CN118955620A - 包含成纤维细胞活化蛋白配体的化合物及其用途 - Google Patents

包含成纤维细胞活化蛋白配体的化合物及其用途 Download PDF

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Publication number
CN118955620A
CN118955620A CN202411047668.1A CN202411047668A CN118955620A CN 118955620 A CN118955620 A CN 118955620A CN 202411047668 A CN202411047668 A CN 202411047668A CN 118955620 A CN118955620 A CN 118955620A
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amino acid
compound
cys
pro
group
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Chinese (zh)
Inventor
F·奥斯特坎普
D·兹博拉尔斯基
E·施奈德
C·哈泽
M·帕施克
A·赫内
J·翁格维斯
C·斯梅林
U·赖内克
A·布雷登贝克
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3B Pharmaceuticals GmbH
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3B Pharmaceuticals GmbH
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Priority claimed from EP19000325.1A external-priority patent/EP3763726A1/en
Application filed by 3B Pharmaceuticals GmbH filed Critical 3B Pharmaceuticals GmbH
Publication of CN118955620A publication Critical patent/CN118955620A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/14—Dipeptidyl-peptidases and tripeptidyl-peptidases (3.4.14)
    • C12Y304/14005—Dipeptidyl-peptidase IV (3.4.14.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN202411047668.1A 2019-07-08 2020-07-08 包含成纤维细胞活化蛋白配体的化合物及其用途 Pending CN118955620A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP19000325.1A EP3763726A1 (en) 2019-07-08 2019-07-08 Compounds comprising a fibroblast activation protein ligand and use thereof
EP19000325.1 2019-07-08
EP19198810.4 2019-09-20
EP19198810 2019-09-20
CN202080062641.3A CN114341158B (zh) 2019-07-08 2020-07-08 包含成纤维细胞活化蛋白配体的化合物及其用途
PCT/EP2020/069308 WO2021005131A1 (en) 2019-07-08 2020-07-08 Compounds comprising a fibroblast activation protein ligand and use thereof

Related Parent Applications (1)

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CN202080062641.3A Division CN114341158B (zh) 2019-07-08 2020-07-08 包含成纤维细胞活化蛋白配体的化合物及其用途

Publications (1)

Publication Number Publication Date
CN118955620A true CN118955620A (zh) 2024-11-15

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CN202411047668.1A Pending CN118955620A (zh) 2019-07-08 2020-07-08 包含成纤维细胞活化蛋白配体的化合物及其用途
CN202411047674.7A Pending CN118930608A (zh) 2019-07-08 2020-07-08 包含成纤维细胞活化蛋白配体的化合物及其用途
CN202080062641.3A Active CN114341158B (zh) 2019-07-08 2020-07-08 包含成纤维细胞活化蛋白配体的化合物及其用途

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CN202411047674.7A Pending CN118930608A (zh) 2019-07-08 2020-07-08 包含成纤维细胞活化蛋白配体的化合物及其用途
CN202080062641.3A Active CN114341158B (zh) 2019-07-08 2020-07-08 包含成纤维细胞活化蛋白配体的化合物及其用途

Country Status (12)

Country Link
US (1) US20220315554A1 (enExample)
EP (1) EP3997104A1 (enExample)
JP (2) JP7801207B2 (enExample)
KR (1) KR20220032078A (enExample)
CN (3) CN118955620A (enExample)
AU (2) AU2020309161A1 (enExample)
BR (1) BR112022000144A2 (enExample)
CA (1) CA3145872A1 (enExample)
CL (1) CL2022000016A1 (enExample)
IL (2) IL324399A (enExample)
MX (1) MX2022000251A (enExample)
WO (1) WO2021005131A1 (enExample)

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EP4050018A1 (en) * 2021-01-07 2022-08-31 3B Pharmaceuticals GmbH Compounds comprising a fibroblast activation protein ligand and use thereof
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Publication number Publication date
WO2021005131A1 (en) 2021-01-14
MX2022000251A (es) 2022-02-21
JP7801207B2 (ja) 2026-01-16
CN114341158A (zh) 2022-04-12
AU2020309161A1 (en) 2022-01-27
EP3997104A1 (en) 2022-05-18
IL289673B1 (en) 2025-12-01
AU2026202638A1 (en) 2026-05-21
IL324399A (en) 2026-01-01
CN118930608A (zh) 2024-11-12
IL289673B2 (en) 2026-04-01
IL289673A (en) 2022-03-01
JP2022541752A (ja) 2022-09-27
BR112022000144A2 (pt) 2022-02-22
CL2022000016A1 (es) 2022-08-19
KR20220032078A (ko) 2022-03-15
CA3145872A1 (en) 2021-01-14
JP2026062901A (ja) 2026-04-10
CN114341158B (zh) 2024-08-06
US20220315554A1 (en) 2022-10-06

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