JP2024533426A - 糖誘導体の薬物コンジュゲート及び老化細胞除去剤としてのその使用 - Google Patents

糖誘導体の薬物コンジュゲート及び老化細胞除去剤としてのその使用 Download PDF

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Publication number
JP2024533426A
JP2024533426A JP2024515577A JP2024515577A JP2024533426A JP 2024533426 A JP2024533426 A JP 2024533426A JP 2024515577 A JP2024515577 A JP 2024515577A JP 2024515577 A JP2024515577 A JP 2024515577A JP 2024533426 A JP2024533426 A JP 2024533426A
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Japan
Prior art keywords
compound
disease
diseases
methyl
residue
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JP2024515577A
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Japanese (ja)
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JP2024533426A5 (cg-RX-API-DMAC10.html
Inventor
マルコ クアルタ，
マーク エイ． ギャロップ，
ジェフリー アール． ジャスパー，
ポール キーツ，
ガス バーグネス，
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Rubedo Life Sciences Inc
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Rubedo Life Sciences Inc
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Publication of JP2024533426A publication Critical patent/JP2024533426A/ja
Publication of JP2024533426A5 publication Critical patent/JP2024533426A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2024515577A 2021-09-13 2022-09-13 糖誘導体の薬物コンジュゲート及び老化細胞除去剤としてのその使用 Pending JP2024533426A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163243539P 2021-09-13 2021-09-13
US63/243,539 2021-09-13
PCT/US2022/076360 WO2023039600A1 (en) 2021-09-13 2022-09-13 Drug conjugates of sugar derivatives and uses thereof as senolytic agents

Publications (2)

Publication Number Publication Date
JP2024533426A true JP2024533426A (ja) 2024-09-12
JP2024533426A5 JP2024533426A5 (cg-RX-API-DMAC10.html) 2025-09-22

Family

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Family Applications (1)

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JP2024515577A Pending JP2024533426A (ja) 2021-09-13 2022-09-13 糖誘導体の薬物コンジュゲート及び老化細胞除去剤としてのその使用

Country Status (7)

Country Link
US (3) US20230137021A1 (cg-RX-API-DMAC10.html)
EP (1) EP4380575A4 (cg-RX-API-DMAC10.html)
JP (1) JP2024533426A (cg-RX-API-DMAC10.html)
CN (1) CN118475356A (cg-RX-API-DMAC10.html)
AU (1) AU2022342245A1 (cg-RX-API-DMAC10.html)
CA (1) CA3232213A1 (cg-RX-API-DMAC10.html)
WO (1) WO2023039600A1 (cg-RX-API-DMAC10.html)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11897915B2 (en) * 2021-09-13 2024-02-13 Rubedo Life Sciences, Inc. Sugar derivatives and uses thereof to prepare novel senolytic agents

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020014409A1 (en) * 2018-07-11 2020-01-16 Rubedo Life Sciences, Inc. Senolytic compositions and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2890981T3 (en) * 2012-08-28 2019-03-04 Univ Tuebingen Medizinische Fakultaet Senescence tracers
US9993472B2 (en) * 2014-01-28 2018-06-12 Unity Biotechnology, Inc. Treatment for osteoarthritis in a joint by administering a means for inhibiting MDM2
JP7419347B2 (ja) * 2018-04-23 2024-01-22 エイジェックス・セラピューティクス・インコーポレイテッド 哺乳動物細胞における組織再生の誘導及びセノリシスのための改良された方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020014409A1 (en) * 2018-07-11 2020-01-16 Rubedo Life Sciences, Inc. Senolytic compositions and uses thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
"CID 146297652", PUBCHEM [ONLINE], JPN6026027919, 27 June 2020 (2020-06-27), ISSN: 0005900375 *
LINCLAU, BRUNO ET AL.: ""Fluorinated carbohydrates as chemical probes for molecular recognition studies. Current status and", CHEMICAL SOCIETY REVIEWS, vol. 49, no. 12, JPN6026027920, 2020, pages 3863 - 3888, ISSN: 0005900376 *
TRIANA-MARTNEZ, FRANCISCO ET AL.: ""Identification and characterization of Cardiac Glycosides as senolytic compounds"", NATURE COMMUNICATIONS, vol. 10, no. 1, JPN6026027922, 21 October 2019 (2019-10-21), ISSN: 0005900377 *

Also Published As

Publication number Publication date
US20240299555A1 (en) 2024-09-12
AU2022342245A1 (en) 2024-03-28
EP4380575A1 (en) 2024-06-12
WO2023039600A1 (en) 2023-03-16
CN118475356A (zh) 2024-08-09
US20230137021A1 (en) 2023-05-04
US20250222115A1 (en) 2025-07-10
CA3232213A1 (en) 2023-03-16
EP4380575A4 (en) 2025-07-23

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