CN119455077A - 一种负载碘纳米片的可塑形抗菌复合水凝胶及其制备方法 - Google Patents
一种负载碘纳米片的可塑形抗菌复合水凝胶及其制备方法 Download PDFInfo
- Publication number
- CN119455077A CN119455077A CN202411681504.4A CN202411681504A CN119455077A CN 119455077 A CN119455077 A CN 119455077A CN 202411681504 A CN202411681504 A CN 202411681504A CN 119455077 A CN119455077 A CN 119455077A
- Authority
- CN
- China
- Prior art keywords
- iodine
- composite hydrogel
- solution
- polyvinyl alcohol
- antibacterial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000017 hydrogel Substances 0.000 title claims abstract description 95
- 239000002131 composite material Substances 0.000 title claims abstract description 80
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 title claims abstract description 58
- 239000011630 iodine Substances 0.000 title claims abstract description 58
- 229910052740 iodine Inorganic materials 0.000 title claims abstract description 58
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 45
- 239000002135 nanosheet Substances 0.000 title claims abstract description 35
- 229920003023 plastic Polymers 0.000 title claims description 11
- 238000002360 preparation method Methods 0.000 title claims description 10
- UQLDLKMNUJERMK-UHFFFAOYSA-L di(octadecanoyloxy)lead Chemical compound [Pb+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O UQLDLKMNUJERMK-UHFFFAOYSA-L 0.000 claims abstract description 28
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract description 25
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract description 25
- 238000003756 stirring Methods 0.000 claims abstract description 20
- 239000002243 precursor Substances 0.000 claims abstract description 18
- 239000000725 suspension Substances 0.000 claims abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 229910021538 borax Inorganic materials 0.000 claims abstract description 17
- 239000004328 sodium tetraborate Substances 0.000 claims abstract description 17
- 235000010339 sodium tetraborate Nutrition 0.000 claims abstract description 16
- 239000012154 double-distilled water Substances 0.000 claims abstract description 12
- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 claims abstract description 11
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000001263 FEMA 3042 Substances 0.000 claims abstract description 11
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 claims abstract description 11
- 235000010413 sodium alginate Nutrition 0.000 claims abstract description 11
- 229940005550 sodium alginate Drugs 0.000 claims abstract description 11
- 239000000661 sodium alginate Substances 0.000 claims abstract description 11
- 235000015523 tannic acid Nutrition 0.000 claims abstract description 11
- 229920002258 tannic acid Polymers 0.000 claims abstract description 11
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 claims abstract description 11
- 229940033123 tannic acid Drugs 0.000 claims abstract description 11
- 238000010438 heat treatment Methods 0.000 claims abstract description 10
- 239000000843 powder Substances 0.000 claims abstract description 9
- 230000007935 neutral effect Effects 0.000 claims abstract description 5
- 238000000227 grinding Methods 0.000 claims abstract description 4
- 238000000034 method Methods 0.000 claims description 9
- 239000000499 gel Substances 0.000 claims description 6
- 239000006228 supernatant Substances 0.000 claims description 3
- 230000001580 bacterial effect Effects 0.000 abstract description 10
- 230000007547 defect Effects 0.000 abstract description 6
- 208000015181 infectious disease Diseases 0.000 abstract description 5
- 208000035143 Bacterial infection Diseases 0.000 abstract description 4
- 206010059866 Drug resistance Diseases 0.000 abstract description 4
- 208000022362 bacterial infectious disease Diseases 0.000 abstract description 4
- 238000011049 filling Methods 0.000 abstract description 3
- 230000001105 regulatory effect Effects 0.000 abstract description 3
- 239000000243 solution Substances 0.000 description 42
- 239000000463 material Substances 0.000 description 10
- 241000894006 Bacteria Species 0.000 description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 238000010586 diagram Methods 0.000 description 5
- 238000003760 magnetic stirring Methods 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 4
- 241000191967 Staphylococcus aureus Species 0.000 description 4
- 206010052428 Wound Diseases 0.000 description 4
- 239000003242 anti bacterial agent Substances 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 241000588724 Escherichia coli Species 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 229940088710 antibiotic agent Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229910021645 metal ion Inorganic materials 0.000 description 3
- 239000002064 nanoplatelet Substances 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 2
- -1 alkyl trimethyl iron Chemical compound 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 210000002421 cell wall Anatomy 0.000 description 2
- 229960003260 chlorhexidine Drugs 0.000 description 2
- 239000000084 colloidal system Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 238000011068 loading method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 239000012086 standard solution Substances 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 125000003158 alcohol group Chemical group 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical group OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 description 1
- 230000021164 cell adhesion Effects 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 125000003473 lipid group Chemical group 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 238000001000 micrograph Methods 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 230000002522 swelling effect Effects 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0004—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/18—Iodine; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0085—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/009—Materials resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/025—Other specific inorganic materials not covered by A61L27/04 - A61L27/12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/106—Halogens or compounds thereof, e.g. iodine, chlorite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Materials Engineering (AREA)
- Pharmacology & Pharmacy (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Abstract
一种负载碘纳米片的可塑形抗菌复合水凝胶及其制备方法，包括以下步骤：研磨碘块得到碘粉，将碘粉加入双蒸水中超声剥离得到碘纳米片悬浮液；在搅拌且水浴加热的条件下，用双蒸水溶解聚乙烯醇得到聚乙烯醇溶液，分批次加入海藻酸钠，继续水浴下搅拌得到可塑形复合水凝胶前体溶液；采用碘纳米片悬浮液溶解单宁酸后加入到可塑形复合水凝胶前体溶液中，室温下搅拌均匀，调节溶液pH值至中性，最后滴加硼砂溶液搅拌成胶得到I2/PBST可塑形抗菌复合水凝胶。所制备的复合水凝胶不仅可发挥抗菌作用，降低感染位点细菌感染概率且无细菌耐药性，还可具有可塑性、拉伸性、自愈性、粘附性、可降解等优良性能，便于填充形态各异的缺损部位且附着牢固。
Description
技术领域
本发明属于生物医用材料技术领域，具体涉及一种负载碘纳米片的可塑形抗菌复合水凝胶及其制备方法。
背景技术
目前，临床上常用的抗菌药物材料有抗生素类药物、碘液、洗必泰、过氧化氢、无机金属离子，但分别存在以下缺点：抗生素在感染缺损中应用广泛，但长期使用抗生素抗菌会导致细菌耐药性的产生，不利于持续消炎治疗工作。碘液作为临床上常见的消毒剂，因其具有良好的生物相容性、广谱杀菌作用和低成本等优点，被广泛运用于皮肤及粘膜的消毒，但碘液因溶解性差和易挥发性，使得局部消毒部位无法长时间存在足够浓度的碘液，进而导致其无法作为药物持续作用于组织进行杀菌作用。洗必泰溶液含有少量嗅化烷基三甲铁能有效地对抗大多数的革兰氏阳性和革兰氏阴性菌，它们常用于手术室中的创伤或其它开放性伤口，但其作用在有血的情况下会减弱。过氧化氢是一种氧化剂，能够引发细菌细胞内分子或原子的电离，从而导致细胞壁上脂链的断裂，破坏细胞壁；但过氧化氢会损害新的上皮组织并能引起周围皮肤的皮疹；如果在压力下或深部伤口中应用上述制剂，还会产生氧气泡进入血管形成气栓而威胁病人的生命。无机金属离子主要是指以银铜锌等金属或其离子，采用物理吸附离子交换方法，附载于多孔材料，利用金属离子的抗菌能力，通过缓释作用达到长效抑菌的目的；不足之处在于价格较高和抗菌的迟效性，不能像有机抗菌剂那样迅速杀灭细菌，而且对真菌、霉菌几乎没有抑制效果。
水凝胶是一种具有亲水性的三维网状交联结构的高分子网络体系，能够吸收并保持大量体积的水分，水凝胶性质柔软，并且可以通过调控水凝胶的组分和结构来实现不同的功能，是作为创面敷料的极佳材料。根据实际的临床需求，可以赋予水凝胶敷料良好的生物相容性和生物降解性能，同时具有自愈合、黏附、抗菌和抗氧化等性能。水凝胶由于其内部疏松多孔的结构，也可作为药物或其他具有生物活性物质的载体。
发明内容
本发明的目的是提供一种负载碘纳米片的可塑形抗菌复合水凝胶及其制备方法，该制备方法简单，所制备得到的复合水凝胶一方面可发挥抗菌作用，降低感染位点细菌感染概率且无细菌耐药性；另一方面可具有可塑性、拉伸性、自愈性、粘附性、可降解等优良性能，便于填充形态各异的缺损部位且附着牢固。
为实现上述目的，本发明采用的技术方案是：一种负载碘纳米片的可塑形抗菌复合水凝胶及其制备方法，包括以下步骤：
S1、制备碘纳米片悬浮液：充分研磨碘块得到碘粉，将碘粉加入双蒸水中，超声剥离得到碘纳米片悬浮液；
S2、制备可塑形复合水凝胶前体溶液：在搅拌且85～95℃水浴加热的条件下，用85～95℃的双蒸水溶解聚乙烯醇，待聚乙烯醇完全溶解得到聚乙烯醇溶液，分批次加入海藻酸钠，继续85～95℃水浴下搅拌0.5～1.5h，得到可塑形复合水凝胶前体溶液；
S3、采用步骤S1制备得到的碘纳米片悬浮液溶解单宁酸得到单宁酸-I2复合溶液，然后将单宁酸-I2复合溶液加入到步骤S2所制备的可塑形复合水凝胶前体溶液中，在室温下搅拌均匀，并调节溶液pH值至中性；
S4、在步骤S3所得溶液中滴加硼砂溶液搅拌成胶，得到I2/PBST可塑形抗菌复合水凝胶。
优选的，步骤S1中，碘纳米片悬浮液的浓度为5mg/mL；放入超声波清洗仪中超声剥离4小时。
优选的，步骤S2中，聚乙烯醇溶液的质量分数为8％；海藻酸钠与聚乙烯醇溶液之间的质量体积比为30mg：1.06mL。
优选的，步骤S2中，在搅拌且90℃水浴加热的条件下，用90℃的双蒸水溶解聚乙烯醇，待聚乙烯醇完全溶解，分批次加入海藻酸钠，继续90℃水浴下搅拌1h，得到可塑形复合水凝胶前体溶液。
优选的，步骤S3中，单宁酸-I2复合溶液浓度为40mg/mL；单宁酸-I2复合溶液与可塑形复合水凝胶前体溶液之间的体积比为1:2.65。
优选的，步骤S4中，硼砂溶液的浓度为29mg/mL；硼砂溶液与步骤S2中的可塑形复合水凝胶前体溶液之间的体积比为1:3.53。
为实现上述目的，本发明还提供一种上述制备方法所制备得到的负载碘纳米片的可塑形抗菌复合水凝胶。
与现有技术相比，本发明具有以下有益效果：
(1)本发明中的水凝胶作为一种独特的三维网状聚合物，其结构和天然的细胞外基质相似，因此，水凝胶材料可以为细胞粘附、增殖、生长提供支撑作用和代谢空间，水凝胶吸水膨胀的特性以及对小分子的渗透扩散使其具有良好的生物相容性。硼砂-聚乙烯醇水凝胶的网络主要由聚乙烯醇链的顺式二醇位点与硼砂之间的硼砂酯键相连。海藻酸钠是一种含量丰富的生物多糖，其具有良好的生物相容性和生物可降解性，且加入水凝胶体系中，可显著增加水凝胶的机械性能，在组织中具有优异的促凝效果和止血性能。单宁酸是一种含有丰富儿茶酚基团的植物源多酚类化合物，具有良好的粘接性能。聚乙烯醇-海藻酸钠-单宁酸-硼砂复合水凝胶体系中，海藻酸钠和单宁酸与硼砂-聚乙烯醇网络由氢键相连，由于动态可逆的氢键和硼砂酯键，使得该复合水凝胶呈现自我修复能力。且该复合水凝胶具有良好的机械强度、自粘特性、可重塑性、良好的生物相容性以及生物降解性，是良好的生物包埋支架材料。
(2)本发明中的碘纳米片作为一种二维的纳米结构材料，相比较于碘液增加了与细菌作用的表面积，从而提高了与细菌反应效率。碘纳米片在体外具有良好的稳定性，当与细胞培养接触时，表现出优异的生物降解性；同时，其利用细菌所产生的H2O2进行同素异构转化，不仅保留了原本碘制剂的消毒杀菌作用，转化前的二维结构有效避免了碘液作为流体的不可控性，并且缓慢释放抗菌效果，持续时间久，可作为药物对感染位点进行杀菌消毒，避免区域细菌感染。
(3)本发明将水凝胶与碘纳米片材料结合，既最大效益地发挥抗菌作用，又兼具高可塑性，且组织排斥反应小，具有无需二期手术取出支架材料等优点。
综上，本发明一方面通过负载抗菌材料碘纳米片I2，从而发挥抗菌作用，降低感染位点细菌感染概率且无细菌耐药性；另一方面通过使用可塑形复合水凝胶作为负载体系，从而使本产品具有可塑性、拉伸性、自愈性、粘附性、可降解等优良性能，便于填充形态各异的缺损部位且附着牢固。故实用性很高，适合广泛推广。
附图说明
图1为PBST水凝胶及PBST/I2可塑性抗菌复合水凝胶扫描电镜图；(a)为300μm尺度的PBST水凝胶、(b)为300μm尺度的PBST/I2复合水凝胶、(c)为100μm尺度的PBST水凝胶、(d)为3μm尺度的PBST/I2复合水凝胶；
图2为PBST水凝胶及PBST/I2可塑性抗菌复合水凝胶成胶图；(a)PBST水凝胶倾斜状态图、(b)PBST/I2复合水凝胶倾斜状态图、(c)PBST水凝胶倒立图、(d)PBST/I2复合水凝胶倒立图；
图3为PBST/I2可塑性抗菌复合水凝胶理化性质：(a)PH敏感性、(b)黏附性、(c)拉伸性、(d)可塑形性及(e)自愈性测试图。
图4为PBST/I2可塑性抗菌复合水凝胶抗菌效果图；(a)抑制大肠杆菌效果；(b)抑制金黄色葡萄球菌效果。
具体实施方式
以下结合附图和具体实施例对本发明作进一步详细说明。
本申请实施例中的所有原料试剂均是在市场上购买或按照本领域技术人员熟知的常规方法制备获得。
对比例1
一种水凝胶的制备方法，包括以下步骤：
S1、在磁力搅拌(转速为300r)且90℃水浴加热的条件下，用90℃的双蒸水溶解0.85g聚乙烯醇至10.6mL后继续水浴加热，待聚乙烯醇完全溶解得到聚乙烯醇溶液，将300mg海藻酸钠分4～5次加入聚乙烯醇溶液中，继续在磁力搅拌(转速为300r)且90℃水浴下搅拌1h，得到可塑形复合水凝胶前体溶液；
S2、将单宁酸加入到步骤S1所制备的可塑形复合水凝胶前体溶液中，在室温下继续磁力搅拌(转速为300r)均匀，并滴加氢氧化钠标准溶液调节pH值至中性；
S3、在步骤S2所得溶液中滴加硼砂溶液(将87.387mg硼砂用双蒸水溶至3mL配制得到硼砂溶液)搅拌成胶，得到PBST水凝胶，其扫描电镜如图1a和图1c所示，宏观图如图2a和图2c所示。
从图1a和图1c可以看出，PBST水凝胶微观结构呈多孔结构，有利于细胞的黏附和组织液的渗入，是理想的支架材料；从图2a和图2c可以看出PBST水凝胶的宏观结构为黄白色胶状，粘附性较好且不具有流动性；相较于实施例1，由于未加入碘纳米片，所以微观不可见碘纳米片颗粒，宏观颜色较淡，尚不具备较强的抗菌性能。
实施例1
一种负载碘纳米片的可塑形抗菌复合水凝胶的制备方法，包括以下步骤：
S1、制备碘纳米片悬浮液：称取1g碘，称重50mL离心管的质量并记录；用研钵充分研磨碘块至粉末状，放至离心管中，加入50mL双蒸水后置于超声波清洗仪，超声剥离4h。将超声剥离后的浑浊液离心处理，转速为12000r，时间为30min，取上清液，将沉淀物连同离心管放入烘箱中烘干处理；待其干燥后，称重。去除离心后未溶解的碘，得到上清液为5mg/mL的碘纳米片悬浮液；
S2、制备可塑形复合水凝胶前体溶液：在磁力搅拌(转速为300r)且90℃水浴加热的条件下，用90℃的双蒸水溶解0.85g聚乙烯醇至10.6mL后继续水浴加热，待聚乙烯醇完全溶解得到聚乙烯醇溶液，将300mg海藻酸钠分4～5次加入聚乙烯醇溶液中，继续在磁力搅拌(转速为300r)且90℃水浴下搅拌1h，得到可塑形复合水凝胶前体溶液；
S3、将200mg单宁酸用5mg/mL的碘纳米片悬浮液溶至5mL得到单宁酸-I2复合溶液，然后将单宁酸-I2复合溶液加入到步骤S2所制备的可塑形复合水凝胶前体溶液中，在室温下继续磁力搅拌(转速为300r)均匀，并滴加氢氧化钠标准溶液调节pH值至中性；
S4、在步骤S3所得溶液中滴加硼砂溶液(将87.387mg硼砂用双蒸水溶至3mL配制得到硼砂溶液)搅拌成胶，得到I2/PBST可塑形抗菌复合水凝胶，其扫描电镜如图1b和1d所示，宏观图如图2b和图2d所示。
从图1b和图1d可以看出，I2/PBST可塑形抗菌复合水凝胶在扫描电镜下可见碘纳米片颗粒；从图2b和图2d可以看出，I2/PBST可塑形抗菌复合水凝胶为棕黄色胶状，有较强的粘附性且不具有流动性；相较于对比例，I2/PBST可塑形抗菌复合水凝胶中更具备抗菌性能。
将本实施例所制备的复合水凝胶进行pH敏感性、粘附性、拉伸性、可塑性、自愈性测试：取同等体积的复合水凝胶分别置于pH＝5.5、pH＝6、pH＝6.5以及15％的盐酸中进行pH敏感测试，结果如图3(a)所示复合水凝胶在pH为5.5、6、6.5的环境中能保持完整的凝胶状态，在15％的盐酸中则会溶解；将复合水凝胶放置于手指，进行活动，如图3(b)所示水凝胶牢固地黏附在手指上，验证复合水凝胶具有粘附性。取1cm2的复合水凝胶，由1cm拉伸至极限，如图3(c)所示测量得出40cm，验证复合水凝胶具有较强的拉伸性；如图3(d)所示，复合水凝胶可塑形为多种形状，验证其具有较强的可塑性；将复合水凝胶切开，再使断端接触，保持30～60s，如图3(e)所示断端发生愈合，验证其具有自愈性。
将本实施例所制备的复合水凝胶进行抗菌效果测试：分别将30μL大肠杆菌、金黄色葡萄球菌的细菌悬浮液和270μL的LB液体培养基混匀后，加在可塑形抗菌复合水凝胶表面，37℃培养箱共培养3小时，对照组为空白孔。取100μL稀释后的菌液接种至琼脂平板上后，37℃培养箱中培养12小时观察并计算抗菌率；其结果如图4(a)及图4(b)所示，从图中可以看出，在进行大肠杆菌(4a)和金黄色葡萄球菌(4b)菌落培养后，两种细菌实验中PBST组的菌落数量较空白组均有所减少，而PBST/I2组中的菌落数量均为最少，大肠杆菌和金黄色葡萄球菌抑菌率均达到90％以上。说明PBST中加入碘纳米片后显著增强了抗菌效果，进一步证明了复合水凝胶的抗菌性能。
实施例2
本实施例仅仅是步骤S3中单宁酸的含量不同“将160mg单宁酸用5mg/mL的碘纳米片悬浮液溶至4mL得到单宁酸-I2复合溶液”，其他步骤均保持与实施例1一致。
实施例3
本实施例仅仅是步骤S3中单宁酸的含量不同“将80mg单宁酸用5mg/mL的碘纳米片悬浮液溶至2mL得到单宁酸-I2复合溶液”，其他步骤均保持与实施例1一致。
参考实施例1，将实施例2和实施3分别所制备得到的复合水凝胶分别进行pH敏感性、粘附性、拉伸性、可塑性、自愈性测试以及抗菌效果测试，其测试效果均与实施例类似。
对于本领域技术人员而言，本发明不限于上述示范性实施例的细节。实施例是示范性且非限制性的，本发明的保护范围根据所附权利要求而不是上述说明限定，因此，不应将权利要求中的任何附图标记视为限制所涉及的权利要求。
Claims (7)
1.一种负载碘纳米片的可塑形抗菌复合水凝胶的制备方法，其特征在于，包括以下步骤：
S1、制备碘纳米片悬浮液：充分研磨碘块得到碘粉，将碘粉加入双蒸水中，超声剥离、离心，取上清液即为碘纳米片悬浮液；
S2、制备可塑形复合水凝胶前体溶液：在搅拌且85～95℃水浴加热的条件下，用85～95℃的双蒸水溶解聚乙烯醇，待聚乙烯醇完全溶解得到聚乙烯醇溶液，分批次加入海藻酸钠，继续85～95℃水浴下搅拌0.5～1.5h，得到可塑形复合水凝胶前体溶液；
S3、采用步骤S1制备得到的碘纳米片悬浮液溶解单宁酸得到单宁酸-I2复合溶液，然后将单宁酸-I2复合溶液加入到步骤S2所制备的可塑形复合水凝胶前体溶液中，在室温下搅拌均匀，并调节溶液pH值至中性；
S4、在步骤S3所得溶液中滴加硼砂溶液搅拌成胶，得到I2/PBST可塑形抗菌复合水凝胶。
2.根据权利要求1所述的一种负载碘纳米片的可塑形抗菌复合水凝胶的制备方法，其特征在于，步骤S1中，碘纳米片悬浮液的浓度为5mg/mL；放入超声波清洗仪中超声剥离4小时。
3.根据权利要求1或2所述的一种负载碘纳米片的可塑形抗菌复合水凝胶的制备方法，其特征在于，步骤S2中，聚乙烯醇溶液的质量分数为8％；海藻酸钠与聚乙烯醇溶液之间的质量体积比为30mg：1.06mL。
4.根据权利要求1或2所述的一种负载碘纳米片的可塑形抗菌复合水凝胶的制备方法，其特征在于，步骤S2中，在搅拌且90℃水浴加热的条件下，用90℃的双蒸水溶解聚乙烯醇，待聚乙烯醇完全溶解，分批次加入海藻酸钠，继续90℃水浴下搅拌1h，得到可塑形复合水凝胶前体溶液。
5.根据权利要求1或2所述一种负载碘纳米片的可塑形抗菌复合水凝胶的制备方法，其特征在于，步骤S3中，单宁酸-I2复合溶液浓度为40mg/mL；单宁酸-I2复合溶液与可塑形复合水凝胶前体溶液之间的体积比为1:2.12-5.30。
6.根据权利要求1或2所述的一种负载碘纳米片的可塑形抗菌复合水凝胶的制备方法，其特征在于，步骤S4中，硼砂溶液的浓度为29mg/mL；硼砂溶液与步骤S2中的可塑形复合水凝胶前体溶液之间的体积比为1:3.53。
7.如权利要求1-6中任一项所述的制备方法所制备得到的负载碘纳米片的可塑形抗菌复合水凝胶。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202411681504.4A CN119455077A (zh) | 2024-11-22 | 2024-11-22 | 一种负载碘纳米片的可塑形抗菌复合水凝胶及其制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202411681504.4A CN119455077A (zh) | 2024-11-22 | 2024-11-22 | 一种负载碘纳米片的可塑形抗菌复合水凝胶及其制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN119455077A true CN119455077A (zh) | 2025-02-18 |
Family
ID=94575437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202411681504.4A Pending CN119455077A (zh) | 2024-11-22 | 2024-11-22 | 一种负载碘纳米片的可塑形抗菌复合水凝胶及其制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN119455077A (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116036124A (zh) * | 2022-11-22 | 2023-05-02 | 北京化工大学 | 二维碘纳米片在制备抗菌材料上的应用 |
-
2024
- 2024-11-22 CN CN202411681504.4A patent/CN119455077A/zh active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116036124A (zh) * | 2022-11-22 | 2023-05-02 | 北京化工大学 | 二维碘纳米片在制备抗菌材料上的应用 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Song et al. | Enhanced strength for double network hydrogel adhesive through cohesion‐adhesion balance | |
| CN110117369B (zh) | 一种抗菌粘附的导电水凝胶及其制备方法和应用 | |
| Yu et al. | Novel composite double-layered dressing with improved mechanical properties and wound recovery for thermosensitive drug, Lactobacillus brevis | |
| CN119455077A (zh) | 一种负载碘纳米片的可塑形抗菌复合水凝胶及其制备方法 | |
| CN115501339B (zh) | 一种用于多种难愈合创面修复的铜基纳米酶活性材料及其应用和伤口修复凝胶 | |
| CN114949324B (zh) | 一种生物相容性抗菌凝胶膜的制备方法 | |
| Xiao et al. | A novel conductive antibacterial nanocomposite hydrogel dressing for healing of severely infected wounds | |
| CN105837837B (zh) | 一种含有纳米银的医用壳聚糖温敏水凝胶的制备方法 | |
| CN112353754B (zh) | 一种导电聚吡咯/中药复合水凝胶及其制备方法与应用 | |
| CN116570758A (zh) | 可用于不规则伤口修复的可注射抗菌水凝胶及其制备方法与应用 | |
| Wu et al. | A Microenvironment‐Responsive Graphdiyne‐Iron Nanozyme Hydrogel with Antibacterial and Anti‐Inflammatory Effect for Periodontitis Treatment | |
| CN108404224A (zh) | 一种硼硅酸盐生物玻璃/聚乙烯醇杂化水凝胶的制备方法及其应用 | |
| CN110876814A (zh) | 一种富含抗菌肽的液体创可贴及其制备方法 | |
| CN114129780B (zh) | 一种光控释放一氧化氮的复合水凝胶的制备及应用 | |
| CN111184906B (zh) | 一种基于pva的液体敷料及其制备方法 | |
| Yu et al. | An Injectable, Self‐Adaptive Hydrogel with Metallic‐Functionalized Metal Organic Frameworks for Enhanced Wound Healing in Dynamic Infectious and Inflammatory Microenvironment | |
| US20230381325A1 (en) | Long-lasting hydrogel for use against drug-resistant bacteria and preparation method and use thereof | |
| CN117919520A (zh) | 一种引导骨组织再生纳米复合膜及其制备方法和应用 | |
| Guo et al. | Bacterial-responsive biodegradable silver nanoclusters composite hydrogel for infected wound therapy | |
| Wei et al. | Multifunctional liquid metal active material for wound repair and motion monitoring via free radical polymerization assembly | |
| CN115785480B (zh) | 一种具有流动性和降解性的黄芩素复合水凝胶及其制备方法和应用 | |
| CN107602901B (zh) | 高密度接枝酸基催化细菌裂解的抗生物被膜材料及其制备方法和应用 | |
| CN115785533A (zh) | 一种具有粘附性和抗菌性的芦荟苷聚合水凝胶及其制备方法和应用 | |
| Zhang et al. | Preparation of bacterial cellulose/acrylic acid-based pH-responsive smart dressings by graft copolymerization method | |
| CN116236609B (zh) | 一种抑菌消炎绷带及其制备方法和应用 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |