name " Avicel " by FMC Corp., these products contain 80 microcrystalline cellulose and about 10 cellulose gums to about 20% (weight) to about 90% (weight) of having an appointment usually.The magnitude range of gel particle is from the sub-micron meter, that is, less than 0.2 micron to about 100 microns, preferred about 0.2 micron to about 20 microns.Particularly preferred cellulose gel is Avicel RC-591-F among the present invention, this product is a kind of spray dry cellulosic gel with following composition and character: % microcrystalline cellulose 88% colloid (0.2 micron) 70% carboxymethyl cellulose 12 initial viscosity * were that the viscosity * * after the 39-175 preparation was the 1250cps* initial viscosity at 1.2% o'clock at 1.2% o'clock: 120 seconds, utilize Brookfield RVT fluid meter #1 rotor, rotating speed 20rpm (per minute rotating speed).Viscosity after the * preparation: 24 hours, utilize Brookfield RVT fluid meter #3 rotor, rotating speed 20rpm.
The concentration that is blended in the thickening agent (as Avicel RC-591-F) in the dentifrice components of the present invention is about 0.05 to about 2% (weight), and preferred about 0.1 to about 1.5% (weight).
Adopted inhibiter when preparing dentifrice components of the present invention, helped dentifrice components when using, can be dispersed in fully in the whole oral cavity like this, also improved cosmetics applicability and washing performance and foamability simultaneously in conjunction with component.The concentration of inhibiter in the dentifrice carrier of each component of the present invention is about 0.5 to about 3.0% (weight), and preferred about 1.0 to about 2.0% (weight).
Used inhibiter is a higher alkyl sulfates in the embodiment of the present invention, and for example dodecyl sodium or other suitable alkyl group have the alkyl sulfate of 8 to 18 carbon atoms; Dodecyl sulfoacetic acid sodium, the salt of higher fatty acid sulfonation monoglyceride, for example the sulfonation monoglyceride of coconut palm base coconut monoglyceride or other suitable aliphatic acid with 10 to 18 carbon atoms; Higher fatty acid amides salt for example has the acid of amino acid whose 12 to 16 carbon atoms of lower aliphatic, and is concrete as N-methyl-N-palmityl-sodium taurocholate, N-lauroyl, N-myristoyl and N-palmitoyl sarcosine sodium; Above-mentioned aliphatic acid with wait ooze acid (isotonic acid) or with the salt of the ester of sulfate mono glycerin ester, the sodium salt of for example hydrogenation cocoyl aliphatic acid sulfate mono monoglyceride, ethylenic sulfonate, for example, the sulfonated alkene or sulfonated alkene or their compound that contain 12 to 16 carbon atoms on the molecule carbon chain; With, the higher fatty acid soap, for example those have the fatty acid soaps of 12 to 18 carbon atoms, for example coconut palm base aliphatic acid.The cation of salt can for sodium, potassium or single-, two or triethanolamine.
Embodiment of the present invention are widely used in each other must physically separated dentifrice components, and these components contain the composition that can react to each other with other component separately.For example, peroxide is as lively as a cricket composition, need open with many dentifrice component separating, and fragrance compound for example, vitamin (A, C, E), antiseptic (for example triclosan), and polyphosphate (for example sodium tripolyphosphate).Cationic compound (tin ion for example, didextrose pickling must Taihe county cetylpyridinium chloride) also needs the anionic group with dentifrice, and for example the abrasive material of winestone controlling agent (sodium tripolyphosphate), calcium and Si oxide etc. separates.
Specific examples is more specifically, and depositing fluorinated calcium is when fluoridizing on tooth when needs, and first component of dual component dentifrice agent composite contains the water miscible villiaumite of releasing, and for example alkali metal fluoride is (as NaF, KF, sodium monofluorophosphate or SnF
2).Being suitable for preferred villiaumite of the present invention is NaF.The concentration of described villiaumite in Dentrifice composition first component is about 0.1 to about 1% (weight), and preferred about 0.25 to about 0.5% (weight).Under preferred concentration so, when first component of Dentrifice composition and second component when being used for tooth and mixing, useful effect is about 750ppm about 1500ppm extremely in the fluorine ion of tooth.
The particular instance of the active component in be blended in dentifrice in addition first component comprises: peroxide, as hydrogen peroxide and calper calcium peroxide; Or acid organic component, for example citric acid or their salt; The concentration that is included in the active component in first dentifrice components is about 0.5 to about 5%, in composition weight.
Second component of Dentrifice composition of the present invention comprises a kind of active polishing compound or abrasive ingredients, for example Dicalcium Phosphate or alkali metal hydrogencarbonate.When dentifrice second component contains the Dicalcium Phosphate abrasive material of hydration or dicalcium orthophosphate dihydrate, it is about 1 to about 60% (weight) that described abrasive mixed is combined in concentration in Dentrifice composition second component of the present invention, and be preferably second component about 20% to about 50% (weight).When abrasive material is an alkali-metal bicarbonate for example during sodium bicarbonate, it is about 5 to about 25% (weight) that this bicarbonate is blended in concentration in second component.
Other instantiation of two kinds of component dentifrice composites that can adopt in the embodiment of this invention comprises: contain conventional activity but the dentifrice components of composition incompatible with each other, described composition for example is calcic abrasive material and poly-carboxylated polymers (for example Cantrez) or potassium nitrate.
Active abrasive material is present in the carrier, this carrier is formulated into to have and the similar composition of the carrier of first dentifrice components, so that two kinds of components have approximate physical property, but such characteristic makes them be easier to be mixed with coextrusion when the compressive force that is subjected to being equal to substantially.For example, thereby, compressive force obtains best calcium fluoride precipitation for can substantially equally being extruded two kinds of components with accurate pre-selected proportion, the carrier compositions of second component should be adjusted to and be suitable for the difference that the component ingredient causes, especially humectant content.Therefore, in a kind of component fluoride and another component is in the example of dual component dentifrice agent of calcium abrasive material, the humectant content of second component is adjusted to allows and contains the Dicalcium Phosphate abrasive material.The concentration of described abrasive material in second dentifrice components is about 10 to about 30% (weight), and is preferably about 15 to about 25% (weight).Under such level of abrasive, the scope of humectant concentration is between about 15 to about 70% (weight), and preferred about 20 to about 40% (weight).
Sodium bicarbonate concentration in second dentifrice components of polycomponent dentifrice of the present invention also can be done similar adjusting, so that it is basic identical to extrude the required compressive force of two kinds of components, thereby use component with pre-selected proportion, make the bicarbonate composition of second component and the organic acid or the peroxide composition of first component carry out best reaction thus.
Implement to obtain banded dentifrice product when of the present invention, wherein, the colorant with contrast colors is blended in respectively in the dentifrice components of the present invention, but colorant is recommending to be pharmaceutically acceptable and physiology avirulence under the consumption.Be applicable to that colorant of the present invention comprises pigment and dyestuff.
The pigment that adopts in the invention process comprises nontoxic water-insoluble inorganic pigment, for example titanium dioxide and chrome oxide green, ultra marine blue and pink colour and ferric oxide and from FD﹠amp; The water-insoluble dyestuff color lake of calcium salt that the C dyestuff is derived or the preparation of aluminium salt, for example FD﹠amp; The green #1 of C color lake, FD﹠amp; The blue #2 of C color lake, FD﹠amp; C R﹠amp; D#30 color lake and FD﹠amp; The yellow #15 of C color lake.The grain size of described pigment is the 5-1000 micron, preferred 250-500 micron, and its concentration is 0.5 to 3% (weight) simultaneously.
The used dyestuff of the present invention evenly fully is distributed in the dentifrice components and is generally the food color additive, and these additives are by food, medicine and cosmetics law (FoodDrug﹠amp; Cosmetic Act) approval is used for food and intestines medicine, comprises dyestuff, for example FD﹠amp; C red No. 3 (tetraiodofluorescein sodium salts), FD﹠amp; C yellow No. 5 (4-is to the sodium salt of sulfo group phenylazo-1-to sulfo group phenyl-5-hydroxypyrazoles base-3-carboxylic acid), FD﹠amp; C yellow No. 6 (sodium salt of the single sulfonic acid of right-the sulfo group phenylazo-the B-naphthols-6-), FD﹠amp; Green No. 3 of C (4-{[4-(N-ethyl-right-sulfo group benzylamino)-phenyl]-(4-hydroxyl-2-sulfur phenenyl)-methene-disodium salt of [1-(N-ethyl-N-right-sulfo group benzyl)-PE-3,5-hexamethylene diimine]), FD﹠amp; C blue No. 1 (disodium salt of dibenzyl diethyl-diamido triphenylcarbinol trisulfonic acid anhydrite), FD﹠amp; The compound of blue No. 2 (the indigo disulfonic acid sodium salts) of C and their different proportions.The concentration that can produce the dyestuff of optimum efficiency in the present invention be Dentrifice composition about 0.0005 to about 2% (weight).
Preferably include pigment as colorant in a kind of dentifrice components, titanium dioxide for example, and the colorant that is distributed in fully in other dentifrice components body is a dyestuff, and dyestuff have with first dentifrice components in the different color of contained pigment.
Also can use any suitable flavouring agent or sweetener material.The example of suitable flavouring agent composition is a flavor oil, for example spearmint oil, peppermint oil, wintergreen, sassafras oil, clove oil, sage oil, eucalyptus oil, origanum oil, cinnamon oil, lemon oil and mandarin oil, and gaultherolin.Suitable sweetener comprises sucrose, lactose, maltose, D-sorbite, cyclohexane sulfamic acid sodium, perillartine and saccharin sodium.Suitable flavouring agent and sweetener account for 0.01 to 5% of preparation jointly.
Can contain multiple other material in the dentifrice components of the present invention.Infinite example comprises anti fouling composition, polysiloxane and chlorophyll compound, antiseptic (for example chlorohexidene), halogenated diphenyl ethers (for example triclosan), desensitiser (for example potassium nitrate and potassium citrate and their compound).The amount that above-mentioned assistant agent is blended in the dentifrice components should not be as the criterion required character and characteristic are not had side effects substantially, and selects in suitable weight range and use, and this depends on the particular type of this dentifrice components.
For preparing each dentifrice components of the present invention, wetting agent (for example glycerine, carbowax) composition and sweetener are disperseed to become even gel phase until compound in the mixer of routine.In this gel phase, add fluoride salt or Dicalcium Phosphate abrasive material.Mix these compositions until obtaining uniform phase.After this add thickening agent, sweetener and surfactant component and mixing at a high speed and under the vacuum of about 20-100mmHg.Products obtained therefrom be evenly, semisolid, extrudable paste product.Applying container
Implement the present invention and adopt multi-chamber container, the sidewall of described container body is to be made by flexible elastoplast raw material, and this material deflects when wooden partition is subjected to application force.In embodiment of the present invention, this plastics wooden partition can be owing to the deflection force that applies (about 1.0 to about 3.0 pounds) deflects, have now found that plastics wooden partition of the present invention is particularly useful for dentifrice components is used consistently altogether according to the proportioning of preliminary election of the present invention in the folding pipe that chamber arranged.
Herein and in the attached claims " deflection force " speech be meant with pound represent the plastics wooden partition is deflected to the U-shaped of counter-rotating the time required maximum force, this deflection force is to be finished by the setting sleeve pipe (for example Instron Tensile TesingMachine) that is assemblied on the compression platform.This power is axially down to act on the arch section of U-shape wooden partition and apply with the speed of 12 inch per minute clocks.
The sleeve pipe that is contained on the Instron Machine has 5.5 inches high, and by 0.25 inch thick 1 inch square piece of stainless steel and curved downwards stainless steel cable (diameter the is 0.125cm) composition to a right angle opening portion (wide 5 inches, high 2.5 inches).With this sleeve pipe pack into Instron Machine clamp mouth part and move down so that its contact and the deflection wooden partition surface of being tried.
The plastics wooden partition that is tried is sandwiched on the sample fixer, and this solid device is to be that 0.125 inch the corrosion-resistant steel pedestal that has wide 1 inch, long 4 inches and high 2 an inches slit constitutes by thickness.Length under this pedestal is that a member of 1 inch is embedded in pedestal on the bench board of Instron Machine.Have a sample connecting element to be positioned at pedestal, it clamps the plastics wooden partition in the pedestal, and this sample connecting element is to be made of long 4 inches, wide 0.975 inch and the high 2 inches passage with 0.625 inch wall thickness.The sample connecting element can be fixed the wooden partition in the pedestal with the U-shaped of counter-rotating.
In the mensuration of deflection force, 6 plastics wooden partition samples are blocked by longitudinal direction and with other 6 by transversely truncation.Each given the test agent is all 4 inches * 4 inches.Each sample all is placed on the sample fixer build-in test, and is sandwiched in the U-shaped of the position of connecting element with the formation counter-rotating.Any sample all can not repeated usage.The sample fixer that accompanies sample is contained in the Instron Machine and this sleeve pipe is reduced to the top that is positioned at sample just, subsequently, reduce, make 0.35 inch of its deflection thereby act on wooden partition with the speed of 12 inch per minute clocks.The application force of deflection wooden partition (in pound) is as the deflection force record in such a manner.
The plastic sheet of making sidewall can be made of suitable plastic materials, for example: the copolymer and the polyethylene terephthalate of polyethylene (high density and low-density), polypropylene, ethene and propylene.Plastic sheet can be a rhythmo structure, and wherein, gas shield material (for example ethylene-vinyl alcohol, nylon or Vingon) is between the centre of the lamination of being made up of polyethylene or polypropylene or their copolymers.This gas shield material is used to prevent that some composition of dentifrice from also suffering a loss through the plastics of no gas shield structure because of entering gas phase.
Multi-chamber container of the present invention has collapsible lateral wall and removable barrier film, container is separated into a plurality of chambers, thereby the lateral wall that makes chamber under the compressive force of outer wall is folding being applied to, and be that each dentifrice components is released in the distortion of compensating pipe outer wall by moveable bulkhead from each chamber, make it extrude the compressive force that balance imposes on each dentifrice components thus from container.Accompanying drawing
Referring to accompanying drawing, the corresponding and similar portions of wherein said accompanying drawing is represented with same indication code name by different visual angles.
Accompanying drawing 1 is the lateral plan of a specific embodiment (flexible pipe) of multi-cavity type container of the present invention.
The accompanying drawing 2. vertically section drawing longitudinally that to be multi-cavity type pipe shown in the accompanying drawing 1 do along the 2-2 line.
Accompanying drawing 3 is the cross sectional drawing that the lower edge of Guan Zaiwei folded condition shown in the accompanying drawing 2 2-2 line is done.
Accompanying drawing 4 is the view of pipe shown in the accompanying drawing 3 under folded situation.
Accompanying drawing 1 illustrates a multi-cavity type pipe, and this pipe is applicable to store and contains the dentifrice components of active component and they are physically separated.Pipe shown in the accompanying drawing 2-4 comprises circular body 10, but its also other shape is for example oval.The body 10 of described pipe should be easy to push, compress or be folding and comprise the sidewall of being made by the elastoplast raw material 12, and this sidewall deflects as the time spent to about 3.0 pounds deflection force being subjected to aforementioned about 1.0.One end 20 of body 10 is closed and the other end 22 is to open wide and have neck 22a, and the polycomponent dentifrice components is released through this neck from perforate 23 and 23a.Neck 22a also has the coupling device (not shown) that matches with the pipe lid.
Sidewall 12 common thickness are about 0.25 to about 1.20mm.In preferred version of the present invention, the thickness of sidewall 12 is about 0.25 to about 0.35mm.
In the above-described embodiment, the inside of body 10 is two chambers 14 and 16 by barrier film or dividing plate 18 longitudinal subdivisions.But dividing plate 18 soft and parallel motions.According to the structure of body 10, dividing plate 18 can constitute the whole of body 10 and become the part unified with body 10 with sidewall.In addition, dividing plate 18 can be the member that forms respectively, its suitable inside that is retained in container body.Particularly, when body 10 and dividing plate 18 are when for example polyethylene is assembled into by thermoplastic material, can adopt heating or gluing sealing mode that two of body 10 are in charge of with the periphery of dividing plate 18 with sidewall 12 and be connected.The periphery of dividing plate 18 is for good and all to be bonded together by suitable heat seal mode or adhesive means and side wall inner surfaces 12.
Accompanying drawing 2 vertically illustrates the dividing plate 18 of corrugated or pleated, and thus, the outer wall of pipe is compressed or is out of shape, and causes the parallel motion of dividing plate 18.
Accompanying drawing 3 illustrates the original and quiescence before container side wall 12 compressions, accompanying drawing 4 illustrates when collapsible container sidewall 12 and is compressed so that each dentifrice components is used from chamber 14 and 16 altogether, and the transposition of dividing plate 18 horizontal directions ground is to by the position shown in the dotted line.
Dividing plate 18 comprises a kind of extremely soft and lax thermoplastic film material, for example low density polyethylene (LDPE) or polypropylene, or a kind ofly have the gas shield layer to be positioned at lamination in the middle of relative polyethylene or the polypropylene layer.The thickness of dividing plate 18 is thinner than the plastics that constitute sidewall 12 substantially, and thickness is 0.005 to 0.20mm usually, and preferred about 0.075 to about 0.15mm.
20 can be any suitable configuration at the bottom of the pipe of body 10.By curling or the extruding sealing, the gluing or heat bonding of these body 10 walls and internal partition 18 together with the wall of body 10 in the bottom of body 10.
In a usual manner dentifrice components is charged into before 20 end closures of body 10 in the chamber 14 and 16 of container body 10, that is, container has a capping (not shown); Counter-rotating and fill then from the bottom.The dentifrice components that contains the different activities composition shows different flow characteristiies when the compressive force that is subjected to from sidewall 12, dentifrice components is compared each other when flowing through side wall inner surfaces and run into different, promptly bigger or less resistance to flows.For remedying the above-mentioned difference that produces because of compression flow, dentifrice components should be formulated into can offset above-mentioned difference, and each component required compressive force that flows is basic identical like this, and compressive force is usually between about 0.5 to about 20Ibs, and preferably about 1 to 10Ibs.When being applied to the compressive force in this scope on the container side wall 10,, flow when can cause each dentifrice components for example by the squeeze receptacle sidewall.Dividing plate 18 will move because of the difference of pressure occurred level that exists in managing and to balance compressive force thus poor.When the difference of extruding the required compressive force of each component has surpassed 20% and can't remedy by the remodeling of dentifrice formulation the time, can extrude the difference of required compressive force by the geometric configuration adjustment that improves perforate 23 that component must flow through and 23a.
After the multi-cavity type container was filled, shown in accompanying drawing 2 and 3, dividing plate 18 was folding substantially, and it can move to both direction with the difference of pressure that acts on it like this.In the accompanying drawing 4, because the compression displacement in pipe left side, dividing plate 18 levels move right, and wherein, this left side displacement is bigger than the compression displacement of opposite side walls.
Because component is extruded from neck 22a through perforate 23,23a from chamber 14 and 16, each component will merge together the streams that forms a single band shape.Finite table area is accurately used and is easy to have in the mono-logistics always, under the toothpaste component situation, it can smoothly and be advantageously used on the toothbrush of narrower width, when component layers by brush teeth or the brushing chamber in other dental tissue when mixed, it provides best curative active component to discharge with pre-selected proportion.
In operation, off and on squeeze receptacle 10 with the dentifrice two component fractions of filling in chamber 14 and 16 use.When this container was had many user's grasping of different big or small hands, described extruding can be that the pressure that a kind of component is subjected to will be bigger than another kind.When above-mentioned phenomenon took place, the difference of pressure that acts on dividing plate 18 moved this dividing plate 18 until equilibrium of pressure.Therefore, the pressure formula of answering that dividing plate 18 is used for equilibrium composition pressure moves wooden partition, product component is used altogether with constant relatively ratio, because two kinds of dentifrice components green phases compressive force is together prepared and extruded, their relative rate of extrusion will be by moveable bulkhead 18 balances.
The diameter of the wall scroll product of extruding can be adjusted by regulating perforate 23 and 23a according to package insert.Usually, this product bar is the cylinder bar of diameter about 0.3 to about 2.0cm.When each dentifrice contained different colorants, the dentifrice components bar of multilayer occurred from the neck exit passageway with pleasant banded toothpaste.
The following example is used for explanation rather than limits the present invention.Except as otherwise noted, all percentums be weight percentage and temperature in ℃.Embodiment
A series of diameters are the dual cavity pipe of 40mm, and their body length is 158mm and is formed by the laminated sheet of PE/EVOH/PE structure that wherein PE is that polyethylene and EVOH are the ethylene/vinyl alcohol copolymer, and described sheet material has the thickness of 0.3mm.When test, the deflection force that needs 1.6Ibs is with this sheet material deflection, and the Instron Machine in the said method is adopted in test.
The barrier film longitudinal subdivision that this pipe is had a pleat is approximate isopyknic two chambers, and this barrier film is made by polyethylene and had the thickness of 0.12mm and deflect under the 0.077Ibs deflection force.
Dentifrice components 1 and 2 is filled in the chamber of bicavate pipe, this polycomponent dentifrice is called as " dentifrice A " and contains table I ingredients listed.
The viscosity of two kinds of dentifrice components is equal substantially when measuring under 5rpm in Brookfield unit and with Brookfield RVT fluid meter-E rotor, the viscosity ratio component 1 of component 2 little by 17%.
The table I
| Dentifrice A | ||
| Composition | Component 1 weight % silicon dioxide prescription | Component 2 weight % dicalcium prescription |
| D-sorbite (70%) | ????36.36 | ????- |
| Glycerine | ????10.00 | ????22.0 |
| Carbowax-600 | ????3.00 | ????- |
| Carrageenan | ????0.60 | ????0.92 |
| ????Avicel?RC591-F | ????0.30 | ????- |
| Tetra sodium pyrophosphate | ????0.50 | ????0.25 |
| ????TiO 2 | ????0.30 | ????- |
| Saccharin sodium | ????0.25 | ????0.20 |
| ????NaF | ????0.510 | ????- |
| Dicalcium Phosphate | ????- | ????48.76 |
| Abrasive silica | ????22.0 | ????- |
| Silicon dioxide thickening agents | ????2.50 | ????- |
| Color | ????0.03 | ????- |
| Flavor oil | ????0.95 | ????0.89 |
| Lauryl sodium sulfate | ????1.20 | ????1.20 |
| Deionized water | In right amount | In right amount |
| Viscosity, Brookfild Units | ????42 | ????36 |
Act on dentifrice A component 1 and 2 and the compressive force measured according to said method equal substantially, in fact be to extrude the required compressive force of dentifrice A component 1 little by 2.4% than component 2.It is listed as the table III to extrude the required compressive force of dentifrice A component 1 and 2.
Repeat the embodiment process but what use is the reference polycomponent dentifrice that is called " dentifrice B " in order to contrast.The component 1 of reference dentifrice B and 2 composition and their viscosity are recorded in the table II.
Extrude the required compressive force of each component of dentifrice B all to have exceeded mutually ± 20%, in other words, the required compressive force of dentifrice B component 2 is littler by 45% than component 1.It is listed as the table III that each component of dentifrice B is extruded required compressive force.
The viscosity of reference dentifrice B component 2 substantially with the equating of component 1, the viscosity ratio component 1 of component 2 little by 12%.
The table II
| Dentifrice B | ||
| Composition | Component 1 weight % | Component 2 weight % |
| ????NaF | ????- | ????0.486 |
| Asccharin | ????0.20 | ????0.20 |
| D-sorbite | ????- | ????38.524 |
| Glycerine | ????22.00 | ????25.00 |
| Carbowax-600 | ????- | ????3.00 |
| Dicalcium Phosphate | ????48.76 | ????- |
| Abrasive silica | ????- | ????18.0 |
| Silicon dioxide thickening agents | ????- | ????5.50 |
| Flavouring agent | ????0.89 | ????0.89 |
| Lauryl sodium sulfate | ????1.20 | ????1.20 |
| ????TiO 2 | ????- | ????- |
| Carboxymethyl cellulose | ????1.00 | ????- |
| Water | ????25.75 | ????- |
| Tetra sodium pyrophosphate | ????0.25 | ????- |
| Viscosity, Brookfild Units | ????65 | ????58 |
The table III
| The required compressive force (Ibs) of extruding | ||
| Dentifrice A | Dentifrice B | |
| Component 1 | ????2.53 | ????5.5 |
| Component 2 | ????2.59 | ????10.0 |
Though the viscosity of each component is equal substantially in two kinds of dentifrices, the component 1 and 2 of the dentifrice A that uses out in the pipe of multi-cavity chamber is equal substantially, and the component 1 of dentifrice B is then different with 2.
Claims (27)
1. one kind is used for will being contained in simultaneously the method for the interior active component of at least two kinds of dentifrice components with regulatable equal proportion coextrusion, described dentifrice components is stored in multi-cavity type and uses in the body and physically separated, this applicator has folding body sidewall, an internal volume that exports and will use body is divided into the internal partition device that plurality of separate is stored chamber, outlet has and separates the output perforate that chamber is communicated with, this dividing plate is to be made of and removable the thickness plastic raw materials littler than body sidewall, extrude the difference of flow velocity based on the component of compression-side wall with compensation, this method comprises: each component is filled into respectively in the chamber of separation, use for described group and be made as under the basic above-mentioned compression force that equates and in perforate, extrude, body sidewall be by plastic raw materials constitute and be subjected to aforesaid about 1.0 or more pounds deflection force effect under deform, compression body sidewall subsequently, thereby in perforate, extrude the multilayer component bar of a band shape, this component bar contains the active component of pre-selected proportion, with when extrude the active composition that optimum level is provided when component is mixed in the oral cavity.
2. according to the method in the claim 1, wherein, cause that compressive force that dentifrice components begins to extrude is respectively in ± 20%.
3. according to the method in the claim 1, wherein, dentifrice components is formulated into about 0.5 and can extrudes to about 20 pounds compression force.
4. according to the method in the claim 1, wherein, dentifrice components is formulated into about 1 and can extrudes to about 10 pounds compression force.
5. according to the method in the claim 1, wherein, the plastic raw materials that constitutes the applicator body sidewall is out of shape to about 3 pounds compression force about 1.
6. according to the method in the claim 1, wherein, sidewall has about thickness of 0.25 to about 1.2mm.
7. according to the method in the claim 1, wherein, described dividing plate is by the deflection force deflection less than 0.5Ibs.
8. according to the method in the claim 1, wherein, described dividing plate has about wall thickness of 0.0005 to about 0.20mm.
9. according to the method in the claim 1, wherein, described dividing plate be pleat arranged and be moved with the compressive force that acts on body sidewall.
10. according to the method in the claim 1, wherein, described dentifrice components contains the thickening agent that can give the component elastic construction.
11. according to the method in the claim 10, wherein, described thickening agent is a cellulose gel.
12. according to the method in the claim 10, wherein, described thickening agent is a carrageenan.
13. according to the method in the claim 1, wherein, the active component that is contained in the dentifrice components is the calcic abrasive material and releases villiaumite.
14. according to the method in the claim 13, wherein, this releases villiaumite is NaF.
15. according to the method in the claim 13, wherein, described calcium abrasive material is a calcium phosphate.
16. according to the method in the claim 1, wherein, the active component that is contained in the dentifrice components is the polishing compound and the organic acid of bicarbonate alkali metal salt.
17. according to the method in the claim 16, wherein, this bicarbonate alkali metal salt is a sodium bicarbonate.
18. according to the method in the claim 16, wherein, described organic acid is a citric acid.
19. according to the method in the claim 1, wherein, the active component that is contained in the dentifrice components is bicarbonate alkali metal salt and peroxide.
20. according to the method in the claim 19, wherein, peroxide is hydrogen peroxide or calper calcium peroxide.
21. according to the method in the claim 1, wherein, the active component that is contained in the dentifrice components is calcic abrasive material and potassium nitrate.
22. according to the method in the claim 21, wherein, the active component that is contained in the dentifrice components is calcic abrasive material and multi-carboxylation poly-mer.
23. according to the method in the claim 1, wherein, the active component that is contained in the dentifrice components is peroxide and tripolyphosphate.
24. according to the method in the claim 1, wherein, the active component that is contained in the dentifrice components is peroxide and perfume compound.
25. according to the method in the claim 1, wherein, the active component that is contained in the dentifrice components is peroxide and vitamin.
26. according to the method in the claim 1, wherein, the active component that is contained in the dentifrice components is peroxide and antiseptic.
27. according to the method in the claim 1, wherein, the active component that is contained in the dentifrice components is cationic compound and cationic compound.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65973496A | 1996-06-06 | 1996-06-06 | |
| US08/659,734 | 1996-06-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1221384A true CN1221384A (en) | 1999-06-30 |
| CN1071248C CN1071248C (en) | 2001-09-19 |
Family
ID=24646604
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN97195267A Expired - Fee Related CN1071248C (en) | 1996-06-06 | 1997-05-21 | Codispensing of physically segregated dentifrices at consistant ratios |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0918698B1 (en) |
| CN (1) | CN1071248C (en) |
| AT (1) | ATE208327T1 (en) |
| AU (1) | AU722898B2 (en) |
| BR (1) | BR9709290A (en) |
| CA (1) | CA2254338A1 (en) |
| CO (1) | CO4700512A1 (en) |
| DE (1) | DE69708117T2 (en) |
| DK (1) | DK0918698T3 (en) |
| ES (1) | ES2167757T3 (en) |
| HU (1) | HU223420B1 (en) |
| MY (1) | MY123112A (en) |
| PL (1) | PL187283B1 (en) |
| PT (1) | PT918698E (en) |
| TR (1) | TR199802521T2 (en) |
| WO (1) | WO1997046462A1 (en) |
| ZA (2) | ZA974983B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102233984A (en) * | 2010-04-26 | 2011-11-09 | 李康俊 | Dual-structure tube vessel and method of producing the same |
| CN110507064A (en) * | 2018-05-21 | 2019-11-29 | 株式会社爱茉莉太平洋 | The more filled type containers and its fill method of rod type content |
| CN113086419A (en) * | 2021-03-17 | 2021-07-09 | 安牧乳业(江苏)有限公司 | Milk beverage with high safety |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6350436B1 (en) | 1996-11-21 | 2002-02-26 | The Procter & Gamble Company | Method of reducing staining of stannous in dentifrice compositions |
| US6187295B1 (en) | 1996-11-21 | 2001-02-13 | The Procter & Gamble Company | Methods of reducing the astringency of stannous in dentifrice compositions |
| US6713049B1 (en) | 1999-11-12 | 2004-03-30 | The Procter & Gamble Company | Oral compositions providing optimal surface conditioning |
| US5950873A (en) * | 1996-11-26 | 1999-09-14 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Dental product |
| US5820852A (en) * | 1996-11-26 | 1998-10-13 | The Proctor & Gamble Company | Oral compositions containing fluoride, pyrophosphate, and peroxide |
| US5855871A (en) * | 1997-08-12 | 1999-01-05 | Colgate-Palmolive Company | Effervescent two component bicarbonate and acid containing dentifrice |
| US5814303A (en) * | 1997-09-17 | 1998-09-29 | Chesebrough-Pond's Usa Co., Division Of Conocpo, Inc. | Dental product |
| US5958381A (en) * | 1998-03-12 | 1999-09-28 | Colgate Palmolive Company | Bis-biguanide antiplaque dentifrice exhibiting reduced staining |
| ES2350177T3 (en) | 1999-11-12 | 2011-01-19 | THE PROCTER & GAMBLE COMPANY | ORAL COMPOSITIONS CONTAINING STANNY IONS. |
| CA2387956C (en) | 1999-11-12 | 2007-02-06 | The Procter & Gamble Company | Improved dual phase stannous oral compositions |
| US20040146466A1 (en) | 1999-11-12 | 2004-07-29 | The Procter & Gamble Company | Method of protecting teeth against erosion |
| US10470985B2 (en) | 1999-11-12 | 2019-11-12 | The Procter & Gamble Company | Method of protecting teeth against erosion |
| US6447758B1 (en) * | 2001-05-02 | 2002-09-10 | Colgate Palmolive Company | Cationic antibacterial dentifrice exhibiting superior foaming properties |
| CA2448818C (en) | 2001-07-11 | 2007-10-09 | The Procter & Gamble Company | Multi-chambered, uniform dispensing tube |
| DE60237889D1 (en) | 2001-07-11 | 2010-11-18 | Procter & Gamble | MULTI-CHAMBER TUBE WITH A FLOW CONTROL ELEMENT FOR THE EQUIVALENT DISTRIBUTION OF FLUIDS |
| US6613310B1 (en) * | 2002-07-29 | 2003-09-02 | Colgate Palmolive Company | Dual component bis-biguanide containing dentifrice of improved stability |
| US10123953B2 (en) | 2012-06-21 | 2018-11-13 | The Procter & Gamble Company | Reduction of tooth staining derived from cationic antimicrobials |
| EP3958983A1 (en) | 2019-04-26 | 2022-03-02 | The Procter & Gamble Company | Reduction of tooth staining derived from cationic antimicrobials |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR572054A (en) * | 1923-10-18 | 1924-05-28 | Double flattenable flask tube, delivering pasty products | |
| FR2260506A1 (en) * | 1974-02-13 | 1975-09-05 | Allet Coche Pierre | Tube with two compartments for paste products - avoids need for separate tubes for materials used at point of mixing |
| US4089437A (en) * | 1976-06-18 | 1978-05-16 | The Procter & Gamble Company | Collapsible co-dispensing tubular container |
| US4487757A (en) * | 1981-12-28 | 1984-12-11 | Colgate-Palmolive Company | Dispensing container of toothpaste which effervesces during toothbrushing |
| GB9207292D0 (en) * | 1992-04-02 | 1992-05-13 | Unilever Plc | Fluid dispensers |
-
1997
- 1997-05-21 BR BR9709290A patent/BR9709290A/en not_active IP Right Cessation
- 1997-05-21 DE DE69708117T patent/DE69708117T2/en not_active Expired - Fee Related
- 1997-05-21 AU AU35669/97A patent/AU722898B2/en not_active Ceased
- 1997-05-21 CN CN97195267A patent/CN1071248C/en not_active Expired - Fee Related
- 1997-05-21 DK DK97932135T patent/DK0918698T3/en active
- 1997-05-21 HU HU0003316A patent/HU223420B1/en not_active IP Right Cessation
- 1997-05-21 EP EP97932135A patent/EP0918698B1/en not_active Expired - Lifetime
- 1997-05-21 PL PL97330312A patent/PL187283B1/en not_active IP Right Cessation
- 1997-05-21 TR TR1998/02521T patent/TR199802521T2/en unknown
- 1997-05-21 ES ES97932135T patent/ES2167757T3/en not_active Expired - Lifetime
- 1997-05-21 WO PCT/US1997/008622 patent/WO1997046462A1/en not_active Application Discontinuation
- 1997-05-21 AT AT97932135T patent/ATE208327T1/en not_active IP Right Cessation
- 1997-05-21 CA CA002254338A patent/CA2254338A1/en not_active Abandoned
- 1997-05-21 PT PT97932135T patent/PT918698E/en unknown
- 1997-06-03 MY MYPI97002431A patent/MY123112A/en unknown
- 1997-06-04 CO CO97031030A patent/CO4700512A1/en unknown
- 1997-06-05 ZA ZA974983A patent/ZA974983B/en unknown
- 1997-06-05 ZA ZA974980A patent/ZA974980B/en unknown
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102233984A (en) * | 2010-04-26 | 2011-11-09 | 李康俊 | Dual-structure tube vessel and method of producing the same |
| CN110507064A (en) * | 2018-05-21 | 2019-11-29 | 株式会社爱茉莉太平洋 | The more filled type containers and its fill method of rod type content |
| CN110507064B (en) * | 2018-05-21 | 2022-07-15 | 株式会社爱茉莉太平洋 | Multi-filling container for stick-type contents and method of filling the same |
| CN113086419A (en) * | 2021-03-17 | 2021-07-09 | 安牧乳业(江苏)有限公司 | Milk beverage with high safety |
Also Published As
| Publication number | Publication date |
|---|---|
| PL187283B1 (en) | 2004-06-30 |
| ZA974980B (en) | 1998-12-07 |
| DE69708117T2 (en) | 2002-07-04 |
| WO1997046462A1 (en) | 1997-12-11 |
| HUP0003316A3 (en) | 2002-11-28 |
| BR9709290A (en) | 1999-08-10 |
| PT918698E (en) | 2002-04-29 |
| AU3566997A (en) | 1998-01-05 |
| HUP0003316A2 (en) | 2001-02-28 |
| CA2254338A1 (en) | 1997-12-11 |
| DK0918698T3 (en) | 2002-02-25 |
| EP0918698A1 (en) | 1999-06-02 |
| EP0918698B1 (en) | 2001-11-07 |
| ZA974983B (en) | 1998-12-07 |
| TR199802521T2 (en) | 1999-04-21 |
| HU223420B1 (en) | 2004-06-28 |
| MY123112A (en) | 2006-05-31 |
| ATE208327T1 (en) | 2001-11-15 |
| ES2167757T3 (en) | 2002-05-16 |
| DE69708117D1 (en) | 2001-12-13 |
| AU722898B2 (en) | 2000-08-17 |
| CN1071248C (en) | 2001-09-19 |
| PL330312A1 (en) | 1999-05-10 |
| CO4700512A1 (en) | 1998-12-29 |
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