CN1221276C - Compound Huangyangning (Chinese littleleaf box) small pills - Google Patents

Compound Huangyangning (Chinese littleleaf box) small pills Download PDF

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Publication number
CN1221276C
CN1221276C CN 03113001 CN03113001A CN1221276C CN 1221276 C CN1221276 C CN 1221276C CN 03113001 CN03113001 CN 03113001 CN 03113001 A CN03113001 A CN 03113001A CN 1221276 C CN1221276 C CN 1221276C
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China
Prior art keywords
buxine
compound
effect
small
present
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Expired - Fee Related
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CN 03113001
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Chinese (zh)
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CN1438011A (en
Inventor
梁秉文
方泰惠
袁厚亮
狄留庆
夏和柱
李祥
李泓
张玲莉
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NANJING XIAOYING PHARMACEUTICAL FACTORY
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NANJING XIAOYING PHARMACEUTICAL FACTORY
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Priority to CN 03113001 priority Critical patent/CN1221276C/en
Publication of CN1438011A publication Critical patent/CN1438011A/en
Application granted granted Critical
Publication of CN1221276C publication Critical patent/CN1221276C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention relates to a compound buxine dropping pill for curing angiocardiopathy and cerebrovascular diseases, which is composed of buxine, borneol and medicinal excipient, wherein the dosage ratio of the buxine to the borneol is equal to 1:0.1 to 0.5. in the present invention, the buxine is prepared into a medicine in the preparation form of compound dropping pills which has rapid medicinal effect, high bioavailability and small side effect. The dropping pill of the present invention can increase the stability of medicines, is not easy to oxidize because the medicine has a small contact area with air after merging with a substrate, and has the characteristics of simple production equipment, easy operation, small weight variation, low cost, no powder dust, favorableness of labour protection, etc. The compound buxine dropping pill using buxine as a main raw material, and is mainly used for researches on arrhythmia. Pharmacological experiments verify that the compound buxine dropping pill has better effect than amiodarone tablets and buxine tablets, and has the characteristics of good medicinal curative effect, small toxic and side effect, and obvious effect.

Description

Compound drop pills of ' Huangtangning '
Technical field
The present invention relates to a kind of Chinese patent medicine for the treatment of cardiovascular and cerebrovascular disease, particularly a kind of Chinese patent medicine drop pill.
Background technology
Cardiovascular and cerebrovascular disease is commonly encountered diseases, frequently-occurring disease, and all patients need to adopt Drug therapy.The effective ingredient that the applicant extracts from the natural plants Ramulus Buxi Sinicae---Buxine, a large amount of clinical proofs through more than 20 years, Buxine is resisting myocardial ischemia, is reducing myocardial oxygen consumption, is improving the myocardial ischemia ability, is improving coronary circulation, is dwindling myocardial infarct size, is strengthening myocardial contraction, preventing that aspect such as arrhythmia is evident in efficacy, and toxic and side effects is little.The applicant has been developed into tablet and has been used for clinical.And the Western medicine antiarrhythmic drug is a lot of at present, but the overwhelming majority all has sizable toxic and side effects, is the fatal shortcoming of chemical synthetic drug.
Summary of the invention
Purpose of the present invention is utilized compound preparation exactly, and it is faster to seek a kind of drug effect, and effective percentage is higher, the medicine for treatment that has no side effect---compound drop pills of ' Huangtangning '.
Technical solution of the present invention:
A kind of compound drop pills of ' Huangtangning ' is characterized in that it is made up of Buxine, Borneolum Syntheticum and pharmaceutical excipient, and wherein, the ratio of the weight of Buxine and Borneolum Syntheticum is 1: 0.1-0.5.
The present invention makes the compound dripping pill dosage form with Buxine, and its drug effect performance rapidly, bioavailability is high, side effect is little.Drop pill of the present invention can increase stability of drug, and is less with the air contact area because of after medicine and substrate merges, and is difficult for oxidation, has that production equipment is simple, processing ease, and weight differential is less, and cost is low, and no dust helps characteristics such as labor protection.It is primary raw material that compound drop pills of ' Huangtangning ' is used Buxine, and emphasis carries out primary study to the arrhythmia disease, proves through pharmacological experiment, its effect is better than amiodarone and Buxine tablet, and pharmaceutical effectiveness is good, and toxic and side effects is little, and rapid-action, be the unique distinction of compound drop pills of ' Huangtangning '.
The specific embodiment
Compound drop pills of ' Huangtangning ' of the present invention is made up of Buxine, Borneolum Syntheticum and pharmaceutical excipient, and wherein, the ratio of the consumption of Buxine and Borneolum Syntheticum is Buxine: Borneolum Syntheticum=1: 0.1-0.5.
Embodiment:
The Borneolum Syntheticum powder mix homogeneously of getting 1 gram Buxine powder and 0.1 gram adds in the pharmaceutical excipient (as Macrogol 4000), and the pill technology can make about 1000 compound drop pills of ' Huangtangning ' routinely.
Perhaps, the Borneolum Syntheticum powder mix homogeneously of getting 1 gram Buxine powder and 0.3 gram or 0.5 gram adds in the pharmaceutical excipient (as Macrogol 4000), and the pill technology also can make about 1000 compound drop pills of ' Huangtangning ' routinely.
Through modern pharmacology proof Borneolum Syntheticum experimental myocardial infarction there is decreased heart rate, improves the effect of coronary flow and reduction myocardial oxygen consumption, and certain sedation and gentle analgesic effect are arranged.On traditional Chinese medical science angle, Borneolum Syntheticum is the merit that " minister " helps " monarch " medicine, can directly go into thinking by priming, gets very speed of effect and make, and the mind must be pacified.The present invention plays promoting flow of QI and blood altogether with the mutual compatibility of two medicines, and the merit of the mind calming of having one's ideas straightened out makes heart ruton smooth, and the disease of cardiopalmus, irregularly intermittent and regularly intermittent pulse can be separated.

Claims (1)

1, a kind of compound drop pills of ' Huangtangning ' is characterized in that it is made up of Buxine, Borneolum Syntheticum and pharmaceutical excipient, and wherein, the ratio of the weight of Buxine and Borneolum Syntheticum is 1: 0.1-0.5.
CN 03113001 2003-03-19 2003-03-19 Compound Huangyangning (Chinese littleleaf box) small pills Expired - Fee Related CN1221276C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN 03113001 CN1221276C (en) 2003-03-19 2003-03-19 Compound Huangyangning (Chinese littleleaf box) small pills

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN 03113001 CN1221276C (en) 2003-03-19 2003-03-19 Compound Huangyangning (Chinese littleleaf box) small pills

Publications (2)

Publication Number Publication Date
CN1438011A CN1438011A (en) 2003-08-27
CN1221276C true CN1221276C (en) 2005-10-05

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN 03113001 Expired - Fee Related CN1221276C (en) 2003-03-19 2003-03-19 Compound Huangyangning (Chinese littleleaf box) small pills

Country Status (1)

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CN (1) CN1221276C (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1872074B (en) * 2005-06-01 2010-12-01 天津天士力制药股份有限公司 Compound drop pills of 'Huangtangning', and preparation method
CN102389434B (en) * 2011-09-28 2013-02-13 广州中医药大学 Medicinal composition for treating ischemic cerebrovascular disease, and preparation method thereof

Also Published As

Publication number Publication date
CN1438011A (en) 2003-08-27

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C56 Change in the name or address of the patentee

Owner name: NANJING XIAOYING MEDICINE GROUP CO.,LTD.

Free format text: FORMER NAME: NANJING XIAOYING PHARMACEUTICAL FACTORY

CP03 Change of name, title or address

Address after: No. 18, Shun Fa Road, Dongshan high tech Industrial Zone, Nanjing, Jiangsu, Jiangning

Patentee after: Nanjing Xiaoying Pharmaceutical Group Co. Ltd.

Address before: Nanjing City, Jiangsu province Longpan Road No. 29

Patentee before: Nanjing Xiaoying pharmaceutical factory

C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20051005

Termination date: 20120319