CN1192248A - 检测调节肥胖症蛋白作用的化合物的方法 - Google Patents

检测调节肥胖症蛋白作用的化合物的方法 Download PDF

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Publication number
CN1192248A
CN1192248A CN96195983A CN96195983A CN1192248A CN 1192248 A CN1192248 A CN 1192248A CN 96195983 A CN96195983 A CN 96195983A CN 96195983 A CN96195983 A CN 96195983A CN 1192248 A CN1192248 A CN 1192248A
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CN
China
Prior art keywords
obesity
compound
albumen
response element
reporter gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN96195983A
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English (en)
Chinese (zh)
Inventor
L·J·比莱
R·A·G·史密斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9510857.7A external-priority patent/GB9510857D0/en
Priority claimed from GBGB9511602.6A external-priority patent/GB9511602D0/en
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of CN1192248A publication Critical patent/CN1192248A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN96195983A 1995-05-30 1996-05-28 检测调节肥胖症蛋白作用的化合物的方法 Pending CN1192248A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9510857.7 1995-05-30
GBGB9510857.7A GB9510857D0 (en) 1995-05-30 1995-05-30 Novel assay
GB9511602.6 1995-06-08
GBGB9511602.6A GB9511602D0 (en) 1995-06-08 1995-06-08 Novel assay

Publications (1)

Publication Number Publication Date
CN1192248A true CN1192248A (zh) 1998-09-02

Family

ID=26307107

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96195983A Pending CN1192248A (zh) 1995-05-30 1996-05-28 检测调节肥胖症蛋白作用的化合物的方法

Country Status (15)

Country Link
EP (1) EP0832284A1 (xx)
JP (1) JPH11505725A (xx)
KR (1) KR19990022134A (xx)
CN (1) CN1192248A (xx)
AU (1) AU715215B2 (xx)
BR (1) BR9608686A (xx)
CA (1) CA2222409A1 (xx)
CZ (1) CZ379097A3 (xx)
HU (1) HUP9801744A3 (xx)
MX (1) MX9709360A (xx)
NO (1) NO975504L (xx)
NZ (1) NZ309777A (xx)
PL (1) PL323638A1 (xx)
TR (1) TR199701469T1 (xx)
WO (1) WO1996038586A1 (xx)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001968A (en) 1994-08-17 1999-12-14 The Rockefeller University OB polypeptides, modified forms and compositions
US6429290B1 (en) 1994-08-17 2002-08-06 The Rockefeller University OB polypeptides, modified forms and derivatives
WO1997040380A1 (en) * 1996-04-22 1997-10-30 Merck & Co., Inc. Leptin assay
US6007998A (en) * 1996-04-22 1999-12-28 Merck & Co., Inc. Leptin assay
US6001816A (en) * 1996-06-20 1999-12-14 Merck & Co., Inc. Gene therapy for leptin deficiency
CA2270431A1 (en) * 1996-11-01 1998-05-14 Lee James Beeley Method for the detection of compounds that modulate the effects of the obese (ob) protein
IT1293533B1 (it) * 1997-07-14 1999-03-01 Angeletti P Ist Richerche Bio Metodo per la selezione di molecole in grado di mimare, inibire o potenziare gli effetti della interazione tra leptina e cellule che
WO1999023493A1 (en) * 1997-10-31 1999-05-14 The Rockefeller University Methods of identifying agents that modulate leptin activity
AU2668699A (en) * 1998-02-11 1999-08-30 Beth Israel Deaconess Medical Center Methods and compositions for modulating leptin activity
GB9814199D0 (en) * 1998-06-30 1998-08-26 Univ Buckingham Novel method
GB9828087D0 (en) * 1998-12-18 1999-02-17 Smithkline Beecham Plc Novel method

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995008001A1 (en) * 1993-09-15 1995-03-23 New York University Dna sequence which binds transcriptional regulatory proteins activated in response to various cytokines and uses thereof
AU2285995A (en) * 1994-04-14 1995-11-10 Ligand Pharmaceuticals Incorporated Dna spacer regulatory elements responsive to cytokines and methods for their use

Also Published As

Publication number Publication date
PL323638A1 (en) 1998-04-14
EP0832284A1 (en) 1998-04-01
AU6002396A (en) 1996-12-18
NO975504D0 (no) 1997-11-28
HUP9801744A2 (hu) 1998-10-28
MX9709360A (es) 1998-02-28
CA2222409A1 (en) 1996-12-05
KR19990022134A (ko) 1999-03-25
AU715215B2 (en) 2000-01-20
HUP9801744A3 (en) 2000-06-28
NZ309777A (en) 2000-01-28
JPH11505725A (ja) 1999-05-25
TR199701469T1 (xx) 1998-03-21
BR9608686A (pt) 1999-07-06
NO975504L (no) 1997-11-28
WO1996038586A1 (en) 1996-12-05
CZ379097A3 (cs) 1998-05-13

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C02 Deemed withdrawal of patent application after publication (patent law 2001)
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