CN118451088A - 化合物的制造方法、化合物文库的制造方法、化合物文库及筛选方法 - Google Patents

化合物的制造方法、化合物文库的制造方法、化合物文库及筛选方法 Download PDF

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Publication number
CN118451088A
CN118451088A CN202280081706.8A CN202280081706A CN118451088A CN 118451088 A CN118451088 A CN 118451088A CN 202280081706 A CN202280081706 A CN 202280081706A CN 118451088 A CN118451088 A CN 118451088A
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China
Prior art keywords
amino acid
limf
acid sequence
peptide
compound
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Pending
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CN202280081706.8A
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English (en)
Chinese (zh)
Inventor
菅裕明
后藤佑树
张宇琛
冈田正弘
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University of Tokyo NUC
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University of Tokyo NUC
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Publication of CN118451088A publication Critical patent/CN118451088A/zh
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN202280081706.8A 2021-10-19 2022-10-19 化合物的制造方法、化合物文库的制造方法、化合物文库及筛选方法 Pending CN118451088A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2021-170768 2021-10-19
JP2021170768 2021-10-19
PCT/JP2022/038924 WO2023068296A1 (ja) 2021-10-19 2022-10-19 化合物の製造方法、化合物ライブラリーの製造方法、化合物ライブラリー及びスクリーニング方法

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Publication Number Publication Date
CN118451088A true CN118451088A (zh) 2024-08-06

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CN202280081706.8A Pending CN118451088A (zh) 2021-10-19 2022-10-19 化合物的制造方法、化合物文库的制造方法、化合物文库及筛选方法

Country Status (6)

Country Link
US (1) US20250320471A1 (https=)
EP (1) EP4431519A4 (https=)
JP (1) JPWO2023068296A1 (https=)
CN (1) CN118451088A (https=)
CA (1) CA3236034A1 (https=)
WO (1) WO2023068296A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025089420A1 (ja) * 2023-10-25 2025-05-01 国立大学法人東京大学 環状化合物の製造方法、化合物ライブラリーの製造方法、スクリーニング方法、及び環状化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5605602B2 (ja) 2007-03-26 2014-10-15 国立大学法人 東京大学 環状ペプチド化合物の合成方法
EP2647721B1 (en) 2010-12-03 2019-02-27 The University of Tokyo Peptide with safer secondary structure, peptide library, and production methods for same
JP6754997B2 (ja) 2013-08-26 2020-09-16 国立大学法人 東京大学 大環状ペプチド、その製造方法、及び大環状ペプチドライブラリを用いるスクリーニング方法
US20220275534A1 (en) 2018-10-17 2022-09-01 The University Of Tokyo Peptide Library Production Method

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JPWO2023068296A1 (https=) 2023-04-27
WO2023068296A1 (ja) 2023-04-27
CA3236034A1 (en) 2023-04-27
EP4431519A1 (en) 2024-09-18
EP4431519A4 (en) 2025-12-03
US20250320471A1 (en) 2025-10-16

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