Purpose of the present invention just is to overcome the inconvenience of taking of present Colla Corii Asini, absorbance is not high, act on single shortcoming, and a kind of taking convenience, absorbance height and action range, effective, the simple health-care food oral liquid of its production technology and production technology thereof are provided.
The present invention realizes like this.
With Colla Corii Asini, Gallus Domesticus, Fructus Lycii is principal agent, makes oral liquid, and three medicines are all gone into Liver and kidney with replenishing vital essence and blood.
The present invention also adds the Lentinus Edodes base of a fruit, Concha Ostreae, Cortex Cinnamomi, Pericarpium Citri Reticulatae, Flos Chrysanthemi, Flos Carthami, Poria, Fructus Crataegi, Radix Glycyrrhizae nine flavor medicines, makes oral liquid with Mel and above all medicines.
The oral liquid that contains the health food of Colla Corii Asini of the present invention, the ratio of its each medicine are (weight portion):
5~20 parts of 50~70 parts of Flos Chrysanthemis of Colla Corii Asini
10~20 parts on 40~60 parts of Flos Carthamis of Gallus Domesticus (removing internal organs)
15~25 parts in 30~50 parts of Poria of Fructus Lycii
20~40 parts of 30~40 portions of Fructus Crataegis of the Lentinus Edodes base of a fruit
20~40 parts in 30~50 portions of Radix Glycyrrhizaes of Concha Ostreae
150~250 parts of 3~10 parts of Mel of Cortex Cinnamomi
15~25 parts of Pericarpium Citri Reticulataes
But restrain into oral liquid about 3.5 milliliters or redilution by drug weight is every.
The oral liquid that contains the health food of Colla Corii Asini of the present invention, the optimal proportion of its each medicine is:
Colla Corii Asini 60kg Flos Chrysanthemi (white Flos Chrysanthemi) 13kg
Gallus Domesticus (removing internal organs) 48kg flower 16kg
Fructus Lycii 42kg Poria 18kg
Lentinus Edodes base of a fruit 36kg Fructus Crataegi 30kg
Concha Ostreae 40kg Radix Glycyrrhizae 30kg
Cortex Cinnamomi 6kg Mel 200kg
Pericarpium Citri Reticulatae 20kg
Making 100000 * 20ml/ props up.
The Lentinus Edodes base of a fruit is the base of a fruit of Lentinus Edodes.
Oral liquid of the present invention is based on Colla Corii Asini, Gallus Domesticus, Fructus Lycii, and three medicines are all gone into Liver and kidney with replenishing vital essence and blood, is the key medicine of flat invigorating the liver and kidney, and the Colla Corii Asini nature and flavor are sweet flat, go into liver, kidney channel, can be nourshing Yin and drynsessmoistening prescription, prove that through modern medicine study the effect of obvious treatment anemia is arranged; The sweet flat matter profit of Fructus Lycii, focus on nourishing the liver and kidney, contain vitamin A, B1, B, C, trace element, calcium, phosphorus, ferrum, and have and suppress fat deposited and promoted hepatocyte new life in hepatocyte function, Gallus Domesticus benefiting vital QI and blood, dredge the meridian passage, the three is the vital essence in the kidney invigorating all, " element is asked golden deficient the truth opinion " " husband essence person, root of life also ".Former ancients claim that the kidney being the origin of congenital constitution, and kidney essense then is bases of dirty negative and positive, Source of life.Cortex Cinnamomi, Xin Gan, big heat is gone into liver, kidney, the heart, spleen, all warps of stomach, and merit is at warming the meridian and promoting blood circulation, and it is supporing yang to mend fire, ancients' cloud " blood gets Wen Zehang, must tremble with fear and coagulate ", this side also has the meaning of supporing yang living the moon with Cortex Cinnamomi.Flos Carthami, hot, warm, go into the heart, liver two warps, merit is at blood circulation promoting and blood stasis dispelling, and two medicines close it, hot Wen Dare, play warming the meridian and promoting blood circulation altogether, the merit of vigor blood stasis dispelling, the product of the above three flavor nourishing essence-bloods of assistant, make YIN and YANG in a relative equilibrium, the passages through which vital energy circulates tonneau, and fresh blood has life, this i.e. " I " " all things on earth is born cloudy and armful sun ", and " easily biography " " the meaning road of monoyin and monoyang " is also, Lentinus Edodes base of a fruit property and flavor of peppery and warm in the side, can warming YANG eliminating stagnation, also can QI invigorating and abnormal smells from the patient is thick and heavy, can strengthen the effect of Cortex Cinnamomi and Flos Carthami.Crataegolic acid is sweet, and tepor is gone into spleen, stomach, Liver Channel, can promoting digestion and removing stagnation, and dispelling the stagnated QI clots absorbing and manage irritability.Flos Chrysanthemi, sweet in the mouth, little hardship is gone into lung, liver two warps, can dredge the gas heat radiation, and suppressing the hyperactive liver makes eye bright.Concha Ostreae is salty and bitter, is slightly cold, and goes into liver, gallbladder, stomach warp, and merit causes palpitation and restlessness, fidgety being insomnia effectively in the tonifying YIN YANG hyperactivity suppressing to deficiecny of liver-YIN.Poria, nature and flavor are sweet flat, go into spleen, stomach, the heart, lung, all warps of kidney.Pericarpium Citri Reticulatae, nature and flavor suffering, sweet, warm is gone into spleen, lung two warps, but the spleen invigorating eliminating dampness by diuresis that two medicines close, the invigorating middle warmer mind calming with Fructus Crataegi, Flos Chrysanthemi, Concha Ostreae compatibility, makes blood stored in the liver and catharsis, The spleen governs the blood and fortune, the liver spleen is in harmonious proportion that then gas is spontaneous.Radix Glycyrrhizae, nature and flavor are sweet, flat, go into 12 warps, merit is in the spleen invigorating invigorating middle warmer, mind tranquilizing and the heart calming, clearing away heat and expelling pathogen in the exterior, coordinating the actions of various ingredients in a prescription, again with Mel and above all medicines, play compensate qi and blood altogether, the effect of building body.
Oral liquid of the present invention through acute toxicity test, long term toxicity test, bone marrow micronucleus test, sperm malformation test, Salmonella reversion test, does not see that toxic and side effects and three causes reaction.
The production technology that contains the health-care food oral liquid of Colla Corii Asini of the present invention is:
(1) gets dried Concha Ostreae, clean, be cut into bulk, soaked one day, get Gallus Domesticus (removing internal organs) and be cut into bulk, both merge, and add water to 10 times of medication amount, boil 2 hours, filter, and filtering residue adds 5 times of water boils 1~2 hour, filter, carry altogether 2~3 times, merge each time filtrate, remove oil reservoir, cross 100 mesh sieves;
2. get Fructus Lycii, the Lentinus Edodes base of a fruit, Cortex Cinnamomi, Pericarpium Citri Reticulatae, Flos Chrysanthemi, Flos Carthami, Poria, Fructus Crataegi, Radix Glycyrrhizae, add the water of 2~3 times of amounts of medical material, soaked one day, the water that adds 2~3 times of amounts of medical material again boiled 2 hours, filtered, filtering residue adds the water boil 1~2 hour of 3 times of medical material amounts, carries altogether 2~3 times; Merge each time filtrate, cross 80 mesh sieves;
(3) concentrate by vacuum concentrator, be not less than 1.02 to proportion;
(4) get the Colla Corii Asini stock solution of Donga, Shandong glue group in addition, cross 120 mesh sieves, mix with concentrated solution, mixed liquor is in 0~4 ℃, and cold preservation is standby;
(5) add winter honey, warm fire refines non-foam to the solution, removes the foam on upper strata, mixes with above-mentioned mixed liquor, and adding distil water is to full dose, in 60~80 ℃ of plate-and-frame filtration to clarification;
(6) fill, sterilization, promptly.
The invention will be further described below in conjunction with embodiment.Embodiment 1 (following weight is unit with kg, and volume is unit with ml): Colla Corii Asini 60 Flos Chrysanthemis (white Flos Chrysanthemi) are spent 16 Fructus Lycii, 42 Poria, the 18 Lentinus Edodes bases of a fruit, 36 Fructus Crataegis, 30 Concha Ostreaes, 40 Radix Glycyrrhizaes, 30 Cortex Cinnamomis, 6 Mel, 200 Pericarpium Citri Reticulataes 20 to make 100000 * 20ml/ and are propped up by 13 Gallus Domesticuss (removing internal organs) 48.Embodiment 2: Colla Corii Asini 60 Fructus Lycii, 40 Gallus Domesticuss (removing internal organs) 40 Mel 150 all the other with embodiment 1.Embodiment 3: the Colla Corii Asini 65 Lentinus Edodes bases of a fruit, 45 Gallus Domesticuss (removing internal organs) 50 Concha Ostreaes 50 Fructus Lycii 50 Cortex Cinnamomis 10 all the other with embodiment 1.Embodiment 4: Colla Corii Asini 50 Flos Chrysanthemis, 15 Gallus Domesticuss (removing internal organs) 40 are spent 20 Fructus Lycii, 30 Poria, the 25 Lentinus Edodes bases of a fruit, 30 Fructus Crataegis, 40 Concha Ostreaes, 50 Radix Glycyrrhizaes, 40 Cortex Cinnamomis, 10 Mel 250
Pericarpium Citri Reticulatae 25
Use 1 pair of iron deficiency anemia of embodiment and as follows: get 163 routine iron deficiency anemia persons to leukopenia crowd's experimental result, be divided into two groups at random, be 1 group of (experimental group) 114 example of embodiment, solid E-gelatin group (matched group) 49 examples, before and after the relevant index experiment such as the subjective symptoms that observed result is two groups, erythrocyte, hemoglobin, serum levels of iron notable difference, P<0.0005 are arranged all.Prompting embodiment 1 or solid E-gelatin have good experiment effect to iron deficiency anemia, the clinical effectiveness synthetic determination between two groups, and the former is 68.9% for its total effective rate, the latter is a zero difference between 67.3%, two group, P>0.5.Prompting embodiment 1 or solid E-gelatin are identical to the experiment effect of ischemia anemi.In the research of utilization embodiment 1, solid E-gelatin experiment leukopenia 57 examples, be divided into experimental group (embodiment 1) 34 examples at random, matched group (solid E-gelatin) 23 examples, two groups age, body constitution, the state of an illness etc. are basic identical.Experimental result, the variation of two groups symptom, total white blood cells, neutrophilic granulocyte counting, all there were significant differences (P<0.0005~0.01) before and after using.Clinical effectiveness synthetic determination, total effective rate experimental group are 79.4%, and matched group is 78.2%, two group of zero difference of comparing (P>0.5), and embodiment 1 is identical with solid E-gelatin on clinical effectiveness in prompting.
The health-care food oral liquid delicious taste that contains Colla Corii Asini of the present invention, easy to use, be superior to solid E-gelatin, simultaneously, experiment shows that oral liquid of the present invention is better than solid E-gelatin to rapid relieving fatigue, the aspect that regains one's strength.