CN1204534A - Cellulose ester wound dressing - Google Patents
Cellulose ester wound dressing Download PDFInfo
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- CN1204534A CN1204534A CN 98115621 CN98115621A CN1204534A CN 1204534 A CN1204534 A CN 1204534A CN 98115621 CN98115621 CN 98115621 CN 98115621 A CN98115621 A CN 98115621A CN 1204534 A CN1204534 A CN 1204534A
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- wound dressing
- dressing
- cellulose
- acetic acid
- wound
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Abstract
A wound dressing that releases, via hydrolysis and in a controlled manner, acetic acid when subjected to body temperatures and moisture, and is made from a cellulose ester substrate with a partial solvent thereon.
Description
The present invention relates to a kind of wound dressing of energy controlled release acetic acid, this dressing is made of cellulose esters and partial solvent.
The wound dressing of being made by cellulose diacetate is known.Disclose the wound dressing that a kind of cellulose diacetate gauze is made in Chinese patent application publication number CN87101823A (on August 31st, 1988), its curative effect is better than the cotton gauze wound dressing of routine, because dressing and the wound adhesion that should invent.In addition, the NA cellulose acetate wound dressing that a kind of process vaseline Emulsion is impregnated, trade mark is called Adaptic has been sold by the Johnson﹠Johnson company of N.J. New Brunswich on market since 3 days February in 1984.
Can obtain preferable curative effect with acetic acid (or vinegar) processing wound extensively knows in folk medicine.Referring to " Medical Technologist in ancient times and wound " (The Healing Hand Man and Wound inthe Ancient World) of G.Majno, Harvard University Press, paperback edition,, the 186th page in 1991.It also is that people know that vinegar and ethanol are used in combination the processing wound effective.The PCT/FR88/00238 that on November 17th, 1988 announced discloses the invention of handling burn with vinegar, distilled water and alcohol treatment liquid.
It is known using glycerol triacetate, trimethylene glycol diacetate and glycol monomethyl ethylidene acetate on cellulose acetate tow.In this use, glycerol triacetate, trimethylene glycol diacetate and glycol monomethyl ethylidene acetate are as plasticizer, with the caking property between the fortifying fibre monofilament.
A kind of wound dressing that needs is controlledly to discharge acetic acid at present, thereby helps wound healing.
Therefore the present invention relates to a kind of wound dressing that is made of cellulose esters bottom and top partial solvent thereof, this dressing is under the condition of body temperature and humidity, by hydrolysis controlled release acetic acid.
In order to illustrate purpose of the present invention, showed for information about of the present invention in the accompanying drawings; But this information is appreciated that and just is used for explaining the present invention rather than limits it.
Fig. 1 is from one embodiment of the invention, be the release (milligram every gram dressing acetic acid/every day) that illustrates acetic acid with temperature (℃) function that changes.
Fig. 2 is the temperature variant function of release acetic acid amount (microgram every gram cellulose acetate acetic acid/every day) that illustrates the cellulose acetate of about 2.5 substitution values.
" wound dressing " used herein refers to bandage or its analog, be used for cover cap and the protection various wounds Mouthful, such as scratch, knife wound or burn. Wound dressing of the present invention also floods without vaseline liquid.
" cellulose esters " used herein is meant organic ester.The example of this organic ester comprises: cellulose acetate, and cellulose propionate, cellulose butyrate, cellulose acetate-propionate, cellulose acetate butyrate (CAB), propanoic acid-cellulose butyrate, or the like, and their various combinations.The cellulose esters that the present invention uses can prepare by any known technology.Referring to " encyclopedia of chemical technology " the 3rd edition the 5th volume of Kirk-othmer, John Wiley Sons publishes, New York,, 89-129 page or leaf in 1979; And Libscomb, " cellulose acetate: its manufacturing and application thereof " of A.G, Ernest Benn.Ltd. London 1933.These two pieces of data are all quoted as a reference at this.Cellulose esters among the present invention preferably has at least 2 glucose anhydro rings, most preferably is to have 2-5000 glucose anhydro ring.And these polymer typically have the logarithmic viscosity number (IV) of about 0.2-3.0 decilitre/every gram; Most preferably be about 1-1.6 decilitre/every gram, this is to measure from the phenol/sym-tetrachloroethane weight ratio of 0.5 gram sample and 100 milliliters is 60/40 solution when 25 ℃ of temperature.In addition, in the cellulose esters used herein, the excursion of substitution value/every anhydroglucose unit (DS/AGV) is about 1.5-2.7, particularly preferably is 1.7-2.6, and the DS/AGU of most preferred cellulose acetate is that 1.8-2.2 and IV are 1.3-1.5.
Aforesaid cellulose esters can contain matting agent (for example titanium dioxide) and decorative yarn agent, and these all are known.
" bottom " used herein refers to the fabric (weaving or knitting) or the form of film of cellulose esters, do not comprise tow or yarn, unless to spin or knitting form.For example, this cellulose esters can make fibrous or unit is thread, and spun yarn is further spun or be knitted into fabric more then.Perhaps, cellulose esters also can be made thin film, and this thin film can be porous, as micropore.Gauze preferably.
" partial solvent " used herein refers to such as glycerol triacetate (being also referred to as glyceryl triacetate), trimethylene glycol diacetate, ethylene glycol monomethyl ether acetate, and their various combinations.The preferably glycerine triacetate.This solvent can be sprayed at above the cellulose esters bottom, and content accounts for the 4-15% of bottom weight, preferably 10%.
" body temperature and humidity " refers to wound or the typical state of wound circumference.For example, the temperature of wound or wound circumference can be about 98.6 ± 5 °F on the human body.
The present invention can be through hydrolysis controlled release acetic acid.Specifically, the speed that dressing discharges acetic acid surpasses 1000 micrograms/every day, preferably 4-6 milligram/every day.The cellulose ester fiber that has partial solvent (being glyceryl triacetate) above Fig. 1 has shown (as cellulose acetate, (DS/AGU=2.5) discharges a large amount of acetic acid.Fig. 2 has shown that the cellulose ester fiber of unprocessed mistake is (as a spot of acetic acid of the cellulose acetate of DS/AGU=2.5/discharge.
Below the present invention is further illustrated for the embodiment of usefulness indefiniteness.
Embodiment 1 (comparison)
The cellulose acetate that will have about 2.5 substitution values relative humidity near 100% condition under 100 ℃ of heated constant temperature.Under this condition, every gram cellulose acetate hydrolysis every day produces about 400 microgram acetic acid.See Fig. 2.
In embodiment 1 described cellulose acetate, add 10% glycerol triacetate by weight.The cellulose acetate of handling is like this placed under the same condition of embodiment 1.Formed 4.5 milligrams of cellulose acetate/glycerol triacetates in one day approximately.See Fig. 1.
The present invention also can other ad hoc fashion implements and does not break away from design of the present invention or basic feature, and therefore should be with the description of appended claim rather than front as protection scope of the present invention.
Claims (5)
1. a wound dressing contains cellulose esters bottom and top partial solvent thereof, and wherein said bottom is a kind of knit goods, and described dressing is by the hydrolysis and controlled release goes out acetic acid under 98.6 ± 5 condition of described cellulose esters.
2. the dressing of claim 1, wherein partial solvent is selected from glycerol triacetate, trimethylene glycol diacetate, glycol monomethyl ethylidene acetate, and their combination.
3. the wound dressing of claim 2, wherein partial solvent is a glycerol triacetate.
4. the wound dressing of claim 1, wherein the acetic acid amount that discharges of this dressing is greater than 1000 microgram/skies.
5. the wound dressing of claim 1, wherein cellulose esters is a cellulose acetate, its substitution value is every anhydroglucose unit about 2.5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 98115621 CN1204534A (en) | 1997-07-01 | 1998-06-30 | Cellulose ester wound dressing |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US886749 | 1997-07-01 | ||
| CN 98115621 CN1204534A (en) | 1997-07-01 | 1998-06-30 | Cellulose ester wound dressing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1204534A true CN1204534A (en) | 1999-01-13 |
Family
ID=5224650
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 98115621 Pending CN1204534A (en) | 1997-07-01 | 1998-06-30 | Cellulose ester wound dressing |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1204534A (en) |
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1998
- 1998-06-30 CN CN 98115621 patent/CN1204534A/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C53 | Correction of patent for invention or patent application | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: APPLICANT; FROM: CELANESE ACETATE, LLC TO: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
|
| CP03 | Change of name, title or address |
Address after: California Applicant after: The Regents of the University of California Address before: North Carolina Applicant before: Celanese Acetate, LLC |
|
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |