CN120519520A - 用于生成car-t细胞的两类基因载体及其用途 - Google Patents

用于生成car-t细胞的两类基因载体及其用途

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Publication number
CN120519520A
CN120519520A CN202510607212.4A CN202510607212A CN120519520A CN 120519520 A CN120519520 A CN 120519520A CN 202510607212 A CN202510607212 A CN 202510607212A CN 120519520 A CN120519520 A CN 120519520A
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China
Prior art keywords
seq
promoter
cells
sequence
sequence identity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202510607212.4A
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English (en)
Chinese (zh)
Inventor
R·伊斯梅尔
李韵沁
M·鲁滨逊
陈颖欣
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mindas Therapeutics Inc
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Medix Medical Pte Ltd
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Application filed by Medix Medical Pte Ltd filed Critical Medix Medical Pte Ltd
Publication of CN120519520A publication Critical patent/CN120519520A/zh
Pending legal-status Critical Current

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/41—Vertebrate antigens
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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CN202510607212.4A 2018-11-14 2019-11-14 用于生成car-t细胞的两类基因载体及其用途 Pending CN120519520A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862767069P 2018-11-14 2018-11-14
US62/767,069 2018-11-14
PCT/US2019/061549 WO2020102589A1 (en) 2018-11-14 2019-11-14 Two-gene vectors for generating car-t cells and uses thereof
CN201980082104.2A CN113227144B (zh) 2018-11-14 2019-11-14 用于生成car-t细胞的两类基因载体及其用途

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CN120519520A true CN120519520A (zh) 2025-08-22

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CN201980082104.2A Active CN113227144B (zh) 2018-11-14 2019-11-14 用于生成car-t细胞的两类基因载体及其用途

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US (1) US20210395779A1 (https=)
EP (1) EP3864052A4 (https=)
JP (2) JP2022512994A (https=)
KR (1) KR20210091250A (https=)
CN (2) CN120519520A (https=)
AU (1) AU2019378039A1 (https=)
CA (1) CA3119296A1 (https=)
MA (1) MA53877A (https=)
SG (1) SG11202104334SA (https=)
WO (1) WO2020102589A1 (https=)

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CN118221810A (zh) * 2024-03-05 2024-06-21 武汉生物制品研究所有限责任公司 一种能够结合ev-a71的单克隆抗体及其应用
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EP3784776A4 (en) * 2018-05-23 2022-01-26 National University of Singapore Blockade of cd2 surface expression and expression of chimeric antigen receptors for immunotherapy of t-cell malignancies
JP2021525067A (ja) * 2018-05-23 2021-09-24 ナショナル ユニバーシティ オブ シンガポール Ｔ細胞悪性腫瘍の免疫療法のためのキメラ抗原受容体およびｃｄ２の遺伝子編集

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CN113227144B (zh) 2025-04-25
CN113227144A (zh) 2021-08-06
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MA53877A (fr) 2022-01-19
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