CN118475356A - 糖衍生物的药物偶联物及其作为衰老细胞裂解剂的用途 - Google Patents
糖衍生物的药物偶联物及其作为衰老细胞裂解剂的用途 Download PDFInfo
- Publication number
- CN118475356A CN118475356A CN202280072208.7A CN202280072208A CN118475356A CN 118475356 A CN118475356 A CN 118475356A CN 202280072208 A CN202280072208 A CN 202280072208A CN 118475356 A CN118475356 A CN 118475356A
- Authority
- CN
- China
- Prior art keywords
- compound
- senescent
- disease
- diseases
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163243539P | 2021-09-13 | 2021-09-13 | |
| US63/243,539 | 2021-09-13 | ||
| PCT/US2022/076360 WO2023039600A1 (en) | 2021-09-13 | 2022-09-13 | Drug conjugates of sugar derivatives and uses thereof as senolytic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN118475356A true CN118475356A (zh) | 2024-08-09 |
Family
ID=85507744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202280072208.7A Pending CN118475356A (zh) | 2021-09-13 | 2022-09-13 | 糖衍生物的药物偶联物及其作为衰老细胞裂解剂的用途 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US20230137021A1 (cg-RX-API-DMAC10.html) |
| EP (1) | EP4380575A4 (cg-RX-API-DMAC10.html) |
| JP (1) | JP2024533426A (cg-RX-API-DMAC10.html) |
| CN (1) | CN118475356A (cg-RX-API-DMAC10.html) |
| AU (1) | AU2022342245A1 (cg-RX-API-DMAC10.html) |
| CA (1) | CA3232213A1 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2023039600A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11897915B2 (en) * | 2021-09-13 | 2024-02-13 | Rubedo Life Sciences, Inc. | Sugar derivatives and uses thereof to prepare novel senolytic agents |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2890981T3 (en) * | 2012-08-28 | 2019-03-04 | Univ Tuebingen Medizinische Fakultaet | Senescence tracers |
| US9993472B2 (en) * | 2014-01-28 | 2018-06-12 | Unity Biotechnology, Inc. | Treatment for osteoarthritis in a joint by administering a means for inhibiting MDM2 |
| JP7419347B2 (ja) * | 2018-04-23 | 2024-01-22 | エイジェックス・セラピューティクス・インコーポレイテッド | 哺乳動物細胞における組織再生の誘導及びセノリシスのための改良された方法 |
| MX2021000395A (es) * | 2018-07-11 | 2021-05-12 | Rubedo Life Sciences Inc | Composiciones senolíticas y usos de las mismas. |
-
2022
- 2022-09-13 CN CN202280072208.7A patent/CN118475356A/zh active Pending
- 2022-09-13 WO PCT/US2022/076360 patent/WO2023039600A1/en not_active Ceased
- 2022-09-13 CA CA3232213A patent/CA3232213A1/en active Pending
- 2022-09-13 US US17/943,824 patent/US20230137021A1/en not_active Abandoned
- 2022-09-13 JP JP2024515577A patent/JP2024533426A/ja active Pending
- 2022-09-13 AU AU2022342245A patent/AU2022342245A1/en active Pending
- 2022-09-13 EP EP22868391.8A patent/EP4380575A4/en active Pending
-
2024
- 2024-05-06 US US18/655,834 patent/US20240299555A1/en not_active Abandoned
-
2025
- 2025-02-10 US US19/049,614 patent/US20250222115A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20240299555A1 (en) | 2024-09-12 |
| AU2022342245A1 (en) | 2024-03-28 |
| EP4380575A1 (en) | 2024-06-12 |
| WO2023039600A1 (en) | 2023-03-16 |
| US20230137021A1 (en) | 2023-05-04 |
| US20250222115A1 (en) | 2025-07-10 |
| JP2024533426A (ja) | 2024-09-12 |
| CA3232213A1 (en) | 2023-03-16 |
| EP4380575A4 (en) | 2025-07-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |