CN121698765A - pH敏感性阳离子性脂质、脂质纳米粒子、含有脂质纳米粒子的医药用组合物以及脂质纳米粒子的用途 - Google Patents

pH敏感性阳离子性脂质、脂质纳米粒子、含有脂质纳米粒子的医药用组合物以及脂质纳米粒子的用途

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Publication number
CN121698765A
CN121698765A CN202511824200.3A CN202511824200A CN121698765A CN 121698765 A CN121698765 A CN 121698765A CN 202511824200 A CN202511824200 A CN 202511824200A CN 121698765 A CN121698765 A CN 121698765A
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CN
China
Prior art keywords
lipid
formula
group
lipid nanoparticle
chemical formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202511824200.3A
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English (en)
Chinese (zh)
Inventor
佐藤悠介
原岛秀吉
桥场一毅
田口将光
坂元左知子
宍户卓矢
大津彩夏
前田佳己
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hokkaido University NUC
Nitto Denko Corp
Original Assignee
Hokkaido University NUC
Nitto Denko Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hokkaido University NUC, Nitto Denko Corp filed Critical Hokkaido University NUC
Publication of CN121698765A publication Critical patent/CN121698765A/zh
Pending legal-status Critical Current

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    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
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    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0033—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being non-polymeric
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    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
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    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
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    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
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CN202511824200.3A 2020-10-02 2021-10-01 pH敏感性阳离子性脂质、脂质纳米粒子、含有脂质纳米粒子的医药用组合物以及脂质纳米粒子的用途 Pending CN121698765A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2020-167928 2020-10-02
JP2020167928 2020-10-02
CN202180067522.1A CN116367718A (zh) 2020-10-02 2021-10-01 脂质纳米粒子
PCT/JP2021/036449 WO2022071582A1 (ja) 2020-10-02 2021-10-01 脂質ナノ粒子

Related Parent Applications (1)

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CN202180067522.1A Division CN116367718A (zh) 2020-10-02 2021-10-01 脂质纳米粒子

Publications (1)

Publication Number Publication Date
CN121698765A true CN121698765A (zh) 2026-03-20

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CN202511824200.3A Pending CN121698765A (zh) 2020-10-02 2021-10-01 pH敏感性阳离子性脂质、脂质纳米粒子、含有脂质纳米粒子的医药用组合物以及脂质纳米粒子的用途
CN202180067522.1A Pending CN116367718A (zh) 2020-10-02 2021-10-01 脂质纳米粒子

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CN202180067522.1A Pending CN116367718A (zh) 2020-10-02 2021-10-01 脂质纳米粒子

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US (1) US12458605B2 (https=)
EP (1) EP4223314A4 (https=)
JP (1) JPWO2022071582A1 (https=)
KR (1) KR20230080451A (https=)
CN (2) CN121698765A (https=)
AU (1) AU2021355199A1 (https=)
CA (1) CA3194148A1 (https=)
IL (1) IL301837A (https=)
TW (1) TW202228652A (https=)
WO (1) WO2022071582A1 (https=)

Families Citing this family (8)

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Publication number Priority date Publication date Assignee Title
JP2025081791A (ja) * 2022-03-31 2025-05-28 日東電工株式会社 がん送達用医薬組成物または免疫賦活用組成物
WO2023188830A1 (ja) * 2022-03-31 2023-10-05 国立大学法人北海道大学 脂質ナノ粒子
CN119585236A (zh) 2022-07-19 2025-03-07 国立大学法人北海道大学 中性脂质及脂质纳米粒
JPWO2024024156A1 (https=) * 2022-07-29 2024-02-01
JPWO2024071409A1 (https=) * 2022-09-30 2024-04-04
WO2025180480A1 (zh) * 2024-03-01 2025-09-04 北京剂泰医药科技有限公司 靶向肌肉的脂质纳米颗粒
TW202602853A (zh) * 2024-03-21 2026-01-16 日商日東電工股份有限公司 ｐＨ—敏感性陽離子脂質、包含其之脂質奈米顆粒及傳遞核酸之方法
WO2026009946A1 (ja) * 2024-07-04 2026-01-08 日東電工株式会社 非対称構造脂質

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Publication number Priority date Publication date Assignee Title
EP0632008B1 (en) 1993-06-01 1998-02-04 Ono Pharmaceutical Co., Ltd. Pentanoic acid derivatives
WO2007102481A1 (ja) 2006-03-07 2007-09-13 National University Corporation Hokkaido University 目的物質の核内送達用ベクター
AU2012347605B2 (en) 2011-12-07 2017-09-21 Alnylam Pharmaceuticals, Inc. Branched alkyl and cycloalkyl terminated biodegradable lipids for the delivery of active agents
US10182987B2 (en) * 2014-05-20 2019-01-22 National University Corporation Hokkaido University Lipid membrane structure for intracellular delivery of siRNA
HUE053990T2 (hu) 2015-07-22 2021-08-30 Nitto Denko Corp Nanorészecske liofilizált formák készítményei és eljárások
CN110520214B (zh) 2017-04-13 2023-03-21 国立大学法人北海道大学 使用流路构造体的脂质粒子或微胞的形成方法
KR102676927B1 (ko) * 2017-06-15 2024-06-24 국립대학법인 홋가이도 다이가쿠 siRNA 세포 내 송달을 위한 지질막 구조체
JP2019151589A (ja) * 2018-03-02 2019-09-12 国立大学法人北海道大学 脂質ナノ粒子

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EP4223314A4 (en) 2026-04-22
EP4223314A1 (en) 2023-08-09
US20240024252A1 (en) 2024-01-25
AU2021355199A1 (en) 2023-05-25
KR20230080451A (ko) 2023-06-07
CN116367718A (zh) 2023-06-30
TW202228652A (zh) 2022-08-01
WO2022071582A1 (ja) 2022-04-07
IL301837A (en) 2023-06-01
US12458605B2 (en) 2025-11-04
AU2021355199A9 (en) 2024-09-26
CA3194148A1 (en) 2022-04-07
JPWO2022071582A1 (https=) 2022-04-07

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