CN118576673A - Traditional Chinese medicine composition for treating calf viral pneumonia and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating calf viral pneumonia and preparation method and application thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for treating calf viral pneumonia and a preparation method and application thereof, and belongs to the technical field of veterinary medicines. The traditional Chinese medicine composition provided by the invention comprises the following raw materials in parts by weight: 15-20 parts of gentian, 15-20 parts of cape jasmine, 15-20 parts of baical skullcap root, 10-15 parts of Chinese thorowax root, 25-35 parts of dried rehmannia root, 25-35 parts of plantain seed, 15-20 parts of oriental waterplantain rhizome, 25-35 parts of common akebia stem, 10-15 parts of Chinese angelica, 25-35 parts of glabrous greenbrier rhizome, 15-20 parts of yam rhizome, 25-35 parts of dittany bark and 10-15 parts of honey-fried licorice root. The traditional Chinese medicine composition disclosed by the invention can be used for effectively treating calf viral pneumonia, and has the advantages of environment friendliness, safety, no residue, small toxic and side effects, low cost, convenience in production, difficulty in producing drug-resistant bacteria and the like, wherein the antibiotics cannot be used for the environment-friendly and safe treatment of calf viral pneumonia.
Description
Technical Field
The invention belongs to the technical field of veterinary medicines, and particularly relates to a traditional Chinese medicine composition for treating calf viral pneumonia and a preparation method and application thereof.
Background
Calf viral pneumonia is a disease caused by viral infection. The calf is infected with viral pneumonia by virus (such as parainfluenza virus, infectious bovine rhinotracheitis virus, bovine adenovirus, and bovine respiratory syncytial virus). After the lung inflammation is caused after the lung diseases of the calves are caused, the symptoms such as dyspnea, listlessness, anorexia and even abolishment of the calves can be caused, the body is gradually emaciated, the resistance is reduced, bacterial infection is sometimes secondary, the digestive tract diseases are caused, diarrhea and the like are caused, and the condition is further aggravated. If the calves can not be treated in time, the health and the growth and development of the calves can be greatly influenced, and death is caused seriously. At present, the common medicine for treating calf viral pneumonia uses antibiotics. However, the long-term use of antibiotics in large quantities has problems of drug resistance, drug residues and the like.
Disclosure of Invention
In view of the above, the invention aims to provide a traditional Chinese medicine composition for treating calf viral pneumonia, a preparation method and application thereof, and the traditional Chinese medicine composition has good treatment effect on calf viral pneumonia and has no problems of drug resistance, drug residues and the like.
In order to achieve the above object, the present invention provides the following technical solutions:
the invention provides a traditional Chinese medicine composition for treating calf viral pneumonia, which comprises the following raw materials in parts by weight: 15-20 parts of gentian, 15-20 parts of cape jasmine, 15-20 parts of baical skullcap root, 10-15 parts of Chinese thorowax root, 25-35 parts of dried rehmannia root, 25-35 parts of plantain seed, 15-20 parts of oriental waterplantain rhizome, 25-35 parts of common akebia stem, 10-15 parts of Chinese angelica, 25-35 parts of glabrous greenbrier rhizome, 15-20 parts of yam rhizome, 25-35 parts of dittany bark and 10-15 parts of honey-fried licorice root.
Preferably, the material comprises the following raw materials in parts by weight: 16-19 parts of gentian, 16-19 parts of cape jasmine, 16-19 parts of baical skullcap root, 11-14 parts of Chinese thorowax root, 28-32 parts of dried rehmannia root, 28-32 parts of plantain seed, 16-19 parts of oriental waterplantain rhizome, 28-32 parts of common akebia stem, 11-14 parts of Chinese angelica, 28-32 parts of glabrous greenbrier rhizome, 16-19 parts of yam rhizome, 28-32 parts of dittany bark and 11-14 parts of honey-fried licorice root.
Preferably, the material comprises the following raw materials in parts by weight: 18 parts of gentian, 18 parts of cape jasmine, 18 parts of baical skullcap root, 12 parts of Chinese thorowax root, 30 parts of dried rehmannia root, 30 parts of plantain seed, 18 parts of oriental waterplantain rhizome, 30 parts of common akebia stem, 12 parts of Chinese angelica, 30 parts of glabrous greenbrier rhizome, 18 parts of yam rhizome, 30 parts of dittany bark and 12 parts of honey-fried licorice root.
The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps: mixing the Chinese medicine and water, decocting twice, and mixing the filtrates to obtain the Chinese medicine composition.
Preferably, the dosage of the water is 2-5 cm less than that of the traditional Chinese medicine, the decoction temperature is 80-120 ℃, and the decoction time is 10-25 min/time.
The invention also provides application of the traditional Chinese medicine composition or the traditional Chinese medicine composition prepared by the preparation method in preparation of medicines for treating calf viral pneumonia.
Compared with the prior art, the invention has the following beneficial effects:
The traditional Chinese medicine composition can effectively treat calf viral pneumonia, the cure rate reaches 93.33%, and the total effective rate reaches 96.67%. Meanwhile, the method has the advantages of no environment-friendly and safe antibiotics, no residue, small toxic and side effects, low cost, convenient production, difficult generation of drug-resistant bacteria and the like.
Detailed Description
The invention provides a traditional Chinese medicine composition for treating calf viral pneumonia, which comprises the following raw materials in parts by weight: 15-20 parts of gentian, 15-20 parts of cape jasmine, 15-20 parts of baical skullcap root, 10-15 parts of Chinese thorowax root, 25-35 parts of dried rehmannia root, 25-35 parts of plantain seed, 15-20 parts of oriental waterplantain rhizome, 25-35 parts of common akebia stem, 10-15 parts of Chinese angelica, 25-35 parts of glabrous greenbrier rhizome, 15-20 parts of yam rhizome, 25-35 parts of dittany bark and 10-15 parts of honey-fried licorice root.
In the invention, the dosage of the gentian is preferably 16-19 parts, more preferably 18 parts; gentian is bitter and cold; enter liver and gallbladder meridians; has effects of clearing heat, eliminating dampness, and purging liver and gallbladder fire.
The dosage of the gardenia is preferably 16-19 parts, more preferably 18 parts; fructus Gardeniae, which are Chinese medicinal materials, are called yellow Gardebuae fructus, fructus Gardeniae, and Bufonis venenum; bitter and cold properties; it enters heart, lung and triple energizer meridians. Has effects of purging pathogenic fire, relieving restlessness, clearing heat, promoting diuresis, cooling blood, removing toxic substances, and relieving swelling and pain.
The dosage of the baical skullcap root is preferably 16-19 parts, more preferably 18 parts; bai Huang is bitter and cold in nature. It enters lung, gallbladder, spleen, large intestine and small intestine meridians. Baical skullcap root, radix Scutellariae, bitter in flavor and cold in nature, clears away heat and dryness, and enters the lung and large intestine meridians, as well as the gallbladder, spleen and stomach meridians. Not only clearing heat and purging fire to cool blood and stop bleeding, preventing abortion and relieving fever and toxin, but also drying dampness and removing dampness degree to relieve damp-heat toxin. It is an essential herb for damp-heat fire toxin, and is widely indicated for damp-heat fire toxin.
The amount of bupleurum is preferably 11-14 parts, more preferably 12 parts; chai Hu is pungent and bitter in flavor and slightly cold in nature. Has effects of relieving exterior syndrome, dispersing stagnated liver qi, relieving qi stagnation, invigorating yang, relieving heat and preventing malaria.
The amount of the dried rehmannia root is preferably 28 to 32 parts, more preferably 30 parts; sheng Di is sweet in flavor and cold in nature, and enters heart, liver and kidney meridians. Has effects of clearing heat, cooling blood, nourishing yin, and promoting fluid production.
The amount of the semen plantaginis is preferably 28 to 32 parts, more preferably 30 parts; qian Zi is sweet in flavor and cold in nature, enters liver, kidney, lung and small intestine meridians. Has effects of clearing heat, promoting urination, relieving stranguria, eliminating dampness, relieving diarrhea, improving eyesight, and eliminating phlegm.
The dosage of the alisma is preferably 16-19 parts, and more preferably 18 parts; alismatis rhizoma is sweet and bland in flavor and cold in nature, and enters kidney and bladder meridians. Has effects of promoting diuresis, removing dampness, clearing heat, eliminating turbid pathogen, and reducing blood lipid.
The dosage of the clematis stem is preferably 28-32 parts, more preferably 30 parts; chuan mu is bitter in flavor, cold in nature, enters heart, small intestine and bladder meridian. Has effects of inducing diuresis for treating stranguria, clearing heart fire, relieving restlessness, dredging channels and promoting lactation.
The dosage of the angelica is preferably 11-14 parts, more preferably 12 parts; dang Gui is sweet in flavor, pungent in flavor and warm in nature, and enters liver, heart and spleen meridians. Has effects of replenishing blood, promoting blood circulation, regulating menstruation, relieving pain, and loosening bowel to relieve constipation.
The dosage of the glabrous greenbrier rhizome is preferably 28-32 parts, more preferably 30 parts; rhizoma smilacis glabrae is sweet and light in nature, and can calm the liver and stomach meridians. Has effects of removing toxic substances, removing dampness, and relieving joint pain.
The dosage of the yam rhizome is preferably 16-19 parts, more preferably 18 parts; the yam rhizome has bitter and flat property, enters kidney and stomach meridians, and has the effects of promoting diuresis, removing turbid pathogen, dispelling wind and eliminating arthralgia.
The dosage of the dittany bark is preferably 28-32 parts, more preferably 30 parts; di Xian Pi is bitter in flavor and cold in nature. Enter spleen, stomach and bladder meridians. Has effects of clearing heat, eliminating dampness, dispelling pathogenic wind and removing toxic substances.
The amount of the honey-fried licorice root is preferably 11 to 14 parts, more preferably 12 parts. The honey-fried licorice root has the effects of tonifying qi, restoring pulse, tonifying spleen, harmonizing stomach, harmonizing drug property and the like.
The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps: mixing the Chinese medicine and water, decocting twice, and mixing the filtrates to obtain the Chinese medicine composition.
In the invention, the water is preferably used for 2-5 cm of the traditional Chinese medicine, and more preferably 3-4 cm of the traditional Chinese medicine; the temperature of the decoction is preferably 80-120 ℃, and more preferably 90-110 ℃; the time of the decoction is preferably 10 to 25 min/time, more preferably 12 to 22 min/time.
The invention also provides application of the traditional Chinese medicine composition or the traditional Chinese medicine composition prepared by the preparation method in preparation of medicines for treating calf viral pneumonia.
The technical solutions provided by the present invention are described in detail below with reference to examples, but they should not be construed as limiting the scope of the present invention.
Example 1
A traditional Chinese medicine composition for treating calf viral pneumonia consists of the following raw materials in parts by weight: 18 parts of gentian, 18 parts of cape jasmine, 18 parts of baical skullcap root, 12 parts of Chinese thorowax root, 30 parts of dried rehmannia root, 30 parts of plantain seed, 18 parts of oriental waterplantain rhizome, 30 parts of common akebia stem, 12 parts of Chinese angelica, 30 parts of glabrous greenbrier rhizome, 18 parts of yam rhizome, 30 parts of dittany bark and 12 parts of honey-fried licorice root.
The preparation method of the traditional Chinese medicine composition comprises the following steps: mixing the Chinese medicine with 3cm water which is not used for the Chinese medicine, decocting for 15min at the temperature of 100 ℃, decocting the residues obtained by filtering for one time according to the operation, and combining the filtrates obtained by the two times of decoction to obtain the Chinese medicine composition.
Example 2
A traditional Chinese medicine composition for treating calf viral pneumonia consists of the following raw materials in parts by weight: 15 parts of gentian, 15 parts of cape jasmine, 15 parts of baical skullcap root, 10 parts of Chinese thorowax root, 25 parts of dried rehmannia root, 25 parts of plantain seed, 15 parts of oriental waterplantain rhizome, 25 parts of common akebia stem, 10 parts of Chinese angelica, 25 parts of glabrous greenbrier rhizome, 15 parts of yam rhizome, 25 parts of dittany bark and 10 parts of honey-fried licorice root.
The preparation method of the traditional Chinese medicine composition comprises the following steps: mixing the Chinese medicine with water 2cm from which the Chinese medicine is soaked, decocting at 80deg.C for 10min, decocting the residue obtained by filtering again according to the above operation, and mixing the filtrates obtained by the two decoctions to obtain the Chinese medicinal composition.
Example 3
A traditional Chinese medicine composition for treating calf viral pneumonia consists of the following raw materials in parts by weight: 20 parts of gentian, 20 parts of cape jasmine, 20 parts of baical skullcap root, 15 parts of Chinese thorowax root, 35 parts of dried rehmannia root, 35 parts of plantain seed, 20 parts of oriental waterplantain rhizome, 35 parts of common akebia stem, 15 parts of Chinese angelica, 35 parts of glabrous greenbrier rhizome, 20 parts of yam rhizome, 35 parts of dittany bark and 15 parts of honey-fried licorice root.
The preparation method of the traditional Chinese medicine composition comprises the following steps: mixing the Chinese medicine and water which is 5cm away from the Chinese medicine, decocting for 25min at 120 ℃, decocting the residues obtained by filtering again according to the operation, and combining the filtrates obtained by the two decoction to obtain the Chinese medicine composition.
Experimental example 1
1. Epidemiological investigation of calves in a farm:
Diseased calf: 3 months of age
Cough in calves, feverish lung, diarrhea, anorexia, etc.
The weather temperature difference is greatly changed.
2. Normal blood of the sick calf:
TABLE 1 conventional test results table for blood of sick calves
Note that: the above data is bolded as being higher relative to the reference range, underlined as being lower relative to the reference range, "-" indicates no data detected.
3. Biochemical indexes of blood of the sick calf:
TABLE 2 results of detection of biochemical indicators of blood of diseased calves
Note that: the above data is bolded as being higher relative to the reference range and underlined as being lower relative to the reference range.
4. The feeding mode is as follows:
the weight of 120kg calf was used, one pair of the traditional Chinese medicine composition prepared in example 1 was taken daily, and 2 pairs were taken as one treatment course, for 2 treatment courses.
5. The prognosis effect is as follows: as shown in tables 3 and 4, it is clear from table 3 that the lymphocyte, hemoglobin content and average volume of platelets, which are higher in the conventional blood test result, return to the normal range after administration of the Chinese medicinal composition of the present invention, and the hemoglobin, hemoglobin concentration and total number of platelets are significantly reduced although they do not return to the normal range; the total number of red blood cells and the distribution width of red blood cells with lower detection results are also returned to the normal range.
As shown in Table 4, the total protein and the aspartic acid transferase with higher detection results in the biochemical index detection results of blood return to the normal range, and the triglyceride with lower detection results also returns to the normal range after the traditional Chinese medicine composition is taken.
TABLE 3 conventional detection results of blood of sick calf after administration
TABLE 4 results of biochemical index detection of blood of sick calf after administration
Experimental example 2
Clinical efficacy experiment
Clinical observations: the total number of calves is 60, and the calves are all calves with different ages between 60 and 90 days. The groups were randomly divided into 2 groups, i.e., experimental and control groups, 30 heads per group, with no significant differences between the groups.
The experimental method comprises the following steps: the experimental group took the traditional Chinese medicine composition prepared in example 1 one pair per day, taking 2 pairs as one treatment course, and total 2 treatment courses. The control group took the drug florfenicol. The effect of the traditional Chinese medicine composition on treating calf viral pneumonia is observed.
Diagnostic criteria: the clinical characteristics are depression of spirit, appetite drop and body temperature rise; when lying on the ground, the cough and the breathing times are increased, the abdomen type breathing is realized, the auscultation lung has dry or wet rales, and when serious, the mouth opening breathing is realized, the cough with different degrees is realized, and the dyspnea is even failure.
During clinical trial, i.e. before, during and 3 days after administration, 1 day of observation was performed to record the number of coughs, increased respiration, apparent asthma, decreased appetite or promotion, increased body temperature, mental and other systemic symptoms of the tested calf, and whether death occurred.
Determination criteria:
And (3) healing: after administration, the symptoms disappear, the spirit and appetite are normal, the body temperature is normal, no cough is caused, and the respiratory frequency is normal. Auscultatory alveolar sounds are normal, inaudible and dry or wet.
The effect is shown: the symptoms are obviously relieved after the medicine is taken, the spirit is improved, the appetite is normal, the body temperature is reduced, the cough frequency is obviously reduced, the respiratory frequency is basically normal, and the auscultation lung has dry or wet sound.
The traditional Chinese medicine composition has the advantages of alleviating symptoms after administration, improving spirit and appetite, reducing body temperature, reducing cough times, reducing respiratory frequency compared with the case without administration, and enabling auscultation lung to have less sexual or moist rales.
Invalidation criteria: symptoms are unchanged after administration, and aggravated or die.
The administration dose is calculated according to the weight of the sick calf, and the administration is orally carried out. Each dose was administered 1 time before feeding every day and afternoon, and was administered continuously for 5d, and after stopping the administration, observation was continued for 3d. Florfenicol was selected as the positive drug control group. During the treatment period, the tested calves can eat and drink water freely.
Treatment results: the traditional Chinese medicine composition disclosed by the invention has the advantages that the cure rate is 93.33% for treating naturally-occurring calf viral pneumonia, the cure rate is 96.67%, the effective rate is 28, 0,1 and 1, and the total effective rate is 96.67%. The control group heals, shows effect, is effective and ineffective respectively at 28 heads, 1 head, 0 head and 1 head, the cure rate is 93.33% respectively, and the total effective rate is 96.67%. The traditional Chinese medicine composition has the treatment effect on calf pneumonia, can relieve symptoms and reduce death rate. The traditional Chinese medicine composition can achieve the effects of treating diseases and improving survival rate, and has no obvious difference (P is more than 0.05) between clinical cure rate and total effective rate. No adverse reaction is found in the clinical test process, and the treatment effect is equivalent to that of florfenicol.
The embodiment and experimental example show that the traditional Chinese medicine composition has the functions of clearing heat and detoxicating, clearing lung and relieving cough, eliminating phlegm and relieving asthma and the like, and can effectively treat calf viral pneumonia.
The foregoing is merely a preferred embodiment of the present invention and it should be noted that modifications and adaptations to those skilled in the art may be made without departing from the principles of the present invention, which are intended to be comprehended within the scope of the present invention.
Claims (6)
1. The traditional Chinese medicine composition for treating calf viral pneumonia is characterized by comprising the following raw materials in parts by weight: 15-20 parts of gentian, 15-20 parts of cape jasmine, 15-20 parts of baical skullcap root, 10-15 parts of Chinese thorowax root, 25-35 parts of dried rehmannia root, 25-35 parts of plantain seed, 15-20 parts of oriental waterplantain rhizome, 25-35 parts of common akebia stem, 10-15 parts of Chinese angelica, 25-35 parts of glabrous greenbrier rhizome, 15-20 parts of yam rhizome, 25-35 parts of dittany bark and 10-15 parts of honey-fried licorice root.
2. The traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 16-19 parts of gentian, 16-19 parts of cape jasmine, 16-19 parts of baical skullcap root, 11-14 parts of Chinese thorowax root, 28-32 parts of dried rehmannia root, 28-32 parts of plantain seed, 16-19 parts of oriental waterplantain rhizome, 28-32 parts of common akebia stem, 11-14 parts of Chinese angelica, 28-32 parts of glabrous greenbrier rhizome, 16-19 parts of yam rhizome, 28-32 parts of dittany bark and 11-14 parts of honey-fried licorice root.
3. The traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 18 parts of gentian, 18 parts of cape jasmine, 18 parts of baical skullcap root, 12 parts of Chinese thorowax root, 30 parts of dried rehmannia root, 30 parts of plantain seed, 18 parts of oriental waterplantain rhizome, 30 parts of common akebia stem, 12 parts of Chinese angelica, 30 parts of glabrous greenbrier rhizome, 18 parts of yam rhizome, 30 parts of dittany bark and 12 parts of honey-fried licorice root.
4. The method for preparing the traditional Chinese medicine composition as claimed in claim 1, which is characterized by comprising the following steps: mixing the Chinese medicine and water, decocting twice, and mixing the filtrates to obtain the Chinese medicine composition.
5. The preparation method according to claim 4, wherein the water is used in an amount of 2-5 cm less than the traditional Chinese medicine, the decoction temperature is 80-120 ℃, and the decoction time is 10-25 min/time.
6. Use of the traditional Chinese medicine composition according to any one of claims 1-3 or the traditional Chinese medicine composition prepared by the preparation method according to claim 4 or 5 in preparing a medicament for treating calf viral pneumonia.
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