CN106380388A - A method of preparing medicinal magnesium acetate tetrahydrate - Google Patents
A method of preparing medicinal magnesium acetate tetrahydrate Download PDFInfo
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- CN106380388A CN106380388A CN201610709833.4A CN201610709833A CN106380388A CN 106380388 A CN106380388 A CN 106380388A CN 201610709833 A CN201610709833 A CN 201610709833A CN 106380388 A CN106380388 A CN 106380388A
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
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- C—CHEMISTRY; METALLURGY
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
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Abstract
A method of preparing medicinal magnesium acetate tetrahydrate is disclosed and belongs to the technical field of chemical bulk drug synthesis. The method includes steps of 1) weighing analytically pure magnesium hydroxide and analytically pure glacial acetic acid, adding water, heating to 75-80 DEG C, and cooling to 35 DEG C or below after the reaction is finished, 2) adjusting the pH value to 7.7-9.0 by adopting the magnesium hydroxide, filtering, and adjusting the pH value of the filtrate to 4.8-5.7 by adopting the glacial acetic acid to obtain a solution, 3) performing vacuum concentration until the density of the concentrate is 1.250-1.310, and crystallizing under stirring, 4) filtering and washing and 5) performing air blast drying to obtain a finished product. Through strictly controlling the pH value of the reaction solution, the pH value of the filtrate and the density before crystallization, the prepared magnesium acetate tetrahydrate reaches magnesium acetate tetrahydrate quality standards in the European Pharmacopoeia, and a prepared product is stable in quality and convenient to store and meets quality requirements on the magnesium acetate tetrahydrate of the medicinal grade.
Description
Technical field
The invention belongs to the technical field of medicinal chemicals synthesis, particularly relate to a kind of side preparing medicinal four water acetic acid magnesium
Method.
Background technology
Magnesium acetate is a kind of industrial chemicals, as chemical reagent, the raw material of pharmaceuticals, organic catalyst compound.In medicine
Field, magnesium acetate is used for some injections, such as children electrolyte injection K1, children electrolyte injection K2 as electrolyte
Deng all containing magnesium acetate in its prescription；Therefore, this is accomplished by the magnesium acetate raw material of highly purified crude drug rank.
Currently, prepare magnesium acetate method mainly have several as follows：（1）Magnesium nitrate and acetic acid are directly total to thermal response and vinegar are obtained
Sour magnesium, this method course of reaction generates with nitric acid, is not readily separated, and produces corrosion, is not suitable for the other production of pharmaceutical grade；（2）Carbon
Sour magnesium and acetic acid reaction can be obtained magnesium acetate, release great amount of carbon dioxide bubble in this method course of reaction, and, product may be residual
Deposit magnesium carbonate；（3）Magnesium oxide and acetic acid reaction prepare magnesium acetate, and the essence of this method is magnesium oxide elder generation and water generating magnesium hydroxide,
Again with acetic acid reaction, course of reaction bubble-free is released, and byproduct of reaction is water, more no other by-products generate.
The above-mentioned method preparing magnesium acetate hardly results in the magnesium acetate of pharmaceutical grade, and its quality standard does not meet European Pharmacopoeia mark
Accurate（EUROPEAN PHARMACOPOEIA 8.0 P2668）, be mainly shown as that aluminium composition is exceeded, product pH value is not up to standard,
Moisture is up to standard etc., when aluminium ion causes to accumulate in vivo, can lead to chronic poisoning, if as children's electricity in injection
Solution matter K1 or K2, are directly entered blood, increased the infringement to human body.
Content of the invention
The present invention provides a kind of method preparing medicinal four water acetic acid magnesium, solves four water acetic acid magnesium of the prior art
The problem that preparation method products obtained therefrom does not meet quality criteria requirements and cannot be carried out using.
A kind of method preparing medicinal four water acetic acid magnesium of the present invention, it is mainly realized by the following technical programs
's：Comprise the following steps：1）Take analytically pure magnesium hydroxide and analytically pure glacial acetic acid, add appropriate water, be heated to 75-80
DEG C, fully reacted, after completion of the reaction, be cooled to less than 35 DEG C, obtain reactant liquor；2）Using magnesium hydroxide regulating step 1）Institute
Reactant liquor pH value so as to pH value is 7.7-9.0, filter, then, the pH value of filtrate adjusted so as to pH value using glacial acetic acid
For 4.8-5.7, obtain solution；3）By step 2）Resulting solution carries out concentrating under reduced pressure, and measures the density of concentrated solution, when concentrated solution
When density is 1.250-1.310, stops concentrating under reduced pressure, concentrated solution stirring and crystallizing obtains crystallized product；4）To step 3）Gained is tied
Brilliant product is filtered, and washs filter cake, obtains head product；5）By step 4）Gained head product carries out forced air drying, obtains finished product.
The present invention prepares magnesium acetate using analytically pure magnesium hydroxide and analytically pure glacial acetic acid as raw material, by strict
Control density before pH value, the pH value of filtrate and the crystallize of reactant liquor, so that the indices of four water acetic acid magnesium of preparation is all reached
Requirement to four water acetic acid magnesium quality standards in European Pharmacopoeia, meets the prescription of medical rank four water acetic acid magnesium；The present invention
Products obtained therefrom steady quality, storage is convenient, during depositing, maintains good stability.
As a kind of preferred embodiment, described step 4）In, using dehydrated alcohol, filter cake is washed, described step
Rapid 5）In, baking temperature is 45-55 DEG C, and drying time is 2-4h.Filter cake is fully washed, in washing process, is typically adopted
With the more commonly used ethanol, certainly, other alcohols can also use, such as isopropanol；When being washed using other alcohol, need suitable
When adjusting baking temperature.
As a kind of preferred embodiment, described step 5）In, baking temperature is 50 DEG C, and drying time is 3h.Air blast
Drying is carried out in air dry oven, by controlling baking temperature and drying time, thus further improving product
Quality.
As a kind of preferred embodiment, described step 1）In, magnesium hydroxide is 1 with the mol ratio of glacial acetic acid：2.1,
Response time is 0.5-1.5h, is cooled to 10-25 DEG C after completion of the reaction.By strict control magnesium hydroxide and glacial acetic acid mole
Than, it is to avoid the waste of raw material, improves reaction efficiency and the economic benefit producing；The present invention can also be controlled anti-by the response time
Whether should carry out completely, and control the temperature after cooling further, make processing ease, it is convenient to judge, improves conventional efficient.
As a kind of preferred embodiment, described step 2）In, using magnesium hydroxide adjust reactant liquor pH value to
8.1-8.4, then, adjusts the pH value of filtrate to 5.1-5.4 using glacial acetic acid.Control the pH value of reactant liquor further to 8.1-
8.4, so that the impurity such as the aluminium ion in reactant liquor is fully precipitated；Meanwhile, control the pH value of filtrate to 5.1-5.4 further, filling
The quality of product is further lifted while demonstrate,proving the quality of product by code insurance.
As a kind of preferred embodiment, described step 3）In, when the density of concentrated solution is 1.275-1.290, stop
Only concentrating under reduced pressure.Control the density of concentrated solution further, to improve the yield of product it is important that strictly controlling each in product
The content of item impurity, to improve the quality of product.
As a kind of preferred embodiment, described step 3）In, temperature during concentrating under reduced pressure is 80-85 DEG C.Decompression is dense
During contracting, reduced pressure using conventional water pump, the temperature control of water is at 80-85 DEG C it is ensured that can steam water, it is to avoid temperature mistake
The harm of high multi-product.
As a kind of preferred embodiment, described step 3）In, concentrated solution is stirred crystallize at room temperature.Concentrated solution
Crystallized at room temperature, advantageously reduced energy consumption, cost-effective.
As a kind of preferred embodiment, acetic acid is added to be stirred crystallize in described concentrated solution, the crystallize time is 5-
7h.Add a small amount of acetic acid, the crystallization rate of concentrated solution can be improved, reduce experimental cost.
The invention has the beneficial effects as follows：The present invention adopts analytically pure magnesium hydroxide and analytically pure glacial acetic acid as raw material
Prepare magnesium acetate, by dry in density, and dry run before the strict pH value controlling reactant liquor, the pH value of filtrate and crystallize
Dry temperature and drying time, the indices of four water acetic acid magnesium of preparation are made all to have reached magnesia to four water acetic acids in European Pharmacopoeia
The requirement of amount standard, meets the prescription of medical rank four water acetic acid magnesium；Products obtained therefrom steady quality of the present invention, storage side
Just, during depositing, maintain good stability；The preparation method of the present invention is simple, and technological process is short, and energy consumption is low, section
About cost, it is easy to accomplish industrialization.
Specific embodiment
Specific embodiment below in conjunction with the present invention is clearly and completely described to technical scheme, shows
So, described embodiment is only a part of embodiment of the present invention, rather than whole embodiments.Based in the present invention
Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under the premise of not making creative work, all
Belong to the scope of protection of the invention.
A kind of method preparing medicinal four water acetic acid magnesium of the present invention, comprises the following steps：1）Take analytically pure hydroxide
Magnesium and analytically pure glacial acetic acid, add appropriate water, are heated to 75-80 DEG C, are fully reacted, after completion of the reaction, be cooled to
Less than 35 DEG C, obtain reactant liquor；2）Using magnesium hydroxide regulating step 1）The pH value of gained reactant liquor so as to pH value is 7.7-9.0,
Filter, then, the pH value of filtrate is adjusted so as to pH value is 4.8-5.7 using glacial acetic acid, obtains solution；3）By step 2）Gained is molten
Liquid carries out concentrating under reduced pressure, and measures the density of concentrated solution, when the density of concentrated solution is 1.250-1.310, stops concentrating under reduced pressure,
By concentrated solution stirring and crystallizing, obtain crystallized product；4）To step 3）Gained crystallized product is filtered, and washs filter cake, obtains head product；
5）By step 4）Gained head product carries out forced air drying, obtains finished product.
Preferably, described step 4）In, using dehydrated alcohol, filter cake is washed, described step 5）In, baking temperature
For 45-55 DEG C, drying time is 2-4h.
Specifically, described step 5）In, baking temperature is 50 DEG C, and drying time is 3h.
It is highly preferred that described step 1）In, magnesium hydroxide is 1 with the mol ratio of glacial acetic acid：2.1, the response time is 0.5-
1.5h, is cooled to 10-25 DEG C after completion of the reaction.
Further, described step 2）In, the pH value of reactant liquor is adjusted to 8.1-8.4 using magnesium hydroxide, then, adopts
Glacial acetic acid adjusts the pH value of filtrate to 5.1-5.4.
Yet further, described step 3）In, when the density of concentrated solution is 1.275-1.290, stop concentrating under reduced pressure.
Further, described step 3）In, temperature during concentrating under reduced pressure is 80-85 DEG C.
It is further preferred that described step 3）In, concentrated solution is stirred crystallize at room temperature.
More specifically, described concentrated solution adds acetic acid to be stirred crystallize, the crystallize time is 5-7h.
Embodiment one
In reaction bulb, add glacial acetic acid 216.2g（2.1 molar equivalent）, water 800mL, starts mechanical agitation, adds hydroxide
Magnesium 100g（1 molar equivalent）, then, it is heated to 75 DEG C of reaction 1h, reactant liquor is cooled to room temperature；Solution is adjusted using magnesium hydroxide
PH value to 7.70, filter, adjust the pH to 5.22 of filtrate using glacial acetic acid；This solution carries out concentrating under reduced pressure, detects concentrated solution
Density, when density reaches 1.283, stop concentrating, concentrated solution is stirred at room temperature crystallize；After crystallize about 6h, filter, filter cake is adopted
Washed with dehydrated alcohol 100mL；Finally, it is placed in 50 DEG C of forced air drying 3h in air dry oven, obtain finished product.
Embodiment two
In reaction bulb, add glacial acetic acid 216.2g（2.1 molar equivalent）, water 800mL, starts mechanical agitation, adds hydroxide
Magnesium 100g（1 molar equivalent）, then, it is heated to 80 DEG C of reaction 0.5h, reactant liquor is cooled to less than 35 DEG C；Adjusted using magnesium hydroxide
The pH value of section solution, to 8.31, filters, and adjusts the pH to 5.21 of filtrate using glacial acetic acid；This solution carries out concentrating under reduced pressure, detection
The density of concentrated solution, when density reaches 1.284, stops concentrating, stirring and crystallizing under concentrated solution room temperature；After crystallize 5h, filter, filter cake
Washed with dehydrated alcohol 100mL；Finally, it is placed in 50 DEG C of forced air drying 4h in air dry oven, obtain finished product.
Embodiment three
In reaction bulb, add glacial acetic acid 216.2g（2.1 molar equivalent）, water 800mL, starts mechanical agitation, adds hydroxide
Magnesium 100g（1 molar equivalent）, then, it is heated to 78 DEG C, reacts 1.5h, reactant liquor is cooled to 25 DEG C；Adjusted using magnesium hydroxide
The pH value of solution, to 9.0, filters, and adjusts the pH to 5.22 of filtrate using glacial acetic acid；This solution carries out concentrating under reduced pressure, concentrating under reduced pressure
When temperature be 80 DEG C, the density of detection concentrated solution, when density reaches 1.281, stop concentrating, concentrated solution stirs analysis at room temperature
Brilliant；After crystallize 7h, filter, filter cake is washed with dehydrated alcohol 100mL；Finally, it is placed in 55 DEG C of forced air drying 2h in air dry oven,
Obtain finished product.
Example IV
In reaction bulb, add glacial acetic acid 216.2g（2.1 molar equivalent）, water 800mL, starts mechanical agitation, adds hydroxide
Magnesium 100g（1 molar equivalent）, then, it is heated to 80 DEG C, reacts 1h, reactant liquor is cooled to 10 DEG C；Adjusted molten using magnesium hydroxide
The pH value of liquid, to 8.27, filters, and adjusts the pH to 4.80 of filtrate using glacial acetic acid；This solution carries out concentrating under reduced pressure, and detection concentrates
The density of liquid, when density reaches 1.285, stops concentrating, concentrated solution is stirred at room temperature crystallize；After crystallize about 6h, filter, filter cake
Washed with dehydrated alcohol 100mL；Finally, it is placed in 45 DEG C of forced air drying 4h in air dry oven, obtain finished product.
Embodiment five
In reaction bulb, add glacial acetic acid 216.2g（2.1 molar equivalent）, water 800mL, starts mechanical agitation, adds hydroxide
Magnesium 100g（1 molar equivalent）, then, it is heated to 75 DEG C, reacts 1h, reactant liquor is cooled to room temperature；Adjusted molten using magnesium hydroxide
The pH value of liquid, to 8.24, filters, and adjusts the pH to 5.70 of filtrate using glacial acetic acid；This solution carries out concentrating under reduced pressure, and detection concentrates
The density of liquid, density reaches and stops when 1.283 concentrating, stirring and crystallizing under concentrated solution room temperature；After crystallize about 6h, filter, filter cake is used
Dehydrated alcohol 100mL washs；Finally, it is placed in air dry oven, 50 DEG C of forced air drying 3h, obtain finished product.
Embodiment six
In reaction bulb, add glacial acetic acid 216.2g（2.1 equivalent）, water 800mL, starts mechanical agitation, adds magnesium hydroxide
100g（1 molar equivalent）, then, it is heated to 80 DEG C, reacts 1.2h, reactant liquor is cooled to room temperature；Adjusted molten using magnesium hydroxide
The pH value of liquid, to 8.30, filters, and adjusts the pH to 5.20 of filtrate using glacial acetic acid；This solution carries out concentrating under reduced pressure, concentrating under reduced pressure
When temperature be 85 DEG C, detection concentrated solution density, when density reaches 1.250, stop concentrate, under concentrated solution room temperature stirring analysis
Brilliant；After crystallize about 5h, filter, filter cake is washed with dehydrated alcohol 100mL；Finally, it is placed in air dry oven, 50 DEG C of forced air dryings
3h, obtains finished product.
Embodiment seven
In reaction bulb, add glacial acetic acid 216.2g（2.1 equivalent）, water 800mL, starts mechanical agitation, adds magnesium hydroxide
100g（1 molar equivalent）, then, it is heated to 80 DEG C, reacts 0.8h, reactant liquor is cooled to room temperature；Adjusted molten using magnesium hydroxide
The pH value of liquid, to 8.20, filters, and adjusts the pH to 5.24 of filtrate using glacial acetic acid；This solution carries out concentrating under reduced pressure, and detection concentrates
The density of liquid, when density reaches 1.310, stops concentrating, concentrated solution adds a small amount of acetic acid stirring and crystallizing at room temperature；Crystallize about 6h
Afterwards, filter, filter cake is washed with dehydrated alcohol 100mL；Finally, it is placed in air dry oven, 50 DEG C of forced air drying 3h, obtain finished product.
By institute in the embodiment of the present invention one to the total amount implementing seven products obtained therefroms and yield measurement result collect statistics such as table 1
Show, Example one is to implementing seven products obtained therefroms and head office of commercially available Chinese Medicine group（Abbreviation Chinese medicines group）Analysis pure four
Water acetic acid magnesium（Abbreviation control sample）Requirement according to related detection method carries out quality analysiss to it, testing result such as table 2 institute
Show.
By Tables 1 and 2 as can be seen that the present invention is using analytically pure magnesium hydroxide and analytically pure glacial acetic acid as raw material system
Four standby water acetic acid magnesium, its product has good purity, and in product, the content of four water acetic acid magnesium reaches 99.8-100.1%；Product
Yield all more than 40%, maximum yield reaches 55.1%；Solvent due to crystallization is water, and dissolubility in water for the magnesium acetate compares
Greatly, therefore, the yield of recrystallization products obtained therefrom all will not be too high.The pH value of product, all between 7.64-8.44, meets European medicine
Allusion quotation standard；And the pH value of control sample is 9.23 hence it is evident that the maximum of the pH value specifying beyond European Pharmacopoeia standard.Gained of the present invention
The chloride ion content of product, nitrate anion and sulfate radical content are respectively smaller than 300ppm, 3ppm and 600ppm, and this also all meets Europe
Standards of pharmacopoeia.The aluminium composition of products obtained therefrom of the present invention is less than or equal to 1ppm, meets European Pharmacopoeia standard；And in control sample
Aluminium composition is then more than 1ppm hence it is evident that regulation beyond European Pharmacopoeia standard.The calcium ion of products obtained therefrom of the present invention, sodium from
Son, heavy metal and moisture also all meet European Pharmacopoeia standard.And, the potassium content of products obtained therefrom of the present invention exists
Between 11.1-30.4ppm, this also comply with European Pharmacopoeia standard regulation less than 0.1%；And potassium content reaches in control sample
1214ppm, this is equivalent to 1.214%, its obvious regulation beyond European Pharmacopoeia standard.
Therefore, the four water acetic acid magnesium that the present invention is prepared using analytically pure magnesium hydroxide and analytically pure glacial acetic acid as raw material
All quality index of product all meet the regulation of European Pharmacopoeia standard, and product purity is high, has higher yield；And, this
The steady quality of invention gained four water acetic acid magnesium products, convenient storage, by the embodiment of the present invention one to embodiment seven products obtained therefrom
Room temperature is uncovered place 10 days after, above-mentioned indices all no significant changes, still conform to above-mentioned European Pharmacopoeia standard after testing
Require.
The yield statistical table of table 1 product of the present invention
| Project | Embodiment one | Embodiment two | Embodiment three | Example IV | Embodiment five | Embodiment six | Embodiment seven |
| Gross mass（g） | 174.2 | 179.8 | 180.8 | 169.0 | 174.2 | 151.3 | 202.5 |
| Yield（%） | 47.4 | 48.9 | 49.2 | 46.0 | 47.4 | 41.2 | 55.1 |
The quality testing analysis result of table 2 product of the present invention
The invention has the beneficial effects as follows：The present invention adopts analytically pure magnesium hydroxide to prepare as raw material with analytically pure glacial acetic acid
Magnesium acetate, by the dry temperature in density, and dry run before the strict pH value controlling reactant liquor, the pH value of filtrate and crystallize
Degree and drying time, the indices of four water acetic acid magnesium of preparation are made all to have reached in European Pharmacopoeia to four water acetic acids magnesia amount mark
Accurate requirement, meets the prescription of medical rank four water acetic acid magnesium；Products obtained therefrom steady quality of the present invention, storage is convenient,
During depositing, maintain good stability；The preparation method of the present invention is simple, and technological process is short, and energy consumption is low, saves into
This, it is easy to accomplish industrialization.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all essences in the present invention
Within god and principle, any modification, equivalent substitution and improvement made etc., should be included within the scope of the present invention.
Claims (9)
1. a kind of method preparing medicinal four water acetic acid magnesium is it is characterised in that comprise the following steps：
1）Take analytically pure magnesium hydroxide and analytically pure glacial acetic acid, add appropriate water, be heated to 75-80 DEG C, carry out fully
Reaction, after completion of the reaction, is cooled to less than 35 DEG C, obtains reactant liquor；
2）Using magnesium hydroxide regulating step 1）The pH value of gained reactant liquor, so as to pH value is 7.7-9.0, filters, then, adopts
Glacial acetic acid adjusts the pH value of filtrate so as to pH value is 4.8-5.7, obtains solution；
3）By step 2）Resulting solution carries out concentrating under reduced pressure, and measures the density of concentrated solution, when the density of concentrated solution is 1.250-
When 1.310, stop concentrating under reduced pressure, concentrated solution stirring and crystallizing obtains crystallized product；
4）To step 3）Gained crystallized product is filtered, and washs filter cake, obtains head product；
5）By step 4）Gained head product carries out forced air drying, obtains finished product.
2. the method preparing medicinal four water acetic acid magnesium according to claim 1 it is characterised in that：
Described step 4）In, using dehydrated alcohol, filter cake is washed, described step 5）In, baking temperature is 45-55 DEG C, does
The dry time is 2-4h.
3. the method preparing medicinal four water acetic acid magnesium according to claim 2 it is characterised in that：
Described step 5）In, baking temperature is 50 DEG C, and drying time is 3h.
4. the method preparing medicinal four water acetic acid magnesium according to claim 1 it is characterised in that：
Described step 1）In, magnesium hydroxide is 1 with the mol ratio of glacial acetic acid：2.1, the response time is 0.5-1.5h, and reaction finishes
After be cooled to 10-25 DEG C.
5. the method preparing medicinal four water acetic acid magnesium according to claim 1 it is characterised in that：
Described step 2）In, the pH value of reactant liquor is adjusted to 8.1-8.4 using magnesium hydroxide, then, filter is adjusted using glacial acetic acid
The pH value of liquid is to 5.1-5.4.
6. the method preparing medicinal four water acetic acid magnesium according to claim 1 it is characterised in that：
Described step 3）In, when the density of concentrated solution is 1.275-1.290, stop concentrating under reduced pressure.
7. the method preparing medicinal four water acetic acid magnesium according to claim 1-6 any one it is characterised in that：
Described step 3）In, temperature during concentrating under reduced pressure is 80-85 DEG C.
8. the method preparing medicinal four water acetic acid magnesium according to claim 1 it is characterised in that：
Described step 3）In, concentrated solution is stirred crystallize at room temperature.
9. the method preparing medicinal four water acetic acid magnesium according to claim 8 it is characterised in that：
Acetic acid is added to be stirred crystallize in described concentrated solution, the crystallize time is 5-7h.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107324987A (en) * | 2017-07-05 | 2017-11-07 | 青海盐湖工业股份有限公司 | A kind of magnesium acetate（Four Heshuis）Preparation technology |
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| CN1174877A (en) * | 1997-08-18 | 1998-03-04 | 黄梅芬 | Heavy oil vanddium-inhibition agent for gas turbine or boiler in electric power plant |
| CN1488359A (en) * | 2002-10-11 | 2004-04-14 | 兰为民 | Magnesium-calcium ion composite preparation and production precess thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107324987A (en) * | 2017-07-05 | 2017-11-07 | 青海盐湖工业股份有限公司 | A kind of magnesium acetate（Four Heshuis）Preparation technology |
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