CN118660909A - 亲和力增强的抗ecm纳米抗体-细胞因子融合体及其应用 - Google Patents

亲和力增强的抗ecm纳米抗体-细胞因子融合体及其应用 Download PDF

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Publication number
CN118660909A
CN118660909A CN202380019368.XA CN202380019368A CN118660909A CN 118660909 A CN118660909 A CN 118660909A CN 202380019368 A CN202380019368 A CN 202380019368A CN 118660909 A CN118660909 A CN 118660909A
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seq
nanobody
eiiib
nanobodies
fibronectin
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Chinese (zh)
Inventor
理查德·O·海因斯
卡尔·戴恩·维特鲁普
努尔·扎伊尔哈尼
努尔·莫明
埃米·卢茨
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Massachusetts Institute of Technology
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Massachusetts Institute of Technology
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/6843—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a material from animals or humans
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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CN202380019368.XA 2022-01-31 2023-01-31 亲和力增强的抗ecm纳米抗体-细胞因子融合体及其应用 Pending CN118660909A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263304954P 2022-01-31 2022-01-31
US63/304,954 2022-01-31
PCT/US2023/061658 WO2023147588A2 (en) 2022-01-31 2023-01-31 Enhanced-affinity anti-ecm nanobody-cytokine fusions and their applications

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Publication Number Publication Date
CN118660909A true CN118660909A (zh) 2024-09-17

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CN202380019368.XA Pending CN118660909A (zh) 2022-01-31 2023-01-31 亲和力增强的抗ecm纳米抗体-细胞因子融合体及其应用

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US (1) US20230295284A1 (https=)
EP (1) EP4473015A2 (https=)
JP (1) JP2025504036A (https=)
CN (1) CN118660909A (https=)
AU (1) AU2023211706A1 (https=)
WO (1) WO2023147588A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116143945A (zh) * 2022-12-09 2023-05-23 浙江大学杭州国际科创中心 一种趋化因子与免疫检查点抑制剂融合表达蛋白及其生产方法和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220175833A1 (en) * 2019-03-07 2022-06-09 Children's Medical Center Corporation Targeted delivery of immune-modulating vhh and vhh-fusion protein

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116143945A (zh) * 2022-12-09 2023-05-23 浙江大学杭州国际科创中心 一种趋化因子与免疫检查点抑制剂融合表达蛋白及其生产方法和应用

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AU2023211706A1 (en) 2024-07-25
WO2023147588A3 (en) 2023-09-28
WO2023147588A2 (en) 2023-08-03
US20230295284A1 (en) 2023-09-21
EP4473015A2 (en) 2024-12-11
JP2025504036A (ja) 2025-02-06

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