CN118660723A - 治疗诊断学叶酸酯缀合物 - Google Patents

治疗诊断学叶酸酯缀合物 Download PDF

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Publication number
CN118660723A
CN118660723A CN202380019559.6A CN202380019559A CN118660723A CN 118660723 A CN118660723 A CN 118660723A CN 202380019559 A CN202380019559 A CN 202380019559A CN 118660723 A CN118660723 A CN 118660723A
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CN
China
Prior art keywords
compound
radiometal
compound according
dota
present disclosure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202380019559.6A
Other languages
English (en)
Chinese (zh)
Inventor
V·格罗恩
M-L·伦茨
R·莫泽
R·施布利
C·M·穆勒
M·贝尼索瓦
P·古兹克
L·M·德贝勒
A·E·贝克尔
S·D·巴斯林格
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of CN118660723A publication Critical patent/CN118660723A/zh
Pending legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0497Organic compounds conjugates with a carrier being an organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0402Organic compounds carboxylic acid carriers, fatty acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN202380019559.6A 2022-02-01 2023-01-30 治疗诊断学叶酸酯缀合物 Pending CN118660723A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP22154653 2022-02-01
EP22154653.4 2022-02-01
PCT/EP2023/052116 WO2023148115A1 (en) 2022-02-01 2023-01-30 Theragnostic folate conjugates

Publications (1)

Publication Number Publication Date
CN118660723A true CN118660723A (zh) 2024-09-17

Family

ID=80119142

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202380019559.6A Pending CN118660723A (zh) 2022-02-01 2023-01-30 治疗诊断学叶酸酯缀合物

Country Status (9)

Country Link
US (1) US20250108138A1 (enExample)
EP (1) EP4472676A1 (enExample)
JP (1) JP2025504028A (enExample)
KR (1) KR20240142514A (enExample)
CN (1) CN118660723A (enExample)
AU (1) AU2023214599A1 (enExample)
CA (1) CA3243526A1 (enExample)
IL (1) IL314507A (enExample)
WO (1) WO2023148115A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025220711A1 (ja) * 2024-04-17 2025-10-23 日本メジフィジックス株式会社 化合物、放射性標識化合物及びその製造方法、並びに放射性医薬組成物
WO2026014283A1 (ja) * 2024-07-09 2026-01-15 日本メジフィジックス株式会社 化合物、放射性標識化合物およびその製造方法、並びに放射性医薬組成物

Also Published As

Publication number Publication date
AU2023214599A1 (en) 2024-09-19
IL314507A (en) 2024-09-01
US20250108138A1 (en) 2025-04-03
JP2025504028A (ja) 2025-02-06
EP4472676A1 (en) 2024-12-11
KR20240142514A (ko) 2024-09-30
CA3243526A1 (en) 2023-08-10
WO2023148115A1 (en) 2023-08-10

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