CN119136833A - 膜易位结构域及其用途 - Google Patents

膜易位结构域及其用途 Download PDF

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Publication number
CN119136833A
CN119136833A CN202380038153.2A CN202380038153A CN119136833A CN 119136833 A CN119136833 A CN 119136833A CN 202380038153 A CN202380038153 A CN 202380038153A CN 119136833 A CN119136833 A CN 119136833A
Authority
CN
China
Prior art keywords
peptide
cell
amino acid
cells
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202380038153.2A
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English (en)
Chinese (zh)
Inventor
裴德华
P·巴特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ohio State Innovation Foundation
Original Assignee
Ohio State Innovation Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ohio State Innovation Foundation filed Critical Ohio State Innovation Foundation
Publication of CN119136833A publication Critical patent/CN119136833A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202380038153.2A 2022-03-17 2023-03-17 膜易位结构域及其用途 Pending CN119136833A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263320978P 2022-03-17 2022-03-17
US63/320,978 2022-03-17
PCT/US2023/064659 WO2023178327A1 (en) 2022-03-17 2023-03-17 Membrane translocation domains and uses thereof

Publications (1)

Publication Number Publication Date
CN119136833A true CN119136833A (zh) 2024-12-13

Family

ID=88024540

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202380038153.2A Pending CN119136833A (zh) 2022-03-17 2023-03-17 膜易位结构域及其用途

Country Status (6)

Country Link
EP (1) EP4493217A4 (enExample)
JP (1) JP2025509645A (enExample)
CN (1) CN119136833A (enExample)
AU (1) AU2023236380A1 (enExample)
CA (1) CA3246149A1 (enExample)
WO (1) WO2023178327A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4519308A4 (en) * 2022-05-04 2026-03-11 Ohio State Innovation Foundation COMPOSITIONS FOR THE DISTRIBUTION OF AGENTS IN PLANT CELLS
WO2025064985A1 (en) * 2023-09-22 2025-03-27 Ohio State Innovation Foundation Myc INHIBITOR PROTEINS AND USES THEREOF
WO2025096245A1 (en) * 2023-11-02 2025-05-08 The Regents Of The University Of California Design rules for endosomal escape
WO2025117903A1 (en) * 2023-11-29 2025-06-05 Ohio State Innovation Foundation Intracellular delivery of gene-editing enzymes and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013177231A1 (en) * 2012-05-21 2013-11-28 Massachusetts Institute Of Technology Translocation of non-natural chemical entities through anthrax protective antigen pore
JP6807831B2 (ja) * 2014-05-21 2021-01-06 エントラーダ セラピューティクス，インコーポレイテッド 細胞膜透過性ペプチド、並びにこの作製方法及び使用方法
CA3166422A1 (en) * 2019-12-30 2021-07-08 Ohio State Innovation Foundation Looped proteins comprising cell penetrating peptides
EP4519308A4 (en) * 2022-05-04 2026-03-11 Ohio State Innovation Foundation COMPOSITIONS FOR THE DISTRIBUTION OF AGENTS IN PLANT CELLS

Also Published As

Publication number Publication date
CA3246149A1 (en) 2023-09-21
JP2025509645A (ja) 2025-04-11
EP4493217A4 (en) 2026-03-11
AU2023236380A1 (en) 2024-10-03
EP4493217A1 (en) 2025-01-22
WO2023178327A1 (en) 2023-09-21

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