CN1099282A - Compound lotus plumule liquid and its preparation - Google Patents
Compound lotus plumule liquid and its preparation Download PDFInfo
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- CN1099282A CN1099282A CN93116925A CN93116925A CN1099282A CN 1099282 A CN1099282 A CN 1099282A CN 93116925 A CN93116925 A CN 93116925A CN 93116925 A CN93116925 A CN 93116925A CN 1099282 A CN1099282 A CN 1099282A
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Abstract
The compound lotus seed liquid is prepared from lotus seed, seed of ziziphus spinosa and tangerine peel by the steps of boil-extracting, concentrating, removing impurities with alcohol precipitating, recovering of alcohol, filtering and packing into oral liquid, it is helpful to prevent and treat insomnia, thirst, hidrosis, palpitation and neurastheniac; the preparation process is simple, the produce is safe, stable and convenient in use.
Description
The present invention relates to a kind of extract oral liquid formulation.
Among the people, often, be used for treating clearing away heart-fire, hemostasis, arresting seminal emission with the soaked tea-drinking of working as of Plumula Nelumbinis.But this folk remedy is single, and therapeutic domain is narrower.
The objective of the invention is on the basis of folk remedy, screening meticulously, rigorous prescription increases some new medicines, forms compound formulation, enlarges the scope of treatment disease, and it is perfect that prescription is more attained.And with the Chinese herbal medicine extracting method of the modern science Impurity removal with Chinese herbal medicine, thereby purified medicinal liquid is more tended towards stability, dosage is accurate, taking convenience.
Purpose of the present invention adopts following prescription to reach (by weight):
Plumula Nelumbinis 100 Semen Ziziphi Spinosaes 100 Pericarpium Citri Reticulataes 200 Mel 200
Antiseptic is an amount of
The preparation technology who produces medicine of the present invention is:
Plumula Nelumbinis, Semen Ziziphi Spinosae, Pericarpium Citri Reticulatae three flavor medicines are decocted with water secondary, and each two hours, collecting decoction filtered, and added 70% ethanol stirring.Left standstill 24-48 hour, and reclaimed ethanol, filter.Other gets Mel 200 and is heated to 85-95 ℃, is incubated 0.5-1 hour, and adding preservative agent stirs evenly in right amount, filters, and puts cold.Be added in the above-mentioned concentrated solution, add water and stir evenly, filter, fill promptly.
Now further specify the present invention in conjunction with the embodiments.
Embodiment:
Plumula Nelumbinis 100g, Semen Ziziphi Spinosae 100g, Pericarpium Citri Reticulatae 200g, Mel 200g
Benzoic acid is an amount of
Make 1000 milliliters altogether
With Plumula Nelumbinis 100g, Semen Ziziphi Spinosae 100g, Pericarpium Citri Reticulatae 200g, three flavor medicines decoct with water secondary, and each two hours, collecting decoction filtered, and added 70% ethanol stirring.Left standstill 48 hours, and reclaimed ethanol, filter.Other gets 200g Mel and is heated to 90 ℃, is incubated 1 hour, adds benzoic acid and stirs evenly in right amount, filters, and places room temperature, is added in the above-mentioned concentrated solution, and adding distil water to 1000 milliliter stirs evenly filtration, and 10 milliliters every of fills promptly.
In order to keep the stability of product, the pH value of medicinal liquid should be controlled between the 4.0-5.0.
Compound lotus plumule liquid is according to having increased the new Chinese medicine oral liquid that Pericarpium Citri Reticulatae, Semen Ziziphi Spinosae two flavor medicines are drafted on the soaked basis of curing the disease when tea-drinking of folk remedy Plumula Nelumbinis, and this oral liquid formulations has mind calming, calms the nerves, nourishes blood, the effect of clearing heat and relieving fidgetness.Take the effectiveness that can reach life lengthening throughout the year.Preparation has been carried out pharmacodynamic study according to its function with curing mainly, every 100ml medicinal liquid contains embryo nelumbinis 10g, Pericarpium Citri Reticulatae 20g, Semen Ziziphi Spinosae 10g.Now result of the test is reported as follows:
Material
Medicine: compound lotus plumule liquid, develop by Yujiang Pharmaceutical Factory
DIAOXINXUE KANG: pharmaceutical factory of Chendu Inst. of Biology, Chinese Academy of Sciences produces
SHENRONG FENGWANG JIANG: Chinese Tonghua Bai Shan pharmaceutical factory produces
BABAO JINGFENG SAN: Xingning, Guangdong pharmaceutical factory produces
Animal: mice is planted by Switzerland; Animal housing of Jiangxi Medical College provides
One, to the influence of mice normal pressure anoxia enduring
Get 48 of white mice, body weight 17.0 ± 0.6g, male and female dual-purpose are divided into four groups at random: (1) normal saline group, (2) compound lotus plumule liquid high dose group (0.167ml/kg); (3) compound lotus plumule liquid low dose group (0.083ml/kg); (4) SHENRONG FENGWANG JIANG group (0.16ml/kg) is pressed above dosage gastric infusion, 1 time/day, continuous 3 days respectively, after the last administration 50 minutes, mice is put in the 125ml wide mouthed bottle that fills the 2g sodica calx close plug, write down each Mus in the following time-to-live of anoxia condition, result such as table 1.
Table 1 compound lotus plumule liquid is to the influence of mice anoxia enduring existence
Group dosage number of animals hypoxia endurance time
(ml/kg) (only) (min)
Normal saline group 0.17 12 26.08 ± 4.8
Compound lotus plumule liquid 0.167 12 32.56 ± 6.0
*
High dose group
Compound lotus plumule liquid 0.083 12 30.03 ± 5.7
Low dose group
SHENRONG FENGWANG JIANG group 0.167 12 46.66 ± 7.6
*
Compare P＜0.01 with the normal saline group
Table 1 result shows that compound lotus plumule liquid high dose group energy significant prolongation mice anoxia enduring life span (P＜0.01) is similar to the SHENRONG FENGWANG JIANG effect, and the compound lotus plumule liquid low dosage also prolonged to some extent to the mice anoxia enduring time-to-live.
Two, to the influence of spontaneous activity in mice
Get 40 of mices, body weight 20.9 ± 2.7g male and female dual-purpose is divided into 4 groups at random: (1) normal saline group; (2) compound lotus plumule liquid high dose group (0.167ml/kg); (3) compound lotus plumule liquid low dose group (0.083ml/kg); (4) BABAO JINGFENG SAN group (1.8g/kg) is respectively by above dosage gastric infusion, 1 time/day, continuous 3 days, after the last administration 1 hour, mice is counted spontaneous activity in mice number of times in 2 minutes by only being put in YSD-4 type animal activity counting box (production of honeybee port radio two factories), the results are shown in Table 2.
Table 2 compound lotus plumule liquid is to the influence of spontaneous activity in mice
Group dosage number of animals spontaneous activity number of times
(ml/kg) (only) (inferior)
Normal saline group 0.2 9 50.0 ± 13.9
Compound lotus plumule liquid 0.167 10 27.9 ± 11.5
*
High dose group
Compound lotus plumule liquid 0.083 10 27.8 ± 13.0
*
Low dose group
BABAO JINGFENG SAN 1.8 10 41.2 ± 17.6
Compare P＜0.01 with the normal saline group
Can significantly reduce spontaneous activity in mice number of times (P＜0.01) by the visible compound lotus plumule liquid of table 2 result.
Three, the influence that hemolysin in the sheep red blood cell (SRBC) sensitized mice body is formed
Get 40 of mices, the male and female dual-purpose, body weight 17.16 ± 0.4g is divided into 4 groups at random by method 1, the difference gastric infusion, 1 time/day, continuous 6 days, in administration the 2nd day, every Mus is lumbar injection sheep red blood cell (SRBC) suspension (erythrocyte: 0.2ml sensitization normal saline=3: 5) respectively, the 5th day mouse orbit got blood after sensitization, measures the mice half hemolysis value, result such as table 3.
The influence that table 3 compound lotus plumule liquid forms hemolysin in the red sheep red blood cell (SRBC) sensitized mice body
Group dosage number of animals half hemolysis value
(ml/kg) (only)
Normal saline group 0.17 10 129.06 ± 55.6
Compound lotus plumule liquid 0.167 10 214.63 ± 6.64
*
High dose group
Compound lotus plumule liquid 0.083 10 180.31 ± 68.4
Low dose group
SHENRONG FENGWANG JIANG group 0.167 10 166.8 ± 42.5
Compare P＜0.01 with the normal saline group
Table 3 result shows that the high dose compound lotus plumule liquid can significantly increase the formation (P＜0.01) of hemolysin in the mice body, and the low dosage compound lotus plumule liquid also forms hemolysin in the mice body and strengthens to some extent.
Four, chloroform is caused the ARR influence of mice
Get 64 of mices, the male and female dual-purpose, body weight 23.02 ± 1.4g is divided into four groups at random: (1) normal saline group; (2) compound lotus plumule liquid high dose group (0.167ml/kg); (3) compound lotus plumule liquid low dose group (0.083ml/kg); (4) DIAOXINXUE KANG group (200mg/kg), respectively by above dosage gastric infusion, 1 time/day, continuous 9 days, after the last administration 1 hour, mice by only being put in the inverted 600ml beaker that contains 3ml chloroform cotton balls, is treated that mouse breathing stops, take out recording ecg (II is led) immediately and cut open breast and line-of-sight observation ventricular fibrillation situation, result such as table 4.
Table 4 compound lotus plumule liquid causes the influence of mice arrhythmia to chloroform
Group dosage number of animals incidence of arrhythmia
(ml/kg) (only) (%)
Normal saline group 0.17 15 80.0
Compound lotus plumule liquid 0.167 13 30.7
*
High dose group
Compound lotus plumule liquid 0.083 16 37.5
*
Low dose group
DIAOXINXUE KANG 0.20 16 25.0
*
Compare with the normal saline group
*P＜0.01 is through X
2Check
The visible compound lotus plumule liquid of table 4 result can significantly resist the mice arrhythmia that chloroform causes, through X
2Check P＜0.01, similar to the DIAOXINXUE KANG effect.
Above-mentioned experimental result shows: compound lotus plumule liquid can resist the mice arrhythmia that chloroform causes; Reduce the spontaneous activity in mice number of times; Prolong the mice hypoxia endurance time; Promote the formation of hemolysin in the sheep red blood cell (SRBC) sensitized mice body, improve antibody horizontal in the body, illustrate this oral liquid have clear away heart-fire, calm the nerves, sedation, and can the enhancing human body immunity function, enhancing body has certain tonic effect to the adaptive capacity of adverse circumstances.
The Main Ingredients and Appearance liensinine of bibliographical information compound lotus plumule liquid has blood pressure lowering to the antiarrhythmic effect; Pericarpium Citri Reticulatae has dual regulation to the human body cardiovascular system; Semen Ziziphi Spinosae has tranquilizing effect, cures mainly the neurasthenia.The above-mentioned pharmacological tests of compound lotus plumule liquid and reported in literature basically identical.
Compound lotus plumule liquid is carried out the acute toxicity test result to be shown: no abnormality seens such as outward appearance behavior after 20 mice administrations, diet, defecation, animal does not have death in 7 days.Compound lotus plumule liquid to the maximum tolerated dose of mice more than 50ml/kg.Press weighing machine, this dosage consumption per day (10ml/60kg) that is equivalent to be grown up is 0.167ml/kg) 300 times.This test prompting, compound lotus plumule liquid toxicity is very little.
This preparation is taked low temperature, room temperature, carried out Study on Stability, the result shows that compound lotus plumule liquid was placed 6 months at ambient temperature, 37-40 ℃, the condition of relative humidity 75% was placed after 3 months, its character, discriminating, relative density, pH value, the equal no change of projects such as health examination illustrates its steady quality, with reference to the regulation of FDA, said preparation can be decided to be 2 years storage period.Alcove temperature investigation method table.Observation index:
1, color and luster: with new preparation finished product color and luster is benchmark, color and luster is changed be divided into fourth gear.
(1) basic no change (±); (2) color and luster is slightly deepened (±);
(3) color and luster is deepened (++); (4) color and luster very dark (+++);
2, clarity is benchmark with new system finished product clarity, muddy Cheng Du, is divided into third gear, be followed successively by ± ,+, ++, (± expression sample does not change substantially)
Investigation the results are shown in Table 1, table 2, table 3
Table 1(lot number: 920614)
Time color and luster clarity pH value relative density is differentiated sanitary inspection
0 month pale brown color clarifies 4.4 1.10, and to be positive reaction up to specification
2 months ± ± 4.4 1.10 to be positive reaction up to specification
4 months ± ± 4.5 1.10 to be positive reaction up to specification
6 months ± ± 4.5 1.10 to be positive reaction up to specification
Table 2 (lot number: 920616)
Time color and luster clarity pH value relative density is differentiated health examination
0 month pale brown color clarifies 4.5 1.11, and to be positive reaction up to specification
2 months ± ± 4.5 1.11 to be positive reaction up to specification
4 months ± ± 4.6 1.11 to be positive reaction up to specification
6 months ± ± 4.6 1.11 to be positive reaction up to specification
Table 3 (lot number: 920618)
Time color and luster clarity pH value relative density is differentiated health examination
0 month pale brown color clarifies 4.6 1.12, and to be positive reaction up to specification
2 months ± ± 4.6 1.12 to be positive reaction up to specification
4 months ± ± 4.7 1.12 to be positive reaction up to specification
6 months ± ± 4.8 1.12 to be positive reaction up to specification
The usage of compound lotus plumule liquid and consumption: oral, each 10 milliliters, every day three times, or follow the doctor's advice.
Plumula Nelumbinis in the side, the nature and flavor bitter cold, clearing away heart-fire, hemostasis, arresting seminal emission, the Semen Ziziphi Spinosae the liver benefiting that nourishes heart, the arresting sweating of calming the nerves, Pericarpium Citri Reticulatae circulation of qi promoting spleen invigorating, all medicines share the receipts mind calming, feel at ease to calm the nerves, and the clearing heat and relieving fidgetness that nourishes blood provides a kind of health care medicine of long-term drink for people.
Claims (3)
1, a kind of compound lotus plumule liquid is characterized in that forming its proportioning (by weight) with Plumula Nelumbinis, Semen Ziziphi Spinosae, Pericarpium Citri Reticulatae, Mel:
Plumula Nelumbinis 100 Semen Ziziphi Spinosaes 100 Pericarpium Citri Reticulataes 200 Mel 200
Antiseptic is an amount of
2, a kind of preparation method of compound lotus plumule liquid is characterized in that it being to make by following preparation technology:
Plumula Nelumbinis, Semen Ziziphi Spinosae, Pericarpium Citri Reticulatae three flavor medicines are decocted with water secondary, and each two hours, collecting decoction filtered, and added 70% ethanol stirring.Left standstill 24-48 hour, and reclaimed ethanol, filter.Other gets Mel 200 and is heated to 85-95 ℃, is incubated 0.5-1 hour, and adding preservative agent stirs evenly in right amount, filters, and puts cold.Be added in the above-mentioned concentrated solution, add water and stir evenly, filter, fill promptly, every 10ml.
3, compound lotus plumule liquid according to claim 1 and 2 and preparation method thereof is characterized in that the medicinal liquid that extracts is an oral liquid formulations, and every is 10 milliliters, and the pH value of its medicinal liquid should be controlled between the 4.0-5.0.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93116925A CN1099282A (en) | 1993-08-21 | 1993-08-21 | Compound lotus plumule liquid and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93116925A CN1099282A (en) | 1993-08-21 | 1993-08-21 | Compound lotus plumule liquid and its preparation |
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| Publication Number | Publication Date |
|---|---|
| CN1099282A true CN1099282A (en) | 1995-03-01 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93116925A Pending CN1099282A (en) | 1993-08-21 | 1993-08-21 | Compound lotus plumule liquid and its preparation |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1060364C (en) * | 1996-10-30 | 2001-01-10 | 江苏省医药工业研究所 | Anti-neurosism preparation and its preparing technology |
| CN1742837B (en) * | 2005-09-19 | 2010-04-28 | 江西天施康中药股份有限公司 | Compound lotus core oral liquid and its preparing method |
| CN105724691A (en) * | 2016-03-02 | 2016-07-06 | 杭州韩创文化创意有限公司 | Preparation method of heat-clearing and nerve-soothing lotus seed tea |
| CN112450433A (en) * | 2020-10-23 | 2021-03-09 | 瑞腾丰科技发展(北京)有限公司 | Medicinal and edible preparation with immunity enhancing function and preparation method thereof |
-
1993
- 1993-08-21 CN CN93116925A patent/CN1099282A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1060364C (en) * | 1996-10-30 | 2001-01-10 | 江苏省医药工业研究所 | Anti-neurosism preparation and its preparing technology |
| CN1742837B (en) * | 2005-09-19 | 2010-04-28 | 江西天施康中药股份有限公司 | Compound lotus core oral liquid and its preparing method |
| CN105724691A (en) * | 2016-03-02 | 2016-07-06 | 杭州韩创文化创意有限公司 | Preparation method of heat-clearing and nerve-soothing lotus seed tea |
| CN112450433A (en) * | 2020-10-23 | 2021-03-09 | 瑞腾丰科技发展(北京)有限公司 | Medicinal and edible preparation with immunity enhancing function and preparation method thereof |
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