CN1192246A - 产生治疗疼痛的止痛化合物的细胞系 - Google Patents

产生治疗疼痛的止痛化合物的细胞系 Download PDF

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Publication number
CN1192246A
CN1192246A CN96195750A CN96195750A CN1192246A CN 1192246 A CN1192246 A CN 1192246A CN 96195750 A CN96195750 A CN 96195750A CN 96195750 A CN96195750 A CN 96195750A CN 1192246 A CN1192246 A CN 1192246A
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China
Prior art keywords
cell
dna
ires
seq
sequence
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Pending
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CN96195750A
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English (en)
Chinese (zh)
Inventor
J·塞多夫
S·王
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CTI Biopharma Corp
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Cell Therapeutics Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/70—Enkephalins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Neurosurgery (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN96195750A 1995-06-07 1996-06-07 产生治疗疼痛的止痛化合物的细胞系 Pending CN1192246A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48191795A 1995-06-07 1995-06-07
US08/481,917 1995-06-07

Publications (1)

Publication Number Publication Date
CN1192246A true CN1192246A (zh) 1998-09-02

Family

ID=23913905

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96195750A Pending CN1192246A (zh) 1995-06-07 1996-06-07 产生治疗疼痛的止痛化合物的细胞系

Country Status (20)

Country Link
EP (1) EP0833935A1 (enrdf_load_stackoverflow)
JP (1) JPH11507530A (enrdf_load_stackoverflow)
KR (1) KR19990022414A (enrdf_load_stackoverflow)
CN (1) CN1192246A (enrdf_load_stackoverflow)
AR (1) AR004494A1 (enrdf_load_stackoverflow)
AU (1) AU6263696A (enrdf_load_stackoverflow)
BR (1) BR9608746A (enrdf_load_stackoverflow)
CA (1) CA2223246A1 (enrdf_load_stackoverflow)
CZ (1) CZ392497A3 (enrdf_load_stackoverflow)
EE (1) EE9700326A (enrdf_load_stackoverflow)
HU (1) HUP9901191A2 (enrdf_load_stackoverflow)
IL (1) IL122415A0 (enrdf_load_stackoverflow)
IN (1) IN181898B (enrdf_load_stackoverflow)
IS (1) IS4628A (enrdf_load_stackoverflow)
NO (1) NO975545L (enrdf_load_stackoverflow)
PL (1) PL323867A1 (enrdf_load_stackoverflow)
SK (1) SK167997A3 (enrdf_load_stackoverflow)
TR (1) TR199701520T1 (enrdf_load_stackoverflow)
WO (1) WO1996040959A1 (enrdf_load_stackoverflow)
ZA (1) ZA964880B (enrdf_load_stackoverflow)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107964047A (zh) * 2017-12-18 2018-04-27 哈尔滨工业大学 基于内吗啡肽-1和神经降压素(8-13)的嵌合肽及其合成方法和应用
CN112891337A (zh) * 2021-03-26 2021-06-04 河北医科大学 高良姜素及其衍生物在制备预防和治疗神经系统疾病药物中的用途

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU751811B2 (en) * 1997-11-28 2002-08-29 Medical Research Council Vectors
WO2000016799A1 (en) 1998-09-23 2000-03-30 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Methods of treating chronic pain
AU1324100A (en) * 1998-10-27 2000-05-15 Anticancer, Inc. Method and model for hair pigmentation
US6372489B1 (en) 1998-10-27 2002-04-16 Anticancer, Inc. Method and model for hair pigmentation
US6903244B1 (en) 1999-02-26 2005-06-07 University Of Utah Research Foundation Mice which are +/− or −/− for the elastin gene as models for vascular disease
AU2002952993A0 (en) 2002-11-29 2002-12-12 The Corporation Of The Trustees Of The Order Of The Sisters Of Mercy In Queensland Therapeutic and diagnostic agents
NZ547767A (en) 2003-12-24 2010-05-28 Inst Medical W & E Hall Therapeutic agents and uses therefor
NZ551828A (en) 2004-05-12 2009-03-31 Inst Medical W & E Hall A method of cell isolating a homogenous population of mammary stem cells using specific cell surface marker proteins
DK2407484T3 (en) 2005-06-24 2016-09-05 The Walter And Eliza Hall Inst Of Medical Res Therapeutic pro-apoptotic BH3-like molecules, and methods of generating and / or selecting those
US9717775B2 (en) 2006-07-18 2017-08-01 University Of Utah Research Foundation Methods for treating pain and screening analgesic compounds
US8889173B2 (en) * 2008-04-18 2014-11-18 Warsaw Orthopedic, Inc. Alpha adrenergic receptor agonists for treatment of pain and/or inflammation
US10633417B2 (en) 2013-05-31 2020-04-28 University Of Utah Research Foundation Conotoxin peptides, pharmaceutical compositions and uses thereof
CN108884135B (zh) 2015-10-27 2024-03-26 昆士兰大学 治疗方法以及可用于其中的药剂

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE218893T1 (de) * 1993-08-12 2002-06-15 Neurotech Sa Biokompatible immunoisolatorische kapseln, die genetisch veränderte zellen enthalten

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107964047A (zh) * 2017-12-18 2018-04-27 哈尔滨工业大学 基于内吗啡肽-1和神经降压素(8-13)的嵌合肽及其合成方法和应用
CN107964047B (zh) * 2017-12-18 2018-11-02 哈尔滨工业大学 基于内吗啡肽-1和神经降压素(8-13)的嵌合肽及其合成方法和应用
CN112891337A (zh) * 2021-03-26 2021-06-04 河北医科大学 高良姜素及其衍生物在制备预防和治疗神经系统疾病药物中的用途

Also Published As

Publication number Publication date
JPH11507530A (ja) 1999-07-06
KR19990022414A (ko) 1999-03-25
IS4628A (is) 1997-12-04
EE9700326A (et) 1998-06-15
PL323867A1 (en) 1998-04-27
CZ392497A3 (cs) 1998-12-16
AU6263696A (en) 1996-12-30
AR004494A1 (es) 1998-12-16
ZA964880B (en) 1997-01-07
CA2223246A1 (en) 1996-12-19
EP0833935A1 (en) 1998-04-08
TR199701520T1 (xx) 1998-04-21
IN181898B (enrdf_load_stackoverflow) 1998-10-24
HUP9901191A2 (hu) 1999-08-30
NO975545L (no) 1998-02-04
NO975545D0 (no) 1997-12-02
SK167997A3 (en) 1998-05-06
WO1996040959A1 (en) 1996-12-19
IL122415A0 (en) 1998-06-15
BR9608746A (pt) 1999-05-11

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