CA3232213A1 - Drug conjugates of sugar derivatives and uses thereof as senolytic agents - Google Patents

Drug conjugates of sugar derivatives and uses thereof as senolytic agents Download PDF

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Publication number
CA3232213A1
CA3232213A1 CA3232213A CA3232213A CA3232213A1 CA 3232213 A1 CA3232213 A1 CA 3232213A1 CA 3232213 A CA3232213 A CA 3232213A CA 3232213 A CA3232213 A CA 3232213A CA 3232213 A1 CA3232213 A1 CA 3232213A1
Authority
CA
Canada
Prior art keywords
compound
disease
diseases
residue
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3232213A
Other languages
English (en)
French (fr)
Inventor
Marco Quarta
Mark A. Gallop
Jeffrey R. JASPER
Paul Keitz
Gus BERGNES
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rubedo Life Sciences Inc
Original Assignee
Rubedo Life Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rubedo Life Sciences Inc filed Critical Rubedo Life Sciences Inc
Publication of CA3232213A1 publication Critical patent/CA3232213A1/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
CA3232213A 2021-09-13 2022-09-13 Drug conjugates of sugar derivatives and uses thereof as senolytic agents Pending CA3232213A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163243539P 2021-09-13 2021-09-13
US63/243,539 2021-09-13
PCT/US2022/076360 WO2023039600A1 (en) 2021-09-13 2022-09-13 Drug conjugates of sugar derivatives and uses thereof as senolytic agents

Publications (1)

Publication Number Publication Date
CA3232213A1 true CA3232213A1 (en) 2023-03-16

Family

ID=85507744

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3232213A Pending CA3232213A1 (en) 2021-09-13 2022-09-13 Drug conjugates of sugar derivatives and uses thereof as senolytic agents

Country Status (7)

Country Link
US (3) US20230137021A1 (cg-RX-API-DMAC10.html)
EP (1) EP4380575A4 (cg-RX-API-DMAC10.html)
JP (1) JP2024533426A (cg-RX-API-DMAC10.html)
CN (1) CN118475356A (cg-RX-API-DMAC10.html)
AU (1) AU2022342245A1 (cg-RX-API-DMAC10.html)
CA (1) CA3232213A1 (cg-RX-API-DMAC10.html)
WO (1) WO2023039600A1 (cg-RX-API-DMAC10.html)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11897915B2 (en) * 2021-09-13 2024-02-13 Rubedo Life Sciences, Inc. Sugar derivatives and uses thereof to prepare novel senolytic agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2890981T3 (en) * 2012-08-28 2019-03-04 Univ Tuebingen Medizinische Fakultaet Senescence tracers
US9993472B2 (en) * 2014-01-28 2018-06-12 Unity Biotechnology, Inc. Treatment for osteoarthritis in a joint by administering a means for inhibiting MDM2
JP7419347B2 (ja) * 2018-04-23 2024-01-22 エイジェックス・セラピューティクス・インコーポレイテッド 哺乳動物細胞における組織再生の誘導及びセノリシスのための改良された方法
MX2021000395A (es) * 2018-07-11 2021-05-12 Rubedo Life Sciences Inc Composiciones senolíticas y usos de las mismas.

Also Published As

Publication number Publication date
US20240299555A1 (en) 2024-09-12
AU2022342245A1 (en) 2024-03-28
EP4380575A1 (en) 2024-06-12
WO2023039600A1 (en) 2023-03-16
CN118475356A (zh) 2024-08-09
US20230137021A1 (en) 2023-05-04
US20250222115A1 (en) 2025-07-10
JP2024533426A (ja) 2024-09-12
EP4380575A4 (en) 2025-07-23

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