CN121843933A - 单一的轴手性化合物的选择性制造法 - Google Patents

单一的轴手性化合物的选择性制造法

Info

Publication number
CN121843933A
CN121843933A CN202480055263.4A CN202480055263A CN121843933A CN 121843933 A CN121843933 A CN 121843933A CN 202480055263 A CN202480055263 A CN 202480055263A CN 121843933 A CN121843933 A CN 121843933A
Authority
CN
China
Prior art keywords
compound
formula
group
salt
following
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202480055263.4A
Other languages
English (en)
Chinese (zh)
Inventor
吉成友博
今田直
石冈裕贵
川口贤一
河南英次
大高遵平
广濑勇树
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of CN121843933A publication Critical patent/CN121843933A/zh
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D451/00Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN202480055263.4A 2023-09-08 2024-09-06 单一的轴手性化合物的选择性制造法 Pending CN121843933A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JPPCT/JP2023/032816 2023-09-08
PCT/JP2023/032816 WO2025052649A1 (ja) 2023-09-08 2023-09-08 単一の軸不斉化合物の選択的製造法
PCT/JP2024/031959 WO2025053242A1 (ja) 2023-09-08 2024-09-06 単一の軸不斉化合物の選択的製造法

Publications (1)

Publication Number Publication Date
CN121843933A true CN121843933A (zh) 2026-04-10

Family

ID=94923286

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202480055263.4A Pending CN121843933A (zh) 2023-09-08 2024-09-06 单一的轴手性化合物的选择性制造法

Country Status (7)

Country Link
JP (1) JP7700399B1 (https=)
CN (1) CN121843933A (https=)
AU (1) AU2024337896A1 (https=)
CO (1) CO2026004110A2 (https=)
MX (1) MX2026002723A (https=)
TW (1) TW202527939A (https=)
WO (2) WO2025052649A1 (https=)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20190186A1 (ar) * 2017-02-02 2019-08-01 Astellas Pharma Inc مركب كينازولين
WO2022173032A1 (ja) * 2021-02-15 2022-08-18 アステラス製薬株式会社 G12d変異krasタンパクの分解を誘導するためのキナゾリン化合物
EP4293025B1 (en) * 2021-02-15 2025-10-29 Astellas Pharma Inc. 4-aminoquinazoline compound
TW202346270A (zh) * 2022-03-11 2023-12-01 日商安斯泰來製藥股份有限公司 用於誘發g12d突變kras蛋白分解之雜環化合物
US20250145631A1 (en) * 2022-07-21 2025-05-08 Astellas Pharma Inc. Heterocyclic compound acting on g12d mutant kras protein
TW202412789A (zh) * 2022-08-05 2024-04-01 日商安斯泰來製藥股份有限公司 用於誘導突變kras蛋白分解之雜環化合物
EP4570794A1 (en) * 2022-08-09 2025-06-18 Astellas Pharma, Inc. Heterocyclic compound for inhibiting and/or inducing degradation of kras protein
EP4570795A1 (en) * 2022-08-09 2025-06-18 Astellas Pharma, Inc. Heterocyclic compound for inducing degradation of g12v mutant kras protein

Also Published As

Publication number Publication date
MX2026002723A (es) 2026-04-01
TW202527939A (zh) 2025-07-16
JP7700399B1 (ja) 2025-06-30
WO2025052649A1 (ja) 2025-03-13
WO2025053242A1 (ja) 2025-03-13
CO2026004110A2 (es) 2026-04-16
AU2024337896A1 (en) 2026-03-19
JPWO2025053242A1 (https=) 2025-03-13

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