CN118613478A - Kif18a抑制剂 - Google Patents

Kif18a抑制剂 Download PDF

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Publication number
CN118613478A
CN118613478A CN202380018165.9A CN202380018165A CN118613478A CN 118613478 A CN118613478 A CN 118613478A CN 202380018165 A CN202380018165 A CN 202380018165A CN 118613478 A CN118613478 A CN 118613478A
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CN
China
Prior art keywords
group
membered
pharmaceutically acceptable
general formula
compound according
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Pending
Application number
CN202380018165.9A
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English (en)
Chinese (zh)
Inventor
谢雨礼
吴应鸣
钱立晖
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Wigen Biomedicine Technology Shanghai Co Ltd
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Wigen Biomedicine Technology Shanghai Co Ltd
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Publication of CN118613478A publication Critical patent/CN118613478A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN202380018165.9A 2022-03-17 2023-03-10 Kif18a抑制剂 Pending CN118613478A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN202210266719 2022-03-17
CN2022102667194 2022-03-17
PCT/CN2023/080775 WO2023174175A1 (zh) 2022-03-17 2023-03-10 Kif18a抑制剂

Publications (1)

Publication Number Publication Date
CN118613478A true CN118613478A (zh) 2024-09-06

Family

ID=88022235

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202380018165.9A Pending CN118613478A (zh) 2022-03-17 2023-03-10 Kif18a抑制剂

Country Status (7)

Country Link
US (1) US20250197382A1 (https=)
EP (1) EP4495113A4 (https=)
JP (1) JP2025508192A (https=)
CN (1) CN118613478A (https=)
AU (1) AU2023236101A1 (https=)
CA (1) CA3246028A1 (https=)
WO (1) WO2023174175A1 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20250027560A (ko) * 2022-06-30 2025-02-26 쑤저우 젠하우스 바이오 컴퍼니 리미티드 질소 함유 화합물 및 이의 용도
WO2024022508A1 (zh) * 2022-07-29 2024-02-01 武汉人福创新药物研发中心有限公司 Kif18a抑制剂及用途
TW202416973A (zh) 2022-08-18 2024-05-01 美商雅客森醫療公司 Ｋｉｆ１８ａ抑制劑及其用途
KR20250044780A (ko) * 2022-09-08 2025-04-01 장춘 진사이언스 파마슈티컬 씨오., 엘티디. Kif18a 억제제 화합물, 약제학적 조성물 및 이의 제조 방법과 적용
CN119907796A (zh) * 2022-09-09 2025-04-29 海南先声再明医药股份有限公司 酰胺类化合物、其组合物及用途
CN119562952A (zh) * 2022-09-30 2025-03-04 山东轩竹医药科技有限公司 Kif18a抑制剂
WO2024083208A1 (zh) * 2022-10-21 2024-04-25 杭州邦顺制药有限公司 Kif18a蛋白抑制剂
JP2025538601A (ja) * 2022-11-24 2025-11-28 インベンティスバイオ カンパニー リミテッド 複素環化合物、その製造方法および用途
EP4628486A1 (en) * 2022-12-02 2025-10-08 Shenzhen Zhongge Biological Technology Co., Ltd. Amide or urea compound
CN120641408A (zh) * 2022-12-16 2025-09-12 抟相医药(上海)有限公司 含氮化合物、药物组合物及其用途
WO2024140799A1 (en) * 2022-12-28 2024-07-04 Insilico Medicine Ip Limited Inhibitors of kif18a and uses thereof
WO2024149189A1 (zh) * 2023-01-09 2024-07-18 浙江海正药业股份有限公司 芳香酰胺类衍生物及其制备方法和用途
JP2026509288A (ja) * 2023-03-10 2026-03-17 浙江海正薬業股▲ふん▼有限公司 芳香族アミド誘導体、その製造方法、およびその使用
WO2024217348A1 (zh) * 2023-04-18 2024-10-24 南京同诺康医药科技有限公司 Kif18a抑制剂及其制备方法和用途
WO2025167861A1 (zh) * 2024-02-06 2025-08-14 上海齐鲁制药研究中心有限公司 螺环kif18a抑制剂
WO2025190364A1 (zh) * 2024-03-14 2025-09-18 山东轩竹医药科技有限公司 Kif18a抑制剂及其用途
WO2025201531A1 (zh) * 2024-03-29 2025-10-02 深圳众格生物科技有限公司 三环类化合物及其用途
WO2025242166A1 (en) * 2024-05-22 2025-11-27 InventisBio Co., Ltd. Heterocyclic compounds, preparation methods and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA54543A (fr) * 2018-12-20 2022-03-30 Amgen Inc Inhibiteurs de kif18a
AU2019401495B2 (en) * 2018-12-20 2025-06-26 Amgen Inc. Heteroaryl amides useful as KIF18A inhibitors
JP7686559B2 (ja) * 2018-12-20 2025-06-02 アムジエン・インコーポレーテツド Ｋｉｆ１８ａ阻害剤
EP4007638A1 (en) * 2019-08-02 2022-06-08 Amgen Inc. Pyridine derivatives as kif18a inhibitors
EP4007752B1 (en) * 2019-08-02 2025-09-24 Amgen Inc. Kif18a inhibitors
EP4007753B1 (en) * 2019-08-02 2025-09-24 Amgen Inc. Kif18a inhibitors
MX2022012992A (es) * 2020-04-14 2022-11-08 Amgen Inc Inhibidores de kif18a para el tratamiento de enfermedades neoplasicas.
TW202400582A (zh) * 2022-05-13 2024-01-01 大陸商上海湃隆生物科技有限公司 驅動蛋白kif18a抑制劑及其應用

Also Published As

Publication number Publication date
CA3246028A1 (en) 2025-01-23
AU2023236101A1 (en) 2024-10-31
WO2023174175A1 (zh) 2023-09-21
EP4495113A1 (en) 2025-01-22
US20250197382A1 (en) 2025-06-19
JP2025508192A (ja) 2025-03-21
EP4495113A4 (en) 2026-02-18

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