CN107441117A - A kind of Muhivitamin Formula With Minerals calcium preparation and preparation method thereof - Google Patents
A kind of Muhivitamin Formula With Minerals calcium preparation and preparation method thereof Download PDFInfo
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- CN107441117A CN107441117A CN201610389687.1A CN201610389687A CN107441117A CN 107441117 A CN107441117 A CN 107441117A CN 201610389687 A CN201610389687 A CN 201610389687A CN 107441117 A CN107441117 A CN 107441117A
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- CN
- China
- Prior art keywords
- preparation
- calcium
- vitamin
- mixed
- calcium carbonate
- Prior art date
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- 238000002360 preparation method Methods 0.000 title claims abstract description 58
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title claims abstract description 56
- 239000011575 calcium Substances 0.000 title claims abstract description 56
- 229910052791 calcium Inorganic materials 0.000 title claims abstract description 56
- 229910052500 inorganic mineral Inorganic materials 0.000 title claims abstract description 21
- 239000011707 mineral Substances 0.000 title claims abstract description 21
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 52
- CPLXHLVBOLITMK-UHFFFAOYSA-N Magnesium oxide Chemical compound [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims abstract description 44
- 229930003316 Vitamin D Natural products 0.000 claims abstract description 29
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims abstract description 29
- 239000011710 vitamin D Substances 0.000 claims abstract description 29
- 235000019166 vitamin D Nutrition 0.000 claims abstract description 29
- 150000003710 vitamin D derivatives Chemical class 0.000 claims abstract description 29
- 229940046008 vitamin d Drugs 0.000 claims abstract description 29
- 229910000019 calcium carbonate Inorganic materials 0.000 claims abstract description 25
- 239000000395 magnesium oxide Substances 0.000 claims abstract description 22
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims abstract description 20
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims abstract description 18
- 229960001763 zinc sulfate Drugs 0.000 claims abstract description 18
- 229910000368 zinc sulfate Inorganic materials 0.000 claims abstract description 18
- 239000011230 binding agent Substances 0.000 claims description 21
- 239000000463 material Substances 0.000 claims description 20
- 238000000576 coating method Methods 0.000 claims description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- 239000011248 coating agent Substances 0.000 claims description 18
- 238000002156 mixing Methods 0.000 claims description 17
- 239000007884 disintegrant Substances 0.000 claims description 16
- 239000008213 purified water Substances 0.000 claims description 13
- 239000000314 lubricant Substances 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 9
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 8
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 6
- 238000005469 granulation Methods 0.000 claims description 6
- 230000003179 granulation Effects 0.000 claims description 6
- 239000011734 sodium Substances 0.000 claims description 6
- 229910052708 sodium Inorganic materials 0.000 claims description 6
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 5
- 229920002472 Starch Polymers 0.000 claims description 5
- 239000012530 fluid Substances 0.000 claims description 5
- 239000004615 ingredient Substances 0.000 claims description 5
- 239000011777 magnesium Substances 0.000 claims description 5
- 229910052749 magnesium Inorganic materials 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 5
- 239000008107 starch Substances 0.000 claims description 5
- 235000019698 starch Nutrition 0.000 claims description 5
- 235000019359 magnesium stearate Nutrition 0.000 claims description 4
- 230000008569 process Effects 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 3
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 3
- 229920003081 Povidone K 30 Polymers 0.000 claims description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 3
- 230000008859 change Effects 0.000 claims description 3
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 3
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 3
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 3
- 239000001301 oxygen Substances 0.000 claims description 3
- 229910052760 oxygen Inorganic materials 0.000 claims description 3
- 239000000377 silicon dioxide Substances 0.000 claims description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 2
- 238000005461 lubrication Methods 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 239000013049 sediment Substances 0.000 claims 1
- 229960005069 calcium Drugs 0.000 description 46
- 239000003826 tablet Substances 0.000 description 19
- 235000010755 mineral Nutrition 0.000 description 11
- 239000011782 vitamin Substances 0.000 description 11
- WIGIZIANZCJQQY-UHFFFAOYSA-N 4-ethyl-3-methyl-N-[2-[4-[[[(4-methylcyclohexyl)amino]-oxomethyl]sulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide Chemical compound O=C1C(CC)=C(C)CN1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCC(C)CC2)C=C1 WIGIZIANZCJQQY-UHFFFAOYSA-N 0.000 description 10
- 230000000694 effects Effects 0.000 description 7
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 6
- 235000013402 health food Nutrition 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 235000015097 nutrients Nutrition 0.000 description 5
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 229910052725 zinc Inorganic materials 0.000 description 4
- 239000011701 zinc Substances 0.000 description 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 3
- 239000005864 Sulphur Substances 0.000 description 3
- 210000000988 bone and bone Anatomy 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- 229920000881 Modified starch Polymers 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000008602 contraction Effects 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- 229910052802 copper Inorganic materials 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 210000004872 soft tissue Anatomy 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- MECHNRXZTMCUDQ-UHFFFAOYSA-N Vitamin D2 Natural products C1CCC2(C)C(C(C)C=CC(C)C(C)C)CCC2C1=CC=C1CC(O)CCC1=C MECHNRXZTMCUDQ-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 238000010009 beating Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 210000001772 blood platelet Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 235000001465 calcium Nutrition 0.000 description 1
- 235000010216 calcium carbonate Nutrition 0.000 description 1
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 description 1
- 239000001354 calcium citrate Substances 0.000 description 1
- 239000004227 calcium gluconate Substances 0.000 description 1
- 229960004494 calcium gluconate Drugs 0.000 description 1
- 235000013927 calcium gluconate Nutrition 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000006694 eating habits Nutrition 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 229960002061 ergocalciferol Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- 239000007941 film coated tablet Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000020983 fruit intake Nutrition 0.000 description 1
- 210000002411 hand bone Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 150000002484 inorganic compounds Chemical class 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 108010048734 sclerotin Proteins 0.000 description 1
- 230000000192 social effect Effects 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 235000013337 tricalcium citrate Nutrition 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 235000001892 vitamin D2 Nutrition 0.000 description 1
- 239000011653 vitamin D2 Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/10—Carbonates; Bicarbonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/08—Oxides; Hydroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/34—Copper; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses a kind of Muhivitamin Formula With Minerals calcium preparation, the Muhivitamin Formula With Minerals calcium preparation contains calcium carbonate, vitamin D, magnesia, copper sulphate, zinc sulfate；The weight ratio of the vitamin D and calcium carbonate is 8 × 10‑4‑9×10‑4；The weight ratio of the vitamin D and magnesia is 3.5 × 10‑3‑3.8×10‑3；The weight ratio 78 of the zinc sulfate and copper sulphate.
Description
Technical field
The present invention relates to a kind of pharmaceutical preparation, more particularly to a kind of Muhivitamin Formula With Minerals calcium preparation and preparation method thereof.
Background technology
With the improvement of people ' s living standards with the enhancing of health care consciousness, and the change of people's eating habit and dietary structure
Change, such as fat, refined sugar intake appraisal, vegetables and fruit intake deficiency, imbalance diet cause certain of people's intake
Nutrient lacks.
Calcium is one of most common element in human body, is referred to as " armored concrete in life ", the content of calcium in human body
The 1.5--2% of total weight is accounted for, wherein bone and tooth accounts for 99%.Body fluid and soft tissue account for 1%.For body metabolism, cell
Vital effect is played in function, nervous system running, protein hormones synthesis etc..
The necessary intake calcium of calcium is present in human body among 60,000,000 cells originally, is to provide all functions of body
Important nutrient.Once that is, calcareous insufficient, body just can not normal operation, and then cause various problems.Due to calcareous
Even if be only some shortcomings all can the critical important nutrient to life security, once so calcareous insufficient, will be from skeleton
Middle absorption.Human body daily from sweat and urine discharge in vivo it is calcareous, these be consumed it is calcareous also must be from every daily ingestion
Go to supplement in nutrition, to reach the calcareous balance of body, but be not easy absorbed nutrient because calcium belongs to, so being to lack one
Can not important nutrient.
The inorganic compound of calcium is a kind of most inorganic salts of people's in-vivo content.In normal human the content of calcium be 1200~
1400 grams, the 1.5%~2.0% of human body weight is accounted for, wherein 99% is present among bone and tooth.In addition, 1% calcium is big
Majority is present in soft tissue, extracellular fluid and blood in ionic condition, and dynamic equilibrium is remain with bone calcium.Calcium in body,
On the one hand bone and tooth are formed, on the other hand various physiological functions and metabolic process is then may participate in, influences each organ-tissue
Activity.
Calcium keeps certain proportion with magnesium, potassium, sodium plasma, nerve, muscle is kept normal reaction；Calcium can adjust the heart
Dirty beating, keep heart continuously alternately contraction and diastole；Calcium can maintain the transmission of contraction and the nerve impulse of muscle；Calcium can pierce
Swash blood platelet, promote the blood clotting on wound；In body, there is the activation that many kinds of enzymes need calcium, its activity could be shown.
The present inventor, which is intended to redesign by prescription, filters out auxiliary material optimum amount, using advanced granulation, tabletting, bag
Film coated tablets production technology, keep various vitamin contents constant, be prepared into it is domestic it is advanced swallow tablet form, with ordinary tablet
Compare：It is more easy to dissolution in vivo, insoluble drug release and is absorbed by the body.
The content of the invention
It is an object of the invention to propose a kind of Muhivitamin Formula With Minerals calcium preparation and preparation method thereof, absorb and imitate so as to output
Rate is high, and toxic side effect is small, the Muhivitamin Formula With Minerals calcium preparation of preparation flow science.
To achieve these goals, the present invention proposes a kind of Muhivitamin Formula With Minerals calcium preparation, it is characterised in that the multidimensional metadata
Plain calcium preparation contains calcium carbonate, vitamin D, magnesia, copper sulphate, zinc sulfate；The weight ratio of the vitamin D and calcium carbonate is
8×10-4-9×10-4；The weight ratio of the vitamin D and magnesia is 3.5 × 10-3-3.8×10-3；The zinc sulfate and sulphur
The weight of sour copper compares 7-8.
Preferably, the weight ratio of the vitamin D and calcium carbonate is 8.5 × 10-4；The weight of the vitamin D and magnesia
Amount is than being 3.7 × 10-3；The weight ratio 7.5 of the zinc sulfate and copper sulphate.
Preferably, the preparation is tablet.
A kind of preparation method of Muhivitamin Formula With Minerals calcium preparation as described in claim 1-3 is any, it is characterised in that the system
Preparation Method comprises the following steps：
(1) prepare calcium carbonate, vitamin D, magnesia, binding agent, disintegrant and press proportion ingredient；
(2) according to the process of mixed in equal amounts, after first mixing vitamin D and binding agent progress equivalent successively, carbonic acid is added
Calcium, magnesia, remaining binding agent and disintegrant are mixed；
(3) material of mixing is put into wet granulator, solubilizer water carries out mixing granulation；
(4) wet granular is put into fluid bed and be dried；
(5) material of step (4) is sieved；
(6) particle that step (5) obtains is put into mixer and first mixed, added lubricant and remix；
(7) dispensing after step (6) is mixed is put into tabletting in tablet press machine；
(8) copper sulphate, zinc sulfate are first dissolved in purified water, coating powder is dissolved in purified water, both are mixed；
(9) the element preparation of the gained of step (7) is put into seed-coating machine, is coated using the coating solution of step (8),
Obtain any described Muhivitamin Formula With Minerals calcium preparations of claim 1-3.
Preferably, the bonding includes PVP K30, pregelatinized starch, microcrystalline cellulose, in sodium carboxymethylcellulose
It is one or more of；The disintegrant includes sodium carboxymethyl starch；The lubricant includes one kind in magnesium stearate, silica
It is or several.
Preferably, the solvent in the step (3) is pure water.
Preferably, the EAT in the step (4) is controlled below 60 DEG C.
Preferably, the material in the step (5) is crossed 20 mesh nets and sieved.
Preferably, the time first mixed in the step (6) is 5-10 minutes, and the time remixed is 10-15 minutes.
Preferably, at 18-22 DEG C, relative humidity controls in 50-60% the environment temperature control in the step (7)；Pressure
The Muhivitamin Formula With Minerals calcium preparation that density is 6-10kg/cm3 is obtained after piece.
Preferably, the concentration that mixing obtains solution in the step (8) is 16%-18%.
It is an advantage of the invention that：1, calcium preparation provided by the invention is convenient to take, and composition collocation is reasonable, and calcium preparation absorbs effect
Fruit is good, is adapted to each age level especially the elderly to take；2, preparation method step science, each composition is bad in tableting processes
Reaction is reduced, and avoids loss of effective components, it is ensured that calcium preparation final product quality, is adapted to large-scale industrial production.3, zinc sulfate and
Copper sulphate is all the relatively good material of dissolubility, water-soluble relatively good, so itself and magnesia not soluble in water, calcium carbonate are divided
Open, more conducively the absorption of human body.4, calcium preparation provided by the invention can delay and resist the loss of sclerotin, supplement people well
It is calcareous required for body, it is adapted to patient long-term use of, it is safe, side effect is effectively avoided, there is positive social effect.
In order that technological means, technical characteristic, goal of the invention and technique effect that the present invention realizes are easy to understand, under
Face combines instantiation, and the present invention is expanded on further.
Embodiment
With reference to specific embodiment, the present invention is expanded on further.Following examples are merely to illustrate the present invention rather than limit
Protection scope of the present invention processed.The experimental method of the total unreceipted actual conditions of the following example, generally according to normal condition or is pressed
According to the proposed condition of manufacturer, unless otherwise stated, all percentage, ratio, ratio or fraction are according to weight
Meter.
The unit in percent weight in volume in the present invention is well-known to those skilled in the art, such as is referred to
The weight of solute in 100 milliliters of solution.
Unless otherwise defined, all specialties and scientific words and meaning familiar to those skilled in the art used in text
Justice is identical.In addition, any method similar or reciprocity to described content and material all can be applied in the inventive method.
Present invention is generally directed to the reform of the production technology of the Muhivitamin Formula With Minerals calcium preparation of in the market.Original element preparation,
Simply being simply mixed and being granulated to material, the distinctive property of material itself is not accounted for.For material, it is divided into：Alkali
Property, neutrality, acidity.For in a tablet, while with the presence of acid and alkalescence material, easily react, influence product
Quality.
Inventor is had found in the manufacturing process of the calcium preparation containing vitamin D, sulfuric acid by in-depth study extensively
Zinc and copper sulphate are all the relatively good materials of dissolubility, water-soluble relatively good, and it is led to magnesia not soluble in water, calcium carbonate
Cross scientific method and carry out the absorption of separating treatment, more conducively human body, and keep the quality of calcium preparation.
(1) composition of calcium preparation
Muhivitamin Formula With Minerals calcium preparation preferred tablet provided by the invention, wherein containing calcium carbonate, vitamin D, magnesia, sulfuric acid
The active ingredients such as copper, zinc sulfate.The weight ratio for stating vitamin D and calcium carbonate is 8 × 10-4-9×10-4；The vitamin D and oxygen
The weight ratio for changing magnesium is 3.5 × 10-3-3.8×10-3；The weight of the zinc sulfate and copper sulphate compares 7-8.Preferably, the dimension
Raw plain D and calcium carbonate weight ratio are 8.5 × 10-4；The weight ratio of the vitamin D and magnesia is 3.7 × 10-3；The sulphur
The weight ratio 7.5 of sour zinc and copper sulphate.
The profound sub- calciferol of vitamin D or vitamine D3 used in calcium preparation provided by the present invention, preferably dimension life
Plain D3.
The preferred calcium carbonate of calcium salt in calcium preparation provided by the invention, or calcium carbonate, calcium gluconate, lactic acid
One or more in calcium, calcium phosphate, calcium citrate.
(2) preparation method
Embodiment 1：
Processing step：
(1) supplementary material prepares：Prepare calcium carbonate, vitamine D3, magnesia, binding agent, disintegrant and press proportion ingredient.Wherein
Formula rate is as follows by weight：Calcium carbonate：65 parts, 0.06 part of vitamine D3,17 parts of magnesia, 0.2 part of copper sulphate, sulfuric acid
1.6 parts of zinc, 10 parts of binding agent, 2.14 parts of disintegrant, 1 part of lubricant, 3 parts of coating powder；The binding agent is pregelatinized starch, is collapsed
Solution agent is sodium carboxymethyl starch, and lubricant is silica.
(2) supplementary material prepares premixing：Parts by weight according to formula rate take each component medicament, first by vitamine D3 and
After binding agent progress equivalent mixes successively, add calcium carbonate, magnesia, remaining binding agent and disintegrant and mixed.
(3) pelletize：The material of mixing is put into wet granulator, adds purified water to carry out mixing granulation.
(4) dry：Wet granular is put into fluid bed and is dried, EAT is controlled at 55 DEG C.
(5) sieve：The material of step (4) is crossed into 20 mesh nets to be sieved.
(6) mix：The particle that step (5) obtains is put into mixer and first mixed 10 minutes, lubricant is added and remixes
10 minutes.
(7) tabletting：Dispensing after step (6) is mixed is put into tabletting in tablet press machine, and environment temperature is controlled at 20 DEG C, relatively
Humid control is 50%.The health food multielement calcium plain piece to density for 6kg/cm3 after tabletting.
(8) size mixing：Copper sulphate, zinc sulfate are first dissolved in purified water, coating powder is dissolved in purified water, both are mixed
Close, the concentration of solution is 16%.
(9) the element preparation of the gained of step (7) is put into seed-coating machine, is coated using the coating solution of step (8),
The tablet of gained is health food multielement calcium tablet.
Embodiment 2：
Processing step：
(1) supplementary material prepares：Prepare calcium carbonate, vitamine D3, magnesia, binding agent, disintegrant and press proportion ingredient.Wherein
Formula rate is as follows by weight：Calcium carbonate：70 parts, 0.06 part of vitamine D3,16 parts of magnesia, 0.2 part of copper sulphate, sulphur
Sour 1.4 parts of zinc, 8 parts of binding agent, 1.34 parts of disintegrant, 1 part of lubricant, 2 parts of coating powder；The binding agent is PVP K30, is collapsed
Solution agent is sodium carboxymethyl starch, and lubricant is magnesium stearate.
(2) supplementary material prepares premixing：Parts by weight according to formula rate take each component medicament, first by vitamine D3 and
After binding agent progress equivalent mixes successively, add calcium carbonate, magnesia, remaining binding agent and disintegrant and mixed.
(3) pelletize：The material of mixing is put into wet granulator, adds purified water to carry out mixing granulation.
(4) dry：Wet granular is put into fluid bed and is dried, EAT is controlled at 60 DEG C.
(5) sieve：The material of step (4) is crossed into 20 mesh nets to be sieved.
(6) mix：The particle that step (5) obtains is put into mixer and first mixed 10 minutes, lubricant is added and remixes
10 minutes.
(7) tabletting：Dispensing after step (6) is mixed is put into tabletting in tablet press machine, and environment temperature is controlled at 18 DEG C, relatively
Humid control is 50%.The health food multielement calcium plain piece to density for 6kg/cm3 after tabletting.
(8) size mixing：Copper sulphate, zinc sulfate are first dissolved in purified water, coating powder is dissolved in purified water, both are mixed
Close, the concentration of solution is 18%.
(9) the element preparation of the gained of step (7) is put into seed-coating machine, is coated using the coating solution of step (8),
The tablet of gained is health food multielement calcium tablet.
Embodiment 3：
Processing step：
(1) supplementary material prepares：Prepare calcium carbonate, vitamine D3, magnesia, binding agent, disintegrant and press proportion ingredient.Wherein
Formula rate is as follows by weight：Calcium carbonate：73.5 parts, 0.06 part of vitamine D3,16 parts of magnesia, 0.2 part of copper sulphate,
1.4 parts of zinc sulfate, 5 parts of binding agent, 1.34 parts of disintegrant, 0.5 part of lubricant, 2 parts of coating powder；The binding agent is microcrystalline cellulose
Element, disintegrant are sodium carboxymethyl starch, and lubricant is magnesium stearate.
(2) supplementary material prepares premixing：Parts by weight according to formula rate take each component medicament, first by vitamine D3 and
After binding agent progress equivalent mixes successively, add calcium carbonate, magnesia, remaining binding agent and disintegrant and mixed.
(3) pelletize：The material of mixing is put into wet granulator, adds purified water to carry out mixing granulation.
(4) dry：Wet granular is put into fluid bed and is dried, EAT is controlled at 60 DEG C.
(5) sieve：The material of step (4) is crossed into 20 mesh nets to be sieved.
(6) mix：The particle that step (5) obtains is put into mixer and first mixed 10 minutes, lubricant is added and remixes 5
Minute.
(7) tabletting：Dispensing after step (6) is mixed is put into tabletting in tablet press machine, and environment temperature is controlled at 20 DEG C, relatively
Humid control is 50%.The health food multielement calcium plain piece to density for 6kg/cm3 after tabletting.
(8) size mixing：Copper sulphate, zinc sulfate are first dissolved in purified water, coating powder is dissolved in purified water, both are mixed
Close, the concentration of solution is 18%.
(9) the element preparation of the gained of step (7) is put into seed-coating machine, is coated using the coating solution of step (8),
The tablet of gained is health food multielement calcium tablet.
The embodiment 1-3 multielement calcium tablets obtained are sampled, and with reference to second annex VII of Chinese Pharmacopoeia 2010 edition
The method of vitamin D content determination method first and the detection of annex x uniformity of dosage units, the vitamin D content uniformity of measure embodiment 1 are
10.05 be 6.05, and the vitamin D content uniformity of measure embodiment 2 is 7.25, for the vitamin D of 10.05 measure embodiments 1
Uniformity of dosage units is 10.08.It can be seen that the tablet vitamin D content uniformity that the embodiment of the present invention obtains is below 15, all
To be qualified, preparation method of the invention can ensure the tablet vitamin D content uniformity, and mixed process time length is to uniform
Degree has certain influence.
In addition, by identical with formula of the embodiment of the present invention, but copper sulphate and zinc sulfate do not added into coatings but
Muhivitamin Formula With Minerals calcium preparation made of direct mixed pressuring plate is compared, the solution absorption time contracting of calcium tablet made of the embodiment of the present invention
Short 15-20%, positive effect.
Claims (11)
1. a kind of Muhivitamin Formula With Minerals calcium preparation, it is characterised in that the Muhivitamin Formula With Minerals calcium preparation contains calcium carbonate, vitamin D, oxidation
Magnesium, copper sulphate, zinc sulfate；The weight ratio of the vitamin D and calcium carbonate is 8 × 10-4-9×10-4；The vitamin D and oxygen
The weight ratio for changing magnesium is 3.5 × 10-3-3.8×10-3；The weight of the zinc sulfate and copper sulphate compares 7-8.
2. Muhivitamin Formula With Minerals calcium preparation according to claim 1, it is characterised in that the weight ratio of the vitamin D and calcium carbonate
For 8.5 × 10-4；The weight ratio of the vitamin D and magnesia is 3.7 × 10-3；The weight ratio of the zinc sulfate and copper sulphate
7.5。
3. Muhivitamin Formula With Minerals calcium preparation according to claim 1 or 2, it is characterised in that the preparation is tablet.
A kind of 4. preparation method of Muhivitamin Formula With Minerals calcium preparation as described in claim 1-3 is any, it is characterised in that the preparation
Method comprises the following steps：
(1) prepare calcium carbonate, vitamin D, magnesia, binding agent, disintegrant and press proportion ingredient；
(2) according to the process of mixed in equal amounts, after first mixing vitamin D and binding agent progress equivalent successively, calcium carbonate, oxygen are added
Change magnesium, remaining binding agent and disintegrant to be mixed；
(3) material of mixing is put into wet granulator, solubilizer water carries out mixing granulation；
(4) wet granular is put into fluid bed and be dried；
(5) material of step (4) is sieved；
(6) particle that step (5) obtains is put into mixer and first mixed, added lubricant and remix；
(7) dispensing after step (6) is mixed is put into tabletting in tablet press machine；
(8) copper sulphate, zinc sulfate are first dissolved in purified water, coating powder is dissolved in purified water, both are mixed；
(9) the element preparation of the gained of step (7) is put into seed-coating machine, is coated, obtained using the coating solution of step (8)
Any described Muhivitamin Formula With Minerals calcium preparations of claim 1-3.
5. preparation method according to claim 4, it is characterised in that the bonding includes PVP K30, pregelatinated forms sediment
Powder, microcrystalline cellulose, the one or more in sodium carboxymethylcellulose；The disintegrant includes sodium carboxymethyl starch；The profit
Lubrication prescription includes the one or more in magnesium stearate, silica.
6. preparation method according to claim 4, it is characterised in that the solvent in the step (3) is pure water.
7. preparation method according to claim 4, it is characterised in that the EAT in the step (4) is controlled 60
Below DEG C.
8. preparation method according to claim 4, it is characterised in that the material in the step (5) crosses the progress of 20 mesh nets
Screening.
9. preparation method according to claim 4, it is characterised in that the time first mixed in the step (6) is 5-10
Minute, the time remixed is 10-15 minutes.
10. preparation method according to claim 4, it is characterised in that the environment temperature control in the step (7) exists
18-22 DEG C, relative humidity is controlled in 50-60%；The Muhivitamin Formula With Minerals calcium preparation that density is 6-10kg/cm3 is obtained after tabletting.
11. preparation method according to claim 4, it is characterised in that mixing obtains the concentration of solution in the step (8)
For 16%-18%.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110354138A (en) * | 2019-07-18 | 2019-10-22 | 宿迁市现代生物科技股份有限公司 | A kind of formula of the granular calcium carbonate of the directly compressible of low abrasion |
| CN111870584A (en) * | 2020-08-25 | 2020-11-03 | 无限极（中国）有限公司 | Composition beneficial to bone health promotion and application thereof |
| CN114431479A (en) * | 2020-11-05 | 2022-05-06 | 浙江创新生物有限公司 | Calcium-magnesium vitamin D chewable tablet and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1080471A (en) * | 1992-07-02 | 1994-01-12 | 辽宁省化工研究院 | The autofrettage of seed coating liquid |
| CN1480061A (en) * | 2002-11-16 | 2004-03-10 | B.I.G.株式会社 | Calcium coated grain and its processing method |
| CN1956734A (en) * | 2004-03-29 | 2007-05-02 | 惠氏公司 | Multi-vitamin and mineral nutritional supplements |
| CN101605468A (en) * | 2007-02-15 | 2009-12-16 | 惠氏公司 | The improved stability of vitamin and mineral supplements |
| CN101912049A (en) * | 2010-07-27 | 2010-12-15 | 广州市正百饲料科技有限公司 | Premix coating trace elements and preparation method thereof |
| CN104304951A (en) * | 2014-10-17 | 2015-01-28 | 戴铭骏 | Novel rice with nutritional formula |
-
2016
- 2016-05-30 CN CN201610389687.1A patent/CN107441117A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1080471A (en) * | 1992-07-02 | 1994-01-12 | 辽宁省化工研究院 | The autofrettage of seed coating liquid |
| CN1480061A (en) * | 2002-11-16 | 2004-03-10 | B.I.G.株式会社 | Calcium coated grain and its processing method |
| CN1956734A (en) * | 2004-03-29 | 2007-05-02 | 惠氏公司 | Multi-vitamin and mineral nutritional supplements |
| CN101605468A (en) * | 2007-02-15 | 2009-12-16 | 惠氏公司 | The improved stability of vitamin and mineral supplements |
| CN101912049A (en) * | 2010-07-27 | 2010-12-15 | 广州市正百饲料科技有限公司 | Premix coating trace elements and preparation method thereof |
| CN104304951A (en) * | 2014-10-17 | 2015-01-28 | 戴铭骏 | Novel rice with nutritional formula |
Non-Patent Citations (1)
| Title |
|---|
| 惠氏制药有限公司: ""钙尔奇牌添佳片"", 《国家食品药品监督管理总局官网》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110354138A (en) * | 2019-07-18 | 2019-10-22 | 宿迁市现代生物科技股份有限公司 | A kind of formula of the granular calcium carbonate of the directly compressible of low abrasion |
| CN111870584A (en) * | 2020-08-25 | 2020-11-03 | 无限极（中国）有限公司 | Composition beneficial to bone health promotion and application thereof |
| CN114431479A (en) * | 2020-11-05 | 2022-05-06 | 浙江创新生物有限公司 | Calcium-magnesium vitamin D chewable tablet and preparation method thereof |
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