CN118619971A - 稠合吡啶酮类化合物及其制备方法和应用 - Google Patents
稠合吡啶酮类化合物及其制备方法和应用 Download PDFInfo
- Publication number
- CN118619971A CN118619971A CN202410656034.XA CN202410656034A CN118619971A CN 118619971 A CN118619971 A CN 118619971A CN 202410656034 A CN202410656034 A CN 202410656034A CN 118619971 A CN118619971 A CN 118619971A
- Authority
- CN
- China
- Prior art keywords
- alkyl
- compound
- membered heterocycloalkyl
- cycloalkyl
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (20)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910892032 | 2019-09-20 | ||
| CN201910892032X | 2019-09-20 | ||
| CN2019111296882 | 2019-11-18 | ||
| CN201911129688 | 2019-11-18 | ||
| CN2019111579398 | 2019-11-22 | ||
| CN201911157939 | 2019-11-22 | ||
| CN202010054188 | 2020-01-17 | ||
| CN2020100541883 | 2020-01-17 | ||
| CN2020101025463 | 2020-02-19 | ||
| CN202010102546 | 2020-02-19 | ||
| CN2020102303038 | 2020-03-27 | ||
| CN202010230303 | 2020-03-27 | ||
| CN202010306926 | 2020-04-17 | ||
| CN2020103069269 | 2020-04-17 | ||
| CN202010367694 | 2020-04-30 | ||
| CN2020103676948 | 2020-04-30 | ||
| CN202010967317 | 2020-09-15 | ||
| CN2020109673178 | 2020-09-15 | ||
| CN202080078771.6A CN114728968B (zh) | 2019-09-20 | 2020-09-21 | 稠合吡啶酮类化合物及其制备方法和应用 |
| PCT/CN2020/116510 WO2021052499A1 (zh) | 2019-09-20 | 2020-09-21 | 稠合吡啶酮类化合物及其制备方法和应用 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080078771.6A Division CN114728968B (zh) | 2019-09-20 | 2020-09-21 | 稠合吡啶酮类化合物及其制备方法和应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN118619971A true CN118619971A (zh) | 2024-09-10 |
Family
ID=74883935
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202410656034.XA Pending CN118619971A (zh) | 2019-09-20 | 2020-09-21 | 稠合吡啶酮类化合物及其制备方法和应用 |
| CN202310905052.2A Active CN116947885B (zh) | 2019-09-20 | 2020-09-21 | 稠合吡啶酮类化合物及其制备方法和应用 |
| CN202411842480.6A Pending CN119462689A (zh) | 2019-09-20 | 2020-09-21 | 稠合吡啶酮类化合物及其制备方法和应用 |
| CN202411842482.5A Pending CN119591618A (zh) | 2019-09-20 | 2020-09-21 | 稠合吡啶酮类化合物及其制备方法和应用 |
| CN202080078771.6A Active CN114728968B (zh) | 2019-09-20 | 2020-09-21 | 稠合吡啶酮类化合物及其制备方法和应用 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310905052.2A Active CN116947885B (zh) | 2019-09-20 | 2020-09-21 | 稠合吡啶酮类化合物及其制备方法和应用 |
| CN202411842480.6A Pending CN119462689A (zh) | 2019-09-20 | 2020-09-21 | 稠合吡啶酮类化合物及其制备方法和应用 |
| CN202411842482.5A Pending CN119591618A (zh) | 2019-09-20 | 2020-09-21 | 稠合吡啶酮类化合物及其制备方法和应用 |
| CN202080078771.6A Active CN114728968B (zh) | 2019-09-20 | 2020-09-21 | 稠合吡啶酮类化合物及其制备方法和应用 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20220389029A1 (https=) |
| EP (1) | EP4043464A4 (https=) |
| JP (1) | JP7642619B2 (https=) |
| KR (1) | KR20220086573A (https=) |
| CN (5) | CN118619971A (https=) |
| AU (1) | AU2020350745B2 (https=) |
| BR (1) | BR112022005193A2 (https=) |
| CA (1) | CA3155066A1 (https=) |
| CL (1) | CL2022000666A1 (https=) |
| CO (1) | CO2022004686A2 (https=) |
| IL (1) | IL291467B1 (https=) |
| MX (1) | MX2022003401A (https=) |
| PH (1) | PH12022550681A1 (https=) |
| TW (1) | TWI761961B (https=) |
| WO (1) | WO2021052499A1 (https=) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019217307A1 (en) | 2018-05-07 | 2019-11-14 | Mirati Therapeutics, Inc. | Kras g12c inhibitors |
| EP3849535A4 (en) | 2018-09-10 | 2022-06-29 | Mirati Therapeutics, Inc. | Combination therapies |
| EA202190749A1 (ru) | 2018-09-10 | 2021-07-09 | Мирати Терапьютикс, Инк. | Способы комбинированной терапии |
| EP3849537B1 (en) | 2018-09-10 | 2024-10-23 | Mirati Therapeutics, Inc. | Combination therapies |
| JP2022500385A (ja) | 2018-09-10 | 2022-01-04 | ミラティ セラピューティクス， インコーポレイテッド | 組み合わせ療法 |
| WO2020085504A1 (ja) | 2018-10-26 | 2020-04-30 | 大鵬薬品工業株式会社 | 光照射ザンドマイヤー反応を用いたクロロアゾールカルボキシレート誘導体の製造方法 |
| MX2021002804A (es) | 2018-12-05 | 2021-07-15 | Mirati Therapeutics Inc | Terapias de combinacion. |
| EP3908283A4 (en) | 2019-01-10 | 2022-10-12 | Mirati Therapeutics, Inc. | KRAS G12C INHIBITORS |
| WO2020231990A1 (en) | 2019-05-13 | 2020-11-19 | Relay Therapeutics, Inc. | Fgfr inhibitors and methods of use thereof |
| MX2022002465A (es) | 2019-08-29 | 2022-05-19 | Mirati Therapeutics Inc | Inhibidores de kras g12d. |
| US12122787B2 (en) | 2019-09-20 | 2024-10-22 | Shanghai Jemincare Pharmaceuticals Co., Ltd | Fused pyridone compound, and preparation method therefor and use thereof |
| WO2021061749A1 (en) | 2019-09-24 | 2021-04-01 | Mirati Therapeutics, Inc. | Combination therapies |
| UA129778C2 (uk) | 2019-10-28 | 2025-07-30 | Мерк Шарп Енд Доум Елелсі | Низькомолекулярні інгібітори g12c-мутантного kras |
| JP7601869B2 (ja) * | 2019-10-30 | 2024-12-17 | ▲勁▼方医▲薬▼科技（上海）有限公司 | 置換された複素環－環系化合物、その調製方法及び医薬への応用 |
| TW202132316A (zh) | 2019-11-04 | 2021-09-01 | 美商銳新醫藥公司 | Ｒａｓ抑制劑 |
| EP4067343A4 (en) | 2019-11-29 | 2024-01-03 | Taiho Pharmaceutical Co., Ltd. | NEW PHENOLIC COMPOUND OR SALT THEREOF |
| PH12022551513A1 (en) | 2019-12-20 | 2023-04-24 | Mirati Therapeutics Inc | Sos1 inhibitors |
| WO2021197499A1 (zh) * | 2020-04-03 | 2021-10-07 | 南京明德新药研发有限公司 | 八氢吡嗪并二氮杂萘啶二酮类化生物 |
| WO2022037630A1 (zh) * | 2020-08-21 | 2022-02-24 | 浙江海正药业股份有限公司 | 四环类衍生物、其制备方法及其医药上的用途 |
| EP4210833A4 (en) | 2020-09-11 | 2024-09-11 | Mirati Therapeutics, Inc. | CRYSTALLINE FORMS OF A KRAS G12C INHIBITOR |
| CA3194067A1 (en) | 2020-09-15 | 2022-03-24 | Revolution Medicines, Inc. | Ras inhibitors |
| TW202233625A (zh) | 2020-11-18 | 2022-09-01 | 美商傳達治療有限公司 | Ｆｇｆｒ抑制劑及其製造及使用方法 |
| JP2023553492A (ja) | 2020-12-15 | 2023-12-21 | ミラティ セラピューティクス， インコーポレイテッド | アザキナゾリン汎ＫＲａｓ阻害剤 |
| EP4262803A4 (en) | 2020-12-16 | 2025-03-12 | Mirati Therapeutics, Inc. | Tetrahydropyridopyrimidine pan-kras inhibitors |
| WO2022143995A1 (zh) * | 2020-12-31 | 2022-07-07 | 正大天晴药业集团股份有限公司 | 四环类化合物及其医药用途 |
| CN116964056B (zh) * | 2021-03-25 | 2026-04-10 | 上海济煜医药科技股份有限公司 | 稠合吡啶酮类化合物盐型、晶型及其应用 |
| CN115124533A (zh) * | 2021-03-26 | 2022-09-30 | 浙江海正药业股份有限公司 | 四环类衍生物、其制备方法和其医药上的用途 |
| CN116848111A (zh) * | 2021-03-26 | 2023-10-03 | 浙江海正药业股份有限公司 | 一种kras抑制剂关键中间体及其制备方法 |
| CN116113632B (zh) * | 2021-03-30 | 2025-08-29 | 浙江海正药业股份有限公司 | 杂环类衍生物、其制备方法及其医药上的用途 |
| WO2022223037A1 (zh) * | 2021-04-22 | 2022-10-27 | 劲方医药科技(上海)有限公司 | Kras抑制剂的盐或多晶型物 |
| WO2023001141A1 (en) * | 2021-07-23 | 2023-01-26 | Shanghai Zion Pharma Co. Limited | Kras g12d inhibitors and uses thereof |
| CN117222654A (zh) * | 2021-09-06 | 2023-12-12 | 苏州赞荣医药科技有限公司 | Kras g12c抑制剂和其用途 |
| WO2023116895A1 (zh) * | 2021-12-24 | 2023-06-29 | 劲方医药科技(上海)有限公司 | Kras抑制剂的多晶型物及其制备方法和用途 |
| CN121466307A (zh) * | 2022-04-01 | 2026-02-06 | 劲方医药科技(上海)股份有限公司 | 药物组合物、其用途及癌症的治疗方法 |
| US12600723B2 (en) | 2022-07-18 | 2026-04-14 | Incyte Corporation | Tetracyclic compounds as DGK inhibitors |
| US12600722B2 (en) | 2022-07-18 | 2026-04-14 | Incyte Corporation | Tetracyclic compounds as DGK inhibitors |
| WO2024081674A1 (en) | 2022-10-11 | 2024-04-18 | Aadi Bioscience, Inc. | Combination therapies for the treatment of cancer |
| WO2025016436A1 (zh) * | 2023-07-19 | 2025-01-23 | 上海济煜医药科技有限公司 | Kras抑制剂的制备方法、其中间体和其中间体的制备方法 |
| CN121773111A (zh) * | 2023-08-15 | 2026-03-31 | 劲方医药科技(上海)股份有限公司 | 吡嗪并萘啶二酮类化合物的制备方法及其中间体 |
| TW202529768A (zh) | 2023-09-29 | 2025-08-01 | 大陸商德昇濟醫藥（無錫）有限公司 | 癌症治療的療法 |
| AU2024361909A1 (en) | 2023-10-20 | 2026-03-26 | Merck Sharp & Dohme Llc | Small molecule inhibitors of kras proteins |
| WO2025256521A1 (zh) * | 2024-06-11 | 2025-12-18 | 上海济煜医药科技有限公司 | 作为kras抑制剂的稠合吡啶酮类化合物的制备方法、中间体及其制备方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3055290B1 (en) * | 2013-10-10 | 2019-10-02 | Araxes Pharma LLC | Inhibitors of kras g12c |
| JO3556B1 (ar) * | 2014-09-18 | 2020-07-05 | Araxes Pharma Llc | علاجات مدمجة لمعالجة السرطان |
| ES2898765T3 (es) * | 2015-04-10 | 2022-03-08 | Araxes Pharma Llc | Compuestos de quinazolina sustituidos y métodos de uso de los mismos |
| US10428064B2 (en) * | 2015-04-15 | 2019-10-01 | Araxes Pharma Llc | Fused-tricyclic inhibitors of KRAS and methods of use thereof |
| RU2722149C1 (ru) * | 2015-09-14 | 2020-05-27 | Пфайзер Инк. | Новые производные имидазо[4,5-c] хинолинов и имидазо[4,5-c][1,5] нафтиридинов в качестве ингибиторов LRRK2 |
| KR20180081596A (ko) * | 2015-11-16 | 2018-07-16 | 아락세스 파마 엘엘씨 | 치환된 헤테로사이클릭 그룹을 포함하는 2-치환된 퀴나졸린 화합물 및 이의 사용 방법 |
| US9988357B2 (en) * | 2015-12-09 | 2018-06-05 | Araxes Pharma Llc | Methods for preparation of quinazoline derivatives |
| US20200010479A1 (en) * | 2017-02-03 | 2020-01-09 | The University Of North Carolina At Chapel Hill | Inhibitors of microbial beta-glucuronidase enzymes and uses thereof |
| EP3621968A1 (en) * | 2017-05-11 | 2020-03-18 | Astrazeneca AB | Heteroaryl compounds that inhibit g12c mutant ras proteins |
| AU2018273356B2 (en) * | 2017-05-22 | 2021-09-16 | Amgen Inc. | KRAS G12C inhibitors and methods of using the same |
| US10597405B2 (en) * | 2017-12-08 | 2020-03-24 | Astrazeneca Ab | Chemical compounds |
| EP3842433B1 (en) * | 2018-01-19 | 2023-11-01 | Medshine Discovery Inc. | Pyridone-pyrimidine derivative acting as krasg12c mutein inhibitor |
| CA3098574A1 (en) * | 2018-05-04 | 2019-11-07 | Amgen Inc. | Kras g12c inhibitors and methods of using the same |
| EP3919483A4 (en) * | 2019-01-29 | 2022-02-09 | Brightgene Bio-medical Technology Co., Ltd. | HETEROCYCLIC BENZOPYRIDONE COMPOUND AND USE THEREOF |
| CN113396147B (zh) * | 2019-05-31 | 2024-06-18 | 上海翰森生物医药科技有限公司 | 芳香杂环类衍生物调节剂、其制备方法和应用 |
| CN112300194B (zh) * | 2019-07-30 | 2022-01-14 | 上海凌达生物医药有限公司 | 一类稠环吡啶酮类化合物、制备方法和用途 |
| JP7601869B2 (ja) * | 2019-10-30 | 2024-12-17 | ▲勁▼方医▲薬▼科技（上海）有限公司 | 置換された複素環－環系化合物、その調製方法及び医薬への応用 |
-
2020
- 2020-09-21 WO PCT/CN2020/116510 patent/WO2021052499A1/zh not_active Ceased
- 2020-09-21 US US17/761,983 patent/US20220389029A1/en active Pending
- 2020-09-21 CA CA3155066A patent/CA3155066A1/en active Pending
- 2020-09-21 MX MX2022003401A patent/MX2022003401A/es unknown
- 2020-09-21 CN CN202410656034.XA patent/CN118619971A/zh active Pending
- 2020-09-21 CN CN202310905052.2A patent/CN116947885B/zh active Active
- 2020-09-21 AU AU2020350745A patent/AU2020350745B2/en active Active
- 2020-09-21 PH PH1/2022/550681A patent/PH12022550681A1/en unknown
- 2020-09-21 KR KR1020227013103A patent/KR20220086573A/ko active Pending
- 2020-09-21 JP JP2022517446A patent/JP7642619B2/ja active Active
- 2020-09-21 CN CN202411842480.6A patent/CN119462689A/zh active Pending
- 2020-09-21 CN CN202411842482.5A patent/CN119591618A/zh active Pending
- 2020-09-21 TW TW109132517A patent/TWI761961B/zh active
- 2020-09-21 CN CN202080078771.6A patent/CN114728968B/zh active Active
- 2020-09-21 EP EP20865331.1A patent/EP4043464A4/en active Pending
- 2020-09-21 BR BR112022005193A patent/BR112022005193A2/pt unknown
-
2022
- 2022-03-17 IL IL291467A patent/IL291467B1/en unknown
- 2022-03-18 CL CL2022000666A patent/CL2022000666A1/es unknown
- 2022-04-12 CO CONC2022/0004686A patent/CO2022004686A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR112022005193A2 (pt) | 2022-08-16 |
| AU2020350745A1 (en) | 2022-04-07 |
| CN119462689A (zh) | 2025-02-18 |
| CA3155066A1 (en) | 2021-03-25 |
| WO2021052499A1 (zh) | 2021-03-25 |
| EP4043464A4 (en) | 2023-10-04 |
| MX2022003401A (es) | 2022-07-13 |
| CO2022004686A2 (es) | 2022-07-08 |
| TWI761961B (zh) | 2022-04-21 |
| CN116947885A (zh) | 2023-10-27 |
| JP2022549171A (ja) | 2022-11-24 |
| PH12022550681A1 (en) | 2023-04-24 |
| CL2022000666A1 (es) | 2022-10-14 |
| US20220389029A1 (en) | 2022-12-08 |
| IL291467A (en) | 2022-05-01 |
| IL291467B1 (en) | 2026-03-01 |
| KR20220086573A (ko) | 2022-06-23 |
| AU2020350745B2 (en) | 2026-03-26 |
| EP4043464A1 (en) | 2022-08-17 |
| TW202126654A (zh) | 2021-07-16 |
| CN114728968B (zh) | 2024-11-15 |
| CN119591618A (zh) | 2025-03-11 |
| CN116947885B (zh) | 2026-01-23 |
| CN114728968A (zh) | 2022-07-08 |
| JP7642619B2 (ja) | 2025-03-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN116947885B (zh) | 稠合吡啶酮类化合物及其制备方法和应用 | |
| WO2023141570A9 (en) | Compounds and methods for the targeted degradation of kras | |
| US11897900B2 (en) | Inhibitors of KEAP1-Nrf2 protein-protein interaction | |
| JP2025081322A (ja) | オルトミクソウイルス感染症を治療するのに有用な縮合三環式ピリダジノン化合物 | |
| AU2017254266B2 (en) | Prodrug of amino acid derivative | |
| JP2021525267A (ja) | ２，３−ジヒドロ−１ｈ−ピロリジン−７−ホルムアミド誘導体およびその使用 | |
| CN117015540A (zh) | 噻吩类化合物及其应用 | |
| US20250382282A1 (en) | Nitrogen-containing saturated heterocyclyl derivative | |
| CA3152836A1 (en) | Substituted urea dihydroorotate dehydrogenase inhibitors | |
| CN113045569B (zh) | 用作ret激酶抑制剂的化合物及其应用 | |
| US12122787B2 (en) | Fused pyridone compound, and preparation method therefor and use thereof | |
| TW202509041A (zh) | 用於治療疾病之ｅｇｆｒ抑制劑 | |
| KR20250073137A (ko) | Egfr 억제제 및 그의 용도 | |
| HK40068840A (en) | Fused pyridone compound, preparation method therefor and use | |
| EA051763B1 (ru) | Конденсированное пиридоновое соединение, способ его получения и его применение | |
| HK40068840B (zh) | 稠合吡啶酮类化合物及其制备方法和应用 | |
| EA053014B1 (ru) | Азотсодержащее насыщенное гетероциклическое кольцевое производное | |
| WO2025199438A1 (en) | 7-azaindazole macrocycles and their use | |
| HK40054771A (en) | Inhibitors of keap1-nrf2 protein-protein interaction | |
| HK40054771B (en) | Inhibitors of keap1-nrf2 protein-protein interaction |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20240910 Assignee: Jinfang Pharmaceutical Technology (Shanghai) Co.,Ltd. Assignor: Shanghai Jiyu Pharmaceutical Technology Co.,Ltd.|JIANGXI JEMINCARE GROUP Co.,Ltd. Contract record no.: X2025980001435 Denomination of invention: Fused pyridone compounds and their preparation methods and applications License type: Common License Record date: 20250113 |
|
| EE01 | Entry into force of recordation of patent licensing contract | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20250402 Address after: 201315, 1st Floor, No. 2, Lane 535, Huanqiao Road, Pudong New Area, Shanghai Applicant after: Shanghai Jiyu Pharmaceutical Technology Co.,Ltd. Country or region after: China Address before: 201203 1st floor, building 1, No. 1118, Halley Road, Pudong New Area pilot Free Trade Zone, Shanghai Applicant before: Shanghai Jiyu Pharmaceutical Technology Co.,Ltd. Country or region before: China Applicant before: JIANGXI JEMINCARE GROUP Co.,Ltd. |
|
| TA01 | Transfer of patent application right | ||
| CB02 | Change of applicant information |
Country or region after: China Address after: 201315, 1st Floor, No. 2, Lane 535, Huanqiao Road, Pudong New Area, Shanghai Applicant after: Shanghai Jiyu Pharmaceutical Technology Co., Ltd. Address before: 1st Floor, No. 2, Lane 535, Huanqiao Road, Pudong New Area, Shanghai Applicant before: Shanghai Jiyu Pharmaceutical Technology Co.,Ltd. Country or region before: China |
|
| CB02 | Change of applicant information | ||
| EM01 | Change of recordation of patent licensing contract |
Change date: 20250924 Contract record no.: X2025980001435 Assignor after: Shanghai Jiyu Pharmaceutical Technology Co.,Ltd. Assignor before: Shanghai Jiyu Pharmaceutical Technology Co.,Ltd. Assignor before: JIANGXI JEMINCARE GROUP Co.,Ltd. |
|
| EM01 | Change of recordation of patent licensing contract |