CN121843933A - 单一的轴手性化合物的选择性制造法 - Google Patents

单一的轴手性化合物的选择性制造法

Info

Publication number
CN121843933A
CN121843933A CN202480055263.4A CN202480055263A CN121843933A CN 121843933 A CN121843933 A CN 121843933A CN 202480055263 A CN202480055263 A CN 202480055263A CN 121843933 A CN121843933 A CN 121843933A
Authority
CN
China
Prior art keywords
compound
formula
group
salt
following
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202480055263.4A
Other languages
English (en)
Chinese (zh)
Inventor
吉成友博
今田直
石冈裕贵
川口贤一
河南英次
大高遵平
广濑勇树
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of CN121843933A publication Critical patent/CN121843933A/zh
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D451/00Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN202480055263.4A 2023-09-08 2024-09-06 单一的轴手性化合物的选择性制造法 Pending CN121843933A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/JP2023/032816 WO2025052649A1 (ja) 2023-09-08 2023-09-08 単一の軸不斉化合物の選択的製造法
JPPCT/JP2023/032816 2023-09-08
PCT/JP2024/031959 WO2025053242A1 (ja) 2023-09-08 2024-09-06 単一の軸不斉化合物の選択的製造法

Publications (1)

Publication Number Publication Date
CN121843933A true CN121843933A (zh) 2026-04-10

Family

ID=94923286

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202480055263.4A Pending CN121843933A (zh) 2023-09-08 2024-09-06 单一的轴手性化合物的选择性制造法

Country Status (6)

Country Link
JP (1) JP7700399B1 (https=)
CN (1) CN121843933A (https=)
AU (1) AU2024337896A1 (https=)
CO (1) CO2026004110A2 (https=)
TW (1) TW202527939A (https=)
WO (2) WO2025052649A1 (https=)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20190186A1 (ar) * 2017-02-02 2019-08-01 Astellas Pharma Inc مركب كينازولين
KR20230145361A (ko) * 2021-02-15 2023-10-17 아스텔라스세이야쿠 가부시키가이샤 G12d 변이 kras 단백의 분해를 유도하기 위한 퀴나졸린화합물
AU2022219651A1 (en) * 2021-02-15 2023-09-07 Astellas Pharma Inc. 4-aminoquinazoline compound
AU2023231912A1 (en) * 2022-03-11 2024-08-15 Astellas Pharma Inc. Heterocyclic compound for inducing degradation of g12d mutant kras protein
TW202409002A (zh) * 2022-07-21 2024-03-01 日商安斯泰來製藥股份有限公司 作用於g12d突變kras蛋白之雜環化合物
CN119630656A (zh) * 2022-08-05 2025-03-14 安斯泰来制药株式会社 用于诱导突变kras蛋白分解的杂环化合物
WO2024034593A1 (ja) * 2022-08-09 2024-02-15 アステラス製薬株式会社 G12v変異krasタンパクの分解を誘導するための複素環化合物
TW202412790A (zh) * 2022-08-09 2024-04-01 日商安斯泰來製藥股份有限公司 用於抑制及/或誘導分解kras蛋白之雜環化合物

Also Published As

Publication number Publication date
JP7700399B1 (ja) 2025-06-30
WO2025052649A1 (ja) 2025-03-13
AU2024337896A1 (en) 2026-03-19
WO2025053242A1 (ja) 2025-03-13
TW202527939A (zh) 2025-07-16
CO2026004110A2 (es) 2026-04-16
JPWO2025053242A1 (https=) 2025-03-13

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