CN1733027A - Cold-treating oral liquid and preparation process thereof - Google Patents
Cold-treating oral liquid and preparation process thereof Download PDFInfo
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- CN1733027A CN1733027A CN 200510032087 CN200510032087A CN1733027A CN 1733027 A CN1733027 A CN 1733027A CN 200510032087 CN200510032087 CN 200510032087 CN 200510032087 A CN200510032087 A CN 200510032087A CN 1733027 A CN1733027 A CN 1733027A
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- radix
- grams
- pericarpium citri
- rhizoma zingiberis
- clear paste
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Abstract
The invention relates to a medicinal oral preparation, which is prepared from six kinds of Chinese medicinal herbs including Bupleurum root, ledebouriella root, dried orange peel, licorice root, root of herbaceous peony, ginger flake through specific process.
Description
One, technical field:
The present invention relates to a kind of is the oral liquid formulations that raw material is prepared from through special process with Radix Bupleuri, Radix Saposhnikoviae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, the Radix Paeoniae Alba, Rhizoma Zingiberis 6 flavor Chinese medicines.Specifically, oral liquid of the present invention is the oral drugs that are used to cure mainly diseases such as affection of exogenous wind-cold, fever with chills, headache, general pain.The extract that relates in particular to above-mentioned 6 flavor Chinese medicines is an active constituents of medicine, has the oral liquid of antiviral, bacteriostasis.
Two, background technology:
Zhengchaihuyin is the flat side of representative that looses of inducing sweat in the well-known doctor of the Ming Dynasty Zhang Jingyue Jing-Yue Complete Works, formed by Radix Bupleuri, Pericarpium Citri Reticulatae, Radix Saposhnikoviae, Radix Paeoniae Rubra, Radix Glycyrrhizae, function with dispersing wind-cold, antipyretic analgesic is mainly treated affection of exogenous wind-cold from the beginning of, fever with aversion to cold, lossless, headache, nasal obstruction, sneeze, itching throat is coughed and is gargled, symptoms such as painful limbs.Recording six in the Jing-Yue Complete Works and be named as the prescription of " Radix Bupleuri drink ", wherein the 6th just is called " Zhengchaihuyin ", and the reasonability of its prescription is well-known in abroad.The clinical practice in hundreds of years of this prescription process, its curative effect has obtained effective confirmation, finds no significant side effects.Zhengchaihuyin pair 10 kind virus, the especially influenza virus relevant with upper respiratory tract infection have significant broad-spectrum disease resistance toxic action.
That passes through relevant Zhengchaihuyin capsule studies have shown that Zhengchaihuyin is at the parainfluenza-1 of 4 mg/ml to the RNA type, RSV, ECHO
11, COXB
4, B
5, B
6Virus and ADV
3, HSV-I, II type all have good inhibition effect.
The Zhengchaihuyin pharmaceutical dosage form has two kinds of electuary and capsules in the market, and these two kinds of dosage forms all exist the molten diffusing time long after taking, and dissolution is low, assimilation effect is poor, take inconvenient shortcoming and defect, thereby influenced bioavailability of medicament, reduced therapeutic effect.
Three, summary of the invention:
The objective of the invention is to replenish the deficiency of the existing dosage form of Zhengchaihuyin, prepare a kind of oral drugs that are mainly used in diseases such as treatment affection of exogenous wind-cold, fever with chills, headache, general pain that do not have at present.Provide a kind of absorption more quick, bioavailability is higher, and produce effects is rapider, the pure Chinese medicine composition oral liquid that toxic and side effects is littler.
Technical scheme of the present invention is: a kind of cold-treating oral liquid is characterized in that: with Radix Bupleuri, Radix Saposhnikoviae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, the Radix Paeoniae Alba, Rhizoma Zingiberis 6 flavor Chinese medicines is raw material, adds purified water and correctives and is prepared from; Its composition by weight is:
Radix Bupleuri 3-5 part Radix Saposhnikoviae 1-3 part Pericarpium Citri Reticulatae 2-4 part
Radix Glycyrrhizae 1-3 part Radix Paeoniae Alba 3-5 part Rhizoma Zingiberis 1-3 part
Best component is:
3 parts of 2 parts of Pericarpium Citri Reticulataes of 4 parts of Radix Saposhnikoviaes of Radix Bupleuri
2 parts of 4 portions of Rhizoma Zingiberis of 2 portions of Radix Paeoniae Albas of Radix Glycyrrhizae
Preparation method of the present invention is:
A, that component takes by weighing Radix Bupleuri, Radix Saposhnikoviae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, the Radix Paeoniae Alba, Rhizoma Zingiberis 1-3 part by weight is standby;
B, with Radix Bupleuri, Radix Saposhnikoviae, Rhizoma Zingiberis water logging 30 minutes, decoct 2 times, each 2 hours, the 4-12 that the 1st amount of water is dose doubly, the 4-10 that the 2nd amount of water is dose doubly filters, merging filtrate, filtrate A is standby;
C, the medicinal residues after filtering in 2 are added Pericarpium Citri Reticulatae, the Radix Paeoniae Alba and Radix Glycyrrhizae, water logging 30 minutes decocts 2 times, and each 2 hours, filter, merging filtrate, must liquor B standby;
D, medicinal liquid A and B are merged, left standstill 24 hours, filter, filtrate is concentrated to the clear paste that relative density is 1.05～1.10 grams.Weigh clear paste weight C;
E, with clear paste weight C, add the purified water and an amount of correctives of 1～30 times of weight, make and contain clear paste 3～30% solution.Fill becomes 10 milliliters/bottle or 20 milliliters/bottle, promptly gets oral liquid of the present invention.
The present invention changes Zhengchaihuyin into oral liquid formulation, has avoided all deficiencies of electuary and capsule, makes drug absorption and utilize more directly conveniently, takes more conveniently, can satisfy the demand of extensive patients better.
Four, the specific embodiment:
Embodiment 1: Radix Bupleuri 400 grams, Radix Saposhnikoviae 200 grams, Pericarpium Citri Reticulatae 300 grams, Radix Glycyrrhizae 200 grams, the Radix Paeoniae Alba 400 grams, Rhizoma Zingiberis 200 grams, according to the extraction process in the content of the present invention, be prepared into 420 gram clear paste, add 13600 ml waters and make the solution that contains clear paste 3%, fill is 10 milliliters/bottle or 20 milliliters/bottle.
Embodiment 2: Radix Bupleuri 400 grams, Radix Saposhnikoviae 200 grams, Pericarpium Citri Reticulatae 300 grams, Radix Glycyrrhizae 200 grams, the Radix Paeoniae Alba 400 grams, Rhizoma Zingiberis 200 grams, according to the extraction process in the content of the present invention, be prepared into 420 gram clear paste, add 8000 ml waters and make the solution that contains clear paste 5%, fill is 10 milliliters/bottle or 20 milliliters/bottle.
Embodiment 3: Radix Bupleuri 400 grams, Radix Saposhnikoviae 200 grams, Pericarpium Citri Reticulatae 300 grams, Radix Glycyrrhizae 200 grams, the Radix Paeoniae Alba 400 grams, Rhizoma Zingiberis 200 grams, according to the extraction process in the content of the present invention, be prepared into 420 gram clear paste, add 3800 ml waters and make the solution that contains clear paste 10%, fill is 10 milliliters/bottle or 20 milliliters/bottle.
Embodiment 4: Radix Bupleuri 400 grams, Radix Saposhnikoviae 200 grams, Pericarpium Citri Reticulatae 300 grams, Radix Glycyrrhizae 200 grams, the Radix Paeoniae Alba 400 grams, Rhizoma Zingiberis 200 grams, according to the extraction process in the content of the present invention, be prepared into 420 gram clear paste, add 1700 ml waters and make the solution that contains clear paste 20%, fill is 10 milliliters/bottle or 20 milliliters/bottle.
Embodiment 5: Radix Bupleuri 400 grams, Radix Saposhnikoviae 200 grams, Pericarpium Citri Reticulatae 300 grams, Radix Glycyrrhizae 200 grams, the Radix Paeoniae Alba 400 grams, Rhizoma Zingiberis 200 grams, according to the extraction process in the content of the present invention, be prepared into 420 gram clear paste, add 1000 ml waters and make the solution that contains clear paste 30%, fill is 10 milliliters/bottle or 20 milliliters/bottle.
Embodiment 6, Radix Bupleuri 300 grams, Radix Saposhnikoviae 200 grams, Pericarpium Citri Reticulatae 300 grams, Radix Glycyrrhizae 200 grams, the Radix Paeoniae Alba 400 grams, Rhizoma Zingiberis 200 grams, according to the extraction process in the content of the present invention, be prepared into 400 gram clear paste, add 13000 ml waters and make the solution that contains clear paste 3%, fill is 10 milliliters/bottle or 20 milliliters/bottle.
Embodiment 7: Radix Bupleuri 300 grams, Radix Saposhnikoviae 200 grams, Pericarpium Citri Reticulatae 300 grams, Radix Glycyrrhizae 200 grams, the Radix Paeoniae Alba 400 grams, Rhizoma Zingiberis 200 grams, according to the extraction process in the content of the present invention, be prepared into 400 gram clear paste, add 7600 ml waters and make the solution that contains clear paste 5%, fill is 10 milliliters/bottle or 20 milliliters/bottle.
Embodiment 8: Radix Bupleuri 300 grams, Radix Saposhnikoviae 200 grams, Pericarpium Citri Reticulatae 300 grams, Radix Glycyrrhizae 200 grams, the Radix Paeoniae Alba 400 grams, Rhizoma Zingiberis 200 grams, according to the extraction process in the content of the present invention, be prepared into 400 gram clear paste, add 3600 ml waters and make the solution that contains clear paste 10%, fill is 10 milliliters/bottle or 20 milliliters/bottle.
Embodiment 9: Radix Bupleuri 300 grams, Radix Saposhnikoviae 200 grams, Pericarpium Citri Reticulatae 300 grams, Radix Glycyrrhizae 200 grams, the Radix Paeoniae Alba 400 grams, Rhizoma Zingiberis 200 grams, according to the extraction process in the content of the present invention, be prepared into 400 gram clear paste, add 1600 ml waters and make the solution that contains clear paste 20%, fill is 10 milliliters/bottle or 20 milliliters/bottle.
Claims (2)
1, a kind of cold-treating oral liquid is characterized in that: with Radix Bupleuri, Radix Saposhnikoviae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, the Radix Paeoniae Alba, Rhizoma Zingiberis 6 flavor Chinese medicines is raw material, adds purified water and correctives and is prepared from; Its composition by weight is:
Radix Bupleuri 3-5 part Radix Saposhnikoviae 1-3 part Pericarpium Citri Reticulatae 2-4 part
Radix Glycyrrhizae 1-3 part Radix Paeoniae Alba 3-5 part Rhizoma Zingiberis 1-3 part
Best component is:
3 parts of 2 parts of Pericarpium Citri Reticulataes of 4 parts of Radix Saposhnikoviaes of Radix Bupleuri
2 parts of 4 portions of Rhizoma Zingiberis of 2 portions of Radix Paeoniae Albas of Radix Glycyrrhizae.
2, the preparation method of cold-treating oral liquid according to claim 1 is characterized in that:
A, that component takes by weighing Radix Bupleuri, Radix Saposhnikoviae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, the Radix Paeoniae Alba, Rhizoma Zingiberis 1-3 part by weight is standby;
B, with Radix Bupleuri, Radix Saposhnikoviae, Rhizoma Zingiberis water logging 30 minutes, decoct 2 times, each 2 hours, the 4-12 that the 1st amount of water is dose doubly, the 4-10 that the 2nd amount of water is dose doubly filters, merging filtrate, filtrate A is standby;
C, the medicinal residues after filtering in 2 are added Pericarpium Citri Reticulatae, the Radix Paeoniae Alba and Radix Glycyrrhizae, water logging 30 minutes decocts 2 times, and each 2 hours, filter, merging filtrate, must liquor B standby;
D, medicinal liquid A and B are merged, left standstill 24 hours, filter, filtrate is concentrated to the clear paste that relative density is 1.05～1.10 grams.Weigh clear paste weight C;
E, with clear paste weight C, add the purified water and an amount of correctives of 1～30 times of weight, make and contain clear paste 3～30% solution.Fill becomes 10 milliliters/bottle or 20 milliliters/bottle, promptly gets oral liquid of the present invention.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510032087 CN1733027A (en) | 2005-08-30 | 2005-08-30 | Cold-treating oral liquid and preparation process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510032087 CN1733027A (en) | 2005-08-30 | 2005-08-30 | Cold-treating oral liquid and preparation process thereof |
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| CN1733027A true CN1733027A (en) | 2006-02-15 |
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|---|---|---|---|
| CN 200510032087 Pending CN1733027A (en) | 2005-08-30 | 2005-08-30 | Cold-treating oral liquid and preparation process thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113101357A (en) * | 2021-04-16 | 2021-07-13 | 包月群 | Medicine for preventing influenza and preparation method thereof |
-
2005
- 2005-08-30 CN CN 200510032087 patent/CN1733027A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113101357A (en) * | 2021-04-16 | 2021-07-13 | 包月群 | Medicine for preventing influenza and preparation method thereof |
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