CN118480125A - 抗pd1和抗ctla4抗体 - Google Patents
抗pd1和抗ctla4抗体 Download PDFInfo
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- CN118480125A CN118480125A CN202410423333.9A CN202410423333A CN118480125A CN 118480125 A CN118480125 A CN 118480125A CN 202410423333 A CN202410423333 A CN 202410423333A CN 118480125 A CN118480125 A CN 118480125A
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| JP2022545834A (ja) | 2019-08-30 | 2022-10-31 | クイル ピュージェット サウンド バイオセラピューティクス コーポレーション | 抗ｃｄ２０抗体、抗ｃｄ３７抗体、およびこれらの混合物 |
| US12473349B2 (en) * | 2020-05-06 | 2025-11-18 | Korea University Research And Business Foundation | PD-1 variants having increased PD-L1 affinity |
| CN111875697B (zh) * | 2020-08-03 | 2021-10-01 | 杭州皓阳生物技术有限公司 | 一种包含肽标签的融合蛋白 |
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| WO2023160517A1 (zh) * | 2022-02-22 | 2023-08-31 | 齐鲁制药有限公司 | 包含抗ctla4和抗pd1的混合抗体的药物组合物及其治疗用途 |
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| EE05627B1 (et) * | 1998-12-23 | 2013-02-15 | Pfizer Inc. | CTLA-4 vastased inimese monoklonaalsed antikehad |
| CA2356215C (en) * | 1998-12-23 | 2015-11-24 | Pfizer Inc. | Human monoclonal antibodies to ctla-4 |
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| DK2161336T4 (en) | 2005-05-09 | 2017-04-24 | Ono Pharmaceutical Co | Human monoclonal antibodies for programmed death 1 (PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapies |
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| EP2035456A1 (en) | 2006-06-22 | 2009-03-18 | Novo Nordisk A/S | Production of bispecific antibodies |
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| CN103189392B (zh) | 2010-10-18 | 2016-03-30 | 米迪亚制药有限责任公司 | ErbB3结合抗体 |
| CN103429619B (zh) | 2011-03-17 | 2017-07-28 | 雷蒙特亚特特拉维夫大学有限公司 | 双特异性和单特异性、不对称抗体和其制备方法 |
| CN202105787U (zh) | 2011-06-03 | 2012-01-11 | 杨自强 | 糠粞分离机 |
| AU2012290121B2 (en) | 2011-08-01 | 2015-11-26 | Genentech, Inc. | Methods of treating cancer using PD-1 axis binding antagonists and MEK inhibitors |
| CN102851338A (zh) | 2012-07-25 | 2013-01-02 | 苏州康宁杰瑞生物科技有限公司 | 利用电荷排斥作用制备同二聚体蛋白混合物的方法 |
| UY35148A (es) | 2012-11-21 | 2014-05-30 | Amgen Inc | Immunoglobulinas heterodiméricas |
| EP3486255A3 (en) | 2013-03-13 | 2019-11-13 | Ibentrus Inc. | Protein in which electrical interaction is introduced within hydrophobic interaction site and preparation method therefor |
| SG11201604738TA (en) * | 2013-12-12 | 2016-07-28 | Shanghai Hengrui Pharm Co Ltd | Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof |
| TWI681969B (zh) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對ｐｄ-１的人類抗體 |
| SG11201804839WA (en) * | 2015-12-14 | 2018-07-30 | Macrogenics Inc | Bispecific molecules having immunoreactivity with pd-1 and ctla-4, and methods of use thereof |
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| EP3538137A2 (en) | 2019-09-18 |
| WO2018089293A3 (en) | 2019-01-24 |
| JP7455897B2 (ja) | 2024-03-26 |
| CN110312523A (zh) | 2019-10-08 |
| JP2022119917A (ja) | 2022-08-17 |
| US20220135683A1 (en) | 2022-05-05 |
| WO2018089293A2 (en) | 2018-05-17 |
| US12037397B2 (en) | 2024-07-16 |
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