CN1205955C - Composition with intelligence-development, immunological regulation and fatigure resistance - Google Patents

Abstract

The present invention relates to a composition with intelligence-development, immunological regulation and fatigue resistance, which comprises the following components by weight: 50 to 600 portions of ginseng, 200 to 2000 portions of Polygala tenuifolia, 100 to 1000 portions of Morinda officinalis and 100 to 1000 portions of ningpo yam rhizome.

Description

A kind of compositions that has Fructus Alpiniae Oxyphyllae, regulates immunity and antifatigue effect

Invention field

The present invention relates to a kind of compositions that has Fructus Alpiniae Oxyphyllae, regulates immunity and antifatigue effect, be referred to as golden brain intelligence treasured again.

Background technology

Corticocerebral function becomes the human object of oneself studying for a long time, up to the initial stage in last century, Pavlov has founded the higher nerve theory, he utilizes trained reflex to begin the objective experimentation of corticocerebral function and mechanics thereof, and the Premium Features of understanding brain have been made important contribution.

Find having a high IQ of groups of people in social activity, groups of people's IQ is low, and part student can be admitted to a university, and it is unable to do what one wishes that part student feels.Some place is turned out talents many, and some place is turned out talents few.Is what reason this? the physicist thinks: the people to the physiological characteristics of the brain of being born be consistent basically, mainly be except that posteriori cultivation, social environment, family life, be exactly the energy feedstuff deficiency of brain.Such as with regard to modern bio electricity, if a certain item of bio electricity lack of material in vivo will cause the generation of disease, can make people's arrhythmia as magnesium deficiency, potassium deficiency can make the people feel tired.These bio electricities play bioelectric balance at human body to a certain extent, and play wireless emission and storage.Such as, done dream evening, the thing that is taken place conforms to fully with daydream every other day.For another example today cardiopalmus always, eyelid flickering, what takes place in it feels like, the result has taken place.These all are bioelectric effects.If so human higher nervous activity lacks energy, will on intelligence, space out.According to the physical energy conservation law, human memory is a kind of bio-electric phenomenon, and the electric weight deficiency is the main cause of amnesia, and additional electric weight will make hypermnesia.Therefore be crucial for additional brain-capacity.

Summary of the invention

The purpose of this invention is to provide a kind of compositions that has Fructus Alpiniae Oxyphyllae, regulates immunity and antifatigue effect, be referred to as golden brain intelligence treasured again.It can replenish brain with energy.Try clothes through hundreds of high school students and brain worker and have no side effect, effect is obvious behind the first quarter moon, feels energetic, and resourceful, memory obviously strengthens.

Compositions of the present invention is made by following bulk drugs:

Radix Ginseng 50-600 weight portion,

Radix Polygalae 200-2000 weight portion,

Radix Morindae Officinalis 100-1000 weight portion and

Rhizoma Dioscoreae Nipponicae 100-1000 weight portion.

Compositions of the present invention is made by following bulk drugs:

Radix Ginseng 200-400 weight portion

Radix Polygalae 900-1200 weight portion

Radix Morindae Officinalis 400-500 weight portion and

Rhizoma Dioscoreae Nipponicae 400-500 weight portion.

The weight portion of each raw material of the present composition is preferably:

Radix Ginseng 300 weight portions,

Radix Polygalae 1000 weight portions,

Radix Morindae Officinalis 500 weight portions and

Rhizoma Dioscoreae Nipponicae 500 weight portions.

Wherein under above various situations, Radix Ginseng is preferably the Radix Ginseng.

Health-care effect of the present invention has: (1) is mainly used in mental work and college admission examination hypermnesis, improves resourceful property.Intelligence raising to low-intelligence children has certain curative effect.Also can be used as the auxiliary treatment of various brain sequela.Neurasthenia, neurosis, convalescent rehabilitation greatly after being ill also there is certain curative effect.(2) can improve the efficient of mental work.The effect that increases immunologic function is arranged: after taking constant as the normal person, times of common cold obviously reduces.(3) can guarantee sleep quality, to serious cardiopalmus, have palpitation, breathe hard, intractable insomnia, cerebral blood supply insufficiency and childhood hyperkinetic syndrome have obvious curative effects.(4) energy blood sugar regulation, stabilizing blood pressure, the symptom of improving apoplexy has positive effect.(5) the oral easy absorption of the present composition takes that the active component haemoconcentration reaches the peak after 2-6 hour, continues about 12-24 hour, and 99% combines with plasma protein.Concentration is higher 10 times than blood concentration approximately in the brain.Can pass through blood-brain barrier.Mainly metabolism in liver, oxidation combines with glucuronic acid.Through renal excretion, part also can be with bile excretion.Half-life is about 12-24 hour.After long-term user's drug withdrawal half a year, still can in urine, measure the metabolite of brain-capacity.

The energy feedstuff of brain is a fat-soluble high material in the blood, more easily passes through blood-brain barrier.Mass exchange between blood-brain is much slower than the mass exchange between human body other parts blood and the tissue.And also have certain selectivity, even this concentration that has just guaranteed some material in the blood has bigger change, also can keep among the central nervous system in environment constant relatively, and stop entering of some harmful substance.The brain-capacity content of starting materials can effectively pass through blood-brain barrier, to increase neural nutrition, guarantees the function of central nervous system's normal intelligence.

The energy feedstuff of brain increases after internal carotid artery and vertebral artery are supplied to brain, and can reach cerebral blood flow and account for 15% of per minute general output.Because the energy consumption of neuron cell space is very high, the energy in the grey matter approximately than the big 4-6 of white matter doubly.The brain power consumption is not only high but also quite constant, under physiological conditions, no matter is nervous mental work, and is excited, even sleep, and total power consumption of brain changes greatly.Neuron is very responsive to lacking brain-capacity, stops all to supply brain-capacity, i.e. loss of consciousness in the brain.Adapt therewith, replenish brain-capacity, consciousness is increased, the data base reserves will be many more.Human body is regulated by brain-capacity and is kept the constant of brain IQ.

Compositions of the present invention can be made various suitable preparations by the common method of this area.

For example, a kind of production method comprises:

The general ball of machinery system joins binding agent gradation such as raw material fine powder and water in the general ball plaque, makes circular motion then, is bonded to spherical ball after making the medicated powder moistening.

1, molding is placed on a small amount of raw material at one end of general ball plaque, with brush dip in water equably brushing at the other end of general ball plaque, by general ball plaque " spread ", action such as " pendulum ", " turning over ", make raw material wetted, and stick on the plaque, the dried brush of reuse with the wet-milling brush down, promptly forms granule gently, adds raw material and water once more, rotate general ball plaque, make its size evenly, form qualified ball mould, use for general ball.

2, after general ball adds water-wet to mould, add a small amount of raw material powder again, constantly stir and make it evenly to be adsorbed on mold surface, add water-wet again, adding powder changes it, and so repeatable operation is smooth until the outward appearance rounding, quality is tight, and size is consistent, and weight is up to specification to get final product.

Diligent screening in the general system process makes the finished product size evenly.Sift out underproof big ball and can add water and make medicine slurry, for general ball once more or make the last capping of pill and use.Piller then can continue general system, until qualified.

General ball adds water, and adding the amount He Jiashui of powder, the blanking time that adds powder is " sparing no effort on a small quantity ", " few earlier back is many ".Adding should be gently general behind the powder, in order to avoid dust from flying, it is general to add the water reserve strength, in order to avoid the bonding in bulk.

3, capping is that the general ball that makes is processed again, its objective is that the ball size is consistent, and color and luster is even, and the profile rounding is bright and clean.Much more general with slurry head (be about to raw material or useless ball and add the glop that water is mixed and made into) capping, promptly general again last layer medicine is starched on general good ball surface.

4, dry water pill generally should be at temperature drying below 80 ℃, in order to avoid the starch in the pill loses the disintegrate ability because of gelatinizing.

5, the purpose of coating water pill coating has: (1) brings into play quick-acting effects, is about in the prescription some pill that need bring into play quick-acting effects and wears into the fine powder coating, makes its dissolving earlier in gastrointestinal, absorbs earlier, so can play quick-acting effects.(2) shield, be difficult for loss, oxidation deterioration and damage by worms rotten because of making the effective ingredient in the water pill behind the coating.(3) can cover the bitterness foreign odor of some drugs.(4) after enteric coated, can reduce to the zest of stomach with by the destructive probability of gastric juice.

Coating equipment and technology process is similar to tablet.With the coating material is ferrum oxide.Must be before the coating with the general drying of water, in order to avoid split ball during coating, also need add the insect wax polishing behind the coating,, rounding bright and clean and compactness with the outward appearance that increases medicine.

6, autoclaving.

7, packing.

Quality standard:

(1) appearance requirement pill size rounding, evenly, color and luster is consistent.

(2) the moisture limit is got test sample according to " measuring with oven drying method or toluene method under Chinese pharmacopoeia version appendix in 1985 the aquametry item, except as otherwise herein provided, must not surpass 9%.

(3) limit test of weight variation is got test sample 10 balls for a, gets 10 parts altogether, divides another name to decide weight, every part of weight is compared with sign weight, should meet following table regulation, what exceed limit test of weight variation should be more than 2 parts, and 1 part of a times of exceeding limit test of weight variation must not be arranged.

(4) inspection method is got 10 bags of test samples, after dividing the weight of the fixed every bag of content of another name, every packed amount is compared with labelled amount, should meet the table regulation, what exceed the content uniformity limit should be more than 2 bags, and one bag of a times of exceeding shape amount difference limit must not be arranged.

(5) dissolve scattered time limit is got test sample 6 balls except as otherwise herein provided, the method inspection under photo agent disintegration, general ball etc. should be in 1 hour all molten loosing.

Above-mentioned inspection is not passed through screen cloth at the appointed time all by screen cloth if any fine particle shape thing, the lattice theory but softening no hard-core person can make a match.

The usage of the present composition is oral, 4-8 year, a 2g; 6g more than 8 years old once-a-day, preferably takes for late about 7, and one month was 1 course of treatment.

Golden brain intelligence of the present invention is precious by 260 person-times of oral experiments of crowd, confirms to truly have the stable regulation immunologic function, and the effect of function of human body, improves memory, resisting fatigue, and blood sugar regulation, stabilizing blood pressure, improving rheumatismal symptom has positive effect.

1, the present composition can be strengthened the excitement and the process of inhibition of animal higher nervous activity, tries to obey the effect that tangible hypermnesis is arranged through 260 mental works and student, and can strengthen the adaptive capacity to all nonspecific stimulations.

2, can reduce feeling of fatigue (can prolong the persistent period of white mice swimming), the precious immersion of 10% gold medal brain intelligence irritates stomach for cat (or rabbit) for 1 milliliter/kilogram, and the amyocardia is had some improvement.Antianaphylaxis shock and cardiac stimulant effect are also arranged.

3, strengthen the resistance of body to harmful factor: (1) can make the plasmodial chicken of infection avoid death, and the body weight of chicken also increases gradually.(2) can strengthen the ability that human body adapts to temperature Change, also can improve the ability of white mice withstand high temperatures.(3) promote the healing of some experimental damage.(4) effect of vitamin antagonist B1, B2, Vc, potassium, calcium deficiency is arranged.(5) can quicken the healing effect of rabbit experiment corneal ulcer.(6) can weaken the effect of some poisonous substance (benzene, tetraethyl-lead, three cresol phosphoric acid etc.) to body.

4, hyperglycemia animal there is the effect of blood sugar lowering; Improve outside the symptom the diabetics decapacitation is conscious, also have slight hypoglycemic activity, and have collaborative effect with islets of langerhans.

5, at suitable dosage, also can weight increase to rabbit, the ratio of plasma albumin and globulin is risen.

6, hemopoietic organ has the effect that improves anemia.

7, various chronic inflammatory diseases there is rehabilitative action, bacteriostatic test:, Diplococcus pneumoniae is all had inhibitory action to staphylococcus aureus, Bacillus typhi, paratyphoid bacillus A and shigella flexneri, dermatophytes, tubercule bacillus medium sensitivity.

Embodiment

Illustrate the present invention by the following examples, but it should be understood that these embodiment only are used for explanation, never limit the present invention.Those skilled in the art will be clear, in scope and spirit of the present invention, can make some variation and modification, and they all will be included in protection scope of the present invention.

Radix Ginseng 300g,

Radix Polygalae 1000g,

Radix Morindae Officinalis 500g and

Rhizoma Dioscoreae Nipponicae 500g,

Prepare by following steps:

1, above-mentioned raw materials is pulverized in molding, sieves, and a small amount of raw material is placed on an end of general ball plaque, with brush dip in water equably brushing at the other end of general ball plaque, by general ball plaque " spread ", action such as " pendulum ", " turning over ", make raw material wetted, and stick on the plaque, the dried brush of reuse with the wet-milling brush down, promptly forms granule gently, adds raw material and water once more, rotate general ball plaque, make its size evenly, form qualified ball mould, use for general ball.

2, after general ball adds water-wet to mould, add a small amount of raw material powder again, constantly stir and make it evenly to be adsorbed on mold surface, add water-wet again, adding powder changes it, and so repeatable operation is smooth until the outward appearance rounding, quality is tight, and size is consistent, and weight is up to specification to get final product.

Diligent screening in the general system process makes the finished product size evenly.Sift out underproof big ball and can add water and make medicine slurry, for general ball once more or make the last capping of pill and use.Piller then can continue general system, until qualified.

3, capping is that the general ball that makes is processed again, its objective is that the ball size is consistent, and color and luster is even, and the profile rounding is bright and clean.Much more general with slurry head (be about to raw material or useless ball and add the glop that water is mixed and made into) capping, promptly general again last layer medicine is starched on general good ball surface.

4, dry water pill generally should be at temperature drying below 80 ℃, in order to avoid the starch in the pill loses the disintegrate ability because of gelatinizing.

5, coating.

6, autoclaving.

7, packing.

Claims (5)

1, a kind of compositions that has Fructus Alpiniae Oxyphyllae, regulates immunity and antifatigue effect, make by following bulk drugs:

Radix Ginseng 50-600 weight portion,

Radix Polygalae 200-2000 weight portion,

Radix Morindae Officinalis 100-1000 weight portion and

Rhizoma Dioscoreae Nipponicae 100-1000 weight portion.

2, according to the compositions of claim 1, make by following bulk drugs:

Radix Ginseng 200-400 weight portion

Radix Polygalae 900-1200 weight portion

Radix Morindae Officinalis 400-500 weight portion and

Rhizoma Dioscoreae Nipponicae 400-500 weight portion.

3, according to the compositions of claim 1, make by following bulk drugs:

Radix Ginseng 300 weight portions,

Radix Polygalae 1000 weight portions,

Radix Morindae Officinalis 500 weight portions and

Rhizoma Dioscoreae Nipponicae 500 weight portions.

4, according to each compositions among the claim 1-3, wherein Radix Ginseng is the Radix Ginseng.

5, according to each preparation of compositions method among the claim 1-3, step is as follows:

(1) molding;

(2) general ball;

(3) capping;

(4) drying;

(5) coating;

(6) autoclaving; With

(7) packing.