CN119497749A - 一种使诱导多能干细胞分化为视网膜色素上皮细胞的方法、视网膜色素上皮细胞和使用该视网膜色素上皮细胞的方法 - Google Patents

一种使诱导多能干细胞分化为视网膜色素上皮细胞的方法、视网膜色素上皮细胞和使用该视网膜色素上皮细胞的方法 Download PDF

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CN119497749A
CN119497749A CN202380031502.8A CN202380031502A CN119497749A CN 119497749 A CN119497749 A CN 119497749A CN 202380031502 A CN202380031502 A CN 202380031502A CN 119497749 A CN119497749 A CN 119497749A
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cells
rpe
medium
days
ips
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CN202380031502.8A
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Chinese (zh)
Inventor
苏心怡
R·卡卡德
M·巴尔加瓦
杨宾霞
W·亨齐克
刘增平
王昊飞
B·H·帕瑞克
陈清烽
赖宪忠
蔡兆
林嘉隆
潘全胜
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Agency for Science Technology and Research Singapore
Singapore Health Services Pte Ltd
CellResearch Corp Pte Ltd
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Agency for Science Technology and Research Singapore
Singapore Health Services Pte Ltd
CellResearch Corp Pte Ltd
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Publication of CN119497749A publication Critical patent/CN119497749A/zh
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
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    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells

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  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
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  • Developmental Biology & Embryology (AREA)
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  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN202380031502.8A 2022-01-27 2023-01-27 一种使诱导多能干细胞分化为视网膜色素上皮细胞的方法、视网膜色素上皮细胞和使用该视网膜色素上皮细胞的方法 Pending CN119497749A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263303849P 2022-01-27 2022-01-27
US63/303,849 2022-01-27
PCT/SG2023/050051 WO2023146477A2 (en) 2022-01-27 2023-01-27 A method of differentiating an induced pluripotent stem cell into a retinal pigment epithelial cell, a retinal pigment epithelial cell and methods of using the retinal pigment epithelial cell

Publications (1)

Publication Number Publication Date
CN119497749A true CN119497749A (zh) 2025-02-21

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CN202380031502.8A Pending CN119497749A (zh) 2022-01-27 2023-01-27 一种使诱导多能干细胞分化为视网膜色素上皮细胞的方法、视网膜色素上皮细胞和使用该视网膜色素上皮细胞的方法

Country Status (8)

Country Link
US (1) US20250197803A1 (https=)
EP (1) EP4469561A4 (https=)
JP (1) JP2025507265A (https=)
CN (1) CN119497749A (https=)
AU (1) AU2023212665A1 (https=)
CA (1) CA3249352A1 (https=)
TW (1) TW202340454A (https=)
WO (1) WO2023146477A2 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2022191216A1 (https=) * 2021-03-09 2022-09-15

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2951290B1 (en) * 2013-02-01 2017-11-29 The United States of America, as represented by The Secretary, Department of Health and Human Services Method for generating retinal pigment epithelium (rpe) cells from induced pluripotent stem cells (ipscs)
CN108531443A (zh) * 2018-04-04 2018-09-14 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 小分子诱导多能性干细胞分化为视网膜色素上皮细胞的方法
CN110205283B (zh) * 2018-04-18 2021-04-23 浙江大学 一种诱导人羊膜上皮细胞向视网膜色素上皮细胞分化的方法及其应用

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Publication number Publication date
AU2023212665A1 (en) 2024-08-15
EP4469561A2 (en) 2024-12-04
JP2025507265A (ja) 2025-03-18
WO2023146477A2 (en) 2023-08-03
CA3249352A1 (en) 2023-08-03
US20250197803A1 (en) 2025-06-19
WO2023146477A3 (en) 2023-10-19
TW202340454A (zh) 2023-10-16
EP4469561A4 (en) 2026-02-25

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