CN1204904C - Process for preparing liniment to treat leukoderma - Google Patents

Abstract

The present invention discloses a method for preparing special liniment for leukoderma. The therapeutic effect of original medicines for curing leukoderma is not ideal. The present invention is composed of the raw materials of the following proportion by weight: 3.5 to 4.5 portions of smilax, 3.5 to 4.5 portions of red sage root, 3.5 to 4.5 portions of dahurian angelica root, 0.5 to 1.5 portions of safflower, 5.5 to 6.5 portions of rhizoma and 1.5 to 2.5 portions of spatholobus stem. The six Chinese herbal medicines are decocted twice; decocted liquids are combined, and a clear liquid is sucked; ethanol is added to the clear liquid after the clear liquid is concentrated; after the clear liquid is precipitated and filtered, ethanol is recovered by decompression, and the rest liquid is concentrated; water, the amount of which is 8 to 12 times that of the rest liquid is added; after the liquid is statically placed, a clear liquid is taken; then, the clear liquid is concentrated, and ethanol and a proper amount of water are added to the clear liquid; the liniment is made by regulating the ethanol content. The liniment has an obvious therapeutic effect on treating leukoderma through clinical observation.

Description

A kind of preparation method of liniment to treat leukoderma

The present invention relates to a kind of preparation method of Chinese patent medicine, especially treat the preparation method of leukodermic special-purpose liniment.

Vitiligo is a kind of common pigment obstacle dermatoses, no conscious sympton, and the course of disease slowly is difficult to cure, though threat to life not, the vitiligo of exposure portion has a strong impact on beauty treatment, causes great misery to patient.Treating this sick medicine in the market has a lot, comprise oral medicine and liniment etc., but therapeutic effect is all not ideal enough.

Purpose of the present invention just provides a kind of preparation method that can effectively treat leukodermic special-purpose liniment.

The present invention is raw material with the Chinese herbal medicine, specifically is made up of 3.5～4.5 parts of (weight ratio) Rhizoma Smilacis Chinensiss, 3.5～4.5 parts of Radix Salviae Miltiorrhizaes, 3.5～4.5 parts of Radixs Angelicae Dahuricae, 0.5～1.5 part of Flos Carthami, 5.5～6.5 parts of Rhizoma Smilacis Glabraes and 1.5～2.5 portions of Caulis Spatholobis; Get this 6 flavor Chinese herbal medicine totally 8～12kg decoct with water twice, 1～3 hour for the first time, 0.5～1.5 hour for the second time, collecting decoction filters, and leaves standstill 12～36 hours, draw supernatant, filter, it is 1.2～1.3 clear paste that filtrate is concentrated into relative concentration, put coldly, add the ethanol of 2.5～3.5 times of amounts, stir evenly, left standstill 12～36 hours, and made precipitation, filter, decompression filtrate recycling ethanol also is concentrated into 450～550ml, adds the water of 8～12 times of amounts, stirs evenly, left standstill 8～24 hours, get supernatant, filter, filtrate is concentrated into 550～650ml, it is an amount of to add the second alcohol and water, and adjust that to contain the alcohol amount be 22～32%, and adjust total amount to 1000ml, placed 1～3 day, the filtering precipitation, add water to 1000ml, stir evenly, packing.

Modern study proves that Radix Salviae Miltiorrhizae has the function of blood circulation promoting and blood stasis dispelling, can change the hemorheology sexual abnormality, and obvious blood viscosity lowering can anticoagulant, activates fibrinolytic, promotes fibrinogenolysis.Radix Salviae Miltiorrhizae also can make microcirculatory blood flow significantly increase, and the open number of capillary network increases, and the blood fluidised form is improved, and erythrocyte has dispersion phenomenon in various degree, increases the foundation of microcirculatory hemoperfusion of local organization and collateral circulation.But Radix Salviae Miltiorrhizae is increasing blood flow speed also, obviously improves oxidation dividing potential drop and blood oxygen saturation.And Flos Carthami has the function of promoting blood circulation to restore menstrual flow, can suppress the ADP induced platelet and assemble, and increases fibrinolysis and suppresses thrombosis.The Radix Angelicae Dahuricae has diffusing wind dehumidification function, can obviously suppress allergic contact dermatitis, and infringement has protective effect to the animal radioactive skin.And according to various doctor's allusion quotation records, Rhizoma Smilacis Glabrae has the detoxifcation dehumidification function, and Caulis Spatholobi has blood circulation-promoting functions, and Rhizoma Smilacis Chinensis has the function of wind-damp dispelling.

Rhizoma Smilacis Chinensis, Radix Angelicae Dahuricae expelling wind and removing dampness are monarch drug.Contain multiple furoeoumarin material in the modern pharmacology report Radix Angelicae Dahuricae, and mainly be ammidin and isoimperatorin in the furoeoumarin material, can improve skin to ultraviolet sensitivity, promote the metabolism of melanocyte, make its restore funcitons and the melanin of regenerating.Other measures trace element such as containing copper in the Radix Angelicae Dahuricae, and it is distinguished to treat the vitiligo curative effect that lacks due to the disorder because of copper ion with the Radix Angelicae Dahuricae.With the Rhizoma Smilacis Glabrae heat-clearing and toxic substances removing, and strengthen the power of Rhizoma Smilacis Chinensis, Radix Angelicae Dahuricae eliminating dampness and dredging channels, so that stay in the noxious dampness of space between skin and muscles and removed, so be accessory drugs.Radix Salviae Miltiorrhizae, Flos Carthami blood circulation promoting and blood stasis dispelling make QI-blood circulation unobstructed, are adjuvant drug.Radix Salviae Miltiorrhizae can be regulated immunologic function, so so as to regulating immunologic function disorder, improve therapeutic effect and stablize the state of an illness.The Caulis Spatholobi promoting the circulation of blood of enriching blood.More than all medicines coordinate, reach jointly: expelling wind and removing dampness, blood circulation promoting and blood stasis dispelling, drive away morbific extrinsic factor, improve the blood circulation and the nutritional status of diseased region, with outside be coated with, make the efficacy of a drug directly act on sick body, absorb, compose the local anomaly melanocyte of the living melanic ability of regenerating through pore, or the formation of stimulation melanin cell, promote its growth and regeneration,, suppress the carrying out that the disease machine changes to produce more melanin, make it no longer continue expansion and progressively painted, effect is remarkable.

Above Six-element Chinese herbal medicine extracts the liniment that makes through processing, has kept its effective ingredient and can effectively treat vitiligo.

The white spirit of China is as the leukodermic special-purpose liniment of a kind of treatment, and its manufacture method is: get 4 parts of (2000g) Rhizoma Smilacis Chinensiss, 4 parts of (2000g) Radixs Angelicae Dahuricae, 6 parts of (3000g) Rhizoma Smilacis Glabraes, 4 parts of (2000g) Radix Salviae Miltiorrhizaes, 1 part of (500g) Flos Carthami, 2 parts of (1000g) Caulis Spatholobis, Six-element Chinese medicine decocts with water twice, 2 hours for the first time, 1 hour for the second time, collecting decoction, filter, left standstill 24 hours, draw supernatant, filter, it is 1.21～1.23 clear paste that filtrate is concentrated into relative concentration, puts cold, the ethanol that adds 3 times of amounts, stir evenly, left standstill 24 hours, make precipitation, filter, decompression filtrate recycling ethanol also is concentrated into about 500ml, adds the water of 10 times of amounts, stirs evenly, left standstill 16 hours, get supernatant, filter, filtrate is concentrated into about 600ml, it is an amount of to add the second alcohol and water, and adjust that to contain the alcohol amount be 30%, and adjust total amount to 1000ml, placed 2 days, the filtering precipitation, add water to 1000ml, stir evenly, packing.

The clinical observation of how tame hospital such as China's Bai Lingjing Zhongshan affiliated hospital of shanghai medical university, Hangzhou Red Cross Hospital, skin disease prevention and treatment institute, Wuhan City and research unit to treating leukodermic total effective rate more than 89%, has significant curative effect.

Claims (3)

1, a kind of preparation method of liniment to treat leukoderma is characterized in that: made by following materials of weight proportions: Rhizoma Smilacis Chinensis 3.5-4.5 part, Radix Salviae Miltiorrhizae 3.5-4.5 part, Radix Angelicae Dahuricae 3.5-4.5 part, Flos Carthami 0.5-1.5 part, Rhizoma Smilacis Glabrae 5.5-6.5 part and Caulis Spatholobi 1.5-2.5 part are got the common 8-12KG of this Six-element Chinese herbal medicine and are decocted with water twice, 1-3 hour for the first time, 0.5-1.5 hour for the second time, collecting decoction, filter, left standstill 12-36 hour, draw supernatant, filter, filtrate is concentrated into the clear paste that relative concentration is 1.2-1.3, puts cold, add the ethanol that 2.5-3.5 doubly measures, stir evenly, left standstill 12-36 hour, make precipitation, filter, decompression filtrate recycling ethanol also is concentrated into 450-550ML, adds the water that 8-12 doubly measures, and stirs evenly, left standstill 8-24 hour, get supernatant, filter, filtrate is concentrated into 550-650ML, it is an amount of to add the second alcohol and water, and adjust and to contain the alcohol amount and be 22-32%, and adjust total amount to 1000ML, placed 1-3 days, the filtering precipitation, add water to 1000ML, stir evenly, packing.

2, the preparation method of a kind of liniment to treat leukoderma as claimed in claim 1 is characterized in that: made by following materials of weight proportions: 2 parts of 4 parts of Rhizoma Smilacis Chinensiss, 4 parts of Radix Salviae Miltiorrhizaes, 4 parts of the Radixs Angelicae Dahuricae, 1 part on Flos Carthami, 6 parts of Rhizoma Smilacis Glabraes and Caulis Spatholobis.

3, the preparation method of a kind of liniment to treat leukoderma as claimed in claim 1 is characterized in that concrete processing step is: get the common 10.5KG of Six-element Chinese herbal medicine in proportion and decoct with water twice, 2 hours for the first time, 1 hour for the second time, collecting decoction filtered, left standstill 24 hours, and drew supernatant, filter, it is 1.22 clear paste that filtrate is concentrated into relative concentration, puts coldly, adds the ethanol of 3 times of amounts, stir evenly, left standstill 24 hours, make precipitation, filter, decompression filtrate recycling ethanol also is concentrated into 500ML, adds the water of 10 times of amounts, stir evenly, left standstill 16 hours, get supernatant, filter, filtrate is concentrated into 600ML, and it is an amount of to add the second alcohol and water, and adjusts that to contain the alcohol amount be 30%, and adjust total amount to 1000ML, placed 2 days, the filtering precipitation adds water to 1000ML, stir evenly packing.