CN1221268C - Magnesium-calcium ion composite preparation and production precess thereof - Google Patents
Magnesium-calcium ion composite preparation and production precess thereof Download PDFInfo
- Publication number
- CN1221268C CN1221268C CN 02130855 CN02130855A CN1221268C CN 1221268 C CN1221268 C CN 1221268C CN 02130855 CN02130855 CN 02130855 CN 02130855 A CN02130855 A CN 02130855A CN 1221268 C CN1221268 C CN 1221268C
- Authority
- CN
- China
- Prior art keywords
- magnesium
- calcium
- calcium ion
- acetate
- gram
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The present invention relates to a magnesium-calcium ion composite preparation and a producing technology thereof, which is characterized in that acetic acid glacial is used by the present invention so as to chemically react with magnesium oxide and calcium carbonate respectively, magnesium acetate solution and calcium acetate solution are generated, and a proper amount of lactose and other auxiliary raw materials are added after the magnesium acetate solution and the calcium acetate solution are mixed so that the magnesium-calcium ion composite preparation is produced. Each 10 milliliters of mixed solution contains 70 milligrams of magnesium ions and 200 milligrams of calcium ions, and the content ratio of the magnesium ions to the calcium ions is 1: 2 to 4.The products are mainly used for specific nutrient replenishers, and are applicable to people who lack magnesium and calcium and are mainly patients with cardiovascular system disease and patients with osteoporosis. The present invention can be used for the prevention and the auxiliary treatment of diseases of the kinds.
Description
Technical field
Dietary supplement-magnesium calcium ion compound formulation and the production technology thereof that the present invention relates to a kind of magnesium calcium macroelement of additional needed by human body and develop.
Background technology
Mineral is relevant with bodily tissue, and is also relevant with the function of various systems, as the formation of blood and skeleton, and neural function, the adjusting of muscle.Mineral can be used as the metabolism that coenzyme participates in material, the production of energy, the utilization of vitamin and other nutrient.Human body must be kept normal chemical equilibrium, and this balance will rely on the ratio of mineral in the body.If a kind of mineral is out of proportion, produce chain reaction just can influence all mineral, so that the chemical reaction disequilibrium, and cause disease.At present, in developed country mineral and vitamin are lumped together and to make tablet, as health food or meals tonic.General mineral is to form with the form of chelating with protein, mineral is absorbed easily and transports in blood.Take mineral in the time of on the feed, the digestion process mineral forms chelate under one's belt and is absorbed.The dose of mineral can not be excessive, and when its major reason was absorption, they were vied each other, if a certain mineral is too much, just can squeeze out other mineral other mineral are lacked.Calcium is one of more element of human body appetite, content in human body is only second to hydrogen, oxygen, carbon, nitrogen and occupy the 5th, and calcium is about 1300g in the total amount of human body, the 1.5-0.75% of about percentage of liveweight, wherein 99% calcium is present in skeleton, and skeleton is the mainstay of human body.Though the calcium outside the skeleton only accounts for 1%, it plays an important role in vivo, and calcium is present in the outer liquid of thin bag, soft tissue, and be one of composition of cell membrane.Calcium participates in coagulation process, to the contraction of muscle, comprises the normal effect and nervimuscular stress the playing an important role of cardiac muscle.If ionized calcium obviously descends in blood plasma, then nervimuscular irritability will increase greatly, so that tetany.On the contrary, if calcium ion is too high in blood, then can cause the depletion of heart and breathing.Magnesium is all relevant to the performance of the many functions of human body, and magnesium is being brought into play extremely delicate effect aspect the balance of keeping the health holistic health.The effect of magnesium maximum is that the calcium of circulation in the pair cell is regulated.This just delicate coordination is determining the frequency of human body cell flame.Magnesium and calcium have been formed special fellowship in the process of production adenosine triphosphate (ATP).The ATP enzyme is that we are engaged in any active power producer, and it is deposited with living cells inside, and magnesium is being guarded these cell gates, and calcium could produce enough ATP inside only entering.Magnesium all plays activation to 300 plurality of enzymes in the human body, and all protein building-up process of human body all need magnesium to participate in.The hydrolysis of nucleic acid absorbs and utilizes process that the participation of magnesium must be arranged.Magnesium not only influences the glucose conversion in the blood, also influences fat and energy metabolism.Now calcium carbonate and magnesium oxide directly are pressed into tablet respectively, the perhaps synthetic tablet that is pressed into is very general abroad.Because calcium magnesium is Yanggao County's of bivalence, need to rely on the gastric acid dissolving after taking, 100 milligrams calcium carbonate dissolves fully needs 230 milliliters gastric acid, and as if every day is overweight less than 1000 milliliters gastric acid burden concerning the old people.If calcium, magnesium are taken respectively, also exist the not wield problem of dose ratio, the competition each other of calcium, magnesium ion absorbs, and dried scratching influenced absorbance mutually.
Summary of the invention
Purpose of the present invention is exactly to develop a kind of best concentration ratio that absorbs by the human intestines and stomach, with magnesium calcium ion compound formulation and the production technology thereof of liquid as calcium, magnesium ion carrier.
Magnesium calcium ion compound formulation production technology scheme of the present invention is as follows:
Need use the burdening calculation materials by the magnesium calcium compound formulation of producing 1000 milliliters, need:
Glacial acetic acid 124-138 milliliter
Calcium carbonate 51-57 gram
Magnesium oxide 11-12 gram
Lactose 9.5-10.5 gram
Stevioside 6-7 gram
All the other are deionized water
Production technology:
Carry out chemical reaction with magnesium oxide and calcium carbonate respectively with acetic acid, generate magnesium acetate solution and calcium acetate solution, calcium acetate solution and magnesium acetate solution are mixed, form mixed liquor.In solution, add an amount of lactose and other auxiliary material.Make solution reach the concentration of regulation: in per 10 milliliters of mixed liquors, to contain 70 milligrams of magnesium ions, 200 milligrams of calcium ions.
The effect that adds glacial acetic acid in the production is to form calcium acetate solution with the acetate dissolution calcium carbonate, acetic acid and magnesium oxide reaction generate magnesium acetate solution, in magnesium acetate and calcium acetate solution, magnesium, calcium are the divalent ionic state and exist, and that is to say that the state that is after gastric acid dissolves exists.Old people's gastric acid secretion and pepsin are synthetic to be reduced, can not fully dissolve absorption to magnesium, calcium, and this product element all is the liquid ions state, is easily directly absorbed by intestinal, acetate is not only to the effect of human body that to be beneficial to several amino acids synthetic, can also strengthen microcirculation by blood vessel dilating.This product adds a certain amount of lactose, promotes the absorption of calcium, magnesium with lactose.Lactose only exists in milk, is that parent is supplied with the most important nutrient substance of baby.After lactose enters human body, be decomposed into galactose rapidly, form tilactase, galactose permease etc. not only promote the absorption of magnesium, can also strengthen the activation of magnesium to enzyme.The concentration ratio of this product magnesium and calcium ion more meets Chinese diet and physiological feature.Medical research finds that magnesium, calcium ion concentration ratio are in the intestinal at 1: 2 o'clock, and absorbance is higher.The magnesium calcium preparation of external import, the magnesium calcium content is than designing by 1: 2 usually.But, Chinese's calcium in diet content is on the low side, majority take the calcium magnesium preparation of import, calcium, magnesium density ratio can not reach 1: 2 state, this product has increased the content of calcium, make magnesium, calcium concentration ratio reach 1: 2-4, after majority took, the magnesium in the intestinal, calcium concentration were than more near 1: 2 state.This product has solved senior health and fitness's principal contradiction, cardiovascular and cerebrovascular disease, diabetes and osteoporosis.Per 10 milliliters this product oral liquid, 200 milligrams of calcium ions, be equivalent to 500 milligrams of calcium carbonate, really (sugar) sour calcium is 1532 milligrams, 2237 milligrams of calcium gluconate, 2853 milligrams of calcium citrates, be the specific nutrient supplement of magnesium supplement and calcium, being applicable to magnesium calcium deficiency crowd, mainly is cardiovascular system diseases and osteoporosis patient, can be used for the prevention and the auxiliary treatment of this type of disease.
Description of drawings
Process chart of the present invention
The specific embodiment
Embodiment 1
Get 64 milliliters of glacial acetic acid, it is diluted to the glacial acetic acid of 10% concentration, drop into then in the reactor, be warming up to 50 ℃, get 54 gram Paris whites, slowly add and stirs and continue to be warming up to 75 ℃, constant temperature continued to react in 35 minutes.Other gets 67 milliliters glacial acetic acid, and it is diluted to the glacial acetic acid of 10% concentration, drops in the reactor, is warming up to 50 ℃, gets 11.5 gram magnesium oxide, slowly adds reactor and stirring, continues to be warming up to 70 ℃, and constant temperature continued reaction in 25 minutes.Above-mentioned two kinds of reaction product calcium acetate solutions and magnesium acetate solution are put into same container mix, in mixed solution, add the stevioside of 6.5 grams, 10 gram lactose.To prepare liquid and be warming up to 90 ℃, and constant temperature to 45 minute, make it fully finish reaction.Naturally cool to room temperature.Solution is filtered with filter.Deionized water is added through filtering preparation liquid, to 1000 milliliters of amount of preparation.Be sub-packed in the vial 100 ℃ of sterilizations of flowing steam 30 minutes then.The product that obtains, magnesium, calcium ion concentration ratio are 1: 2.86.
Embodiment 2
Get 61 milliliters and 63 milliliters of glacial acetic acid respectively, after it is diluted to the glacial acetic acid solution of 10% concentration, get calcium carbonate 51 grams, magnesium oxide 11 grams, with the technology identical with embodiment 1, make the mixed solution of calcium acetate and magnesium acetate, add the stevioside of 6 grams and the lactose of 9.5 grams, use the technology identical to obtain product of the present invention then with embodiment 1.The product magnesium that obtains is 1: 2.4 with the calcium ion concentration ratio.
Embodiment 3
Get 67 milliliters and 71 milliliters of glacial acetic acid respectively, it is diluted to the glacial acetic acid solution of 10% concentration, get calcium carbonate 57 grams, magnesium oxide 12 grams, with the technology identical with embodiment 1, make the mixed solution of calcium acetate and magnesium acetate, add the stevioside of 7 grams and the lactose of 10.5 grams, use the technology identical to obtain product of the present invention then with embodiment 1.The product magnesium that obtains is 1: 4 with the calcium ion concentration ratio.
Claims (2)
1, a kind of production technology of magnesium calcium ion compound formulation, it is characterized in that: glacial acetic acid is diluted to 10% concentration, is warming up to 50 ℃ and carries out chemical reaction with magnesium oxide and calcium carbonate respectively, generate magnesium acetate and calcium acetate solution, after reaction temperature rises to 70-75 ℃, continue reaction 25-35 minute; With magnesium acetate and calcium acetate solution mixing formation mixed liquor, in solution, add an amount of lactose and stevioside, mixed liquor to be heated to 90 ℃, constant temperature 45 minutes is cooled to room temperature; Filter mixed liquor; Add deionized water to formula ratio; Be sub-packed in the vial 100 ℃ of flowing steams, sterilization in 30 minutes; Its prescription is as follows: be as the criterion to produce 1000 milliliters of magnesium calcium ion compound formulations
Glacial acetic acid 124-138 milliliter
Calcium carbonate 51-57 gram
Magnesium oxide 11-12 gram
Lactose 9.5-10.5 gram
Stevioside 6-7 gram
All the other are deionized water.
2, a kind of magnesium calcium ion compound formulation of producing with claim 1 magnesium calcium ion compound formulation production technology, it is characterized in that: it is the mixed solution of magnesium acetate, calcium acetate, lactose and stevioside, its magnesium, calcium ion concentration ratio are 1: 2-4.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02130855 CN1221268C (en) | 2002-10-11 | 2002-10-11 | Magnesium-calcium ion composite preparation and production precess thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02130855 CN1221268C (en) | 2002-10-11 | 2002-10-11 | Magnesium-calcium ion composite preparation and production precess thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1488359A CN1488359A (en) | 2004-04-14 |
| CN1221268C true CN1221268C (en) | 2005-10-05 |
Family
ID=34144651
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02130855 Expired - Fee Related CN1221268C (en) | 2002-10-11 | 2002-10-11 | Magnesium-calcium ion composite preparation and production precess thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1221268C (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1732811B (en) * | 2005-08-10 | 2010-12-22 | 刘志仁 | Biochemical fresh-keeping nutritious liquid |
| EP2257300B1 (en) | 2008-01-28 | 2014-08-27 | Beauty Pearl Group Limited | Formulas comprising calcium, magnesium, zinc, and vitamin d3 for the prevention and amelioration of osteoporosis |
| CN105078950A (en) * | 2015-08-03 | 2015-11-25 | 兰为民 | Composite preparation containing zinc, magnesium and calcium ions and preparing method of composite preparation |
| CN105125579A (en) * | 2015-09-10 | 2015-12-09 | 重庆布尔动物药业有限公司 | Calcium, magnesium and vitamin injection |
| EP3439062B1 (en) * | 2016-05-27 | 2021-09-08 | LG Chem, Ltd. | Organic light emitting element |
| CN106380388A (en) * | 2016-08-24 | 2017-02-08 | 华仁药业股份有限公司 | A method of preparing medicinal magnesium acetate tetrahydrate |
-
2002
- 2002-10-11 CN CN 02130855 patent/CN1221268C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1488359A (en) | 2004-04-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Riesenfeld et al. | Glucose homeostasis in the chicken | |
| CN109007800A (en) | A kind of specific full nutritional formulas and preparation method thereof for diabetic | |
| CN1221268C (en) | Magnesium-calcium ion composite preparation and production precess thereof | |
| JP2002034592A (en) | Method for producing protein-zinc readily absorbable in body | |
| AU2016311131B2 (en) | Mineral compositions for stimulating the carbohydrate metabolism | |
| WO2023005911A1 (en) | Nucleotide composition for adjuvant treatment of diabetes, preparation method therefor, and use thereof | |
| CN101513225A (en) | Composite calcium preparation added with organic germanium and preparation method and use thereof | |
| CN103735556A (en) | Multivitamin mineral composite effervescent tablet and preparation method thereof | |
| Elia | Principles of Clinical Nutrition: Contrasting the practice of nutrition in health and disease | |
| CN107441117A (en) | A kind of Muhivitamin Formula With Minerals calcium preparation and preparation method thereof | |
| CN102948733B (en) | Production method and formula of special-eating life nutrition liquid | |
| CN1252231A (en) | Hemoglobin food series and its production process | |
| CN101129406A (en) | Formula of compound colla carapaeis corii asini series products and method for producing the same | |
| CN107412261A (en) | With clear sugared oral liquid for repairing metabolic function and preparation method thereof | |
| CN100515429C (en) | Medicinal preparation for supplementing calcium magnesium | |
| CN107233432A (en) | It is a kind of that pharmaceutical composition, preparation of liver function and preparation method thereof are protected with reducing pressure and sugar | |
| CN110122866A (en) | A kind of the special medicine purposes food and preparation method of chronic kidney disease angiosteosis | |
| CN101117316A (en) | Oral liquid for preventing and remitting diabetes | |
| CN1225920A (en) | Method for preparing amino acid-magnesium chelate and use thereof | |
| CN107595829B (en) | A kind of composition for preventing and treating renal osteodystrophy | |
| CN101134027A (en) | Oral liquid for preventing and relieving cardiovascular and cerebrovascular diseases | |
| CN107279620A (en) | A kind of electrolyte beverage composition and preparation method thereof | |
| CN1130999A (en) | VC calcium-enriching drink and production method thereof | |
| CN101258935A (en) | Health-care spirulina food | |
| Carter et al. | Nutrition and Clinical Dietetics |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |