JP2025509645A - 膜移行ドメイン及びその使用 - Google Patents

膜移行ドメイン及びその使用 Download PDF

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Publication number
JP2025509645A
JP2025509645A JP2024554922A JP2024554922A JP2025509645A JP 2025509645 A JP2025509645 A JP 2025509645A JP 2024554922 A JP2024554922 A JP 2024554922A JP 2024554922 A JP2024554922 A JP 2024554922A JP 2025509645 A JP2025509645 A JP 2025509645A
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JP
Japan
Prior art keywords
cell
peptide
amino acid
cells
motif
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024554922A
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English (en)
Japanese (ja)
Other versions
JP2025509645A5 (enExample
Inventor
ディーファ ペイ
プラバート バート
Original Assignee
オハイオ ステート イノベーション ファウンデーション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by オハイオ ステート イノベーション ファウンデーション filed Critical オハイオ ステート イノベーション ファウンデーション
Publication of JP2025509645A publication Critical patent/JP2025509645A/ja
Publication of JP2025509645A5 publication Critical patent/JP2025509645A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2024554922A 2022-03-17 2023-03-17 膜移行ドメイン及びその使用 Pending JP2025509645A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263320978P 2022-03-17 2022-03-17
US63/320,978 2022-03-17
PCT/US2023/064659 WO2023178327A1 (en) 2022-03-17 2023-03-17 Membrane translocation domains and uses thereof

Publications (2)

Publication Number Publication Date
JP2025509645A true JP2025509645A (ja) 2025-04-11
JP2025509645A5 JP2025509645A5 (enExample) 2025-12-11

Family

ID=88024540

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024554922A Pending JP2025509645A (ja) 2022-03-17 2023-03-17 膜移行ドメイン及びその使用

Country Status (6)

Country Link
EP (1) EP4493217A4 (enExample)
JP (1) JP2025509645A (enExample)
CN (1) CN119136833A (enExample)
AU (1) AU2023236380A1 (enExample)
CA (1) CA3246149A1 (enExample)
WO (1) WO2023178327A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4519308A4 (en) * 2022-05-04 2026-03-11 Ohio State Innovation Foundation COMPOSITIONS FOR THE DISTRIBUTION OF AGENTS IN PLANT CELLS
WO2025064985A1 (en) * 2023-09-22 2025-03-27 Ohio State Innovation Foundation Myc INHIBITOR PROTEINS AND USES THEREOF
WO2025096245A1 (en) * 2023-11-02 2025-05-08 The Regents Of The University Of California Design rules for endosomal escape
WO2025117903A1 (en) * 2023-11-29 2025-06-05 Ohio State Innovation Foundation Intracellular delivery of gene-editing enzymes and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013177231A1 (en) * 2012-05-21 2013-11-28 Massachusetts Institute Of Technology Translocation of non-natural chemical entities through anthrax protective antigen pore
JP6807831B2 (ja) * 2014-05-21 2021-01-06 エントラーダ セラピューティクス，インコーポレイテッド 細胞膜透過性ペプチド、並びにこの作製方法及び使用方法
CA3166422A1 (en) * 2019-12-30 2021-07-08 Ohio State Innovation Foundation Looped proteins comprising cell penetrating peptides
EP4519308A4 (en) * 2022-05-04 2026-03-11 Ohio State Innovation Foundation COMPOSITIONS FOR THE DISTRIBUTION OF AGENTS IN PLANT CELLS

Also Published As

Publication number Publication date
CA3246149A1 (en) 2023-09-21
EP4493217A4 (en) 2026-03-11
AU2023236380A1 (en) 2024-10-03
CN119136833A (zh) 2024-12-13
EP4493217A1 (en) 2025-01-22
WO2023178327A1 (en) 2023-09-21

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