CN119136783A - 含缓冲剂的组合物和其使用方法 - Google Patents

含缓冲剂的组合物和其使用方法 Download PDF

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Publication number
CN119136783A
CN119136783A CN202380035912.XA CN202380035912A CN119136783A CN 119136783 A CN119136783 A CN 119136783A CN 202380035912 A CN202380035912 A CN 202380035912A CN 119136783 A CN119136783 A CN 119136783A
Authority
CN
China
Prior art keywords
composition
compound
species
phosphate buffer
buffer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202380035912.XA
Other languages
English (en)
Chinese (zh)
Inventor
D·S·福克
N·A·斯塔斯科
R·A·麦克唐纳
J·K·西蒙斯
W·L·罗伯茨二世
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nuo Bio Co ltd
Original Assignee
Nuo Bio Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nuo Bio Co ltd filed Critical Nuo Bio Co ltd
Publication of CN119136783A publication Critical patent/CN119136783A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Otolaryngology (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
CN202380035912.XA 2022-04-28 2023-04-25 含缓冲剂的组合物和其使用方法 Pending CN119136783A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263335822P 2022-04-28 2022-04-28
US63/335822 2022-04-28
PCT/US2023/019807 WO2023211932A1 (en) 2022-04-28 2023-04-25 Buffering agent-containing compositions and methods of using same

Publications (1)

Publication Number Publication Date
CN119136783A true CN119136783A (zh) 2024-12-13

Family

ID=86469370

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202380035912.XA Pending CN119136783A (zh) 2022-04-28 2023-04-25 含缓冲剂的组合物和其使用方法

Country Status (7)

Country Link
US (1) US20250281512A1 (enExample)
EP (1) EP4514319A1 (enExample)
JP (1) JP2025515314A (enExample)
CN (1) CN119136783A (enExample)
AU (1) AU2023260344A1 (enExample)
CA (1) CA3250927A1 (enExample)
WO (1) WO2023211932A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20250339449A1 (en) * 2024-05-02 2025-11-06 Know Bio, Llc Inhalation formulations containing nitric oxide releasing compounds and methods of using same
CN119523952B (zh) * 2024-10-17 2026-03-10 河北医科大学 一种多黏菌素吸入液体制剂及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090196930A1 (en) * 2007-12-27 2009-08-06 Aires Pharmaceuticals, Inc. Aerosolized nitrite and nitric oxide -donating compounds and uses thereof
US20120076859A1 (en) * 2010-09-23 2012-03-29 Activaero Gmbh Targeted Lung Delivery of Citrulline and/or Another Nitric Oxide Precursor and a Method for Treatment of Pulmonary Deficiency of Nitric Oxide in Cystic Fibrosis and Other Pulmonary Diseases
CA3280124A1 (en) * 2013-07-31 2025-10-31 Avalyn Pharma Inc. Aerosol imatinib compounds and uses thereof
EP4548975A3 (en) * 2015-09-09 2025-07-23 Beyond Air Ltd Nitric oxide inhalation therapy for infants with bronchiolitis
US12390479B2 (en) * 2020-02-07 2025-08-19 Know Bio, Llc Nitric oxide-releasing antibacterial compounds, formulations, and methods pertaining thereto
WO2022051606A1 (en) * 2020-09-04 2022-03-10 Know Bio, Llc Nitric oxide donors, compositions, and methods of use

Also Published As

Publication number Publication date
CA3250927A1 (en) 2023-11-02
WO2023211932A1 (en) 2023-11-02
JP2025515314A (ja) 2025-05-14
AU2023260344A1 (en) 2024-11-07
US20250281512A1 (en) 2025-09-11
EP4514319A1 (en) 2025-03-05

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