CN1215599A - Monema flavescens use - Google Patents
Monema flavescens use Download PDFInfo
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- CN1215599A CN1215599A CN 97109283 CN97109283A CN1215599A CN 1215599 A CN1215599 A CN 1215599A CN 97109283 CN97109283 CN 97109283 CN 97109283 A CN97109283 A CN 97109283A CN 1215599 A CN1215599 A CN 1215599A
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Abstract
A use of Monema flavescens features that it can be used to treat rheumatic arthritis, rheumatic arthrodynia, rheumatoid arthritis, tonic rachitis, hyperosteogeny, chronic gastritis, gastric ulcer and duodenal ulcer with high curative effect and no toxic by-effect.
Description
The invention belongs to the medicinal usage invention field, the application of a kind of specifically poplar spicy in medicines such as preparation treatment rheumatism, rheumatoid, gastropathy
The poplar spicy, have another name called the thorn caterpillar, in the Compendium of Material Medica record, " Monema flavescens Walker " arranged still, " sour jujube fructus crotonis ", another names such as " Calyx Seu Fructus Physalis ", it is the hirsutism larva in the insecticide Lepidoptera, be complete metamorphosis, the annual autumn in summer bred for two generations, and ripe larva spins near the underground or tree bar the tree root, when spring and summer replaces, become pupa earlier, the back goes out for the moth cocoon-break, flies the maple of its larva happiness food, poplar and fruit tree tree go up between leaf and lay eggs, and also have annual high-stem plant Semen Ricini, lay eggs on shrub and the wicker, hatch into larva about one week, be poplar spicy worm, grow up by the food leaves, edge is set and is descended (also having on the tree bar) to spin after two months, treat that and for example the above reproduction control is secondary to August in the same year, just spin again until November and to survive the winter, breed the coming year again, and its adult tonsillitis just dies after producing son soon, cocoon on the tree is littler than the cocoon under the tree, shape such as Passeris montani saturati are generally taupe, its cocoon sparrow and chicken happiness food.
Kind surplus poplar spicy worm has ten is divided into redly, yellow, green etc. with hair color, with bodily form branch long garden and flat etc. are arranged.
Poplar spicy worm distributed pole is wide, the middle and lower reach of Yangtze River, and all there is growth in the place of the nearly water of all warm moist.
Put down in writing according to Compendium of Material Medica worm portion the 39th volume: " Monema flavescens Walker ", popular name poplar spicy, abnormal smells from the patient is sweet flat nontoxic, cures mainly cold and heat, stagnation of QI, infantile convulsion, infantum tetanus, newborn pretty young woman, larynx, epilepsy disease, the magical effect ..., China among the people also early useful poplar spicy worm treat children's's disease disease such as anxious chronic infantile convulsion.
Although the poplar spicy is as medicinal with a long history, but all cocoons among the people and the Compendium of Material Medica with the poplar spicy, be that pupa is used as medicine, the poplar spicy that do not appear in the newspapers has treatment " rheumatic four diseases ", be the effect of diseases such as cold rheumatoid joint pain (rheumatic arthralgia), rheumatic arthritis (FENGGUAN inflammation), rheumatoid arthritis and ankylosing spondylitis, cervical spondylosis, chronic gastritis stomach function regulating, duodenal ulcer, also do not see the report that is used as medicine with the larva of poplar spicy.
Rheumatic arthritis and rheumatoid arthritis are allergic disease, because the formation of inflammation makes to discharge a large amount of chemical substances in the body.As: multicolored amine, histamine, kassinin kinin, Kallidin I, chronic reacting substance, prostaglandin, acetylcholine and antigen-antibody mediated immunity complex etc., these materials increase vascular permeability, break because of lysosome membrane in addition, emit multiple digestive enzyme, the disorganize cell causes symptoms such as joint part is red, swollen, hot, pain.
Poplar spicy larva, whole body length has countless sharp keen incomparable telsons, if spread out, can be so that to become hundred people to be stung peppery as to complain bitterly, this very special thorn, make people thundering red, swollen, bitterly, itched a period of time after just met no danger, and the also survival (do not resemble Apis die) still of poplar spicy, the peppery people's of this thorn great power (big evil big benefit must be arranged) why not can with " treating the poisonous disease with poisonous drugs ' and theory be human preventing and curing diseases, remove in people's disease red, swollen, bitterly, sufferings such as itch?
In the practice of three more than ten years, the inventor of thee generations is determined to capture arthritis, this mankind see at most, the most normal persistent ailment, make this polypide that contains telson enter human body, the long-term mass rearing man of poplar spicy worm chicken earlier on probation, find chicken is except how the happiness food lays eggs, also strong especially, no poisoning manifestations begins then with this worm trial-production injection, oral agents, exterior-applied formulation, self uses repeatedly, successively purchase ten thousand jin of poplar spicy borer populations, treat the tens thousand of meters of various arthritis people, find simultaneously that in the treatment arthrosis this kind medicine is not only to the gastrointestinal not damaged, and excellent curative arranged, in for a long time clinical, find simultaneously cervical vertebra, hyperosteogenies such as lumbar vertebra also have good efficacy, find and confirmed some reliably new purposes of poplar spicy worm from face.
One of purpose of the present invention just provides the application of poplar spicy in the medicine of preparation treatment rheumatic arthralgia, rheumatic arthritis, rheumatoid arthritis and ankylosing spondylitis.
Another object of the present invention provides the application of poplar spicy in the medicine of preparation treatment hyperosteogeny.
Another object of the present invention provides the application of poplar spicy in the medicine for preparing treatment chronic gastritis and stomach, intestinal duodenal ulcer.
The poplar spicy can be to be that feedstock production becomes medicament with independent poplar spicy (cocoon or larva) when the medicine of the above-mentioned treatment various diseases of preparation, also the poplar spicy can be cooperated with other drug and make compound preparation.
Generally directly make folk prescription or compound preparation by the Chinese medicine compound method with cocoon or the former medicine of larva of poplar spicy.
Above-mentioned folk prescription or compound preparation can be any form preparation that uses clinically, as tablet, oral liquid, powder, pill, capsule, powder, electuary and injection.
Following clinical data, Therapeutic Method, criterion of therapeutical effect and result and toxicity test are confirmed the purposes of poplar spicy of the present invention.
The inventor makes capsule and injection clinical practice with poplar spicy worm.
The preparation method of poplar spicy worm Drug Capsule is: the poplar spicy worm that get nine, the October becomes heat, and be placed on baking in the iron pan, stir-fry, parch and become black, be ground into the black powder, incapsulate (every capsules contains worm medicine 0.5g).
The preparation method of poplar spicy worm medicine injection: be poplar spicy larva to be fried do after water decoction-alcohol sedimentation is prepared into injection (every ampoule 2ml contains worm medicine 0.5g).
Above-mentioned capsule and injection are offered Beijing, Shanghai, Kunming, the Inner Mongol, Hainan Duo Jia hospital clinical extensive use, to treat rheumatic four diseases: cold rheumatoid joint pain (rheumatic arthralgia), rheumatic arthritis (FENGGUAN inflammation), rheumatoid arthritis (RA) and ankylosing spondylitis (AS), be called for short rheumatic four diseases, simultaneously diseases such as cervical spondylosis, chronic gastritis have also been done clinical observation, obtain gratifying curative effect, existing clinical data and the animal test results that four tame hospitals are provided is expressed as follows.
One, clinical data
This group case is by using the four tame hospitals of poplar spicy insecticide medicine more than 2 years to provide: 1, Longqing Gorge, Beijing hyperosteogeny hospital, outpatient's 128 examples; 2, the hospital of traditional Chinese hospital, Divine Land, Shanghai, inpatient's 69 examples, outpatient's 36 examples; 3, Kunming horse race mountain 57344 hyperosteogeny hospitals of army, inpatient's 195 examples, outpatient's 53 examples; 4, Hailaer, Inner Mongol army is from moving back the body cadre's sanitarium, outpatient's 583 examples.This group case inpatient is totally 264 examples, outpatient's 800 examples; Men and women's ratio: 1: 1.4; The oldest 78 years old, minimum 3 years old; The shortest two weeks of the course of disease, reach 40 most surplus year; Rheumatic arthralgia 512 examples merge chronic gastritis 85 examples; Scorching 146 examples of FENGGUAN, acute 10 examples, chronic 136 examples merge chronic gastritis 64 examples: the RA128 example, initial stages 8 example, mid-terms 86 example, late periods 34, example merged chronic gastritis 32 examples; The AS79 example, early stage 39 examples, late periods 40, example merged chronic gastritis 8 examples; Cervical spondylosis syndrome 130 examples; Other disease 69 examples.Patient all accepted Chinese medicine and western medicine before using poplar spicy medicine and other therapy for treating is invalid.The standard that the national therapy of combining Chinese and Western medicine rheumatism academic conference in 1988 of this group diagnostic criteria regulations is formulated.
Two, Therapeutic Method
Poplar spicy insecticide medicine is made capsule (every capsules contains worm medicine 0.5g) and injection (every ampoule 2ml contains worm medicine 0.5g).Provide poplar spicy insecticide raw material and formulation method by the author, the unit through having dispensing permit is for processing.Preparation procedure all meets Pharmacopoeia of the People's Republic of China version " capsule and injection " in 1985 down relevant every regulation.
Usage: oral capsule: every day 2 times, each 1, after 5 days, every day 2 times, each 2, injection: muscle or the injection of acupuncture point pain spot, every day 1 time, each 2ml, after 10 days, every day 1 time, each 4ml.Inject the patient first, must do the adaptability medication, take out 0.1g injection (0.5ml) and join 2% lignocaine 1ml (alleviating local pain), dilute and be 1.5ml, divide three times every injection in 15 minutes once, local no obvious redness is itched, and reflecting point is less than the equal injectable of 0.5cm.To rheumatic arthralgia and non-acute obvious active stage patient, general oral capsule gets final product, and to acute and obvious active stage patient, can give injection or simultaneously oral, also can cooperate western medicines in treatment as one sees fit.To using the patient of hormone medicine, can after using poplar spicy medicine, gradually reduce hormone dosage to stopping using.Rheumatic arthralgia, FENGGUAN scorching January was 1 course of treatment, totally 1～3 course of treatment; RA, AS2 month was 1 course of treatment, totally 1～5 course of treatment.
Three, criterion of therapeutical effect and result
Curative effect determinate standard meets the academic standard that can formulate of national combination of Chinese and Western medicine rheumatism in 1988.Treatment rheumatism 995 examples, wherein 189 examples merge chronic gastritis, and efficacy result is seen attached list.
Four, toxicity test
Through special toxicity teaching and research room of Shanghai The 2nd Army Medical College test report on October 14th, 90: the oral acute toxicity test of poplar spicy medicine is in 10 days observation of administration, test does not have 1 with 20 of ICR mices and takes place dead, do not see any poisoning symptom yet, weight increase, the mice of test is observed in after dissecting and examines, each organ of internal organs is not seen significant change, and its mouse oral clothes LD50＞5000mg/kg of poplar spicy medicine shows that this medicine is a low toxicity or nontoxic substantially.
Subordinate list 995 examples (189 examples merge chronic gastritis) rheumatism efficacy result table
| The sick kind | The example number | Cure | Produce effects | Effectively | Invalid | Effective percentage | ||||
| Example | (％) | Example | (％) | Example | ?(％) | Example | ?(％) | ????(％) | ||
| Rheumatic arthralgia | 512 | ????198 | ?38.7 | ????177 | ?34.6 | ????101 | ?19.7 | ????36 | ?7.0 | ????93.00 |
| The FENGGUAN inflammation | 146 | ????46 | ?31.9 | ????47 | ?32.2 | ????39 | ?26.7 | ????14 | ?9.6 | ????90.4 |
| ????RS | 128 | ????28 | ?21.9 | ????53 | ?41.4 | ????33 | ?25.8 | ????14 | ?10.9 | ????89.1 |
| ????AS | 79 | ????16 | ?20.3 | ????27 | ?34.2 | ????13 | ?16.5 | ????23 | ?29.1 | ????70.9 |
| Cervical spondylosis | 130 | ????26 | ?20.0 | ????59 | ?45.4 | ????31 | ?23.8 | ????14 | ?10.8 | ????89.2 |
| Chronic gastritis | 189 | ????56 | ?29.6 | ????76 | ?40.2 | ????52 | ?27.5 | ????5 | ?2.6 | ????97.4 |
Clinical acute and obvious active stage patient's 123 examples of single usefulness injection for treating of also having observed; Single with acute and obvious active stage patient's 66 examples of capsule oral agent treatment; Oral and injection mixing treatment patient 875 examples, find that curative effect promptly appearred in 1 day in injection group and mixing treatment group, and oral capsule group patient generally must treatment 3～5 talentes curative effect occur, the combined group curative effect is more stable, the pain spot acupoint injection therapy is fast than the intramuscular injection curative effect, but after continuing treatment 2～3 courses of treatment, three groups of single effective percentage are no significant difference then.
After clinical use was found to remove individual patient and injected first, part or whole body occurred outside the drug eruption, do not have other pairs effect.
Research units of units concerned such as China's insecticide institute studies show that, the chemical constituent of poplar spicy is amine albumen, histamine, acetylcholine, enzyme etc., have analgesia, antiinflammatory, spasmolytic, blood circulation promoting and blood stasis dispelling, repercussive effect, than other treatment rheumatism medicine, good effect not only, the intestines and stomach is not had the effect of paying, and gastrointestinal disease is had positive excellent curative.
Prepare said medicine with the poplar spicy, also have and get material easily, the advantage that with low cost, technology is simple.
Embodiment
The preparation of poplar spicy capsule
Get eight Septembers sophisticated poplar spicy 10kg, put fry in the iron pan do, to burned black, pulverize, No. 1 each capsule of capsule of packing into contains dried medicated powder 0.5g.
Claims (7)
1, the application of poplar spicy in the medicine of preparation treatment rheumatic arthralgia.
2, the application of poplar spicy in the medicine of preparation treatment rheumatic arthritis.
3, the application of poplar spicy in the medicine of preparation treatment rheumatoid arthritis.
4, the application of poplar spicy in the medicine of preparation treatment ankylosing spondylitis.
5, the application of poplar spicy in the medicine of preparation treatment hyperosteogeny.
6, the application of poplar spicy in the medicine of preparation treatment chronic gastritis.
7, the application of poplar spicy in the medicine of preparation treatment stomach, duodenal ulcer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 97109283 CN1215599A (en) | 1997-10-27 | 1997-10-27 | Monema flavescens use |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 97109283 CN1215599A (en) | 1997-10-27 | 1997-10-27 | Monema flavescens use |
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| Publication Number | Publication Date |
|---|---|
| CN1215599A true CN1215599A (en) | 1999-05-05 |
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| CN 97109283 Pending CN1215599A (en) | 1997-10-27 | 1997-10-27 | Monema flavescens use |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100381129C (en) * | 2006-03-28 | 2008-04-16 | 康成礼 | Antitumor animal medicine and its preparing method |
-
1997
- 1997-10-27 CN CN 97109283 patent/CN1215599A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100381129C (en) * | 2006-03-28 | 2008-04-16 | 康成礼 | Antitumor animal medicine and its preparing method |
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