CN1190582A - Antipruritic ointment for dermatitis - Google Patents
Antipruritic ointment for dermatitis Download PDFInfo
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- CN1190582A CN1190582A CN98100946A CN98100946A CN1190582A CN 1190582 A CN1190582 A CN 1190582A CN 98100946 A CN98100946 A CN 98100946A CN 98100946 A CN98100946 A CN 98100946A CN 1190582 A CN1190582 A CN 1190582A
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- glycerol
- distilled water
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- fluocinonide
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Abstract
The antipruritic ointment consists of the components of the recipe of fluocinolone acetonide, components of the recipe of triamcinolone and components of the recipe of clobetasol propionate, and is a kind of compound of cortical hormone, and possesses of very powerful unit-inflammatory, antipruritus actions. There are very good curative effects for eczema, neuroder matitis, allergic dermatitis, puritus, psoriasis etc, the cure rate comes up to 95% odd, the effective rate is 100%.
Description
The present invention relates to a kind of dermatitis and end ancient term for country school ointment.
Dermatosis is the common disease of people's pilosity, and the dermatosis reason that has is very complicated, does not heal because of prolonged, gives that people are in life, work is gone up to reach and made troubles mentally and misery.As chronic eczema, chronic dermatitis etc., course of disease decades-long that has, long-term pruritus, serious generation Keratoderma, thicken, coarse, desquamation, breach, lichenification change puzzlement person patient.And existing extract oral and outer the wiping, methods such as the oral and outer wiping of Western medicine, effect is all bad.
The purpose of this invention is to provide a kind of instant effect, good effect, to antiinflammatory, the specific antipruritic ointment for dermatitis of itching disappears.
Contain fluocinonide recipe ingredient, omcilon carbamide recipe ingredient and clobetasol propionate recipe ingredient in the antipruritic ointment for dermatitis of the present invention; The parts by weight proportioning of described three recipe ingredients is: fluocinonide recipe ingredient 20-40 part, omcilon carbamide recipe ingredient 20-40 part, clobetasol propionate recipe ingredient 20-40 part.
Described fluocinonide recipe ingredient contains fluocinonide, triethanolamine, glycerol, stearic acid, lanoline, white vaseline, nipalgin and distilled water, and wherein the parts by weight proportioning of various compositions is:
15～25 parts of 0.2～0.3 part of triethanolamine of fluocinonide
140～160 parts of 45～55 parts of stearic acid of glycerol
240～260 parts of 15～25 parts of white vaseline of lanoline
500～520 parts of 0.5～1.5 part of distilled water of nipalgin
Described omcilon carbamide recipe ingredient contains triamcinolone, carbamide, white vaseline, octadecanol, liquid paraffin, sodium laurylsulfate, glycerol, ethyl hydroxybenzoate and distilled water, and the parts by weight proportioning of wherein said each composition is:
9～11 parts in 0.05～0.15 part of carbamide of triamcinolone
80～100 parts of 90～110 parts of octadecanol of white vaseline
9～11 parts of 40～60 parts of sodium laurylsulfates of liquid paraffin
0.9～1.1 part of 45～55 parts of ethyl hydroxybenzoate of glycerol
650～750 parts of distilled water
Described clobetasol propionate recipe ingredient contains clobetasol propionate, Laurel nitrogen oxadiazon, white vaseline, octadecanol, liquid paraffin, sodium laurylsulfate, glycerol, ethyl hydroxybenzoate and distilled water, and the parts by weight proportioning of wherein said each composition is:
3～6 parts of 0.01～0.03 portion of Laurel of clobetasol propionate nitrogen oxadiazon
80～100 parts of 90～110 parts of octadecanol of white vaseline
9～11 parts of 40～60 parts of sodium laurylsulfates of liquid paraffin
0.9～1.1 part of 45～55 parts of ethyl hydroxybenzoate of glycerol
650～750 parts of distilled water
Antipruritic ointment for dermatitis of the present invention is a kind of 17-hydroxy-11-dehydrocorticosterone complexing agent, prescription is unique, have very strong antiinflammatory, antipruritic effect, eczema, neurodermatitis, allergic dermatitis, the disease of scratching where it itches there are specially good effect, psoriasis, solar dermatitis, lupus erythematosus, epidermolysis disease, broken skin disease, dermatomyositis, lichen planus, prurigo nodularis and skin carcinoma are all had better curative effect.Cure rate reaches more than 95%, and effective percentage reaches 100%.If plastic sheeting covers the dispenser position in use, can promote skin absorbs better and improve curative effect and reach tens of times.
During preparation, the preparation of can dividing into groups.
Earlier that triethanolamine, glycerol, nipalgin is soluble in water, be heated to 75 ℃ not bathing, other gets stearic acid and melts in water-bath, adds lanoline, white vaseline, and maintains the temperature at 75 ℃, under constantly stirring, this oil phase is added above-mentioned isothermal aqueous phase gradually, move down from water-bath simultaneously, fluocinonide is added gradually stir again, be paste until solidify, can obtain the fluocinonide recipe ingredient;
The process for preparation of omcilon carbamide prescription group is: with the mixed oil phase substrate that gets of white vaseline, octadecanol and liquid paraffin; With the mixed aqueous phase substrate that gets of sodium laurylsulfate, glycerol, ethyl hydroxybenzoate and distilled water, carbamide is added wherein gradually; The oil phase substrate stirring is joined in the aqueous phase substrate down gradually, obtain substrate after stirring; At last omcilon is ground, cross 120 mesh sieves, add gradually in the substrate then, can obtain omcilon carbamide recipe ingredient after stirring evenly;
The preparation process of clobetasol propionate prescription group is substantially with the omcilon process for preparation, just in aqueous phase substrate, do not add carbamide, and in oil phase substrate, add Laurel nitrogen oxadiazon, and in substrate, add clobetasol propionate at last, can obtain the clobetasol propionate recipe ingredient;
At last above-mentioned three recipe ingredients are mixed, stir and to obtain antipruritic ointment for dermatitis of the present invention.
Be that several patients wipe the effect recording with antipruritic ointment for dermatitis of the present invention below.
Case (one)
The Wang, man, 78 years old, the cadre, itched in symmetry shank shin the place ahead in 1975, rises and go up red pimple, over surplus in the of 20 year, skin lesion increases decortication gradually, rough surface and the big pimple of Semen setariae is arranged, there is the lichen sample to change, Beijing various big hospital was all controlled, and the various ways of Chinese medicine and western medicine were all used, and all failed to cure, PIYANPING is crossed in external, fluocinonide, omcilon carbamide cream, clobetasol cream, that itches goes through when harmful oral chlorphenamine, Ke Minling takes medicine and feels like jelly from head to foot, and is dizzy but still itch very much, it is heavy when time thes be light, again and again, the skin lesion development is big as palm, wipes with behind the antipruritic ointment for dermatitis of the present invention, it is promptly antipruritic to spread medicine, one box does not use up, and existing skin flattens, and erythra disappears, it is normal that color of the leather recovers, and cures.
Case (two)
Patient Wu, county other than where one lives cadre, man, 28 years old, there is a slice dermatitis back of the body scapula below, a left side, and was big as palm, peel coarse, itch, the course of disease 4 years, medicines such as PIYANPING, fluocinonide, omcilon carbamide cream are crossed in external, do not feel any better, the surface changes for the lichen sample, gets 20 grams specially good effect antipruritic ointment for dermatitis of the present invention, the outer wiping once cured, skin recovers normal color of the leather fully after one week, and smooth, no gargalesthesia is complete.
Case (three)
Lee, 32 years old, the woman, the cadre, pudendum was itched 3 years, external fluocinonide, omcilon carbamide cream, PIYANPING, outer wiping was antipruritic at that time, still itched later, and the extra-labia inboard is rubescent, a little red pimple was wiped once with specially good effect antipruritic ointment for dermatitis of the present invention is outer, after several weeks, check, the patient says to smear once and no longer itches that local skin is normal, cures.
Further specify the present invention below in conjunction with embodiment.
Embodiment
A kind of antipruritic ointment for dermatitis, it comprises three recipe ingredients, 33 parts of fluocinonide recipe ingredients, 34 parts of 33 parts of omcilon carbamide recipe ingredients and clobetasol propionate recipe ingredients.
Described fluocinonide recipe ingredient contains fluocinonide, triethanolamine, glycerol, stearic acid, lanoline, white vaseline, nipalgin and distilled water, and wherein the parts by weight proportioning of various compositions is:
20 parts of 0.25 part of triethanolamine of fluocinonide
150 parts of 50 parts of stearic acid of glycerol
250 parts of 20 parts of white vaseline of lanoline
510 parts of 1 part of distilled water of nipalgin
Described omcilon carbamide recipe ingredient contains omcilon, carbamide, white vaseline, octadecanol, liquid paraffin, sodium laurylsulfate, glycerol, ethyl hydroxybenzoate and distilled water, and the parts by weight proportioning of wherein said each composition is:
10 parts in 0.1 part of carbamide of triamcinolone
90 parts of 100 parts of octadecanol of white vaseline
10 parts of 50 parts of sodium laurylsulfates of liquid paraffin
1 part of 50 parts of ethyl hydroxybenzoate of glycerol
700 parts of distilled water
Described clobetasol propionate recipe ingredient contains clobetasol propionate, Laurel nitrogen oxadiazon, white vaseline, octadecanol, liquid paraffin, sodium laurylsulfate, glycerol, ethyl hydroxybenzoate and distilled water, and the parts by weight proportioning of wherein said each composition is:
5 parts of 0.02 portion of Laurel of clobetasol propionate nitrogen oxadiazon
90 parts of 100 parts of octadecanol of white vaseline
10 parts of 50 parts of sodium laurylsulfates of liquid paraffin
1 part of 50 parts of ethyl hydroxybenzoate of glycerol
700 parts of distilled water
The contraindication of this antipruritic ointment for dermatitis
Dermatomycosis, tuberculosis, syphilis, suppurative dermatosis are forbidden this preparation allergy sufferers.
Claims (5)
1, a kind of antipruritic ointment for dermatitis is characterized in that it contains fluocinonide recipe ingredient, omcilon carbamide recipe ingredient and clobetasol propionate recipe ingredient; The parts by weight proportioning of described three recipe ingredients is: fluocinonide recipe ingredient 20-40 part, omcilon carbamide recipe ingredient 20-40 part, clobetasol propionate recipe ingredient 20-40 part;
Described fluocinonide recipe ingredient contains fluocinonide, triethanolamine, glycerol, stearic acid, lanoline, white vaseline, nipalgin and distilled water;
Described omcilon carbamide recipe ingredient contains triamcinolone, carbamide, white vaseline, octadecanol, liquid paraffin, sodium laurylsulfate, glycerol, ethyl hydroxybenzoate and distilled water;
Described clobetasol propionate recipe ingredient contains clobetasol propionate, Laurel nitrogen oxadiazon, white vaseline, octadecanol, liquid paraffin, sodium laurylsulfate, glycerol, ethyl hydroxybenzoate and distilled water;
2, ointment as claimed in claim 1 is characterized in that the parts by weight proportioning of each composition of described fluocinonide recipe ingredient is:
15～25 parts of 0.2～0.3 part of triethanolamine of fluocinonide
140～160 parts of 45～55 parts of stearic acid of glycerol
240～260 parts of 15～25 parts of white vaseline of lanoline
500～520 parts of 0.5～1.5 part of distilled water of nipalgin
3, ointment as claimed in claim 1 is characterized in that the parts by weight proportioning of each composition of described omcilon carbamide recipe ingredient is:
9～11 parts in 0.05～0.15 part of carbamide of triamcinolone
80～100 parts of 90～110 parts of octadecanol of white vaseline
9～11 parts of 40～60 parts of sodium laurylsulfates of liquid paraffin
0.9～1.1 part of 45～55 parts of ethyl hydroxybenzoate of glycerol
650～750 parts of distilled water
4, ointment as claimed in claim 1 is characterized in that the parts by weight proportioning of each composition of described clobetasol propionate recipe ingredient is:
3～6 parts of 0.01～0.03 portion of Laurel of clobetasol propionate nitrogen oxadiazon
80～100 parts of 90～110 parts of octadecanol of white vaseline
9～11 parts of 40～60 parts of sodium laurylsulfates of liquid paraffin
0.9～1.1 part of 45～55 parts of ethyl hydroxybenzoate of glycerol
650～750 parts of distilled water
5, ointment as claimed in claim 1 is characterized in that comprising three recipe ingredients, 33 parts of fluocinonide recipe ingredients, 34 parts of 33 parts of omcilon carbamide recipe ingredients and clobetasol propionate recipe ingredients;
Described fluocinonide recipe ingredient contains fluocinonide, triethanolamine, glycerol, stearic acid, lanoline, white vaseline, nipalgin and distilled water, and wherein the parts by weight proportioning of various compositions is:
20 parts of 0.25 part of triethanolamine of fluocinonide
150 parts of 50 parts of stearic acid of glycerol
250 parts of 20 parts of white vaseline of lanoline
510 parts of 1 part of distilled water of nipalgin
Described omcilon carbamide recipe ingredient contains omcilon, carbamide, white vaseline, octadecanol, liquid paraffin, sodium laurylsulfate, glycerol, ethyl hydroxybenzoate and distilled water, and the parts by weight proportioning of wherein said each composition is:
10 parts in 0.1 part of carbamide of triamcinolone
90 parts of 100 parts of octadecanol of white vaseline
10 parts of 50 parts of sodium laurylsulfates of liquid paraffin
1 part of 50 parts of ethyl hydroxybenzoate of glycerol
700 parts of distilled water
Described clobetasol propionate recipe ingredient contains clobetasol propionate, Laurel nitrogen oxadiazon, white vaseline, octadecanol, liquid paraffin, sodium laurylsulfate, glycerol, ethyl hydroxybenzoate and distilled water, and the parts by weight proportioning of wherein said each composition is:
5 parts of 0.02 portion of Laurel of clobetasol propionate nitrogen oxadiazon
90 parts of 100 parts of octadecanol of white vaseline
10 parts of 50 parts of sodium laurylsulfates of liquid paraffin
1 part of 50 parts of ethyl hydroxybenzoate of glycerol
700 parts of distilled water
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98100946A CN1086580C (en) | 1998-03-23 | 1998-03-23 | Antipruritic ointment for dermatitis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98100946A CN1086580C (en) | 1998-03-23 | 1998-03-23 | Antipruritic ointment for dermatitis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1190582A true CN1190582A (en) | 1998-08-19 |
| CN1086580C CN1086580C (en) | 2002-06-26 |
Family
ID=5216362
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98100946A Expired - Fee Related CN1086580C (en) | 1998-03-23 | 1998-03-23 | Antipruritic ointment for dermatitis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1086580C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102813660A (en) * | 2012-09-13 | 2012-12-12 | 前郭尔罗斯蒙古族自治县医院 | External medicine for treating skin eczema |
| CN108601733A (en) * | 2015-12-15 | 2018-09-28 | 治疗学有限公司 | Buprofein foam compositions and its application method |
-
1998
- 1998-03-23 CN CN98100946A patent/CN1086580C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102813660A (en) * | 2012-09-13 | 2012-12-12 | 前郭尔罗斯蒙古族自治县医院 | External medicine for treating skin eczema |
| CN108601733A (en) * | 2015-12-15 | 2018-09-28 | 治疗学有限公司 | Buprofein foam compositions and its application method |
| CN108601733B (en) * | 2015-12-15 | 2021-11-09 | 治疗学有限公司 | Halobetasol foam compositions and methods of use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1086580C (en) | 2002-06-26 |
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|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20020626 Termination date: 20100323 |