CN121195060A - 源自多能干细胞的cd4阳性t细胞、其制造方法以及其用途 - Google Patents

源自多能干细胞的cd4阳性t细胞、其制造方法以及其用途

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Publication number
CN121195060A
CN121195060A CN202480035239.4A CN202480035239A CN121195060A CN 121195060 A CN121195060 A CN 121195060A CN 202480035239 A CN202480035239 A CN 202480035239A CN 121195060 A CN121195060 A CN 121195060A
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China
Prior art keywords
cells
antigen
derived
ipsc
cell
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CN202480035239.4A
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English (en)
Chinese (zh)
Inventor
安藤美树
安藤纯
石井翠
古川芳树
中内启光
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Saitama Medical University
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Saitama Medical University
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Publication of CN121195060A publication Critical patent/CN121195060A/zh
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CN202480035239.4A 2023-05-31 2024-05-31 源自多能干细胞的cd4阳性t细胞、其制造方法以及其用途 Pending CN121195060A (zh)

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JP2023-089785 2023-05-31
JP2023089785 2023-05-31
PCT/JP2024/020126 WO2024248157A1 (ja) 2023-05-31 2024-05-31 多能性幹細胞由来cd4陽性t細胞、その製造方法及びその用途

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JP (1) JPWO2024248157A1 (https=)
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Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9453219B2 (en) 2003-05-15 2016-09-27 Mello Biotech Taiwan Co., Ltd. Cosmetic designs and products using intronic RNA
US8048999B2 (en) 2005-12-13 2011-11-01 Kyoto University Nuclear reprogramming factor
JP5813321B2 (ja) 2007-03-23 2015-11-17 ウィスコンシン アラムニ リサーチ ファンデーション 体細胞の再プログラム化
JP2008307007A (ja) 2007-06-15 2008-12-25 Bayer Schering Pharma Ag 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞
ES2799897T3 (es) 2007-08-31 2020-12-22 Whitehead Inst Biomedical Res Estimulación de la vía wnt en la reprogramación de células somáticas
KR101564044B1 (ko) 2007-10-31 2015-10-28 고쿠리츠 다이가쿠 호진 교토 다이가쿠 핵초기화 방법
JP5558097B2 (ja) 2007-12-10 2014-07-23 国立大学法人京都大学 効率的な核初期化方法
WO2009079007A1 (en) 2007-12-17 2009-06-25 Gliamed, Inc. Stem-like cells and method for reprogramming adult mammalian somatic cells
WO2009091659A2 (en) 2008-01-16 2009-07-23 Shi-Lung Lin Generation of tumor-free embryonic stem-like pluripotent cells using inducible recombinant rna agents
US20100330677A1 (en) 2008-02-11 2010-12-30 Cambridge Enterprise Limited Improved Reprogramming of Mammalian Cells, and Cells Obtained
EP2090649A1 (en) 2008-02-13 2009-08-19 Fondazione Telethon Method for reprogramming differentiated cells
WO2009102983A2 (en) 2008-02-15 2009-08-20 President And Fellows Of Harvard College Efficient induction of pluripotent stem cells using small molecule compounds
MX2010010165A (es) 2008-03-17 2010-11-25 Scripps Research Inst Procedimientos quimicos y geneticos combinados para generacion de celulas madre pluripotentes inducidas.
WO2009114949A1 (en) 2008-03-20 2009-09-24 UNIVERSITé LAVAL Methods for deprogramming somatic cells and uses thereof
KR20110019727A (ko) 2008-04-07 2011-02-28 뉴포텐셜, 인크. Rna 간섭을 통한 다능 유전자의 유도에 의한 세포 재프로그래밍
CA2695590C (en) 2008-06-27 2018-01-09 Kyoto University Method of efficiently establishing induced pluripotent stem cells
US9453204B2 (en) 2008-07-14 2016-09-27 Oklahoma Medical Research Foundation Production of pluripotent cells through inhibition of bright/ARID3a function
WO2010147612A1 (en) 2009-06-18 2010-12-23 Lixte Biotechnology, Inc. Methods of modulating cell regulation by inhibiting p53
US20120021519A1 (en) 2008-09-19 2012-01-26 Presidents And Fellows Of Harvard College Efficient induction of pluripotent stem cells using small molecule compounds
WO2010033920A2 (en) 2008-09-19 2010-03-25 Whitehead Institute For Biomedical Research Compositions and methods for enhancing cell reprogramming
WO2010042800A1 (en) 2008-10-10 2010-04-15 Nevada Cancer Institute Methods of reprogramming somatic cells and methods of use for such cells
JP2012507258A (ja) 2008-10-30 2012-03-29 国立大学法人京都大学 人工多能性幹細胞の作製方法
US20110059526A1 (en) 2008-11-12 2011-03-10 Nupotential, Inc. Reprogramming a cell by inducing a pluripotent gene through use of an hdac modulator
EP2376626A4 (en) 2008-12-13 2012-10-17 Dna Microarray MICRO-ENVIRONMENTAL NICHE ASSAY FOR SCREENING OF INDUCED PLURIPOTENT STEM CELLS (CIPS)
WO2010098419A1 (en) 2009-02-27 2010-09-02 Kyoto University Novel nuclear reprogramming substance
WO2010102267A2 (en) 2009-03-06 2010-09-10 Ipierian, Inc. Tgf-beta pathway inhibitors for enhancement of cellular reprogramming of human cells
WO2010111409A2 (en) 2009-03-25 2010-09-30 The Salk Institute For Biological Studies Pluripotent stem cells
US20120076762A1 (en) 2009-03-25 2012-03-29 The Salk Institute For Biological Studies Induced pluripotent stem cell generation using two factors and p53 inactivation
WO2010115050A2 (en) 2009-04-01 2010-10-07 The Regents Of The University Of California Embryonic stem cell specific micrornas promote induced pluripotency
WO2010124290A2 (en) 2009-04-24 2010-10-28 Whitehead Institute For Biomedical Research Compositions and methods for deriving or culturing pluripotent cells
WO2010147395A2 (en) 2009-06-16 2010-12-23 Korea Research Institute Of Bioscience And Biotechnology Medium composition comprising neuropeptide y for the generation, maintenance, prologned undifferentiated growth of pluripotent stem cells and method of culturing pluripotent stem cell using the same
JPWO2011096482A1 (ja) 2010-02-03 2013-06-13 国立大学法人 東京大学 多能性幹細胞を用いた免疫機能再建法
JP6164746B2 (ja) 2012-05-22 2017-07-19 国立大学法人 東京大学 抗原特異的t細胞の製造方法
JP7171055B2 (ja) 2017-03-14 2022-11-15 国立大学法人京都大学 多能性幹細胞からヘルパーt細胞を製造する方法
JP7407415B2 (ja) 2019-10-30 2024-01-04 学校法人順天堂 Cd4陽性制御性t細胞の製造方法
JP7712198B2 (ja) 2021-12-16 2025-07-23 鹿島建設株式会社 ボルト緩み検知装置及びボルト緩み検知方法

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KR20260017386A (ko) 2026-02-05
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WO2024248157A1 (ja) 2024-12-05

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