CN1219777C - 噻吩类维生素a - Google Patents

噻吩类维生素a Download PDF

Info

Publication number
CN1219777C
CN1219777C CNB01812660XA CN01812660A CN1219777C CN 1219777 C CN1219777 C CN 1219777C CN B01812660X A CNB01812660X A CN B01812660XA CN 01812660 A CN01812660 A CN 01812660A CN 1219777 C CN1219777 C CN 1219777C
Authority
CN
China
Prior art keywords
compound
formula
tetramethyl
hydrogen
rar
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB01812660XA
Other languages
English (en)
Chinese (zh)
Other versions
CN1441798A (zh
Inventor
迈克尔·克劳斯
琼－马克·拉皮埃尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CN1441798A publication Critical patent/CN1441798A/zh
Application granted granted Critical
Publication of CN1219777C publication Critical patent/CN1219777C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
CNB01812660XA 2000-07-10 2001-06-30 噻吩类维生素a Expired - Fee Related CN1219777C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00114767.7 2000-07-10
EP00114767 2000-07-10

Publications (2)

Publication Number Publication Date
CN1441798A CN1441798A (zh) 2003-09-10
CN1219777C true CN1219777C (zh) 2005-09-21

Family

ID=8169205

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB01812660XA Expired - Fee Related CN1219777C (zh) 2000-07-10 2001-06-30 噻吩类维生素a

Country Status (12)

Country Link
US (1) US6403810B2 (enExample)
EP (1) EP1301505A2 (enExample)
JP (1) JP2004502767A (enExample)
KR (1) KR100551778B1 (enExample)
CN (1) CN1219777C (enExample)
AR (1) AR029572A1 (enExample)
AU (2) AU8961901A (enExample)
BR (1) BR0112328A (enExample)
CA (1) CA2414936C (enExample)
MX (1) MXPA03000222A (enExample)
WO (1) WO2002004439A2 (enExample)
ZA (1) ZA200210049B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200510298A (en) * 2003-06-13 2005-03-16 Theravance Inc Substituted pyrrolidine and related compounds
US7476673B2 (en) * 2003-12-30 2009-01-13 Allergan, Inc. Disubstituted chalcone oximes as selective agonists of RARγ retinoid receptors
US7250414B2 (en) * 2004-03-11 2007-07-31 Theravance, Inc. Diphenylmethyl compounds useful as muscarinic receptor antagonists
US20060161076A1 (en) * 2005-01-06 2006-07-20 Diamics, Inc. Systems and methods for collection of cell clusters
US20060189893A1 (en) * 2005-01-06 2006-08-24 Diamics, Inc. Systems and methods for detecting abnormal cells
US7781187B2 (en) * 2005-12-30 2010-08-24 Corning Incorporated Fluorescent dyes
WO2008057930A2 (en) * 2006-11-02 2008-05-15 Aestus Therapeutics, Inc. Methods of treating neuropathic pain with retinoic acid receptor agonists
WO2025109225A1 (en) 2023-11-24 2025-05-30 Etherna Immunotherapies Nv Method for reducing dsrna formation during ivt

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4123469A (en) 1977-06-30 1978-10-31 International Flavors & Fragrances Inc. Process for production of bicyclic compounds
US5324840A (en) * 1992-06-11 1994-06-28 Allergan, Inc. Method of treatment with compounds having retinoid-like activity and reduced skin toxicity and lacking teratogenic effects
US5455265A (en) * 1993-02-11 1995-10-03 Allergan, Inc. Method of treatment with compounds having selective agonist-like activity on RXR retinoid receptors
US5399586A (en) 1993-03-11 1995-03-21 Allergan, Inc. Treatment of mammals afflicted with tumors with compounds having RXR retinoid receptor agonist activity
US5475022A (en) * 1993-10-18 1995-12-12 Allergan, Inc. Phenyl or heteroaryl and tetrahydronaphthyl substituted diene compounds having retinoid like biological activity
FR2743560B1 (fr) * 1996-01-17 1998-04-03 Europ De Bioprospective Centre Derives polycycliques aromatiques de type retinoide, leur procede de preparation et leur utilisation pour la fabrication de compositions pharmaceutiques et cosmetiques
FR2753091B1 (fr) 1996-09-09 2001-03-16 Oreal Utilisation d'un agoniste des recepteurs des retinoides de type rxr pour stimuler ou induire la pousse des cheveux et/ou stopper leur chute

Also Published As

Publication number Publication date
WO2002004439A3 (en) 2002-09-26
KR20030040350A (ko) 2003-05-22
KR100551778B1 (ko) 2006-02-13
US6403810B2 (en) 2002-06-11
MXPA03000222A (es) 2003-06-06
AU2001289619B2 (en) 2006-07-13
BR0112328A (pt) 2003-07-22
CA2414936C (en) 2006-12-05
AR029572A1 (es) 2003-07-02
WO2002004439A2 (en) 2002-01-17
ZA200210049B (en) 2004-03-11
AU8961901A (en) 2002-01-21
CN1441798A (zh) 2003-09-10
JP2004502767A (ja) 2004-01-29
EP1301505A2 (en) 2003-04-16
CA2414936A1 (en) 2002-01-17
US20020019438A1 (en) 2002-02-14

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee